Clinical trials: PreDiabetes, completed
PreDiabetes
Prevention and Treatment of Diabetes in Adults
Currently, an estimated 3.9 million Malaysians continue to live with diabetes with many more who live with prediabetes. Diabetes was the one of the leading causes of death in the Malaysia and the leading cause for kidney failure…
- Trial name
- NCT04832984
- Testing
- Mobile health, Usual care
- Where
- Malaysia
- Volunteers
- 91 people
- Sponsor
- Monash University
PreDiabetes, Obesity
Effect of Mango Consumption on Individuals with Pre-diabetes
This study is designed to explore the effect of mango consumption on glycemic indices, cardiovascular health, and body composition in overweight and obese individuals with prediabetes.
- Trial name
- NCT05571800
- Testing
- Mango
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Florida State University
Cardiovascular Risk Factor, Prediabetes
Active You: A Novel Exercise Program for African Americans
Barriers to physical activity (PA) among African Americans (AAs) have been extensively studied, yet there is a paucity of innovative PA interventions designed to address them.
- Conditions
- Cardiovascular Risk Factor, Prediabetes, Overweight and Obesity, Sedentary Behavior
- Trial name
- NCT04280783
- Testing
- The Physical Activity for The Heart (PATH) intervention, Be Active Your Way Booklet
- Where
- 2 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Prediabetes
Exploring Unconventional Plant-Derived Metabolites for Glycemic Control: the Case of Pomegranate
The EXPLORER study will investigate whether supplementation with a pomegranate extract rich in ellagitannins is able to improve well-being and metabolic health in individuals without diabetes.
- Trial name
- EXPLORER (NCT06659523)
- Testing
- EPS supplement intervention
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Regina Menezes
Diabetes Mellitus, PreDiabetes
Effects of Physical Activity in Patients With Diabetes
The primary aim of our study is to evaluate the effects of physical activity counseling and pilates exercises on metabolic control variables in patients with prediabetes and type 2 diabetes; Its secondary aim is to examine the…
- Trial name
- NCT04643873
- Testing
- physical activity counseiling +pilates exercise group, physical activity counseiling group
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Istanbul University - Cerrahpasa
PreDiabetes, Glucose Tolerance Impaired
A Study to Evaluate Efficacy and Safety of Distal Jejunal-release Dextrose Beads Formulation in Subjects With a Pathological Oral Glucose Tolerance Test
The primary purpose of the study is to evaluate the efficacy and safety of APHD-012 (distal jejunal-release dextrose [Aphaia technology, AT]) in participants with pre-diabetes (pathological Oral Glucose Tolerance Test (OGTT)).
- Trial name
- NCT05803772
- Testing
- APHD-012, APH-012P
- Where
- 3 sites in Slovakia
- Volunteers
- 31 people
- Sponsor
- Aphaia Pharma US LLC
Overweight and Obesity, PreDiabetes
Continuous Glucose Monitors (CGM) for Type 2 Diabetes (T2D) Risk Evaluation
The purpose of this research study is to determine whether continuous glucose monitors (CGM) are a safe, effective, and acceptable way to evaluate type 2 diabetes risk in youth as compared to the standard 2-hour oral glucose…
- Conditions
- Overweight and Obesity, PreDiabetes, Insulin Resistance
- Trial name
- NCT05404711
- Testing
- CGM
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mary Ellen Vajravelu, MD
PreDiabetes, Metabolic Syndrome
Does Co-administration of Lactate to an Oral Glucose Tolerance Test Lower the Glucose Response?
To investigate whether co-administration of lactate with a glucose load affects postprandial glucose levels/handling, gastrointestinal hormones, gastric emptying, and appetite sensations in individuals with pre-diabetes when…
- Conditions
- PreDiabetes, Metabolic Syndrome, Insulin Resistance
- Trial name
- NCT06265337
- Testing
- Lactate
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Methylglyoxal, PreDiabetes
Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals
The aim of this study is to compare the effects of exercise, standard lifestyle changes and metformin on MGO in prediabetic individuals.
- Conditions
- Methylglyoxal, PreDiabetes, Exercise, Metformin
- Trial name
- NCT06603480
- Testing
- Exercise, Metformin
- Where
- Turkey (Türkiye)
- Volunteers
- 96 people
- Sponsor
- Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Chronic Kidney Diseases, Hypertension
Real Clinical Practice Register of AlbUminuRia Detection in Patients With Previously undiAgnosed Chronic Kidney Disease
Real clinical practice register of Albuminuria detection in patients with previously undiagnosed chronic kidney disease
- Conditions
- Chronic Kidney Diseases, Hypertension, Chronic Heart Failure, Ischemic Heart Disease
- Trial name
- AURA (NCT05690009)
- Where
- Russia
- Volunteers
- 4,580 people
- Sponsor
- Eurasian Association of Therapists
PreDiabetes, Prediabetic State
Couple-Based Lifestyle Intervention to Prevent Type 2 Diabetes
The goal of this randomized pilot clinical trial is to describe the feasibility of a couple-based lifestyle intervention and the study protocol in preparation for a future definitive randomized clinical trial.
