Clinical trials: Pre-diabetic State
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS)
Isoleucine Addition Treatment Effects in a Controlled Diet Study
The primary purpose of this study is to determine whether isoleucine repletion attenuates increases in insulin sensitivity typically observed when people with obesity follow a healthy, low-isoleucine diet.
- Conditions
- Prediabetes (Insulin Resistance, Impaired Glucose Tolerance), Metabolic Syndrome (MetS), Obesity & Overweight
- Trial name
- ISOLATE (NCT07329088)
- Testing
- L-Isoleucine, Low-isoleucine diet
- Where
- United States
- Sponsor
- Jean L. Fry
Type 2 Diabetes, PreDiabetes
The Sunnybrook Type 2 Diabetes Study
The Sunnybrook Type 2 Diabetes Study (S2DS) is a prospective observational study of people with prediabetes or Type 2 Diabetes Mellitus (T2DM), that aims to understand the aetiologies, manifestations, and clinical consequences of…
- Trial name
- S2DS (NCT04455867)
- Testing
- Diabetes Exercise and Healthy Lifestyle Program, Outpatient care
- Where
- Canada
- Volunteers
- 500 people
- Sponsor
- Sunnybrook Health Sciences Centre
Prediabetic State
Evaluation of a Community Health Program for the Prevention of Type 2 Diabetes and Other Cardio-metabolic Risk Factors in Adults: Districts of Barranquilla and Bogota, Colombia - January 2017 - December 2019
The main aim of this study is to evaluate the feasibility and effectiveness of a program for modifying lifestyles for diabetes prevention type 2 and control cardio-metabolic risk factors in adults with different categories of…
- Trial name
- PREDICOL (NCT03049839)
- Testing
- Intervention_ S, Intervention_ I, Intervention_ C
- Where
- 2 sites in Colombia
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Universidad del Norte
Prediabetic State
Minnesota Medicaid Incentives to Prevent Chronic Disease
The objective of this study is to test whether two different participant financial incentive structures are more effective and cost effective than minimal financial incentives in increasing weight loss among Minnesota Medicaid…
- Trial name
- MMIPCD (NCT02422420)
- Testing
- Financial Incentives
- Where
- United States
- Volunteers
- 1,500 people
- Sponsor
- Minnesota Department of Human Services
Diabetes, Gestational, PreDiabetes
A Pragmatic Approach to Lower Diabetes Risk After Gestational Diabetes
This study is testing whether daily metformin for 1 year postpartum can reduce risk of diabetes in patients who had gestational diabetes.
- Conditions
- Diabetes, Gestational, PreDiabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT05280496
- Testing
- Metformin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Tufts Medical Center
Prediabetic State
Rimonabant In Prediabetic Subjects To Delay Onset Of Type 2 Diabetes
Primary objective: To evaluate the effect of long-term administration of Rimonabant on the time of progression to type 2 diabetes in patients with prediabetes (i.e.
- Trial name
- RAPSODI (NCT00325650)
- Testing
- Rimonabant
- Where
- United States
- Volunteers
- 2,420 people
- Sponsor
- Sanofi
Diabetes Mellitus
Exercise, Prediabetes and Diabetes After Renal Transplantation.
This study is designed to evaluate the feasibility of exercise to reverse prediabetes after transplantation to prevent Posttransplantation Diabetes Mellitus (PTDM).
- Trial name
- EXPRED (NCT04489043)
- Testing
- Exercise and healthy lifestyle recommendations
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario de Canarias
PreDiabetes
CGM-Enhanced DPP to Prevent Type 2 Diabetes in Adults With Prediabetes
Prediabetes affects over one-third of adults in the United States, placing them at a higher risk for developing type 2 diabetes and heart disease, which can lead to serious health complications and increased medical costs.
- Trial name
- CGM-DPP (NCT07140848)
- Testing
- CGM-DPP, Control
- Where
- United States
- Volunteers
- 214 people
- Sponsor
- State University of New York at Buffalo
Prediabetes
Evaluation of Chiglitazar Sodium With Lifestyle Intervention for Reversing Prediabetes
This multicenter, randomized, double-blind, placebo-controlled trial aims to evaluate the efficacy and safety of Chiglitazar Sodium combined with lifestyle intervention for reversing prediabetes to normal glucose metabolism.
- Trial name
- NCT07558525
- Testing
- Chiglitazar sodium
- Where
- 30 sites in China
- Volunteers
- 472 people
- Sponsor
- Second Xiangya Hospital of Central South University
Obesity
Effect of Electroacupuncture on Obesity
The investigators describe a protocol for a randomized controlled trial to find out the effect and safety of electroacupuncture on losing weight in obese patients with prediabetes.
