Clinical trials: Prebiotics Effect
Hypercholesterolemia, Flatulence
Fabulous Fibre Study - Effect of Wheat Bran Extract on Gut and General Health in Healthy Aging Subjects (FFS)
This is a placebo controlled, cross-over, randomized, double blinded study. The intervention food products will be taken as diet prebiotic supplements: 1.
- Conditions
- Hypercholesterolemia, Flatulence, Intestinal Diseases
- Trial name
- FFS (NCT02693782)
- Testing
- Fibre supplement
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Aberdeen
Polyphenols, Obesity
Effect of a Low-calorie Diet With a Prebiotic Supplement on Health of Overweight-obese Subjects.
The main objective of this project is to evaluate the effect of prebiotic supplementation on weight loss and other physiological and metabolic parameters related to excess weight in overweight/obese adult men and women, as well…
- Conditions
- Polyphenols, Obesity, Weight Loss
- Trial name
- POSTBIOTICS (NCT06710106)
- Testing
- Prebiotic + hypocaloric diet
- Where
- Spain
- Volunteers
- 156 people, healthy volunteers welcome
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Stress, Psychological, Gut Bacteria
Polyphenols, Prebiotics, the Gut Microbiome and Stress
The aim of this study is to evaluate how different combinations of prebiotics and polyphenols affect the gut microbiota and perceived cognitive state.
- Trial name
- NCT05528575
- Testing
- Blueberry, cranberry, green tea extract, cocoa, GOS, Inulin, RS2, prebiotics and polyphenols
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Reading
Obesity
Prebiotic Fiber as a Modifier of Satiety Hormones and Body Weight in Overweight and Obese Adults
The purpose of this study is to determine if oligofructose supplementation promotes weight loss in overweight and obese adults.
- Trial name
- NCT00522353
- Testing
- Oligofructose
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Mood
Effects of Prebiotics on Intestinal Colonization and Mood in a University Cohort
There is a growing interest within the scientific community of whether prebiotics can aid in clinical outcomes including mood via modulation of the gut microbiota and its resulting metabolites via the gut-brain axis.
- Trial name
- NCT05212545
- Testing
- Prebiotic supplement, Prebiotic combination, Prebiotic oligosaccharides
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Behaviour
Oxford Study of Prebiotics in Children
Recently, there has been an emerging interest in how manipulating gut microbiota (which is composed by microorganisms living in our digestive system) can influence learning, memory and cognition.
- Trial name
- OxPiC (NCT02926508)
- Testing
- Bimuno (BGOS), Maltodextrin
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Infant Nutrition Sciences
Acceptability, Tolerance, Satiety and Prebiotic Effect of a New Infant Cereal
This study evaluates a new infant cereals on acceptability, tolerance, satiety and prebiotic effect in infants.
- Trial name
- ACER (NCT02781298)
- Testing
- New Infant Cereal, Multicereals Infant Cereal
- Where
- 4 sites in Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hero Institute for Infant Nutrition
Metabolomics
The Effect of Feeding Infant Formula Containing Prebiotics and/or Probiotics
The study is intended to evaluate the microorganisms found in infant stools when consuming study formulas containing prebiotics and/or probiotics compared to infants consuming mother's own breast milk.
- Trial name
- NCT02948114
- Testing
- Control: Cow milk-based infant formula, Experimental 1: Cow milk-based infant formula, Experimental 2: Cow milk-based infant formula
- Where
- China
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Mead Johnson Nutrition
Elderly, Bowel Symptoms
Effects of β-glucans on Gut Permeability and Microbiota in Elderly
The investigators aim was to compare healthy young adults, senior orienteers (model of healthy ageing) and elderly with gastrointestinal symptoms on intestinal permeability, microbiota compositions and well-being.
- Conditions
- Elderly, Bowel Symptoms, Prebiotics
- Trial name
- NCT05584254
- Testing
- yeast-beta glucan
- Where
- Sweden
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Örebro University, Sweden
Hypertension, Hyperglycemia
Effect of Dietary Fiber on Metabolic Syndrome, Gastrointestinal Function, Mood and Sleep Quality in Obese People
Metabolic syndrome includes hypertension(high blood pressure), hyperglycemia(high blood suger), dyslipidemia(abnormal blood lipid level) and obesity.
