Clinical trials: Pre-diabetic State
Psoriasis, Plaque Psoriasis
Role of Insulin Action in Psoriasis Pathogenesis
The goal of this study is to collect more information from people with plaque psoriasis and to determine if insulin plays a role in the pathogenesis of psoriasis.
- Conditions
- Psoriasis, Plaque Psoriasis, Insulin Resistance, PreDiabetes
- Trial name
- NCT06242847
- Testing
- Oral glucose tolerance test (OGTT), Skin punch biopsy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Columbia University
PreDiabetes
Attitudes of General Practitioners in Lorraine Towards Prediabetes
Screening for the risk factors of type 2 diabetes is a part of the primary prevention approach. Pre-diabetes is one of the modifiable risk factors; however, it remains under-diagnosed.
- Trial name
- PréDiabMedG (NCT05473078)
- Testing
- online anonymous exploratory study
- Where
- France
- Volunteers
- 162 people
- Sponsor
- Central Hospital, Nancy, France
PreDiabetes, Prediabetic State
Use of Empagliflozin to Treat Prediabetes
The overall purpose of this study is to identify how empagliflozin (a drug commonly used to treat type 2 diabetes) impacts skeletal muscle metabolic health among adults with prediabetes.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05426525
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Oregon State University
Prediabetes / Type 2 Diabetes
Health Assessment of Low Glycaemic Index - High Protein Rice to Enhance Glycemic Control Through Nutrition
Type 2 Diabetes (T2D) represents a critical public health challenge in Singapore, with prevalence projected to reach one million residents by 2050.
- Trial name
- HARVEST (NCT07663123)
- Testing
- Functional rice variaties
- Volunteers
- 225 people
- Sponsor
- Institute for Human Development and Potential (IHDP), Singapore
Type 1 Diabetes, Prediabetic State
Trial of Early Initiation of CGM-Guided Insulin Therapy in Stage 2 T1D
This protocol is an intervention study to determine the best education and monitoring strategy for children ages 2-20 years with pre-symptomatic type 1 diabetes (T1D) because there currently exists no clinical guidelines for…
- Conditions
- Type 1 Diabetes, Prediabetic State, Dysglycemia, Autoimmune Diabetes
- Trial name
- TESS (NCT04335513)
- Testing
- Early CGM-guided education and initiation of insulin therapy., Usual care: glucometer surveillance and basic education.
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pre-diabetes
Diabetes Prevention Program Pilot
This initiative, which is a partnership between State College area Penn State Health ambulatory care clinics located off campus in the State College area, has two primary goals: 1) improve the health and quality of life of Penn…
- Trial name
- NCT04651816
- Testing
- Financial Incentives, Motivational Message, DPP Program
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Penn State University
Prediabetes
Exploring Unconventional Plant-Derived Metabolites for Glycemic Control: the Case of Pomegranate
The EXPLORER study will investigate whether supplementation with a pomegranate extract rich in ellagitannins is able to improve well-being and metabolic health in individuals without diabetes.
- Trial name
- EXPLORER (NCT06659523)
- Testing
- EPS supplement intervention
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regina Menezes
PreDiabetes, Heart Rate Variability (HRV)
Effects of Walking in Greenspace and the Built Environment in Adults With Prediabetes: A Randomized Crossover Trial
The goal of this randomized crossover trial is to compare the differences in psychological and physiological effects of walking in two different outdoor environments (urban/suburban commercial environments vs.
- Conditions
- PreDiabetes, Heart Rate Variability (HRV), Stress and Anxiety, Stress Biomarkers
- Trial name
- NCT06365723
- Testing
- Nature-based Walking, Built-environment/Commercial Walking
- Where
- 3 sites in United States
- Volunteers
- 216 people
- Sponsor
- University of Minnesota
Prediabetes
Prevention of Type 2 Diabetes With Vitamin D Supplementation
PREVENT-WIN study has three components. The work plan will have the following S\&T components. Component 1: Cross-sectional Study Cross-sectional study will be of 1.5 years where 400 women from rural will be screened randomly for…
- Trial name
- PREVENT-WIN (NCT02513888)
- Testing
- vitamin D + diet and lifestyle
- Where
- India
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Diabetes Foundation, India
PreDiabetes, Diabetes Mellitus, Type 2
Continuous Glucose Monitoring for Glucose and Weight Management in Prediabetes and Non-severe Type 2 Diabetes: A Prospective Community-based (Workplace) Cohort Study
This study aimed to evaluate the effectiveness of use of Continuous Glucose Monitoring (CGM), combined with personalized dietary education and use of smartphone applications in improving glucose control and weight management.
