Clinical trials: Prefrail Elderly
Frailty
Effects of Low-Speed and High-Speed Resistance Training Programs on Frailty Status
The present study refers to a three-arm randomized controlled trial that investigated the effects of two types of RT on frailty status, physical performance, cognitive function, and blood pressure of prefrail and frail older…
- Trial name
- RTF (NCT04868071)
- Testing
- Physical Exercise
- Where
- 2 sites in Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
HIV, Frailty
Improving Physical Ability and Cellular Senescence Elimination in HIV
This clinical trial is a Phase II study designed to test the safety and effectiveness of a combination of dasatinib and quercetin (D+Q) in improving physical function for people with HIV who are frail or prefrail.
- Conditions
- HIV, Frailty, Prefrail, Aging Problems
- Trial name
- IPACE-HIV (NCT07144293)
- Testing
- Dasatinib, Quercetin
- Where
- 24 sites in United States
- Volunteers
- 82 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Frailty, Aged
RCT to Analyze the Efficacy of a Spanish Healthcare ministRy Based In InTervention to Reduce Frailty Status in Prefrail Older Adults
Objectives: The main objective is to analyze the efficacy of an intervention based on the algorithm proposed by the Spanish Healtcare Ministry (see figure in annex 1) at Primary Care level to reduce Frailty status or Physical…
- Conditions
- Frailty, Aged, Exercise
- Trial name
- FRAILMERIT (NCT05002439)
- Testing
- Multicomponent physical exercise program and a nutritional intervention
- Where
- Spain
- Volunteers
- 273 people
- Sponsor
- Complejo Hospitalario Universitario de Albacete
Frailty, Inflammation
Fighting Immunosenescence and Promoting Immunity by a Fasting-mimicking Diet Elderly.
Background: Immunosenescence is an aging-dependent phenomenon underlying age dependent deterioration in the function of the immune system, characterized by a decline in B and T cells with a relative increase in natural killer…
- Conditions
- Frailty, Inflammation, Immune System Disorder
- Trial name
- NCT04928963
- Testing
- Prolon - FMD
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Genova
Pre-Frailty, Aging
Exploratory Study on a Multi-nutrient Supplement and Exercise Program for Improving Health Markers Associated to Longevity in Pre-frail Adults
Frailty is associated with biological changes in the gut microbiome and immune system, along with marked declines in physical and cognitive function, leading to an overall reduction in quality of life.
- Trial name
- RtM (NCT07454616)
- Testing
- Supervised exercise program, a balanced micronutrient blend
- Where
- Singapore
- Volunteers
- 40 people
- Sponsor
- National University of Singapore
Prefrail Elderly
SingHealth Polyclinics - Functional Strength Building of Older Persons
The goal of this study is to find out if a 12-week exercise programme for pre-frail seniors will result in an improvement in physical performance measures.
- Trial name
- FABULOS (NCT07133282)
- Testing
- Group exercise programme
- Where
- 4 sites in Singapore
- Volunteers
- 227 people
- Sponsor
- SingHealth Polyclinics
Healthy Young Adults, Prefrail Elderly
GOS and Microbial Fermentation in Aging
The population is aging worldwide, concomitant frailty is increased in older age groups. Frailty has a strong impact on outcomes of multi-morbidity and daily living, thereby negatively influencing quality of life and health care…
- Trial name
- NCT03077529
- Testing
- Galacto-oligosacchride, Maltodextrin
- Where
- Netherlands
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Inflammatory Response
Effects of Metformin in a Non-Diabetic Patient Population
Metformin has a well-established safety profile and it has become clear that metformin has additional salutary effects, including anti-inflammatory, anti-aging, and anti-thrombotic properties.
- Trial name
- NCT03772964
- Testing
- MetFORMIN Hydrochloride ER
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Brian Zuckerbraun
Frailty, Geriatrics
Combating Hospital-related Function Decline Among Prefrail Older Adults: A Pilot Study
This study focuses on the "Strength-based Tailored-Exercise Program at Home (STEP@Home)" aimed at improving health outcomes for geriatric patients at risk of hospitalization-associated functional decline.
- Trial name
- STEP@Home (NCT06191276)
- Testing
- STEP@Home Intervention, Usual care
- Where
- Hong Kong
- Volunteers
- 40 people
- Sponsor
- The University of Hong Kong
Biomarkers
The Effect of Whole-body Vibration Training
The whole-body vibration programme employed in this study partly improved the biomarkers and health beliefs of the prefrail community-dwelling older adults.
