Clinical trials: Preimplantation Genetic Testing
Infertility, Chromosome Abnormality
Embryo Selection by Noninvasive Preimplantation Genetic Test
The objective of this study is to explore whether non-invasive chromosome screening (NICS) can be used as an effective indicator for embryos selection besides morphology through a multicenter randomized controlled trial, by…
- Trial name
- ESNi-PGT (NCT04339166)
- Testing
- Non-invasive chromosome screening（NICS）
- Where
- 13 sites in China
- Volunteers
- 1,152 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer
Correlation Of Clinical Outcomes After Transfer Of Good-Quality Morphology Embryos In Patients With A Favorable Prognosis And Non-Invasive Preimplantation Genetic Testing For Aneuploidy (NiPGT-A) Results
Non-invasive preimplantation genetic testing for aneuploidy (NiPGT-A) is an emerging approach that analyzes embryonic cell-free DNA (cfDNA) released into the spent culture medium (SCM) to assess chromosomal status without…
- Conditions
- Infertility (IVF Patients), Clinical Pregnancy After Single Embryo Transfer, Embryo Diagnosis and Selection
- Trial name
- NCT07700602
- Where
- Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Mỹ Đức Hospital
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Infertility
Overture Metabolomics Non-Selection Study
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04878991
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in United States, Spain
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Overture Life
Aneuploidy, Mosaicism
Pregnancy and Developmental Outcomes After Transfer of Reportedly Aneuploid or Mosaic Embryos
To determine how often embryos reported to be abnormal by preimplantation genetic testing result in liveborn infants. To evaluate whether the pregnancies that result from these embryos are higher risk for complications and…
- Conditions
- Aneuploidy, Mosaicism, Pregnancy Outcome
- Trial name
- TAME (NCT04109846)
- Testing
- Non-euploid embryo transfer, Euploid Transfer
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Stanford University
Subfertility
Preimplantation Genetic Testing for Aneuploidy of Polar Bodies
This study intends to randomly group the patients with advanced maternal age and poor ovarian response, and the study group will undergo polar body biopsy, and the next-generation sequencing(NGS) technology will be used to…
- Trial name
- NCT04538560
- Testing
- polar body biopsy
- Where
- China
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Reproductive & Genetic Hospital of CITIC-Xiangya
Preimplantation Genetic Diagnosis (PGD)
Establishment of Comprehensive Genetic Analysis From a Single Cell
Preimplantation genetic diagnosis (PGD) is the integration of both assisted reproductive technologies and molecular genetic technologies and was shown to improve implantation rate and reduce spontaneous abortions after…
- Trial name
- NCT00173732
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Patient Education
Preimplantation Genetic Testing for Aneuploidy Counseling
Purpose: To evaluate preimplantation genetic testing counseling interventions on patients undergoing in vitro fertilization treatment.
- Trial name
- PGT-A (NCT06018454)
- Testing
- Handout on PGT-A, Handout on PGT-A and genetic counseling
- Where
- United States
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Eyup Hakan Duran
Infertility
Metabolomics Non Selection Study - Vitrolife Media
In this study, study investigators will collect embryo culture media on day 5 of vitro fertilization (IVF) culture, prior to vitrification and embryo transfer for testing via Metabolomic screening.
- Trial name
- NCT04976920
- Testing
- Overture Metabolomics Embryo Selection
- Where
- 2 sites in Argentina, Spain
- Volunteers
- 205 people, healthy volunteers welcome
- Sponsor
- Overture Life
Infertility
Preimplantation Genetic Screening in IVF Treatment
This is the pilot phase of a randomised controlled trial. The purpose of the pilot study is to assess the ability to recruit, randomise, adherence to the study protocol and plan for a full study.
- Trial name
- PGSINIVF (NCT05009745)
- Testing
- PGT-A Strategy
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- King's College London
Infertility, Aneuploidy
Noninvasive Chromosomal Screening for Embryo Selection Trial
To determine the diagnostic accuracy of non-invasive preimplantation genetic testing for aneuploidy (NI-PGT-A) for embryo selection.
- Trial name
- NICEST (NCT04732013)
- Testing
- No clinical intervention is planned; study is observational
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Olive Fertility Centre
Secondary Infertility
Non-invasive Preimplantation Genetic Testing for Aneuploidies Using Cell-free DNA in Spent Culture Media
Analysis of embryonic cell-free DNA (cfDNA) present in the spent culture media (SCM) is a non-invasive alternative for preimplantation genetic testing for aneuploidies (PGT-A) that avoids the technical challenges and limitations…
- Trial name
- niPGT-A (NCT04711239)
- Testing
- PGT-A / niPGT-A
- Volunteers
- healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle
Effects of Trophectoderm (TE) Biopsy on the Health and Development of Children Born After Preimplantation Genetic Testing (PGT) Cycles.
This study aims to investigate the effects of trophectoderm (TE) biopsy on the health and development of children born after preimplantation genetic testing (PGT) cycles.
- Conditions
- Preimplantation Genetic Testing (PGT), Frozen Embryo Transfer Cycle, Assisted Reproduction Technologies, Postnatal Health
- Trial name
- NCT07349966
- Testing
- Questionnaire
- Where
- Italy
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Infertility, Female, Infertility, Male
Cell Free Preimplantation Genetic Testing
This study aims to develop preimplantation genetic testing methods from embryo culture media (cell free). Genetic testing of culture media will be compared to conventional methods based on embryo biopsies.
- Trial name
- NCT04628507
- Testing
- Spent media collection
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Genomic Prediction Inc.