Clinical trials: Pre-term Birth
Pregnancy Related, Periodontitis
MOTOR: Maternal Oral Therapy to Reduce Obstetric Risk
The purpose of this study is to determine whether maternal periodontal therapy (tooth cleaning) decreases the rate of preterm deliveries at <37 weeks gestation and to determine the effects of maternal periodontal therapy on the…
- Conditions
- Pregnancy Related, Periodontitis, Premature Birth
- Trial name
- NCT00097656
- Testing
- multi-center, randomized, controled periodontal therapy
- Where
- United States
- Volunteers
- 1,800 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes
PPROM Registry (Preterm Premature Rupture of Membranes)
Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy is responsible for 40% of preterm births in the United States.
- Conditions
- Fetal Membranes, Premature Rupture, Preterm Premature Rupture of the Membranes, Oligohydramnios, Premature Birth
- Trial name
- NCT02997345
- Testing
- There is no intervention associated with this study.
- Where
- United States
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- American Alliance for pProm Support
Breastfeeding
Pilot Study of the FEEDBACK System for Use With Infants in the Neonatal Intensive Care Unit at University of Virginia
The purpose of this study is to assess the accuracy of FEEDBACK for measuring breastmilk intake of a pre-term baby. Mothers and babies will use the FEEDBACK system during a breastfeeding session in the NICU.
- Trial name
- NCT03702686
- Testing
- FEEDBACK System
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Molex Ventures LLC
Infant, Newborn, Infant, Low Birth Weight
Early-Onset Sepsis Surveillance Study
In this observational study, the NICHD Neonatal Research Network (NRN) is conducting surveillance of all infants born at NRN centers to identify all newborns who are diagnosed with early-onset sepsis (EOS) and/or meningitis.
- Conditions
- Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature
- Trial name
- EOS (NCT00874367)
- Where
- 19 sites in United States
- Volunteers
- 615 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Mid Trimester Cervical Shortening
A Randomized Trial of Cerclage Versus 17 α-Hydroxyprogesterone Caproate for Treatment of a Short Cervix
We hypothesized that weekly intramuscular injections of 17 hydroxyprogesterone caproate(17P) will reduce the number spontaneous preterm births prior to 35 weeks gestation when compared to cerclage therapy.
- Trial name
- NCT00694967
- Testing
- McDonald cerclage placement, 17 hydroxyprogesterone caproate
- Where
- United States
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- Lehigh Valley Hospital
Premature Infant
Effect of Online Education Given to Parent on Motor Social Development for The Premature Babies in The Neonatal Intensive Care Unites
Our study aim to evaluate the effect of online program that provides education to parents of premature infants in which stayed in the neonatal intensive care units (NICU),in their motor,socail-communişcation development and the…
- Trial name
- NCT05410639
- Testing
- online education program, no online education program
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Marmara University
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Preterm Birth
Cervical Pessary to Prevent Preterm Singleton Birth in High Risk Population
DESIGN: Observational prospective study. INCLUSION CRITERIA: All women are 18 years old of age or older with high risk for preterm birth, based on clinical history, and between 18.0 weeks and 23.6 weeks of pregnancy.
- Trial name
- NCT04147117
- Testing
- Cervical pessary
- Where
- Spain
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Hospital Sant Joan de Deu
Suspected Damage to Fetus From Other Disease in the Mother, Affecting Management of Mother, With Delivery, Patient Death or Serious Disability Associated With A Haemolytic Reaction Due to the Administration of ABO-Incompatible Blood or Blood Products
The Use of Lung Ultrasonography in the Delivery Room in Neonates
Lung ultrasonography has become frequently used in neonatal intensive care units because it is a diagnostic, useful, harmless, radiation-free, bedside, reproducible and practical method.
- Trial name
- LUSIN (NCT06314789)
- Testing
- doing lung ultrasonography
- Where
- Turkey (Türkiye)
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Premature Birth, Extremely Premature Infants
Prenatal Counseling in Extreme Prematurity: Professionals' View
This study is part of the PreCo study, evaluating Dutch care in (imminent) extreme preterm birth including current and preferred counseling, barriers and facilitators for preferred counseling from both obstetricians and…
- Trial name
- PreCo-profs (NCT02782650)
- Testing
- survey and interview
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Threatened Premature Birth, Premature Membrane Rupture
Intervention for Fear of Childbirth in High-Risk Pregnant Women
The aim of the study is to examine the effects of mandala activity applied to pregnant women hospitalized due to high-risk pregnancies on pregnancy stress and fear of childbirth. The study was designed as an experimental study.
