Clinical trials: Pre-hypertension
Preeclampsia
Spinal Anaesthesia and Severe Preeclampsia
The use of spinal anesthesia in pre-eclamptic pregnant woman is of considerable benefit, as these patients present particular hazards with general anaesthesia, such as concerns for rapid airway control and cerebral blood flow…
- Trial name
- NCT02633995
- Testing
- spinal anaesthesia
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kasr El Aini Hospital
Hypertension
Cardiac Effects of Mineralocorticoid Receptor Antagonism After Hypertensive Disorders of Pregnancy
The goal of this clinical trial is to determine if the medication eplerenone yields greater improvements in coronary microvascular function than chlorthalidone in women who experienced hypertension during pregnancy and…
- Trial name
- CARDAMOM (NCT07238400)
- Testing
- Eplerenone 100 mg daily, Chlorthalidone 25 mg daily, Potassium Chloride
- Where
- 2 sites in United States
- Volunteers
- 90 people
- Sponsor
- Massachusetts General Hospital
Hypertension in Pregnancy
Perinatal Outcomes in Patients With Elevated sFlt-1/PlGF Ratio
Retrospective cohort study that evaluated 190 subjects admitted with diagnosis of hypertensive disorder of pregnancy, between 24 and 36 6/7 weeks, with an sFlt-1/PlGF index greater than or equal to 110.
- Trial name
- NCT06403722
- Testing
- Standard of care
- Where
- Panama
- Volunteers
- 190 people
- Sponsor
- Saint Thomas Hospital, Panama
Preeclampsia, Intrauterine Growth Restriction
sFlt1/PlGF and Planned Delivery to Prevent Preeclampsia at Term.
Preeclampsia (PE) affects ~5% of pregnancies. Although improved obstetrical care has significantly diminished associated maternal mortality, PE remains a leading cause of maternal morbidity and mortality in the world.
- Conditions
- Preeclampsia, Intrauterine Growth Restriction, Maternal Hypertension, Neonatal Outcome
- Trial name
- PE37 (NCT04766866)
- Testing
- sFlt1/PlGF screening in maternal blood at 35 to 36.6 weeks of gestation
- Where
- 21 sites in Belgium, Colombia and 7 more
- Volunteers
- 9,132 people, healthy volunteers welcome
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Pregnancy Complications, IVF
The START Clinic: a Feasibility Study
This is a study of the feasibility of a translational research clinic for pregnancies conceived by in vitro fertilisation (IVF).
- Conditions
- Pregnancy Complications, IVF, Fetal Growth Retardation, Preeclampsia
- Trial name
- START (NCT04488861)
- Testing
- Non-interventional cohort study
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Manchester Academic Health Science Centre
Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction
Randomized Controlled Trial of Labetalol Versus Hydralazine for Severe Hypertension in Obstetric Patients.
Severe Hypertension in pregnancy demands urgent treatment because of high mortality \& morbidity in obstetric patients. Hydralazine, the most commonly used agent, causes sudden hypo tension and tachycardia.
- Conditions
- Hypertension, Pregnancy Induced, Hydralazine Adverse Reaction, Pre-eclampsia, Pre-eclampsia Superimposed Pre-existing Hypertension
- Trial name
- NCT02050529
- Testing
- Labetalol, Hydralazine
- Where
- Pakistan
- Volunteers
- 190 people
- Sponsor
- Dow University of Health Sciences
Preeclampsia
Novel Biomarkers of Preeclampsia, Aquaporin, Fatty Acid, and S110B
This is a research study designed to help identify preeclampsia in pregnant women earlier, and possibly lead to better treatment for women preeclampsia.
- Trial name
- NCT03567551
- Testing
- Women w/ Preeclampsia w/o Visual Disturbances or Headache, Women w/ Preeclampsia w/ Visual Disturbances or Headaches, Women w/o Preeclampsia
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pulmonary Arterial Hypertension
Sildenafil Therapy For Subjects Who Derive Clinical Benefit From Continued Treatment With Sildenafil
The purpose of this study is to provide Sildenafil therapy for subjects who completed A1481156 study and are judged by the investigator to derive clinical benefit from continued treatment with Sildenafil, prior to reimbursement…
- Trial name
- NCT01897740
- Testing
- sildenafil
- Where
- Russia
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Preeclampsia and Eclampsia
Springfusor for Administration of Magnesium Sulphate in Preeclampsia and Eclampsia
Magnesium Sulphate is the drug of choice for prevention and treatment of seizures in preeclampsia and eclampsia. It is administered parenterally by intravenous (IV) and or intramuscular (IM) routes.
