Clinical trials: Pre-diabetic State
Cystic Fibrosis, Prediabetes
Prevention of Cystic Fibrosis Diabetes
Acute systemic hyperglycemia causes oxidative stress and a pro-inflammatory response. The pro-inflammatory cytokines induced by hyperglycemia are toxic to islet insulin producing cells, and thus worsen glucose intolerance.
- Trial name
- Prevent (NCT00967798)
- Testing
- Sitagliptin
- Where
- 3 sites in United States
- Volunteers
- 33 people
- Sponsor
- Emory University
Prediabetic State
Effect of Exercise on Insulin Resistance
The purpose of this study is to evaluate the effect of exercise on Insulin Resistance (IR) in subjects who do not routinely exercise and who are at risk of developing diabetes (prediabetes).
- Trial name
- EFFORT (NCT01941277)
- Testing
- Current Recommendations Exercise Group, Intensive Exercise Group
- Where
- 2 sites in United Kingdom
- Volunteers
- 3 people
- Sponsor
- Alere San Diego
Type 2 Diabetes
Characterization of the Variability Of Insulin Secretory Parameters in the Meal Tolerance and the Maximal Stimulation Tests of Subjects With Prediabetes
A multi-year clinical study to improve tools for measuring the function of insulin-producing beta cells in people with type 2 diabetes mellitus.
- Trial name
- NCT01663207
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Foundation for the National Institutes of Health
Prediabetic State
Efficacy and Safety of Vildagliptin in Subjects With Impaired Glucose Tolerance
The purpose of this study is to assess the safety and effectiveness of vildagliptin, an unapproved drug, compared to placebo in lowering post-meal blood glucose levels in people with pre-diabetes who have high blood sugar levels…
- Trial name
- NCT00237250
- Testing
- vildagliptin
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- Novartis
Metabolic Syndrome, Prediabetes
Effects of Postprandial Walking and Resistance Snacking on Glucose Responses in Adults With Metabolic Syndrome
This study will examine whether light physical activity after meals can improve 24-hour glucose responses in adults with metabolic syndrome and prediabetes.
- Trial name
- BITE (NCT07620886)
- Testing
- Postprandial walking, Brief resistance exercise snacks
- Volunteers
- 25 people
- Sponsor
- Seoul National University
PreDiabetes, Diabetes Mellitus, Type 2
Continuous Glucose Monitoring for Glucose and Weight Management in Prediabetes and Non-severe Type 2 Diabetes: A Prospective Community-based (Workplace) Cohort Study
This study aimed to evaluate the effectiveness of use of Continuous Glucose Monitoring (CGM), combined with personalized dietary education and use of smartphone applications in improving glucose control and weight management.
- Trial name
- NCT06542627
- Testing
- Freestyle Libre
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- Kangbuk Samsung Hospital
Diabetes Mellitus
Comparison of Cognitive and Motor Dual Task Performance in Individuals With Prediabetes and Diabetes
The aim of this study is to compare the dual task task in individuals with prediabetes and diabetes. According to the results of this study, if there is a difference in dual-task performances and other conditions between people…
- Trial name
- NCT05203042
- Volunteers
- 46 people
- Sponsor
- Bartın Unıversity
Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
Resistance Training for the Improvement of Glycemic Control in Prediabetes
The purpose of this research is to study the effects of resistance exercise training with different degrees of effort on your glucose responses (what we call glycemic control) and psychological responses.
