Clinical trials: Prefrail
Frailty
Effects of Low-Speed and High-Speed Resistance Training Programs on Frailty Status
The present study refers to a three-arm randomized controlled trial that investigated the effects of two types of RT on frailty status, physical performance, cognitive function, and blood pressure of prefrail and frail older…
- Trial name
- RTF (NCT04868071)
- Testing
- Physical Exercise
- Where
- 2 sites in Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
HIV, Frailty
Improving Physical Ability and Cellular Senescence Elimination in HIV
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail.
- Conditions
- HIV, Frailty, Prefrail, Aging Problems
- Trial name
- IPACE-HIV (NCT07144293)
- Testing
- Dasatinib, Quercetin
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Cognitive-prefrailty, Prefrailty
The Cognitive-Prefrail Syndrome and Its Association With Adverse Health Outcomes
Lay Summary Older adults who are prefrail (an intermediate, potentially reversible stage between robustness and frailty) with early symptoms of cognitive impairment are a segment of the population that have hitherto remained…
- Conditions
- Cognitive-prefrailty, Prefrailty, Motoric Cognitive Risk Syndrome
- Trial name
- NCT04240028
- Testing
- Data Collection
- Where
- Canada
- Volunteers
- 1,741 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Frailty, Aged
RCT to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults
Objectives: The main objective is to analyze the efficacy of an intervention based on the algorithm proposed by the Spanish Healtcare Ministry (see figure in annex 1) at Primary Care level to reduce Frailty status or Physical…
- Conditions
- Frailty, Aged, Exercise
- Trial name
- FRAILMERIT (NCT05002439)
- Testing
- Multicomponent physical exercise program and a nutritional intervention
- Where
- Spain
- Volunteers
- 273 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Frailty, Motoric Cognitive Risk Syndrome
Cognitive Prefrail and Frailty, and Motoric Cognitive Risk Syndrome: Prevalence and Association With Incident Adverse Health Events
We defined a new and early condition in the spectrum of cognitive frailty: the "cognitive-prefrailty" which is a combination of prefrailty stage and subjective cognitive impairment (SCI).
- Conditions
- Frailty, Motoric Cognitive Risk Syndrome, Cognitive-prefrailty
- Trial name
- NCT04275817
- Testing
- Data collection
- Where
- Canada
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Jewish General Hospital
Type 2 Diabetes Mellitus
Multi-Modal Intervention In Frail And Prefrail Older People With Type 2 Diabetes
The MID-Frail STUDY project focuses on the use of interventions designed to improve functional status and enhance quality of life (rather than traditional treatments such as glucose- and blood pressure- lowering) by acting on the…
- Trial name
- MID-Frail (NCT01654341)
- Testing
- Exercise, dietary and educational program
- Where
- Spain
- Volunteers
- 986 people
- Sponsor
- Hospital Universitario Getafe
Frailty, Inflammation
Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly.
Background: Immunosenescence is an aging-dependent phenomenon underlying age dependent deterioration in the function of the immune system, characterized by a decline in B and T cells with a relative increase in natural killer…
- Conditions
- Frailty, Inflammation, Immune System Disorder
- Trial name
- NCT04928963
- Testing
- Prolon - FMD
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Genova
Pre-Frailty, Aging
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life.
- Trial name
- RtM (NCT07454616)
- Testing
- Supervised exercise program, a balanced micronutrient blend
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University of Singapore
Prefrail Elderly
SingHealth Polyclinics - Functional Strength Building of Older Persons
The goal of this study is to find out if a 12-week exercise programme for pre-frail seniors will result in an improvement in physical performance measures.
- Trial name
- FABULOS (NCT07133282)
- Testing
- Group exercise programme
- Where
- 4 sites in Singapore
- Volunteers
- 227 people
- Sponsor
- SingHealth Polyclinics
Healthy Young Adults, Prefrail Elderly
GOS and Microbial Fermentation in Aging
The population is aging worldwide, concomitant frailty is increased in older age groups. Frailty has a strong impact on outcomes of multi-morbidity and daily living, thereby negatively influencing quality of life and health care…
- Trial name
- NCT03077529
- Testing
- Galacto-oligosacchride, Maltodextrin
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Inflammatory Response
Effects of Metformin in a Non-Diabetic Patient Population
Metformin has a well-established safety profile and it has become clear that metformin has additional salutary effects, including anti-inflammatory, anti-aging, and anti-thrombotic properties.