- Trial name
- NCT05237089
- Testing
- Electroacupuncture, Health education
- Where
- China
- Volunteers
- 256 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Over Age 60, Prediabetes or Overweight
Curcumin Supplementation for the Improvement of Diabetes-related Outcomes
The goal of this clinical trial is to learn about, test, and compare health outcomes of curcumin supplementation (400 mg). Two primary hypotheses are: 1.
- Trial name
- CUR-T2D (NCT06984640)
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Prediabetes
Establishing a Virtual Health Community Management Model for Pre-Diabetes Patients
This study builds upon the previously developed virtual health community platform, aiming to address the group characteristics and psychological traits of prediabetic patients.
- Trial name
- NCT07354997
- Testing
- Pre-diabetes Virtual Community
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Bread, Hyperglycemia
Bread Replacement - Facing the Challenge to Improve Its Quality for Better Metabolic Health
This is a multicenter study testing the effect of bread containing beta-glucan on glycemic control in participants with intermediate hyperglycemia.
- Conditions
- Bread, Hyperglycemia, Glycemic Control, PreDiabetes
- Trial name
- NCT04994327
- Testing
- Beta-glucan bread
- Where
- Norway
- Volunteers
- 155 people
- Sponsor
- University of Bergen
Prediabetes
Impact of No-carrageenan Diet on Glucose Tolerance in Prediabetes
Participants will be randomly assigned to either regular or no-carrageenan prepared diets to determine whether the no-carrageenan leads to improvement in glucose tolerance. Hemoglobin A1c is the primary outcome measure.
- Trial name
- NCT02720393
- Testing
- No-carrageenan diet, Regular Diet
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Illinois Chicago
PreDiabetes
Almonds and Cognitive Functions
Initial Recruitment and Sensitization: In this free-living randomized control parallel arm study of 24 weeks of almond intervention, we shall recruit apparently healthy middle aged (age range 40-60 years)prediabetic Asian Indians…
- Trial name
- NCT05322304
- Testing
- Almond
- Where
- India
- Volunteers
- 60 people
- Sponsor
- Diabetes Foundation, India
Obesity, Overweight
The Influence of Physical Activity on the Gut Microbiome of Pre-Diabetic Adults
The present study is a 100-participant randomized controlled 2-arm parallel trial that employs a metagenomic approach to examine how 8 weeks of supervised moderate-intensity treadmill walking exercise (MWE) for 30-45 min 3…
- Conditions
- Obesity, Overweight, Overweight and Obesity, PreDiabetes
- Trial name
- NCT04931836
- Testing
- Physical Activity Intervention
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- University of Minnesota
Prediabetes, Prediabetic State
Feasibility and Preliminary Effects of Fasting-Mimicking Diet in Asian Americans With Prediabetes
This is a pilot study to determine the feasibility of studying the Fasting-Mimicking Diet (FMD), a dietary approach that involves the consumption of a specifically formulated, calorie-restricted nutrition regimen with a…
- Trial name
- NCT06518798
- Testing
- Fasting Mimicking Diet
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of California, Irvine
Prediabetes
Effects of a Mediterranean Diet With Sequential Cycling and Rowing Exercise on Blood Sugar in Women With Prediabetes or Prediabetes Remission
The goal of this clinical trial is to learn how a Mediterranean-style diet, with and without added exercise, affects blood sugar control in women with prediabetes.
- Trial name
- NCT07326891
- Testing
- Mediterranean Diet, Supervised Sequential Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Begüm Yücesoy Güneysu
Diabetes, Diabetes Mellitus, Type 1 Diabetes
Argus 2.0 Adoption Study
This study evaluates the usability of the KOS Argus Continuous Glucose Monitoring (CGM) System, a noninvasive, wrist-worn device that estimates blood glucose levels using light-based sensors and artificial intelligence…
- Conditions
- Diabetes, Diabetes Mellitus, Type 1 Diabetes, Diabetes Mellitus, Type 2, Prediabetes
- Trial name
- NCT07425236
- Testing
- KOS Argus Continuous Glucose Monitoring System
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- KOS Inc.
PCOS, Infertility
Glucose Metabolism and Live Birth Outcomes in PCOS
Polycystic ovary syndrome (PCOS) is a common endocrine and reproductive disorder in which insulin resistance (IR) is proposed as a key pathophysiological feature of the disease's symptoms and consequences.
- Conditions
- PCOS, Infertility, Diabetes, PreDiabetes
- Trial name
- NCT04364087
- Testing
- Oral glucose tolerance test
- Where
- Vietnam
- Volunteers
- 1,208 people
- Sponsor
- Mỹ Đức Hospital