Clinical trials: Prediabetes
Prediabetes
Chinese Diabetes Prevention Program (Chinese DPP)
This study is being conducted in two phases. The first phase was a pilot implementation of the study protocol, which provided preliminary data from seeking funding for a larger scale trial.
- Trial name
- NCT02277509
- Testing
- Chinese DPP, Minimal Intervention Control
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
PreDiabetes
Effects of Moringa Oleifera Leaves on Glycemia, Lipemia and Inflammatory Profile in Prediabetic Patients
Moringa oleifera (MO) is a traditional food in tropical and subtropical areas and has attained a growing interest for its medicinal properties. It's a nutrient-rich vegetable, high in protein and polyphenol content.
- Trial name
- NUTRIMOL-DB (NCT04734132)
- Testing
- Moringa
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
HIV Infections, Hypercholesterolemia
Metabolic Abnormalities in HIV Infected and Uninfected Young Women
Though anti-HIV drugs can dramatically improve the health of people with HIV, some people taking these drugs develop serious long term effects in their metabolism.
- Conditions
- HIV Infections, Hypercholesterolemia, Glucose Intolerance
- Trial name
- NCT00067587
- Where
- 11 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Diabetes Mellitus, Type 2, Pre-diabetes
Skeletal Muscle Diacylglycerol and Sphingolipids - Impact of Localization and Species on Insulin Resistance in Humans
The rationale for the proposed research is that elucidating changes in localized diacylglycerol (DAG) and sphingolipid species that predict insulin sensitivity will reveal specific localized lipids to target in therapeutics for…
- Conditions
- Diabetes Mellitus, Type 2, Pre-diabetes, Obesity
- Trial name
- NCT03077360
- Testing
- Lifestyle
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes, Weight Loss
De Por Vida: A Diabetes Risk Reduction Intervention for Hispanic Women
This pragmatic randomized clinical trial will assess the efficacy, cost, and sustainability of a culturally tailored weight-loss program targeting obese Hispanic women with pre-diabetes or T2D.
- Conditions
- Diabetes, Weight Loss, PreDiabetes, Obesity
- Trial name
- NCT03113916
- Testing
- Behavioural Lifestyle Intervention
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Insulin Resistance, Glucose Intolerance
Endothelial Function in Obese Adolescents
Childhood obesity is perhaps the most significant public health problem in the most developed countries and is rapidly becoming so in developing countries.
- Conditions
- Insulin Resistance, Glucose Intolerance, Obesity, Atherosclerosis
- Trial name
- NCT01879033
- Testing
- Reactive hyperemia peripheral artery tonometry (Rh-PAT), Blood levels for glucose, insulin, lipids and adipocytokines
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
PreDiabetes
Insulin and Insulin Pulses During Fasting
Fasting hyperglycemia contributes disproportionately to nonenzymatic glycosylation and the microvascular complications of type 2 diabetes.
- Trial name
- NCT06424015
- Testing
- Intralipid and heparin, Saline
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Glucose Intolerance
C-reactive Protein and Endothelial Dysfunction in Women With Glucose Intolerance
The goal of this study is to determine whether markers of vascular inflammation (such as c-reactive protein) can predict endothelial dysfunction (as measured by flow-mediated dilation) in postmenopausal women with glucose…
- Trial name
- NCT00589355
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Yale University
Pre-diabetes
Motivational Instant Messaging and E-diabetes Prevention Programme for High Risk of Type 2 Diabetes
The overall aim of this feasibility trial is to assess the effectiveness of a wearable technology and an e-diabetes prevention programme delivered via a smartphone application, including motivational messaging, in reducing weight…
- Trial name
- NCT02919397
- Testing
- Wearable technology, Diabetes Prevention Programme educational material, Motivational messaging
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- King's College London
Obese, Normal Body Weight
Cold Induced Changes in White Adipose
An adaptation to a cold environment is a tendency to generate heat within our body. Some of this heat comes from our fat tissue.
- Conditions
- Obese, Normal Body Weight, Prediabetes, Metabolic Syndrome
- Trial name
- NCT02596776
- Testing
- Fat biopsy, Propranolol and fat biopsy, heavy water and fat biopsy
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Philip Kern
Dyslipidemia, Diabetes
Meta-analyses of Fructose and Cardiometabolic Risk
Diabetes and heart associations continue to discourage high intakes of dietary fructose, a constituent part of the sucrose molecule that is found in fruits and vegetables as a natural sugar and in some processed foods and…
- Conditions
- Dyslipidemia, Diabetes, Prediabetes, Dysglycemia
- Trial name
- NCT01363791
- Testing
- Dietary fructose
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Healthy, Obese
Circadian Rhythmicity in Cold-induced Thermogenesis
This study aims to investigate whether maximum cold-induced non-shivering thermogenesis (e.g. thermogenesis as a consequence of BAT activity) differs between morning and evening.
- Conditions
- Healthy, Obese, Glucose Intolerance
- Trial name
- COLDR (NCT04406922)
- Testing
- Personalized cooling protocol
- Where
- Netherlands
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
PreDiabetes, Insulin Resistance
Brown Seaweed Extract on Glycemic Control and Body Weight
The overall goal of this study is to investigate the effects of a daily dietary supplement of brown seaweed (2 capsules of InSea2®) on body weight, glycemic control and insulin secretion in overweight prediabetic men and women in…
- Trial name
- Algues (NCT03075943)
- Testing
- InSea2
- Where
- Canada
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Laval University
Prediabetes, Hypertension
Intervention With a GABA Supplement in Prediabetics
In this double-blind parallel placebo controlled intervention study the effects of 3 times daily 500 mg gamma-aminobutyric acid (GABA) supplementation on glucose tolerance and cardiovascular health will be assessed in…
- Trial name
- NCT04303468
- Testing
- GABA
- Where
- Netherlands
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Wageningen University
Metabolic Syndrome, Pre-diabetes
Effect of Pasteurized Akkermansia Muciniphila on Insulin Resistance in Otherwise Healthy Subjects With Dysglycaemia
The purpose of this study is to demonstrate the efficacy of pasteurized Akkermansia muciniphila (pAKK) in improving insulin sensitivity in hyperglycaemic, but otherwise healthy persons with metabolic syndrome.
- Conditions
- Metabolic Syndrome, Pre-diabetes, Overweight and Obesity
- Trial name
- NCT05114018
- Testing
- Pasteurized A. muciniphila
- Where
- 2 sites in Germany, Ireland
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- A-Mansia Biotech S.A.
Diabete Type 2, Pre Diabetes
Investigation of PJ vs. Sugar on Glucose Levels in Healthy and Prediabetic Subjects
Pomegranate fruits and products, including juice, tea, wine and extracts are widely consumed and recognized for their health benefits.
- Trial name
- PSW (NCT04591782)
- Testing
- PomJuice, Water, Sugar Water
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Diabetes Type 2, PreDiabetes
Cognitive Functions and BDNF in T2DM and Prediabetes Patients
Clinical and epidemiological studies suggest links between cognitive impairments and Type 2 diabetes (T2DM). The underlying mechanisms and causality in diabetes-related cognitive impairment are largely unknown.
- Conditions
- Diabetes Type 2, PreDiabetes, Cognitive Impairment
- Trial name
- NCT05654727
- Where
- Turkey (Türkiye)
- Volunteers
- 230 people, healthy volunteers welcome
- Sponsor
- Bezmialem Vakif University
Weight Loss, Metabolic Syndrome
Signos DM2 Empowerment Study (SIGNOS-CGM-EMPOWER-201-2022)
The use of continuous glucose monitoring (CGM) in earlier data has inspired behavioral changes leading to improved adherence to an exercise plan in individuals and eating habits in people with diabetes.
- Conditions
- Weight Loss, Metabolic Syndrome, Diabetes Mellitus, Type 2, Central Obesity
- Trial name
- NCT05874635
- Testing
- Continuous Glucose Monitor Device
- Where
- United States
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- Signos Inc
Pre Diabetes, Vascular Stiffness
Dietary Exchanges With Avocado and Mango in Pre-diabetes
The research is designed as a randomized, 2-arm, parallel, controlled, human clinical trial to investigate the effects of avocado and mango consumption for 8 weeks on indices of macro- and micro- vascular function in individuals…
- Conditions
- Pre Diabetes, Vascular Stiffness, Vascular Dilation, Cognitive Change
- Trial name
- AVMa (NCT05353790)
- Testing
- Meals + snacks: control, Meals + snacks: Avocado mango
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology