Clinical trials: Pre-frail Elderly
Pre-frail, Elderly
Clinical and Economic Assessment of a Pre-frail Screening Program
The study intervention improves functional capacity and delays frailty status in pre-frail elderly subjects.
- Trial name
- NCT02138968
- Testing
- Multidisciplinary intervention
- Where
- Spain
- Volunteers
- 170 people
- Sponsor
- Consorci Sanitari del Maresme
Frail Elderly w/ Multimorbidity & Functional Limitations
The PAtient-Centred Team - Effectiveness and Cost-effectiveness Study
There is an urgent need to develop new care models for patients with long-term and complex needs. Our goal is services that are seamless, pro-active and person-oriented.
- Trial name
- PACT (NCT02541474)
- Testing
- Integrated care
- Where
- Norway
- Volunteers
- 1,200 people
- Sponsor
- University Hospital of North Norway
Acute Myeloid Leukemia
FLUDARABINE-TREOSULFAN REDUCED INTENSITY CONDITIONING REGIMEN PRIOR HAPLOIDENTICAL STEM CELL TRANSPLANTATION WITH POST TRANSPLANTATION CYCLOPHOSPHAMIDE FOR OLDER AND/OR FRAIL PATIENTS WITH AML
Acute myeloid leukemia (AML) and high-risk myelodysplastic syndromes (MDS) predominantly affect older adults, and their incidence continues to rise with advanced age.
- Trial name
- FT-RIC-HAPLO (NCT07598110)
- Testing
- fludarabine and treosulfan
- Volunteers
- 77 people
- Sponsor
- Institut Paoli-Calmettes
Hypogonadism, Pre-frail Seniors
Effects of Transdermal Testosterone and/or Monthly Vitamin D on Fall Risk in Pre--frail Hypogonadal Seniors
The overall purpose of this study is to test the individual and combined effect of transdermal testosterone and/or Vitamin D in reducing fall risk and improve function in pre-frail hypogonadal senior men.
- Trial name
- T&D (NCT02419105)
- Testing
- Testosterone, Colecalciferol
- Where
- Switzerland
- Volunteers
- 91 people
- Sponsor
- University of Zurich
Frail Elderly, Aortic Valve Stenosis
A STEP for Patients Prior to Undergoing TAVR: A Pilot Study
The aim of this pilot study is to establish whether a Supervised TAVR Exercise Program (STEP) can safely improve the frailty status in patients with symptomatic severe aortic valve stenosis prior to undergoing transcatheter…
- Trial name
- STEP (NCT02766075)
- Testing
- Supervised TAVR Exercise Program
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- OSF Healthcare System
Early Primary Breast Cancer
A Prospective, Multicenter, Open-label 12 Week Neoadjuvant Phase II Trial Optimizing Taxane Therapy in Elderly Patients With Low Response
Comparison of pre-surgical Myocet/ Cyclophosphamide (MC) q3w followed by either MC or Paclitaxel - depending on early response assessment by ultrasound or by toxicity for elderly non frail primary breast cancer patients with…
- Trial name
- NCT02214381
- Testing
- Myocet, Cyclophosphamide, Paclitaxel
- Where
- 2 sites in Germany
- Volunteers
- 80 people
- Sponsor
- Women's Cancer Study Group GmbH
Frailty, Pre-Frailty
In-Person, Online, and Hybrid Healthy-Aging Education for Pre-Frailty and Frailty in Older Adults
The goal of this clinical trial is to determine whether a 6-month healthy-aging education program delivered in person, online, or in a hybrid format reduces frailty and is cost-effective compared with usual care in…
- Trial name
- FRAGSALUD-ON (NCT07738393)
- Testing
- In-person healthy aging education program, Hybrid healthy aging education program, Online healthy aging education program
- Where
- Spain
- Volunteers
- 276 people
- Sponsor
- University of Cadiz
Fragility
Motorized Platform and Autonomy Among the Frail and Pre-frail Older Adult (PLATAUTONOMIE)
Highly diversified programs of physical activity in older people have shown their effectiveness in terms of improving functional capacities. Only one of these programs, to date, has used a motorized platform.
- Trial name
- NCT02850731
- Testing
- plate-forme Hu360®
- Sponsor
- University Hospital, Toulouse
Frailty, Muscle Weakness
Effectiveness of Protein Supplementation on Frailty Improvement, Muscle Strength and Physical Performance Among Pre-Frail Elderly People
The goal of this randomized clinical trial is to study the effectiveness of protein supplements in frailty improvement, muscle strength, physical performance, energy intake and body composition of pre-frail elderly people.