- Trial name
- NCT06697756
- Testing
- High-effort resistance exercise training, Low-effort resistance exercise training
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of New Mexico
PreDiabetes, Prediabetic State
Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes
The goal of this randomized pilot clinical trial is to describe the feasibility of a couple-based lifestyle intervention and the study protocol in preparation for a future definitive randomized clinical trial.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05695170
- Testing
- PreventT2 (Individual intervention), PreventT2 Together (Couple-based intervention)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
Prediabetes, Metabolic Syndrome
Evaluation of Group Lifestyle Balance DVD in Primary Care Practice
The purpose of this study is to examine different methods of delivering the Group Lifestyle Balance (GLB) intervention (1). The GLB is a 12-week lifestyle change program based on the highly successful lifestyle program that was…
- Trial name
- STEPUP (NCT00480779)
- Testing
- GLB Group, GLB DVD
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Pittsburgh
Overweight, Obesity
Effects of Obex in Overweight and Obese Patients
Obesity is an important and growing public health worldwide Obesity is highly related to the development of metabolic syndrome, diabetes, cardiovascular diseases and cancer An extensive body of evidence from efficacy trials has…
- Trial name
- NCT02145442
- Testing
- Obex
- Where
- Cuba
- Volunteers
- 40 people
- Sponsor
- Catalysis SL
Prediabetic State, Obesity
The PRE-D Trial: Effect of Dapagliflozin, Metformin and Physical Activity in Pre-diabetes
The overall objective is to compare the short-term (3 months) effectiveness of three glucose-lowering interventions (dapagliflozin, metformin and physical activity) on glucose variability, body composition, and cardiometabolic…
- Trial name
- NCT02695810
- Testing
- Dapagliflozin, Metformin, Exercise
- Where
- Denmark
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Steno Diabetes Center Copenhagen
Insulin Resistance, Prediabetic State
Human Models of Selective Insulin Resistance: Alpelisib, Part I
The goal of this clinical trial is to understand how the blood sugar-lowering hormone insulin works in healthy adults versus those who are at risk for type 2 diabetes.
- Conditions
- Insulin Resistance, Prediabetic State, Overweight and Obesity, Non-Alcoholic Fatty Liver Disease
- Trial name
- NCT06354088
- Testing
- Alpelisib 300 mg, [1-13C] sodium acetate, [6,6-2H2] D-glucose
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Columbia University
Elevated Body Mass Index
Effect of LIK066 on Body Weight in Patients With Elevated Body Mass Index
A 12-week study to assess LIK066 effect on body weight in diabetics, prediabetics and normoglycemic patients with elevated body mass index (BMI)
- Trial name
- NCT02470403
- Testing
- LIK066
- Where
- United States
- Volunteers
- 181 people
- Sponsor
- Novartis Pharmaceuticals
PreDiabetes
Metformin and Vascular Function in Prediabetes
The goal of this clinical trial is to investigate whether metformin improves vascular function in individuals with prediabetes. The main questions it aims to answer are: 1.
- Trial name
- NCT06526494
- Testing
- Metformin
- Where
- 2 sites in United States
- Sponsor
- Diana Jalal
Diabetes, Prediabetes
Effect of Whole Grain Diet on Insulin Sensitivity, Advanced Glycation End Products and Inflammatory Markers in Pre-diabetes
Food products derived from cereal grains constitute a major part of the daily diet of many Americans . For example, a typical Chinese American eats rice about 9.5 times a week on an average.
- Trial name
- NCT01248286
- Testing
- Whole grain rice, Refined grain rice
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Prediabetes, Intermittent Fasting
The Effects of Intermittent Fasting on Anthropometric Measurements and Metabolic Parameters in Prediabetic Patients
The goal of this randomized controlled trial is to learn about the short-term effects of an 8-hour time-restricted eating (TRE) protocol combined with caloric restriction in women aged 18-55 years with prediabetes.
- Conditions
- Prediabetes, Intermittent Fasting, Weight
- Trial name
- NCT07713394
- Testing
- Intermittent fasting, Caloric restriction
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Ataturk University
PreDiabetes
Effects of Allium Hookeri on Blood Glucose
The researchers investigated the anti-diabetic effects of Allium hookeri root extract for Korean prediabetic participants.
- Trial name
- NCT03330366
- Testing
- Allium hookeri extract
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
Prediabetes
Tangningtongluo Tablet for People With Prediabetes
Prediabetes is an intermediate transition to hyperglycemia between normal blood glucose and diabetes, including impaired fasting glucose (IFG), impaired glucose tolerance (IGT)and the presence of a combination of the two.
- Trial name
- NCT05126251
- Testing
- Tangningtongluo tablet, lifestyle intervention
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Beijing University of Chinese Medicine
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center