- Trial name
- NCT04273308
- Testing
- whole-body vibration training
- Volunteers
- 42 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Sarcopenia
Imaging Biomarkers of the Effects of a Mixed Exercise Program
The aim is quantify, correlate and establish the diagnostic and prognostic value of the variation of the image biomarkers obtained by magnetic resonance (muscle volume, morphological, biochemical and structural biomarkers)…
- Trial name
- SarcoImage (NCT03834558)
- Testing
- Mixed exercise program
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- University of Valencia
Heart Failure, Prefrail Elderly
High-technology TeleRehabilitation for the Treatment of the FRAgile Patient
The aim of this randomized controlled clinical trial is to evaluate the efficacy of an 8-week sensorimotor and cognitive telerehabilitation program in frail and pre-frail older adults with stable chronic heart failure.
- Conditions
- Heart Failure, Prefrail Elderly, Frail Elderly Syndrome
- Trial name
- TeleRiab4Fra (NCT07561021)
- Testing
- Telerehabilitation, Caregiver-Supervised Home Exercise Program
- Volunteers
- 70 people
- Sponsor
- University of Salerno
Elderly People
Immune Benefits of WGP in Elderly
The aim of this research is to assess the immune enhancing property of food fibers in the elderly population.
- Trial name
- NCT02262091
- Testing
- Food fibers, Maltodextrin, Influenza vaccine (incl. criterion)
- Where
- Germany
- Volunteers
- 150 people
- Sponsor
- Société des Produits Nestlé (SPN)
Frailty Syndrome, Frail Elderly Syndrome
Effectiveness of a Multimodal Intervention on Function in Older Frail People With Diabetes in Latinamerican
Randomized clinical trial, international, multicentre, single-blind, two parallel groups, pragmatic. It will be carried out by investigators in several Latin American countries (Chile, Colombia, Mexico and Peru) and with random…
- Conditions
- Frailty Syndrome, Frail Elderly Syndrome, Diabetes Mellitus, Type 2
- Trial name
- DIABFRAIL (NCT04504968)
- Testing
- Multimodal intervention, Usual care group
- Where
- Colombia
- Volunteers
- 713 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Frailty, Sarcopenia
Fit in the Aged by Professional Training
This intervention study tests training methods to stabilize or improve functionality in the high risk group of prefrail elderly persons.
- Trial name
- FiAT (NCT00783159)
- Testing
- Power Training, Strength Training, Control
- Where
- Germany
- Volunteers
- 69 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Frailty Syndrome, Prefrail Elderly
Comparıson of the Effıcacy of Conventıonal Exercıse and Pılates ın Pre-fraıl and Fraıl Older Adults
Brief Summary This clinical study aims to compare the effects of a conventional exercise program and a Pilates exercise program in prefrail and frail older adults.
- Conditions
- Frailty Syndrome, Prefrail Elderly, Frail Elderly, Geriatric
- Trial name
- NCT07458048
- Testing
- PILATES EXERCISES GROUP, CONVENTIONAL EXERCISES GROUP
- Volunteers
- 40 people
- Sponsor
- Istanbul University - Cerrahpasa
Prefrail Elderly, Frail Elderly
The Effect of Teleconsultation, on the Reversibility of Frailty in Geriatric Patients Post Hospitalization
The goal of this clinical trial is to learn if a structured tele-consultation program, delivered 3 times over 12 weeks, can improve (reverse) frailty in geriatric patients recently discharged from the hospital.
- Trial name
- TeleFrailty (NCT07712276)
- Testing
- structured teleconsultation and face to face consultation, face to face consultation
- Where
- Indonesia
- Volunteers
- 116 people
- Sponsor
- Universitas Indonesia
Frail Elderly Syndrome
GrandMove Project to Promote Elders' Robustness Against Frailty
This is a single-blind, cluster randomized, cross-over trial to investigate the effectiveness of (1) a 6-month aerobic exercise program, (2) a 6-month resistance exercise program, versus (3) a 6-month psychoeducation program on…
- Trial name
- GrandMove (NCT05397288)
- Testing
- Resistance exercise (R), Aerobic exercise (A), Healthy lifestyle education (E)
- Where
- Hong Kong
- Volunteers
- 390 people
- Sponsor
- The University of Hong Kong
Elderly, Functional Status
Connecting Emergency Departments With Community Services to Prevent Mobility Losses in Pre-frail & Frail Seniors
About 18% of independent people over 65 who are evaluated in Emergency Departments for minor injuries (fractures, sprains) present some mobility decline up to 3 to 6 months postinjury.
- Trial name
- CEDeComS (NCT03991598)
- Testing
- Exercise program
- Where
- 6 sites in Canada
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- CHU de Quebec-Universite Laval
Prefrail Elderly
Non-invasive Brain Stimulation on Functional Capacity in Prefrail Older Adults
The general objective of this study is to evaluate the effectiveness of non-invasive neuromodulation combined with a therapeutic exercise program on neuroplasticity and, therefore, on variables related to functional capacity and…
- Trial name
- NeuroFit (NCT07346989)
- Testing
- tDCS, Virtual running
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- University of Valencia