- Conditions
- Frailty, Muscle Weakness, Physical Dependence, Weight Loss
- Trial name
- NCT05648617
- Testing
- SUSTINEX Hydrolyzed Whey Protein
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Virtual Reality, Physical Fitness
Effects of Physical Fitness Using a Kinect Interventional System
The Kinect intervention system combined with aerobic exercise training can improve the quality of life of older adults in the community, standardize behavior regulation in exercise and improve fitness enthusiasm.
- Trial name
- NCT06216236
- Testing
- Kinect intervention system combined with aerobic exercise training, aerobic dance training
- Where
- 2 sites in Taiwan
- Volunteers
- 64 people
- Sponsor
- Wan-Yun Huang
Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults
The StayFitLonger Study: an Innovative Computerized Home-based Training to Foster Independent Life at Home
Multimodal training, including physical and cognitive activities, has been associated with a reduction in age-related physical and cognitive decline.
- Conditions
- Cognitive Decline Prevention in Robust Older Adults, Cognitive Decline Prevention in Pre-frail Older Adults, Physical Decline Prevention in Robust Older Adults, Physical Decline Prevention in Pre-frail Older Adults
- Trial name
- SFL (NCT04237519)
- Testing
- SFL training, Active controlled training
- Where
- 4 sites in Belgium, Canada and 1 more
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Hip Osteoarthritis, Knee Osteoarthritis
FitJoints: Getting Fit for Hip and Knee Replacement
Total hip or knee replacement is an important and cost-effective surgical intervention to relieve pain and improve independence and function in patients with osteoarthritis.
- Trial name
- NCT05100966
- Testing
- FitJoints Multi-modal Intervention
- Where
- 4 sites in Canada
- Volunteers
- 192 people
- Sponsor
- McMaster University
Frail Elderly Syndrome
A Health Promotion Program to Prevent Frailty and Improve Frailty Status Among Pre-frail Elderly: Frailty Intervention Through Nutrition Education and Exercises.
Prevention of frailty is a major concern in geriatrics due to its high prevalence and various adverse health outcomes among elderly population.
- Trial name
- FINE (NCT04327544)
- Testing
- Frailty Intervention
- Where
- Malaysia
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Pre-frail Elderly
The Effect of SOD Enzyme on Frailty and HRQOL Among Indonesian Pre-frail Elderly: A Double Blind Randomized Controlled Trial
The primary objective is to determine the effect of SOD enzyme on frailty and health related quality of life among Indonesian pre-frail elderly.
- Trial name
- NCT02753582
- Testing
- SOD+Gliadin Capsule
- Where
- Indonesia
- Volunteers
- 150 people
- Sponsor
- Universitas Indonesia
Frail Elderly Syndrome
Protein Intake and Resistance Training in Aging
Resistance training combined with protein or amino acids supplementation has been shown to be promising for mitigating age-related disabilities and comorbidities.
- Trial name
- NCT01890382
- Testing
- Whey protein, whey plus creatine, leucine supplementation
- Where
- Brazil
- Volunteers
- 200 people
- Sponsor
- University of Sao Paulo
Aging
Project SIRT6 Activator
The global ageing population is increasingly affected by age-related diseases, which are challenging healthcare systems. Current treatments often extend lifespan without improving healthspan.
- Trial name
- NCT07500649
- Testing
- Fucoidan
- Where
- 2 sites in Singapore
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Pre-Frail Older Adults
Pharyngeal Exercise (Plus Protein)
The swallowing muscles are prone to decreased strength and function as part of the natural aging process which can lead to difficulty swallowing, malnutrition, and frailty.
- Trial name
- PE(PP) (NCT05963113)
- Testing
- Pharyngeal Swallowing Exercises, Protein Supplementation, MRI
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Frailty, Frailty Syndrome
Smart Home Technologies for Assessing and Monitoring Frailty in Older Adults
This project aims to address the impact of frailty on older adults, particularly its connection to cognitive impairments such as dementia.
- Conditions
- Frailty, Frailty Syndrome, Frail Elderly Syndrome, Pre-Frailty
- Trial name
- NCT05961319
- Testing
- Smart-Home Monitoring
- Where
- 2 sites in Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Accidental Falls
Effect on Falls Reduction of a Multimodal Intervention in Frail and Pre-frail Elderly Community-dwelling People
Practice guidelines in caring for the geriatric population recommend performing an annual screening of falls . However, one of the problems that interfere with fall prevention programs is the lack of importance accorded to health…
- Trial name
- FAREMAVA (NCT02631330)
- Testing
- Multicomponent physical activity
- Where
- Spain
- Volunteers
- 466 people, healthy volunteers welcome
- Sponsor
- Hospital de la Ribera
Pre-Frailty, Aging
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life.
- Trial name
- RtM (NCT07454616)
- Testing
- Supervised exercise program, a balanced micronutrient blend
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University of Singapore