- Trial name
- NCT03772964
- Testing
- MetFORMIN Hydrochloride ER
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brian Zuckerbraun
Frailty, Geriatrics
Combating Hospital-related Function Decline Among Prefrail Older Adults: A Pilot Study
This study focuses on the "Strength-based Tailored-Exercise Program at Home (STEP@Home)" aimed at improving health outcomes for geriatric patients at risk of hospitalization-associated functional decline.
- Trial name
- STEP@Home (NCT06191276)
- Testing
- STEP@Home Intervention, Usual care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Frailty
South Korean Study to Prevent Frailty and Aging-related Diseases Through Lifestyle Intervention
The goal of this feasibility randomized controlled trial is to investigate the applicability of software that aims to improve symptoms of frailty by implementing customized interventions such as physical exercise and cognitive…
- Trial name
- SUPERAGING (NCT06891573)
- Testing
- Lifestyle Management
- Where
- 3 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- Seong Hye Choi, MD
Biomarkers
The Effect of Whole-body Vibration Training
The whole-body vibration programme employed in this study partly improved the biomarkers and health beliefs of the prefrail community-dwelling older adults.
- Trial name
- NCT04273308
- Testing
- whole-body vibration training
- Volunteers
- 42 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Sarcopenia
Imaging Biomarkers of the Effects of a Mixed Exercise Program
The aim is quantify, correlate and establish the diagnostic and prognostic value of the variation of the image biomarkers obtained by magnetic resonance (muscle volume, morphological, biochemical and structural biomarkers)…
- Trial name
- SarcoImage (NCT03834558)
- Testing
- Mixed exercise program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Heart Failure, Prefrail Elderly
High-technology TeleRehabilitation for the Treatment of the FRAgile Patient
The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure.
- Conditions
- Heart Failure, Prefrail Elderly, Frail Elderly Syndrome
- Trial name
- TeleRiab4Fra (NCT07561021)
- Testing
- Telerehabilitation, Caregiver-Supervised Home Exercise Program
- Volunteers
- 70 people
- Sponsor
- University of Salerno
Elderly People
Immune Benefits of WGP in Elderly
The aim of this research is to assess the immune enhancing property of food fibers in the elderly population.
- Trial name
- NCT02262091
- Testing
- Food fibers, Maltodextrin, Influenza vaccine (incl. criterion)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
Frailty Syndrome, Frail Elderly Syndrome
Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican
Randomized clinical trial, international, multicentre, single-blind, two parallel groups, pragmatic. It will be carried out by investigators in several Latin American countries (Chile, Colombia, Mexico and Peru) and with random…
- Conditions
- Frailty Syndrome, Frail Elderly Syndrome, Diabetes Mellitus, Type 2
- Trial name
- DIABFRAIL (NCT04504968)
- Testing
- Multimodal intervention, Usual care group
- Where
- Colombia
- Volunteers
- 713 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Frailty
Supporting Habit Formation to Attenuate Prefrailty in Elders: Pilot Study
The Supporting Habit Formation to Attenuate Prefrailty in Elders (SHAPE) Pilot Study is a randomized control study. The main objective of this pilot study is to determine the feasibility of using Habit Formation (HF) treatment to…
- Trial name
- SHAPE (NCT04140890)
- Testing
- Habit Formation, Education
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wayne State University
Frailty, Sarcopenia
Fit in the Aged by Professional Training
This intervention study tests training methods to stabilize or improve functionality in the high risk group of prefrail elderly persons.
- Trial name
- FiAT (NCT00783159)
- Testing
- Power Training, Strength Training, Control
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University of Erlangen-Nürnberg Medical School