- Conditions
- PreDiabetes, Prediabetic State, Overweight and Obesity
- Trial name
- NCT05695170
- Testing
- PreventT2 (Individual intervention), PreventT2 Together (Couple-based intervention)
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- University of Utah
PreDiabetes
Achilles Tendon and Balance in Prediabetes
The aim was to evaluate the Achilles tendon size and static and dynamic balance, as well as the role of Achilles tendon on balance in prediabetes.
- Trial name
- NCT06519396
- Testing
- ultrasonography evaluation, tetrax device evaluation
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Insulin Resistance, Impaired Glucose Tolerance
Using a Complex Carbohydrate Mixture to Steer Fermentation and Improve Metabolism in Adults With Overweight and Prediabetes (DISTAL)
The purpose of this study is to investigate the effects of a fibre mixture added to a high-protein diet on metabolic, gut and brain health.
- Conditions
- Insulin Resistance, Impaired Glucose Tolerance, PreDiabetes, Overweight and Obesity
- Trial name
- DISTAL (NCT05354245)
- Testing
- Fibre supplement (potato-pectin), High-protein diet
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Overweight and Obesity, PreDiabetes
Effects of Yogurt With Spirulina on Cardiometabolic Risk Markers
The effects of yogurt with spirulina consumption compared to conventional yogurt (without spirulina) on several cardiometabolic and anthropometric parameters in individuals at risk of cardiovascular disease
- Conditions
- Overweight and Obesity, PreDiabetes, Hypertension, Dyslipidemias
- Trial name
- NCT06114563
- Testing
- Spirulina yogurt, Conventional yogurt
- Where
- Greece
- Volunteers
- 64 people
- Sponsor
- Agricultural University of Athens
PreDiabetes, Aging
Safety and Efficacy of KH-1 for Stimulating Autophagy in Non-diabetic Adults With Elevated Blood Glucose Concentration
Aging significantly impacts overall health and is a risk factor for developing diabetes. An estimated 50% of U.S. adults aged ≥65 years were reported to have prediabetes (defined as having a fasting glucose concentration of…
- Trial name
- NCT06445569
- Testing
- KH-1
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Kalin Health, LLC
PreDiabetes
Effect of the SCL16A11 Risk Haplotype on Treatments to Prevent Type 2 Diabetes
The goal of this randomized clinical trial is to determine the impact of the risk haplotype on SLC16A11 on early therapeutic responses in treatments to prevent T2D in Mexican mestizos with prediabetes.
- Trial name
- PRED2 (NCT05990205)
- Testing
- Life Style Intervention + Metformin, Life Style Intervention
- Where
- Mexico
- Volunteers
- 437 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
PreDiabetes
Shanghai Community Prediabetes Standardized Management Project
Participants with prediabetes is the key targets for diabetes prevention. So, in order to further strengthen and standardize the management of participants with prediabetes in the communities, the investigators start this project…
- Trial name
- NCT04256460
- Testing
- Healthy diet, regular exercises and peer support
- Where
- 53 sites in China
- Volunteers
- 2,500 people
- Sponsor
- Shanghai 6th People's Hospital
PreDiabetes, Cardiovascular Diseases
Individualized Nutrition Therapy for Preventing or Delaying Onset of Type-2 Diabetes
The overall aim of this feasibility study is to conduct a randomized, controlled intervention providing adults with prediabetes either an individualized nutrition therapy (INT) intervention that contains individualized dietary…
- Trial name
- NCT05161897
- Testing
- Individualized Nutrition Therapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- George Mason University
PreDiabetes, Diabetes Mellitus, Type 2
Chronotype, Chrononutrition and Glucose Tolerance Among Prediabetic Individuals
Chronotype and chrononutrition, both are emerging research fields in nutritional epidemiology. However, its association with glycemic control in the global population is less clear.
- Trial name
- NCT05163964
- Testing
- Lifestyle Intervention
- Where
- 11 sites in Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Universiti Tunku Abdul Rahman
Diabetes, PreDiabetes
Study of Diabetes' Risk Factors and Accelerated Aging According to Socio-economic Status in a Population From the North of France
Populations in precarious situations or with low socio-economic status have an increased risk of diabetes and accelerated aging.
- Trial name
- PREVENDIAB (NCT05717491)
- Testing
- Biological analysis, Physical examination and Questionnaires, Physical examination and Questionnaires
- Where
- France
- Volunteers
- 2,014 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille