Clinical trials: Prebiotic
Regurgitation, Gastric
Evaluation of the Tolerance and Safety of a New Partly Fermented Anti-regurgitation Infant Formula
A randomised, controlled, double-blind trial to evaluate the tolerance and safety of a new partly fermented anti-regurgitation infant formula containing prebiotics and locust bean gum in infants with regurgitation.
- Trial name
- Leopard (NCT03371615)
- Testing
- Anti-regurgitation infant formula
- Where
- 2 sites in Poland
- Volunteers
- 182 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Metabolic Syndrome X
Efficacy of a Prebiotic Galactooligosaccharide to Reduce Metabolic Syndrome Risk Factors in Overweight Adults
The traditional risk factors for obesity are inappropriate diet, lack of exercise and genetic factors. However, recent observations have involved gut microbiota profiles as having an additional influence.
- Trial name
- NCT01004120
- Testing
- Bimuno, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Clasado
Subjects With Hyperuricemia
Effect of Prebiotics on Hyperuricemia
Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of Hyperuricemia.
- Trial name
- NCT05385003
- Testing
- anserine, Sunflower peptide
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy
Effect of Prebiotic Intake on Gut Microbiota in Healthy Adults
In recent years, the importance of the gut microbiota to human health has been demonstrated. In adulthood, the microbial profile is relatively stable, yet can be transiently altered by factors such as diet or antibiotic…
- Trial name
- NCT03042494
- Testing
- Control, Prebiotic
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Prebiotics and Human Behavior and Cognition
Measuring Effects of Prebiotics on Human Behavior and Cognition
This study is designed to test the effects of prebiotics on cognition, behavior and physiology in healthy volunteers.
- Trial name
- NCT04055246
- Testing
- Inulin
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Duke University
Child Malnutrition
Effects of Prebiotics on Metagenomic Diversity and Abundance in Young Children With Acute Malnutrition
Malnutrition is a major global public health issue, contributing to poor health and early morbidities in children under five, particularly in developing countries.
- Trial name
- P-MAM (NCT06155474)
- Testing
- Prebiotic galacto-oligosaccharide (GOS) Powder, Starch Only, RUTF + Starch
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of the Punjab
Gut Microbiota
The Effect of Prebiotic Synergy1 Supplementation on Microbiota, Protein Metabolism and Gastrointestinal (GI) Symptoms in People Consuming High Protein Diet
The composition and metabolism of human gut microbiota play crucial roles in health. Microbial colonisation of the gastrointestinal tract varies widely, with the large intestine having not only the highest density of microbes in…
- Trial name
- ITF (NCT02827760)
- Testing
- Synergy1, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading
Healthy
the Dietary Effects of VitaSugar/VitaFiber-IMO in Healthy Adults
The purpose of this study is to re-confirm the already established health effects and dose tolerance of Isomalto-oligosaccharide or IMO, which is a general health/functional food ingredient.
- Trial name
- NCT01462331
- Testing
- Isomaltooligosaccharide (digestion-resistant carbohydrates), Sucrose
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BioNeutra Inc.
Quorum Sensing, Prebiotics
Biological Modulation of Bacterial QSSMs, Innate and Adaptive Immunity by Antibiotics, Probiotics and Prebiotics in Healthy Individuals
It has recently been discovered that bacteria are able to communicate using specialised molecules known as Quorum Sensing Signalling Molecules (QSSMs).
- Conditions
- Quorum Sensing, Prebiotics, Probiotics, Sepsis
- Trial name
- NCT01201577
- Testing
- Bifidobacterium longum BB536, Active hexose correlated compound (AHCC), Bifidobacterium longum BB536 and Active hexose correlated compound (AHCC)
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Metabolomics
The Effect of Feeding Infant Formula Containing Prebiotics and/or Probiotics
The study is intended to evaluate the microorganisms found in infant stools when consuming study formulas containing prebiotics and/or probiotics compared to infants consuming mother's own breast milk.
- Trial name
- NCT02948114
- Testing
- Control: Cow milk-based infant formula, Experimental 1: Cow milk-based infant formula, Experimental 2: Cow milk-based infant formula
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Disturbance of Growth
Low-protein Infant Formula With Partial or Extensive Proteinhydrolysate 4 Year Follow-up
The study is conducted to examine the suitability of partially respectively extensively hydrolyzed low protein infant formulae with and without pro- and prebiotics for healthy, term infants.