- Trial name
- NCT03549767
- Testing
- Springfusor, Standard of care
- Where
- Uganda
- Volunteers
- 241 people
- Sponsor
- Makerere University
Pre-Eclampsia, Gestational Diabetes
Development of Intervention for Women After Gestational Diabetes or Pre-eclampsia
Our objectives in this qualitative exploratory study: To explore the perspectives and preferences of women with preeclampsia and/or GDM history related to a potential health promotion program To identify perception of support…
- Trial name
- NCT04716244
- Testing
- interview/focus group/questionnaire
- Where
- Israel
- Volunteers
- 100 people
- Sponsor
- Hadassah Medical Organization
Emergency Department Patients, Pulmonary Hypertension
Pulmonary Artery Pressure in Predicting Pulmonary Embolism in Patients Presenting To The Emergency Department With Dyspnea
The aim of this study is to determine the usability of echocardiographic PAP changes obtained from emergency department records in the early risk stratification of pulmonary embolism.
- Conditions
- Emergency Department Patients, Pulmonary Hypertension, Pulmonary Embolism
- Trial name
- NCT07641400
- Testing
- Pulmonary embolism (+), pulmonary embolism (-)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Antalya Health Sciences University
Preeclampsia
PP13 and Doppler Study to Predict Preeclampsia
Assessment of biochemical and sonographic marker to predict the risk for developing preeclampsia Among biochemical markers are serum level of Placental Protein 13 (PP13) and Placenta Growth factor (PIGF).
- Trial name
- NCT00928213
- Testing
- Progesterone, Low molecular weight Heparin, No Drug
- Where
- Israel
- Volunteers
- 1,000 people
- Sponsor
- Ben-Gurion University of the Negev
Obesity, Pre-hypertension
Diet and Whole-body Vibration Training on Cardiovascular and Autonomic Function
Obesity is a major risk factor for premature arterial abnormalities including high blood pressure and increased stiffness. Previous studies have shown that weight loss via lifestyle modifications is associated with a decrease in…
- Conditions
- Obesity, Pre-hypertension, Hypertension
- Trial name
- NCT01741779
- Testing
- Whole Body Vibration Training, Hypocaloric diet, Whole body vibration training & diet
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Florida State University
Pre-Eclampsia; Complicating Pregnancy
Comparative Effects of Jacobson's Relaxation Techniques and Stretching Exercises in Preeclampsia
To compare the effect of Jacobson's Relaxation Techniques and stretching exercises on Preeclampsia in pregnant women.
- Trial name
- NCT05863962
- Testing
- walking and Stretching, walking and Jacobsons relaxation technique
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Obesity, Morbid, Preeclampsia
Use of Impedance Cardiography to Decrease the Risk of Pre-eclampsia in Obese Patients
To determine if the use of impedance cardiography can identify appropriate medications for use in treating morbidly obese patients to decrease the risk of preeclampsia.
- Trial name
- NCT03105661
- Testing
- Labetalol Hydrochloride 200 mg, NIFEdipine 60 mg, Atenolol 25 mg
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Prehypertension, Mild Hypertension
Nitric Oxide Mediated Vasodilatory Response to Hawthorn Standardized Extract
Prehypertension and mild hypertension affect an estimated 157 million U.S. adults. Cardiovascular disease (CVD) risk and associated mortality is elevated in this population.
- Trial name
- NCT01331486
- Testing
- Hawthorn
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of North Carolina, Chapel Hill
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Pregnancy Complications, Preeclampsia
High Dose Folic Acid Supplementation Throughout Pregnancy for Preeclampsia Prevention
To determine the efficacy of high dose folic acid supplementation for prevention of preeclampsia in women with at least one risk factor: pre-existing hypertension, pre-pregnancy diabetes (type 1 or 2), twin pregnancy…
- Trial name
- FACT (NCT01355159)
- Testing
- Folic Acid 4 mg
- Where
- 72 sites in Argentina, Australia and 3 more
- Volunteers
- 2,464 people
- Sponsor
- Ottawa Hospital Research Institute
Glaucoma
Proteomic Profiles in Trabeculectomy Patients
Approximately 70 million people world-wide are affected with glaucoma, of whom 6.7 million have bilateral blindness.5 Elevated intro-ocular pressure is the major modifiable risk factor in glaucoma, and reducing intraocular…
- Trial name
- NCT01841580
- Where
- Singapore
- Volunteers
- 36 people
- Sponsor
- Singapore National Eye Centre
Preeclampsia
Social Risks-Focused Lifestyle Intervention to Reduce Preeclampsia (SAIL)
Preeclampsia is a disease of pregnancy and first few weeks after birth. It is diagnosed as new onset of high blood pressure and injury to organs such as kidneys, liver, and brain.
- Trial name
- SAIL (NCT04958057)
- Testing
- SAIL
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin