Clinical trials: Pregnancy in Diabetes
Proteinuria
Safety and Pharmacokinetic Study of Subcutaneous ALXN1720 in Participants With Proteinuria
The primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (PK) of a single dose of ALXN1720 in participants with proteinuria.
- Trial name
- NCT05314231
- Testing
- ALXN1720
- Where
- 2 sites in South Korea
- Volunteers
- 13 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Type 2 Diabetes Mellitus (T2DM), Pregnancy
CGM for Management of Type 2 Diabetes in Pregnancy
The goal of this clinical trial is to learn if continuous glucose monitoring works better than self-monitoring of blood glucose (fingersticks) to treat type 2 diabetes in pregnancy.
- Trial name
- CGM2 (NCT06628453)
- Testing
- CGM
- Where
- 7 sites in United States
- Volunteers
- 564 people
- Sponsor
- University of Alabama at Birmingham
Diabetic Kidney Disease, Diabetic Nephropathies
Patient-Derived Stem Cell Therapy for Diabetic Kidney Disease
The Researchers will assess the safety, tolerability, dosing effect, and early signals of efficacy of intra-arterially delivered autologous (from self) adipose (fat) tissue-derived mesenchymal stem/stromal cells (MSC) in patients…
- Conditions
- Diabetic Kidney Disease, Diabetic Nephropathies, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03840343
- Testing
- Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Lower Dose, Autologous adipose-derived mesenchymal stem/stromal cells (MSC) Higher Dose
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Maturity-Onset Diabetes of the Young
Impact on Birth Weight of Two Therapeutic Strategies (Insulin Therapy From the Beginning of Pregnancy vs. Insulin Therapy Initiated According to Fetal Growth Evaluated by Ultrasonography Measurements) in Pregnant Women With Monogenic Diabetes
Maturity-onset diabetes of youth (MODY) are the most frequent monogenic diabetes with autosomic dominant inheritance (2% of diabetes).
- Trial name
- MODY2 (NCT02556840)
- Testing
- insulin therapy
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
ESRD, Diabetes
IMPENDIA- PEN VS Dianeal Only Improved Metabolic Control In Diabetic CAPD and APD Patients
Primary Objective: To demonstrate that use of glucose sparing prescriptions (PEN vs Dianeal only) in diabetic (Type 1 and Type 2) Continuous Ambulatory Peritoneal Dialysis (CAPD) and Automated Peritoneal Dialysis (APD)patients…
- Conditions
- ESRD, Diabetes, CAPD, APD
- Trial name
- Impendia (NCT00567489)
- Testing
- Physioneal, Dianeal, Extraneal
- Where
- 19 sites in Hong Kong, Russia and 3 more
- Volunteers
- 137 people
- Sponsor
- Vantive Health LLC
Diabetic Kidney Disease, Diabetic Nephropathies
Clinical Outcome of Vinpocetine in Diabetic Nephropathy
The goal of this controlled, randomized, clinical trial is to evaluate the effect of vinpocetine on clinical outcomes on the diabetic nephropathy patients.
- Trial name
- NCT06441591
- Testing
- Vinpocetine, Standard Therapy
- Where
- 2 sites in Egypt
- Volunteers
- 64 people
- Sponsor
- Ain Shams University
Microalbuminuria, Diabetic Nephropathy
Chicken-Diet vs. Enalapril to Reduce Albuminuria
Diabetic nephropathy (DN) is a chronic diabetic complication and affects up to 40% of patients. The first line treatment for DN is angiotensin blockers drugs that are used to reduce the protein concentration in urine.Previous…
- Trial name
- NCT00484068
- Testing
- enalapril, chicken diet
- Where
- Brazil
- Volunteers
- 28 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Gestational Diabetes Mellitus in Childbirth, Neurodevelopmental Disorders
Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
The prospective multicenter study GD-Brain provides a better knowledge on the basis of neurological impairment in children born to mothers with gestational diabetes (GDM).
- Trial name
- GD-BRAIN (NCT03032991)
- Where
- Spain
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Type 2 DM, Type 2 DM /Diabetic Nephropathy
Urinary Proteomics to Guide Early Intervention to Prevent Complications in Type 2 Diabetes - a Feasibility Study
Title: Body fluid proteome SIGnatures for persoNALised intervention to prevent cardiovascular and renal complications in diabetes.
- Conditions
- Type 2 DM, Type 2 DM /Diabetic Nephropathy, Albuminuria
- Trial name
- SIGNAL (NCT06954090)
- Testing
- Semaglutide, 1.34 mg/mL, Finerenone Oral Tablet, Dapagliflozin (DAPA)
- Where
- Denmark
- Volunteers
- 50 people
- Sponsor
- Steno Diabetes Center Copenhagen
Gestational Diabetes
Gestational Diabetes in Uganda and India Improving Screening and Self-management
This trial will evaluate a package of three interconnected educational/behavioural interventions aimed at: a) improving knowledge and skills of GDM guidelines and skills of health providers; b) raising awareness of importance of…
- Trial name
- GUIDES (NCT03937050)
- Testing
- Intervention
- Where
- 2 sites in India, Uganda
- Volunteers
- 16,500 people, healthy volunteers welcome
- Sponsor
- London School of Hygiene and Tropical Medicine
Pregnancy Outcome, Gestational Weight Gain
The Effect of Individualized Exercise Guidance on Pregnancy Outcome
A single center, randomized controlled trial was conducted to investigate whether individualized exercise guidance was more effective in improving pregnancy outcomes in normal pregnant women.