- Conditions
- Threatened Premature Birth, Premature Membrane Rupture, Gestational Hypertension, Intrauterine Growth Retardation (IUGR)
- Trial name
- NCT06716710
- Testing
- Art therapy group, Control group
- Where
- Turkey (Türkiye)
- Volunteers
- 149 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Preterm Birth, Immunologic Activity Alteration
Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model
This study investigates immunological and clinical markers in threatened preterm birth aiming to create a prediction model for preterm birth.
- Trial name
- NCT03796949
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- Linkoeping University
Premature Birth
Cerclage On LOw Risk Singletons: Cervical Cerclage for Prevention of Spontaneous Preterm Birth in Low Risk Singleton Pregnancies With Short Cervix
The aim of this study is to evaluate the efficacy of cervical cerclage in prevention of spontaneous preterm birth in singleton pregnancies with a short transvaginal cervical length (<=25mm) and without prior spontaneous preterm…
- Trial name
- COLORS (NCT03251729)
- Testing
- Cervical cerclage, Vaginal progesterone
- Where
- 3 sites in United States, Italy
- Volunteers
- 93 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Prematurity
Are Newborns Conscious of the Placebo Effect? Result From an RCT in Osteopathy
Results from previous studies suggest the association between Osteopathic Manipulative Treatment (OMT) and length of stay (LOS) reduction in a population of preterm infants.
- Trial name
- NCT01852500
- Testing
- Standard care
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Pregnancy
Vaginal Progesterone to Reduce the Risk of Another Preterm Birth
This research study is being conducted at over 12 pregnancy research centers in the US. The study will compare an investigational treatment with a placebo (a treatment without medication).
- Trial name
- NCT00086177
- Testing
- 8% progesterone vaginal gel
- Where
- 45 sites in United States
- Volunteers
- 636 people, healthy volunteers welcome
- Sponsor
- Juniper Pharmaceuticals, Inc.
Preterm Birth
NICU-HEALTH (Hospital Exposures and Long-Term Health)
The purpose of this study is to evaluate the impact of environmental exposures during the NICU hospitalization on preterm infant development. The research team is interested in both chemical and non-chemical exposures.
- Trial name
- NCT01963065
- Where
- United States
- Volunteers
- 239 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Twin Pregnancy, Preeclampsia
Low-dose Aspirin for Prevention of Adverse Pregnancy Outcomes in Twin Pregnancies
Twin pregnancies are associated with increased risk of perinatal adverse outcomes , including preeclampsia , fetal growth restriction , preterm premature rupture of membranes and preterm birth.
- Conditions
- Twin Pregnancy, Preeclampsia, Preterm Birth, Fetal Growth Restriction
- Trial name
- NCT04051567
- Testing
- Aspirin 100mg
- Where
- China
- Volunteers
- 425 people, healthy volunteers welcome
- Sponsor
- Ministry of Science and Technology of the People´s Republic of China
Premature Birth, Preeclampsia
A Randomized Trial of Docosahexaenoic Acid Supplementation During Pregnancy to Prevent Deep Placentation Disorders
This study evaluates the effectiveness of maternal supplementation with Docosahexaenoic acid (DHA) early in pregnancy to reduce the incidence of deep placentation disorders: preterm birth, preterm labor, preterm premature rupture…
- Conditions
- Premature Birth, Preeclampsia, Fetal Growth Retardation, Stillbirth
- Trial name
- NCT02336243
- Testing
- Docosahexaenoic acid (DHA)
- Where
- 5 sites in Chile
- Volunteers
- 2,400 people, healthy volunteers welcome
- Sponsor
- Pontificia Universidad Catolica de Chile
PREG1, Obesity
Pilot Study: Identification of a Multi-omic Predictive Signature for Preterm Birth in Obese African American Women
1. Determine if the stool or vaginal microbiome and urinary metabolite profiles in a pregnant obese population of African American women differ from their pregnant non-obese counterparts 2.
- Trial name
- NCT03181555
- Testing
- Exploratory
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Baylor University
Premature Birth
Association Between Mother-Infant Attunement During Interaction and the Quality of General Movements
The proposed research has the potential of contributing to the limited empirical literature on the relationship between maternal sensitivity and motor development of preterm infants.
- Trial name
- NCT01764958
- Where
- Israel
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Assuta Hospital Systems