Clinical trials: Prehospital Setting
Injury Traumatic, Pain, Acute
Safety and Efficacy of Sufentanil Administration by Paramedics in Acute Trauma
The safety and efficacy of competence of paramedics to administer sufentanil intravenously in adult acute trauma patients without presence or without phone-call consult with an emergency medical doctor will be assessed in this…
- Trial name
- NCT06514469
- Testing
- Sufentanil intravenous administration followed consultation of remote physician, Sufentanil intravenous administration based on paramedic competency
- Where
- Czechia
- Volunteers
- 300 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Karlovarskeho Kraje, P.O.
Trauma Injury, Pain
Sufentanil Used by Paramedics to Treat Pain in Acute Trauma
The new competence of paramedics to administer opioid analgesics in acute trauma patients without presence or phone-call consult with an emergency medical doctor will be assessed in this study.
- Trial name
- NCT04913402
- Testing
- Sufentanil administered by paramedics after the phone call consultation of medical doctor., Sufentanil administered by paramedics based on their competency, without consultation of medical doctor.
- Where
- Czechia
- Volunteers
- 158 people
- Sponsor
- Zdravotnicka Zachranna Sluzba Karlovarskeho Kraje, P.O.
Stroke
Enhancing Prehospital Stroke Diagnosis
Current American Heart Association Guidelines recommend that stroke patients be promptly rescued and identified so that the accepting hospital can be alerted and prepared to receive and treat them promptly.
- Trial name
- AIPO (NCT06427746)
- Testing
- Standard, Video call, Video call + LARIO
- Where
- Italy
- Volunteers
- 2,197 people
- Sponsor
- Agenzia Regionale emergenza Urgenza
Brain Injuries, Traumatic, Brain Injuries, Acute
Critical Hyperacute Assessment Research On Neurobiomarker Kinetics in Acute Brain Injury
Traumatic brain injury (TBI) and other conditions that reduce blood flow to the brain - such as cardiac arrest (CA) - are life-threatening medical emergencies.
- Conditions
- Brain Injuries, Traumatic, Brain Injuries, Acute, Hypoxia, Brain, Cardiac Arrest (CA)
- Trial name
- CHARON (NCT07782216)
- Where
- 4 sites in Hungary
- Volunteers
- 477 people
- Sponsor
- University of Pecs
Brain Injuries
Feasibility Trial of Traumatic Brain Injured Patients Randomized in the Prehospital Setting to Either Hypertonic Saline and Dextran Versus Normal Saline
This clinical trial will evaluate the ease of conducting a randomized trial on patients with severe head injury who are cared for by paramedics in the out of hospital setting.
- Trial name
- TOPHR HIT (NCT00878631)
- Testing
- hypertonic saline mixed with dextran, Normal Saline
- Where
- 2 sites in Canada
- Volunteers
- 113 people
- Sponsor
- Unity Health Toronto
Stroke Acute, Emergency Medical Services
Sex diffErences in prehoSpitAl Stroke MEdicine
Background: Stroke is a leading cause for individual, family and societal harm with huge health-economic impact. Immediate and correct prehospital acute stroke pathway initiation is key for treatment success.
- Conditions
- Stroke Acute, Emergency Medical Services, Sex Characteristics, Prehospital Setting
- Trial name
- SESAME (NCT06865950)
- Where
- Germany
- Volunteers
- 2,000 people
- Sponsor
- Universität des Saarlandes
Mass Casualty Incident, Dehydration
Recombinant Hyaluronidase in Out-of-Hospital Setting: The EASI Access Trial
The study's overarching aim is to determine whether Enzymatically Augmented Subcutaneous Infusion (EASI) can assist in out-of-hospital situations characterized by mismatch between need for, and ability to achieve, access to the…
- Trial name
- NCT00386386
- Testing
- hypodermoclysis via recombinant hyaluronidase-facilitated subcutaneous infusion
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Hemorrhagic Shock
Safety and Efficacy of PolyHeme(R) in Hemorrhagic Shock Following Traumatic Injuries Beginning in the Pre-Hospital Setting
This study is designed to assess the survival benefit of administering PolyHeme to severely injured trauma patients in hemorrhagic shock beginning in the prehospital setting, where blood is not available, and continuing…
- Trial name
- NCT00076648
- Testing
- Poly SFH-P Injection
- Where
- 32 sites in United States
- Sponsor
- Northfield Laboratories
Emergency Medical Services, Airway Management
The Evaluation of Training an Emergency Reflex Action Drill in the Emergency Surgical Airway in Dutch Paramedics
The goal of this observational study is to learn about the effects of training an Emergency Reflex Action Drill (ERAD) for Emergency Surgical Airway (ESA) in Dutch paramedics.
- Conditions
- Emergency Medical Services, Airway Management, Cricothyroidotomy, Prehospital
- Trial name
- ERAD-ESA (NCT06645288)
- Testing
- Emergency Reflex Action Drill
- Where
- Netherlands
- Volunteers
- 84 people
- Sponsor
- Erasmus Medical Center
Dyspnea
Evaluation of the Impact of Pleuropulmonary Ultrasound on the Diagnosis of Dyspnea
Dyspnea is a subjective symptom perceived by the patient as a sensation of "breathing discomfort", "suffocation", "lack of air" or "difficulty inhaling or exhaling". It is a frequent reason for calling for help (8% of calls).
- Trial name
- LU-SMUR (NCT07104578)
- Testing
- Pleuropulmonary ultra sound
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Toulouse
Pain Acute
Efficacy of Premixed Nitrous Oxide and Oxygen in Elderly Patient With Out-of-hospital Severe Acute Pain
Pain in the elderly is poorly evaluated and clearly under treated. Premixed nitrous oxide and oxygen is used in the emergency medical care of the trauma, burns, during transport of patient with pain.
- Trial name
- MEOPA-PA (NCT01990404)
- Testing
- Premixed 50% nitrous oxide and oxygen, Medical Air
- Where
- 3 sites in France, Reunion
- Volunteers
- 43 people
- Sponsor
- University Hospital, Toulouse
Stroke, Cerebrovascular Disorders
Video Call Assisted Assessment of Acute Stroke
This study aims to investigate whether a live stream video between the on-call neurologist and the emergency medical technicians can increase feasibility and performance of symptom-based prehospital stroke scales.
- Conditions
- Stroke, Cerebrovascular Disorders, Brain Diseases, Nervous System Diseases
- Trial name
- NCT06570681
- Testing
- Video call assisted assessment of acute stroke
- Where
- Denmark
- Volunteers
- 512 people
- Sponsor
- University of Southern Denmark
Heart Failure, COPD
Ultrasound in Acute Dyspnea in the Field
Acute heart failure is one of the main causes of acute respiratory distres in prehospital emergency setting. The early and correct diagnosis is important because the misdiagnosis can result in deleterious consequeance to…
- Conditions
- Heart Failure, COPD, Asthma
- Trial name
- NCT01235182
- Where
- Slovenia
- Volunteers
- 248 people
- Sponsor
- University Medical Centre Maribor
Ventilation
Bispectral Index (BIS) on Ventilated Patients in the Prehospital Setting
To evaluate the effectiveness of use of the bispectral index for monitoring of depth of sedation in ventilated patients during their prehospital management by a physician- staffed EMS.
- Trial name
- OHBIS (NCT00919971)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Beaujon Hospital
Chest Pain, Acute Coronary Syndrome
Digital Decision Support in the Management of Patients With Chest Pain
The goal of this observational study is to develop a decision support system in patients presenting with chest pain in the prehospital setting.
- Conditions
- Chest Pain, Acute Coronary Syndrome, Chest--Diseases
- Trial name
- BRIAN2 (NCT05767619)
- Testing
- Troponin hs-cTnI, Plasma glucose
- Where
- 3 sites in Sweden
- Volunteers
- 2,000 people
- Sponsor
- Vastra Gotaland Region
Acute Pain
Is There an Ideal Dose of Intravenous Fentanyl in the Prehospital Setting
In a previous study the investigators evaluated the apparent efficacy and safety of intravenous fentanyl administered by ambulance personnel and found that 58.4% (CI 56.4-60.4) out of 2348 prehospital patients treated with…
- Trial name
- NCT02914678
- Testing
- Fentanyl
- Volunteers
- 7,093 people
- Sponsor
- University of Aarhus
Severe Traumatic Pain, Numeric Pain Rating Scale > 5 / 10
Intra Nasal Sufentanil Versus Intravenous Morphine for Acute Severe Traumatic Pain Analgesia in Emergency Setting
Intranasal (IN) administration of opiates is an appealing non-invasive way of treating acute traumatic pain in prehospital and Emergency departments (ED).
- Trial name
- ALGOFINE-2 (NCT02095366)
- Testing
- Morphine, Sufentanil
- Where
- 6 sites in France
- Volunteers
- 194 people
- Sponsor
- University Hospital, Grenoble
Injury of Cervical Spine, Cervical Spine Fractures
Prospective Pilot Study Validating the Canadian C-Spine Rule Pre-hospital
This study is designed to evaluate the safety, level of performance and level of comfort with the Canadian C-Spine rule in a prehospital setting by emergency medicine undergraduates.
- Trial name
- NCT01278511
- Testing
- Canadian C-Spine rule
- Where
- Belgium
- Sponsor
- KU Leuven
Endotracheal Intubation
Augmented Reality Smart Glasses Versus Video Laryngoscopy During Ambulance Transport
This randomized crossover simulation study evaluated the performance of augmented reality (AR) smart glasses compared with conventional video laryngoscopy (VL) for endotracheal intubation under simulated prehospital ambulance…
- Trial name
- AR-AMBULANCE (NCT07865663)
- Testing
- Augmented Reality-Assisted Laryngoscopy, Video Laryngoscopy
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- ONUR KARAKAYALI
Heart Arrest
PreCoCa - "Prehospital Cooling With Cool-Caps"
This study shall investigate the feasibility of the use of cool-caps in the preclinical setting in patients with successful primary cardio-pulmonary resuscitation Hypothesis: cool-caps are efficient and feasible to use in the…
- Trial name
- NCT00398671
- Testing
- Application of cool cap after primary successful CPR
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Charite University, Berlin, Germany