Clinical trials: Preimplantation Genetic Diagnosis
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Pregnancy
Does Preimplantation Genetic Diagnosis for Sex Selection Affect the Pregnancy and Miscarriage Rates in Women With an Expected Good Ovarian Response Undergoing IVF/ICSI Cycles?
Records of women who had Pre-genetic diagnosis (PGD) over the last 3 years will be reviewed and its outcome will be compared to other records of women who had IVF/ICSI without PGD.
- Trial name
- NCT02149251
- Testing
- Pre-genetic diagnosis
- Where
- Egypt
- Volunteers
- 11,006 people, healthy volunteers welcome
- Sponsor
- Cairo University
Genetic Disorder, Fertility Disorders
Retrospective Study on Clinical Results of Preimplantation Genetic Screening at Different Embryo Stage
Preimplantational genetic screen (PGS) is tool for diagnosis of embryo chromosome abnormality before transfer. Under this tool, patients with a family history of genetic disease or special genetic disease could avoid to produce…
- Conditions
- Genetic Disorder, Fertility Disorders, Reproductive Disorder
- Trial name
- NCT03065114
- Testing
- PGS
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yeh
Infertility, Female, Infertility, Male
Cell Free Preimplantation Genetic Testing
This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.
- Trial name
- NCT04628507
- Testing
- Spent media collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.
Infertility, Aneuploidy
Noninvasive Chromosomal Screening for Embryo Selection Trial
To determine the diagnostic accuracy of non-invasive preimplantation genetic testing for aneuploidy (NI-PGT-A) for embryo selection.
- Trial name
- NICEST (NCT04732013)
- Testing
- No clinical intervention is planned; study is observational
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Olive Fertility Centre
Females Undergoing PGD Technology for Medical Conditions
Isolation of Cell Free Fetal DNA From Spent Culture Medium and Its Potential Role for Preimplantation Genetic Diagnosis (PGD).
Preimplantation genetic testing for chromosomal screening is, at present, the most reliable method to assess the genetic status of preimplantation embryos.
- Trial name
- NCT06084377
- Testing
- Preimplantation Genetic Screening
- Where
- Syria
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Damascus University
Infertility, Chromosome Abnormality
Embryo Selection by Noninvasive Preimplantation Genetic Test
The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by…
- Trial name
- ESNi-PGT (NCT04339166)
- Testing
- Non-invasive chromosome screening（NICS）
- Where
- 13 sites in China
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Infertility
Prospective Paired Study on the Effectiveness of MitoGrade
Chromosomal abnormalities are a major cause of pregnancy loss. Preimplantation Genetic Screening (PGS) using Next Generation Sequencing (NGS) allows the effective detection of these abnormalities and improves clinical outcomes.
- Trial name
- NCT02673125
- Testing
- MitoGrade
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Reprogenetics
Infertility
Overture Metabolomics Non-Selection Study
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04878991
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in United States, Spain
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Overture Life
Any Single Gene Disorder (Cystic Fibrosis, Tay-Sachs)
Concurrent Single Gene and 24 Chromosome Aneuploidy Preimplantation Genetic Diagnosis (PGD)
Gene Security Network has developed a novel technology called Parental SupportTM (PS) which is used for Preimplantation Genetic Screening/Diagnosis (PGS/D) during in vitro fertilization (IVF).
- Trial name
- IVF008 (NCT01023048)
- Testing
- preimplantation diagnosis
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Natera, Inc.
Infertility, Aneuploidy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing in Vitro Fertilization With Preimplantation Genetic Screening
While IVF offers an effective treatment for infertility, a significant proportion of IVF cycles still result in failed implantation and early miscarriage.
- Trial name
- NCT03981120
- Testing
- Laser and Traditional Acupuncture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Preimplantation Genetic Diagnosis
Follow-up of 5-year Old Children Born After PGD
Since 1995, preimplantation genetic diagnosis (PGD) has been performed in The Netherlands for couples at high risk for transmitting severe or lethal genetic conditions or who have experienced multiple miscarriages due to…
- Trial name
- NCT02149485
- Where
- 2 sites in Netherlands
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Embryo Aneuploidies, Implantation Rates
Preimplantation Genetic Screening (PGS) in Advanced Female Age and Male Severe Factor
Preimplantation Genetic Screening (PGS) is used for the selection of chromosomally normal embryos before the transfer in IVF treatments in many cases.
- Conditions
- Embryo Aneuploidies, Implantation Rates, Infertility
- Trial name
- NCT01571076
- Testing
- PGS, Prolonged culture
- Where
- Spain
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Igenomix
Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer
Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results
Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without…
- Conditions
- Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer, Embryo Diagnosis and Selection
- Trial name
- NCT07700602
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Infertility, Fertility
Mono-menotropins Versus rFSH Protocol on Embryo Quality
This study is for couples pursuing in vitro fertilization (IVF) with preimplantation genetic screening (PGS) of embryos to achieve pregnancy.
- Trial name
- NCT02418533
- Testing
- menotropin, Recominant Follicle Stimulating Hormone (rFSH)
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Main Line Fertility Center
Preimplantation Genetic Diagnosis (PGD)
Establishment of Comprehensive Genetic Analysis From a Single Cell
Preimplantation genetic diagnosis (PGD) is the integration of both assisted reproductive technologies and molecular genetic technologies and was shown to improve implantation rate and reduce spontaneous abortions after…
- Trial name
- NCT00173732
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Effect of PGD on Implantation Rates in IVF Cycles
Study of the Efficacy of 24 Chromosome Preimplantation Genetic Diagnosis (PGD)
The purpose of this study is to determine if 24 chromosome preimplantation genetic diagnosis (PGD) increases implantation and delivery rates in couples attempting to conceive through in vitro fertilization (IVF).
- Trial name
- NCT01219283
- Where
- 3 sites in United States
- Volunteers
- 334 people, healthy volunteers welcome
- Sponsor
- Reproductive Medicine Associates of New Jersey
Embryo Aneuploidies
Embryo Aneuploidies and Ovarian Stimulation
There is a considerable concern about the effects of controlled ovarian hyperstimulation (COH) for In Vitro Fertilization- Embryo Transfer (IVF-ET) on embryo quality and on the incidence of chromosomal abnormalities in oocytes…
- Trial name
- NCT00707525
- Testing
- Preimplantation Genetic Diagnosis
- Where
- Spain
- Volunteers
- healthy volunteers welcome
- Sponsor
- Instituto Valenciano de Infertilidad, IVI VALENCIA