- Conditions
- Pregnancy Outcome, Gestational Weight Gain, Mediation, Macrosomia, Fetal
- Trial name
- NCT05760768
- Testing
- Individualized exercise guidance
- Where
- China
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Gestational Diabetes
MyDiabby Healthcare Vs Diary in Gestational Diabetes Mellitus.
The purpose of the study is to demonstrate the non-inferiority of the onset of maternal, foetal, and neonatal complications for patients who had Gestational diabetes mellitus (GDM) and who had been monitored by myDiabby…
- Trial name
- TELESUR-GDM (NCT05510583)
- Testing
- Control group, Treated group
- Where
- France
- Volunteers
- 668 people
- Sponsor
- Hôpital NOVO
Type 2 Diabetes Mellitus, Chronic Kidney Disease
A Study of Autologous Renal Autologous Cell Therapy (REACT) in Patients With Diabetic Chronic Kidney Disease
The purpose of the present study is to assess the safety and efficacy of up to 2 injections of REACT given 6 months (+4 weeks) apart (maximum).
- Trial name
- NCT03270956
- Testing
- Renal Autologous Cell Therapy (REACT)
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- Prokidney
Proteinuria, Hypertension
Epithelial Sodium Channel (ENaC) as a Novel Mechanism for Hypertension and Volume Expansion in Type 2 Diabetes
The purpose of this study is to determine with the administration of amiloride, observe an enhanced natriuresis, reduction in blood pressure and weight compared to the administration of hydrochlorothiazide in Type 2 Diabetics.
- Conditions
- Proteinuria, Hypertension, Type II Diabetes
- Trial name
- NCT01804777
- Testing
- Amiloride, HCTZ
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of New Mexico
Gestational Diabetes, Hearing Loss
Hearing Screening Outcomes of Two Screening Tests in Newborns of Gestational Diabetic Mothers
In this study, the investigators have aimed to investigate whether GDM is a risk factor for hearing impairment in newborns. To the investigators knowledge, this study is the first prospective, controlled study on this subject.
- Trial name
- NCT04845412
- Testing
- Hearing screening tests
- Where
- Turkey (Türkiye)
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Ankara Training and Research Hospital
Pregnancy in Diabetics
Blood Pressure, Antihypertensive Treatment and Preeclampsia in Pregnant Wom-en With Pre-existing Diabetes
Aim: First, to investigate the prevalence of a) confirmed hypertension, b) white coat hypertension and c) normal blood pressure in pregnant women with pre-existing diabetes.
- Trial name
- NCT02890836
- Testing
- Antihypertensiva, mainly Metyldopa
- Where
- Denmark
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Metabolic Study of Women With Polycystic Ovary Syndrome and Sleep Apnea
The purpose of this study is to look at the metabolic (use of energy) and hormonal features of sleep problems in women with polycystic ovary syndrome (PCOS).
- Trial name
- NCT00696111
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- University of Chicago
Nephrotic Syndrome
Steroid Diabetes in Patients With Kidney Disease
If steroid diabetes is not recognized in time, it will cause irreversible damage to the body. Nephropathy patients are more likely to have steroid diabetes ,the incidence rate up to 25%,due to hypoalbuminemia, high-dose hormone…
- Trial name
- NCT06161701
- Testing
- no intervention
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Zhejiang Provincial People's Hospital
Diabetic Nephropathy Type 2, Microalbuminuria Due to Type 2 Diabetes Mellitus
Efficacy of ACE Inhibitors, MRAs and ACE Inhibitor/ MRA Combination
The aim of our work is to compare the antiproteinuric efficacy of ACEI monotherapy, Selective MRA monotherapy and their combination in mildly hypertensive patients with type 2 diabetes mellitus and microalbuminuria
- Trial name
- NCT04143412
- Testing
- Tritace (Ramipril 10 mg)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Beni-Suef University
Diabetes Mellitus, Chronic Kidney Diseases
Cardiometabolic Devices Accuracy Study
With the rise of cardiovascular diseases (CVD) and diabetes, the global disease burden is shifting towards non-communicable diseases (NCDs).
- Conditions
- Diabetes Mellitus, Chronic Kidney Diseases, Hyperlipidemias
- Trial name
- NCT05257564
- Testing
- Determine the accuracy of quantitative measurements of GLU, HbA1c,CHOL and CRE with POC devices compared to a laboratory reference method (Roche)
- Where
- Nepal
- Volunteers
- 359 people, healthy volunteers welcome
- Sponsor
- Foundation for Innovative New Diagnostics, Switzerland
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