Clinical trials: Prehypertension
Healthy, Pre Hypertension
Race, Natriuretic Peptides and Physiological Perturbations
The purpose of the study is to understand the origins of differential response to beta-blockers in African-Americans and may provide insight regarding racial differences in cardiovascular risk.
- Trial name
- NCT03070184
- Testing
- Exercise capacity VO2 max determination, Standardized meals, Exercise challenge
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Prehypertension
Effect of 7 Days of Grape Seed Extract Supplementation on Cold Pressor Test and Muscle Metaboreflex in Individuals With Elevated and Stage 1 Hypertension
This study aimed to assess the effect of the supplementation with grape seed extract (GSE) on blood pressure during static handgrip exercise and muscle metaboreflex in individuals with elevated and state 1 hypertension.
- Trial name
- NCT06428890
- Testing
- Grape Seed Extract
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- California Baptist University
Pre-diabetes, Pre-hypertension
Primary Prevention of Cardiovascular Disease (CVD) in Pre-diabetic & Pre-hypertensive Subjects
The purpose of this study is to determine whether treating pre-diabetic \& pre-hypertensive individuals using multiple drugs intervention (anti-hypertensive drugs (i.e., ACEI) plus anti-glycemic drug (i.e., metformin) plus…
- Trial name
- PPCVD (NCT01364675)
- Testing
- Metformin+Enalapril+Simvastatin
- Where
- Thailand
- Volunteers
- 8,900 people, healthy volunteers welcome
- Sponsor
- Ramathibodi Hospital
Prehypertension, Cardiovascular Risk Factors
Prehypertension Among Medical Students in Visakhapatnam and Association With Cardiovascular Risk Factors
Student Investigator = Thakkallapalli Zeeshan Muzahid. The study aims to assess the prevalence of prehypertension among medical students of Andhra Medical College, Visakhapatnam, India and its association with other…
- Trial name
- NCT01776294
- Where
- India
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Andhra Medical College
Post-traumatic Stress Disorder, Prehypertension
Sympathetic Overactivity in Post-traumatic Stress Disorder
Post-traumatic stress disorder (PTSD) is a highly prevalent anxiety disorder that is associated with an increased risk of cardiovascular (CV) disease and hypertension.
- Trial name
- SO-PTSD (NCT01627301)
- Testing
- Device-Guided Breathing (DGB), Transcutaneous Vagal Nerve Stimulation (tVNS)
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Emory University
Hypertension
Equol Supplementation on Blood Pressure and Vascular Function
We propose to perform a 24-week randomized, double-blind a placebo-controlled trial among 207 non-equol producing postmenopausal women with prehypertension to examine the effectiveness of equol (10mg and 20mg/d) on 24h ambulatory…
- Trial name
- NCT02515682
- Testing
- High equol group, Low equol group
- Volunteers
- 207 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Low Blood Pressure, Normal Blood Pressure
Clinical Trial of H2-BP Electronic Sphygmomanometer
The study compares H2-BP, a wristband blood pressure monitor, with an auscultatory sphygmomanometer. Both devices are used on the same arm.
- Conditions
- Low Blood Pressure, Normal Blood Pressure, Prehypertension, Hypertension
- Trial name
- NCT06491433
- Testing
- H2-BP
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Gangnam Severance Hospital
Prehypertension, Borderline Dyslipidemia
Smartwatch-based Intervention for Cardiovascular Health (SWITCH)
This study aims to employ a cluster randomized controlled trial to evaluate the effectiveness of an mHealth-Based Multi-faceted Cardiovascular Health Intervention Model among Overweight/Obese Individuals with Cardiometabolic…
- Conditions
- Prehypertension, Borderline Dyslipidemia, Overweight , Obesity, Prediabetes
- Trial name
- NCT07372729
- Testing
- Smartwatch-Based Multi-Faceted Behavioral Intervention Model Led by Exercise and Dietary Interventions, Supported by Primary Medical Staff, Along with the Distribution of Health Education Manuals, Face-to-face health education sessions
- Where
- 3 sites in China
- Volunteers
- 1,400 people, healthy volunteers welcome
- Sponsor
- Beijing Anzhen Hospital
Pre Hypertension, Hypertension
Impact of Sex in the Effect of Dietary Capsaicin on Cardiovascular Health
The investigators long-term goal is to better understand novel interventions to promote cardiovascular health in humans. The goal of the proposed research is to investigate whether there is sex-specificity in the effects of…
- Trial name
- NCT06363305
- Testing
- Dietary capsules
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Skidmore College
Prehypertension
Running Against Prehypertension Trial (RAPT): A Pilot Trial
This study will test strategies to help people with prehypertension adopt a running program to reduce their blood pressure in the long term.