- Trial name
- NCT06542627
- Testing
- Freestyle Libre
- Where
- South Korea
- Volunteers
- 420 people
- Sponsor
- Kangbuk Samsung Hospital
PreDiabetes
Screening for Risk Factors of Prediabetes Among Adult Patients at Sohag University Hospital
Prediabetes is an intermediate state of hyperglycemia with glycemic parameters above normal but below the diabetes threshold.. during the average 3 years of follow-up Prediabetes is diagnosed based on laboratory tests: fasting…
- Trial name
- NCT05864183
- Testing
- HbA1c, lipid profile, CBC
- Where
- Egypt
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Sohag University
Weight Loss, Blood Pressure
Feasibility & Implementation of a Plant-Based Weight-Loss Program in an Office-Based Setting
This prospective study aims to assess the feasibility and implementation of a plant-based, weight-loss program in an office setting.
- Conditions
- Weight Loss, Blood Pressure, Lipid Disorder, PreDiabetes
- Trial name
- NCT04091516
- Testing
- Low-fat plant-based diet
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Physicians Committee for Responsible Medicine
PreDiabetes
Effect of Oral Supplementation With Curcumin on Insulin Sensitivity in Subjects With Prediabetes
This study evaluates the effects of oral supplementation with curcumin on the insulin sensitivity in subjects with prediabetes. The half of participants will receive curcumin and bioperine in combination, while the other half…
- Trial name
- NCT03917784
- Testing
- Curcumin, Starch
- Where
- Mexico
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Hospital General de México Dr. Eduardo Liceaga
PreDiabetes, Pre Diabetes
Comparative Effects of High-Intensity Interval Training and Continuous Endurance Training Among Prediabetic Patients
Prediabetics is a condition where blood sugar levels are normal but not yet high enough to be diagnosed as type 2 diabetes. This phase offers a crucial point for timely intervention to delay or prevent type 2 diabetes.
- Conditions
- PreDiabetes, Pre Diabetes, Prediabetic State
- Trial name
- NCT07713030
- Testing
- High-Intensity Interval Training, Continuous Endurance Training
- Where
- Pakistan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Over Age 60, Prediabetes or Overweight
Curcumin Supplementation for the Improvement of Diabetes-related Outcomes
The goal of this clinical trial is to learn about, test, and compare health outcomes of curcumin supplementation (400 mg). Two primary hypotheses are: 1.
- Trial name
- CUR-T2D (NCT06984640)
- Testing
- Curcumin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Prediabetes
Anti-diabetic Effects of Persimmon Leaf Extract
The investigators performed a 8-week, randomized, double-blind, placebo-controlled crossover human trial to evaluate the efficacy and safety of persimmon leaf extract on blood glucose.
- Trial name
- NCT02706821
- Testing
- Persimmon leaf extract
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Chonbuk National University Hospital
PreDiabetes
The Effects of Dietary Supplements on Glycemic Control, Body Composition and Hepatic Fat Content in People With Prediabetes
This clinical study aims to explore the effects of 3 dietary supplements on metabolic parameters, liver fat content, and body composition in individuals with prediabetes.
- Trial name
- NCT06437938
- Testing
- Dietary supplement A: Wasabi leaf powder (product of BIOGENA GmbH & Co KG), Dietary supplement B: Berberin Phytoactive Gold (product of BIOGENA GmbH & Co KG), Dietary supplement C: DiaPhyt® Formula 3.0 (product of BIOGENA GmbH & Co KG)
- Where
- Austria
- Volunteers
- 50 people
- Sponsor
- Medical University of Vienna
Prediabetes
Continuous Glucose Monitoring in Prediabetes
This research explores how wearable glucose monitors might help prevent type 2 diabetes in people at risk of developing the disease. Type 2 diabetes affects more than 1 in 10 Americans and costs the nation $327 billion annually.
- Trial name
- NCT07455435
- Testing
- CGM Access
- Volunteers
- 50 people
- Sponsor
- University of Hartford
PreDiabetes
Examining the Impact of a Self-compassion Intervention on Physical Activity Behaviour Among People With Prediabetes
The investigators plan to examine whether teaching people at risk for type two diabetes to use self-compassion (orientation to care for oneself during difficult situations) helps them self-manage and increase their physical…
- Trial name
- NCT04863235
- Testing
- Control Group, Intervention Group
- Where
- Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Manitoba