- Trial name
- HippHA (NCT01143233)
- Testing
- control formula, intervention formula 1, intervention formula 2
- Where
- 5 sites in Austria, Germany and 1 more
- Volunteers
- 503 people, healthy volunteers welcome
- Sponsor
- HiPP GmbH & Co. Vertrieb KG
Obesity
The Effect of Prebiotic Fibres on Weight Loss in an Overweight and Obese Population
The aim of this study is to investigate whether a diet supplemented with two prebiotic fibres induces greater changes in body weight compared to placebo during 12 weeks of energy restriction in an obese/overweight population.
- Trial name
- MNGII (NCT03135041)
- Testing
- Fiber-containing dietary supplement
- Where
- Denmark
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Iron-deficiency
Prebiotic GOS and Lactoferrin With Iron Supplements
The ultimate goal of this research is to develop a means to safely administer iron supplements to infants in settings with a high infection burden.
- Trial name
- NCT03866837
- Testing
- Galacto-oligosaccharides, Bovine lactoferrin, Multiple micronutrient powders with 5 mg iron
- Where
- 2 sites in Kenya, Switzerland
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Columbia University
Polycystic Ovary Syndrome
To Study the Effect of SC-FOS Prebiotics in Women With Polycystic Ovary Syndrome
The purpose of this study is to determine if there is a difference in the clinical characteristics of patients with polycystic ovary syndrome after the administration of SC-FOS in the enteral diet compared to patients with a…
- Trial name
- NCT05999097
- Testing
- Short Chain Fructooligosaccharides
- Where
- Mexico
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Chihuahua
Mixed Fiber Supplementation for Healthy Adults
Assessing the Short-Term Effects of Multi-Fiber Supplementation on Gut Health
This is a randomized, parallel-group interventional study evaluating the short-term gastrointestinal effects of a standardized multi-fiber supplement in healthy adults.
- Trial name
- NCT07787026
- Testing
- Prebiotic
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brown University
Obesity, Metabolic Syndrome
Role of Colonic Events on Metabolism and Appetite Control: A Synbiotic Approach
The purpose of the study is to evaluate food factors related to colonically derived regulation of glucose metabolism (and related parameters) and satiety using a semi-acute meal study in healthy subjects as experimental model.
- Trial name
- NCT01718418
- Testing
- test meal, reference
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Overweight and Obesity
Gastrointestinal And Metabolic Effects From a Prebiotic, Lifting, and Aerobic iNtervention
This study aims to determine the independent and combined effects of prebiotic fiber supplementation and exercise on the gut microbiome and human health.
- Trial name
- GAMEPLAN (NCT05207488)
- Testing
- Fructooligosaccharides (FOS), Exercise
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Infectious Disease, Children, Only
Effect of Prebiotic Fructans to Reduce Number of Febrile Infections in Children
The study aims to confirm the effectiveness of chicory-derived prebiotic inulin-type fructans on the reduction of the number of febrile infections diagnosed by the paediatrician in children.
- Conditions
- Infectious Disease, Children, Only, Diet Modification
- Trial name
- NCT03457688
- Testing
- prebiotic inulin-type fructans
- Volunteers
- 850 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Obesity
Evaluation of the Efficacy of the Composite WM Formula in Body Weight Change
This study aims to evaluate the effects of the combined formula WM Formula, used as a dietary supplement, with a focus on improvements in glycemic and lipid parameters, body composition, and gut microbiota profiles.
- Trial name
- NCT07097974
- Testing
- WM formula liquid drink
- Where
- Taiwan
- Volunteers
- healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Sleep Disturbance, Fatigue Syndrome, Chronic
Bao Yuan Tang Extract and Galactooligosaccharides for Sleep Regulation
Certain classical formulas in traditional Chinese medicine and dietary prebiotics have demonstrated beneficial effects on various aspects of suboptimal health status in previous studies.
- Conditions
- Sleep Disturbance, Fatigue Syndrome, Chronic, Endocrine Disorder, Glucose Metabolism Disorder
- Trial name
- NCT07774897
- Testing
- Combination product (Bao Yuan Tang full-component extract 2.0g and galactooligosaccharides 2.0g), Galactooligosaccharides 2.0g
- Where
- 6 sites in China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province