- Trial name
- RAPT (NCT01587183)
- Testing
- Educational material control, Group running style B, Group running style A
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Obesity, Pre-Hypertension
Primary Prevention of Hypertension in Obese Adolescents
The purpose of this study is to examine the consequences of lowering serum uric acid in pre-hypertensive, obese adolescents pathways involved with how uric acid mediated hypertension and renal disease. The specific aims are: 1.
- Conditions
- Obesity, Pre-Hypertension, Hyperuricemia
- Trial name
- NCT00288158
- Testing
- Allopurinol, Probenecid
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pre-hypertension, Cardiovascular Diseases
Watermelon Dose Response Blood Pressure Study
1. Primary outcome: To evaluate the dose response effects of watermelon flesh in regulating Blood Pressure (BP) in individuals with pre-hypertension. 2.
- Trial name
- WMBP (NCT05892328)
- Testing
- Watermelon Flesh Dose 1, Watermelon Flesh Dose 2, Control
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Prehypertension, Hypertension
Nebivolol and the Endothelin (ET)-1 System
The investigators hypothesize that nebivolol will reduce ET-1-mediated vasoconstrictor tone in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NETS (NCT01395329)
- Testing
- Nebivolol, Metoprolol, Forearm Blood Flow (FBF) response to BQ-123 (100 mol/min)
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Prehypertension, Hypertension
Hypertension and Osteopathic Treatment
The goal of this study is to demonstrate the use of osteopathic manipulative therapy (OMT) in the effective management of hypertension.
- Conditions
- Prehypertension, Hypertension, Osteopathic Manipulation, Sympathetic Nervous System
- Trial name
- HOT (NCT02605551)
- Testing
- Osteopathic Manipulative Therapy, Lifestyle Modification
- Volunteers
- healthy volunteers welcome
- Sponsor
- Larkin Community Hospital
Prehypertension, Masked Hypertension
Arterial Function After Two Different Physical Exercise Intensities in Prehypertension
Individuals with prehypertension, diagnosed according to the 7th Brazilian Guidelines on Hypertension with the presence of systolic blood pressure (SBP) between 121 and 139 and / or diastolic (DBP) between 81 and 89 mmHg, are…
- Trial name
- PREHTEXVAS (NCT04200716)
- Testing
- Moderate intensity continuous training - session, High intensity interval training - session
- Where
- Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Prehypertension, Hypertension
Nebivolol and Endothelial Regulation of Fibrinolysis (NERF)
The investigators hypothesize that nebivolol will improve endothelial t-PA release in adult humans with elevated blood pressure to a greater extent than either metoprolol or placebo.
- Trial name
- NCT01595516
- Testing
- Nebivolol, Metoprolol, Bradykinin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Prehypertension
Investigate the Effectiveness of KEFPEP® on Regulating High Blood Pressure
To assess the ability of KEFPEP® to reduce blood pressure
- Trial name
- NCT06393621
- Testing
- KEFPEP®
- Where
- Taiwan
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- National Chung Hsing University
Pre-hypertension
A Study to Investigate the Effect of a Nitric Oxide Supplementation on Pre- and Mildly Hypertensive Adults
This study will investigate the effect of a nitric oxide supplementation product, Neo40 Daily®, on blood pressure in pre-hypertensive and mildly hypertensive adults.
- Trial name
- 15NBHN (NCT02679248)
- Testing
- Neo40 Daily®
- Where
- 2 sites in Canada
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- KGK Science Inc.
Pre-hypertension
Different Dosages of Bioactive Wheat Peptides and Blood Pressure Level and CVD Risk Biomarkers in Healthy Subjects
In this study we will assess the effects of bioactive peptide rich wheat products on blood pressure and estimated cardiovascular disease risk.
- Trial name
- NCT02197910
- Testing
- Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence Low->High), Comparisons of two kind of pasta with low or high content of wheat bioactive peptides (sequence High->Low)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Pre-hypertension
Personalized Blood Pressure Care Using IoMTs and Artificial Intelligence
In this RCT, up to 100 adults classified as pre-hypertensive will be randomized to either an artificial intelligence (AI) based lifestyle intervention group or an active control group with a 1 to 1 ratio.
- Trial name
- NCT04543656
- Testing
- AI-Based Lifestyle Recommendations, No Lifestyle Recommendations
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego