Clinical trials: Prefrontal Cortex
Healthy Volunteers
Magnetic Prefrontal Stimulation for Studying the Role of the Cortex in High-level Cognition Processes and Reward System
The investigators intend to study the role of the cortex in high- level cognition processes and sensory adaptation, by the use of non-invasive Transcranial Magnetic stimulation and various cognitive tests.
- Trial name
- NCT00912522
- Testing
- TMS
- Where
- Israel
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Alzheimer's Disease
Enhancing Working Memory in Patients With Early Alzheimer's Disease Through the Use of rTMS
In this study the investigators aim at assessing and then enhancing neuroplasticity in the dorsolateral prefrontal cortex (DLPFC) and working memory - a key function of DLPFC - in patients with mild Alzheimer's disease (AD).
- Trial name
- rTMS-AD (NCT02537496)
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Treatment Resistant Depression
Dorsomedial Prefrontal Cortex and the Antidepressant Efficacy of Theta Burst Stimulation in Depressed Patients
This study evaluates an association between different dosage and the antidepressant efficacy of theta burst stimulation in patients with treatment-resistant depression.
- Trial name
- NCT04037592
- Testing
- Active standardized iTBS-DMPFC, Active high-dosage iTBS-DMPFC
- Where
- Taiwan
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Stroke, Healthy Participants
Prefrontal Brain Activity and ECG Patterns in Stroke and Healthy Adults
This observational study will evaluate brain activity and heart rhythm patterns in people with and without stroke. Brain activity will be measured using functional near-infrared spectroscopy (fNIRS) and electroencephalography…
- Trial name
- NCT07322107
- Where
- South Korea
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Pusan National University Yangsan Hospital
Autism Spectrum Disorder
The Therapeutic Effects of Continuous Theta Burst Stimulation in Autism Spectrum Disorder
The investigator would like to investigate the impact of theta burst stimulation over left dorsolateral prefrontal cortex in autism spectrum disorder
- Trial name
- NCT04993144
- Testing
- continuous theta burst stimulation
- Where
- Taiwan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Aging
Older Age and Generalization
The goal of this clinical is to learn how the brain supports different kinds of memory decisions in healthy young and older adults.
- Trial name
- NCT07440017
- Testing
- Memory decision type
- Where
- United States
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Caitlin Bowman
Brain Injury, Chronic
Investigating the Role of the Premotor Cortex in Higher Cognitive Functions
This project aims at understanding better the role of the frontal lobe of the brain in our capacity to perceive visual information consciously, and also, in our capacity to perceive others' actions.
- Trial name
- NCT00842413
- Where
- France
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Depressive Disorder, Major
Probing Prefrontal Cortex Hemodynamic Alterations for Major Depression Disorder
Major depression disorder (MDD) has high estimated lifetime prevalence rates of 16.6%. Currently, the diagnosis for the MDD mainly depends on patients' reports of symptoms, observed behaviors and disease course.
- Trial name
- MDD (NCT03595020)
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Major Depressive Disorder, Schizophrenia
Disorder-tailored Transcranial Direct Current Stimulation (tDCS) of the Prefrontal Cortex
Major depressive disorder (MDD) is a common, recurrent, and frequent chronic disorder. Among others, deficient cognitive control over emotional distraction is a central characteristic of MDD (Ochsner \& Gross 2005; Disner et al.
- Trial name
- MRSDC1 (NCT02715128)
- Testing
- Transcranial direct current stimulation (tDCS)
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Schizophrenia
Paired Associative Stimulation in the Dorsolateral Prefrontal Cortex in Patients With Schizophrenia
The purpose of this study is to 1. assess the effect of PAS in schizophrenia in the dorsolateral prefrontal cortex (DLPFC) 2. assess the effect of PAS induced long-term potentiation (LTP) on the performance of patients with…
- Trial name
- NCT01545999
- Testing
- Brain Stimulation via Transcranial Magnetic Stimulation
- Where
- Canada
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Antisocial Behavior, Aggression
The Effect of Prefrontal Cortex Stimulation on Antisocial and Aggressive Behavior
This study investigates the effect of upregulating prefrontal cortex activity on antisocial and aggressive behavior and risk factors for such behavior.
- Trial name
- NCT02427672
- Testing
- Transcranial direct current stimulation
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Current Major Depressive Disorder, Healthy
Evaluating Brain Responses to Facial Expressions in Major Depressive Disorder
This study will evaluate emotional processing biases in the brain while viewing facial expressions in adults with current or remitted major depressive disorder and healthy volunteers.
- Conditions
- Current Major Depressive Disorder, Healthy, Remitted Major Depressive Disorder
- Trial name
- NCT00071123
- Where
- United States
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy
Study of Brain Function During Cognitive Tasks
This study will use magnetic resonance imaging (MRI) to examine which areas of the brain are involved in performing certain cognitive tasks.
- Trial name
- NCT00076739
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Binge-Eating Disorder, Emotional Eating
Study of Emotional Regulation and Underlying Prefrontal Activity in Binge Eating Disorder
The goal of this exploratory, interventional, multicentre study is to compare the prefrontal activity during a negative emotion regulation task in women with Binge-Eating Disorder (BED) and healthy women with and without…
- Conditions
- Binge-Eating Disorder, Emotional Eating, Healthy Volunteers
- Trial name
- EmoBED (NCT06864065)
- Testing
- Emotion regulation task (fNIRS recording during the emotional regulation task)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cognitive Symptom, Healthy
The Effect of Transcranial Direct Stimulation on Cognitive Functions of Healthy Adults
Background: Transcranial direct current stimulation(tDCS) has been used to improve cognitive functions in healthy young adults. Purpose: To investigate the effect of TDCS application on different cortex regions on cognitive…
- Trial name
- NCT04873804
- Testing
- Transcranial Direct Current Stimulation
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Medipol University
Caffeine
Effects of Caffeine on EEG Theta/Beta Ratio and Cognitive Control
Cognitive control driven by the prefrontal cortex (PFC) of the brain is thought to be important for goal-directed control over stimulus-driven processes.
- Trial name
- NCT02940808
- Testing
- Caffeine (200mg)
- Where
- Netherlands
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Leiden University Medical Center
Impulsivity
fNIRS Neurofeedback in Highly Impulsive Participants With ROI Regions DLPFC and IFG
The aim of the following study is to investigate which is the best region of interest (ROI) for a functional near-infrared spectroscopy (fNIRS)-based neurofeedback (NF) training for highly-impulsive individuals (and consequently…
- Trial name
- NCT05863169
- Testing
- fNIRS-Neurofeedback
- Where
- Germany
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Healthy Participants
Functional Roles of Dorsolateral Prefrontal Cortex
Dorsolateral prefrontal cortex (DLPFC) has been found to be involved in cognitive functions such as executive function, response selection, and working memory.
- Trial name
- NCT03882931
- Testing
- Theta Burst Transcranial Magnetic Stimulation, Focused Ultrasound
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Schizophrenia
Brain Stimulation, Clinical Symptoms and Cognition
The purpose of this study is to test the impact of non-invasive brain stimulation, transcranial direct current stimulation (tDCS), on auditory hallucinations, negative symptoms and cognition in schizophrenia.
- Trial name
- NCT05053451
- Testing
- Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Healthy
Brain Encoding for Memory
This two-part study will use transcranial magnetic stimulation, or TMS (see below), to explore how the brain forms memories. People remember only some of the events they experience every day, such as faces they perceive, words…
- Trial name
- NCT00051870
- Testing
- Magstim Rapid Magnetic Stimulator
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)