- Conditions
- Hypertension, Hyperglycemia, Dyslipidemia, Obesity
- Trial name
- NCT06626867
- Testing
- Dietary Fiber Supplementation
- Where
- Taiwan
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Chien-Wen Hou
Gut Microbiota Dysbiosis and Nutrition
Inulin and the Gut Microbiota in Healthy Adults
In this study the effects of a fibre dietary supplement on the gut microbiome in healthy adults will be investigated. For this purpose, a 14-day dietary supplementation with inulin or placebo (maltodextrin) will be carried out in…
- Trial name
- INLITE (NCT05399316)
- Testing
- Inulin, Maltodextrin
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Experimental and Clinical Research Center
Healthy
Influence of Food Matrix on Prebiotic Efficacy in Inulin Type Fructans
The aim of the study is to investigate whether the food matrix has an influence on the prebiotic efficacy (bifidobacteria growth) of chicory-derived Orafti® inulin in healthy adult volunteers.
- Trial name
- NCT05581615
- Testing
- Inulin
- Where
- United Kingdom
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Beneo-Institute
Overweight, Obesity
Effect of Prebiotic Intake on Adiposity, Satiety and Gut Microbiota in Overweight and Obese Children
Currently, over one third of Canadian children and youth aged five to seventeen are overweight or obese. Childhood obesity leads to increased risks of co-morbidities such as type 2 diabetes, fatty liver disease, cardiovascular…
- Trial name
- NCT02125955
- Testing
- Prebiotic fiber
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Eating Behavior, Stress
The Gut Microbiota in Stress, Mood and Eating Behaviours.
Diet has a considerable influence on microbiota composition and the intake of either prebiotics (microbiota-specific food or probiotics (live microbiota species) has been shown to induce positive effects in both anxiety and…
- Conditions
- Eating Behavior, Stress, Mood
- Trial name
- NCT03482258
- Testing
- Prebiotic, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Roehampton
Hypertension, Gastrointestinal Microbiome
Effect of Prebiotics on Blood Pressure Management
This survey is designed to investigate the effect of highland barley β-glucan supplementation on the regulatory of blood pressure, gut microbiota and cardiovascular risk fators in subjects with hypertention.
- Trial name
- NCT05364736
- Testing
- Highland barley β-glucan dietary supplement
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Immunosenescence, Inflammation
Effect of Milk Protein and Prebiotics in Combination With Vitamin D on Innate Immunity in Elderly People
Rationale: The immune system in the ageing population becomes compromised with age (termed "Immunosenescence"). Therefore, elderly people have a decreased ability to respond to infection and vaccination.
- Trial name
- NCT03026244
- Testing
- Milk protein, prebiotics, vitamin D
- Where
- Netherlands
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- NIZO Food Research
Subjects With Hyperuricemia
Effect of Prebiotics on Hyperuricemia
Hyperuricemia is a major risk factor for many chronic diseases. Recently, dysbiosis of gut microbiota has been reported to play an important role in the pathogenesis of Hyperuricemia.
- Trial name
- NCT05385003
- Testing
- anserine, Sunflower peptide
- Where
- 2 sites in China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Gut Microbiota, Gastrointestinal Symptoms
The Effects Of HMO On The Faecal Microbiota And On Gastrointestinal Symptoms In Healthy Volunteers
The study is a randomised, placebo-controlled, double-blind, parallel, dose-finding study with healthy volunteers. A total of 100 male and female volunteers will be included.
- Trial name
- HMO-VOL (NCT01927900)
- Testing
- HMO, Glucose
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Glycom A/S
Healthy Children
Study to Evaluate the Effects of a Formula on the Gut Health of Healthy Chinese Infants and Young Children
The infant gut microbiota, a major driver of the maturation of the immune system, is formed through the successive establishment and development during infancy and early childhood.
- Trial name
- NCT04864665
- Testing
- a formula with prebiotics and milk fat
- Where
- 6 sites in China
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Wellbeing, Healthy
PROMOTE: The Effect of a Six Week Prebiotic Supplementation on Wellbeing of Young Adults.
The study will investigate whether taking a prebiotic for six weeks helps to reduce morning cortisol levels in healthy young adults with mild to moderate stress compared to a placebo.
- Conditions
- Wellbeing, Healthy, Mental Health
- Trial name
- PROMOTE (NCT06566157)
- Testing
- Prebiotic, Maltodextrin (Corn)
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Southampton