Clinical trials: Preoperative Cognitive Impairment
Elective Surgery, Postoperative Cognitive Dysfunction
Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty
Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2.
- Conditions
- Elective Surgery, Postoperative Cognitive Dysfunction, Knee Arthroplasty
- Trial name
- NCT04225702
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Xuzhou Medical University
Postoperative Delirium, Cognitive Function Abnormal
EEG Characteristics and Postoperative Delirium
The goal of this [type of study: observational study ] is to [compare Energy differences in various bands of intraoperative electroencephalogram in elderly patients with postoperative delirium and non delirium.] in [describe…
- Conditions
- Postoperative Delirium, Cognitive Function Abnormal, PSI, Frailty
- Trial name
- NCT06102967
- Testing
- delirium
- Where
- China
- Volunteers
- 66 people
- Sponsor
- Zhuo Liu
Post Operative Cognitive Dysfunction
Preoperative Vitamin B12 and Folic Acid on POCD in Elderly Non-cardiac Surgical Patients
This study will recruit patients more than 65 years old eligible for non-cardiac surgery. Patients who participate will take either vitamin B12 and folic acid supplementation or placebo for 7 days before surgery.
- Trial name
- B12-POCD (NCT03485404)
- Testing
- methylcobalamin, Folic Acid, non-cardiac surgery
- Where
- 13 sites in China
- Volunteers
- 40 people
- Sponsor
- Xijing Hospital
Cognitive Decline, Age Problem
Clinical Outcomes in Elderly Patients With Preoperative Cognitive Dysfunction
Preexisting cognitive impairment, such as mild cognitive impairment, is common in many elderly patients who undergoing major surgeries.
- Conditions
- Cognitive Decline, Age Problem, Outcome
- Trial name
- NCT03143595
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Zhongda Hospital
Mild Cognitive Impairment
The Montreal Cognitive Assessment as a Screening Tool for Preoperative Mild Cognitive Impairment in Geriatric Patients
This is a prospective, double-blinded, control trial. The Montreal Cognitive Assessment is used to screen preoperative mild cognitive impairment in 582 consecutive geriatric patients, scheduled for general, vascular or urological…
- Trial name
- MoCA (NCT01496222)
- Where
- Thailand
- Volunteers
- 582 people
- Sponsor
- Mahidol University
Cognitive Impairment
Improving Surgical Safety of Seniors Through Preoperative Cognitive Screening
The hypothesis is that structured preoperative cognitive screening of seniors is feasible without specialized staff and can help preoperatively identify persons at high risk of complications.
- Trial name
- NCT02570438
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Delirium, Cognitive Impairment
Redesigning the Surgical Pathway (PROMoTE)
Cognitive complications, that is problems with thinking and memory, are incredibly common after surgery, occurring in 10-50% of all older surgical patients.
- Conditions
- Delirium, Cognitive Impairment, Perioperative/Postoperative Complications, Cognitive Dysfunction
- Trial name
- PROMoTE (NCT05114876)
- Testing
- Multicomponent delirium-risk prevention bundle
- Where
- Canada
- Volunteers
- 260 people
- Sponsor
- Sunnybrook Health Sciences Centre
Cognitive Impairment
Preoperative Cognitive Screening in Older Surgical Patients Utility for Predicting Morbidity
The purpose of this work is to determine whether preoperative cognitive screening of patients over the age of 65 can be used as predictor of postoperative outcomes in patients undergoing lower extremity surgical procedures.
- Trial name
- NCT02598050
- Testing
- No Interventions as this is a observational study
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Pain, Postoperative, Atrial Fibrillation
BRS and Outcomes in Cardiothoracic Surgery
The purpose of this study is to determine whether baroreceptor sensitivity (the ability of your body to change your heart rate and/or blood pressure in response to a situation) has any effect on how likely you are to suffer…
- Conditions
- Pain, Postoperative, Atrial Fibrillation, Cognitive Dysfunction
- Trial name
- NCT03243279
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Duke University
Postoperative Cognitive Dysfunction, Depressive Symptoms
Perioperative Cognitive Trajectories in Deferred Surgery (CoTELE-SURGE)
Cognition is the way people use their brains to think, understand, remember and make decisions. Cognitive changes are often seen even up to 1 year after surgery.
- Conditions
- Postoperative Cognitive Dysfunction, Depressive Symptoms, Postoperative Pain
- Trial name
- CoTELE-SURGE (NCT04787536)
- Testing
- Non-cardiac surgery
- Where
- Canada
- Volunteers
- 300 people
- Sponsor
- McMaster University
Preoperative Stress, Postoperative Cognitive Dysfunction
Decreasing Preoperative Stress to Prevent Postoperative Delirium and Postoperative Cognitive Decline in Cardiac Surgical Patients.
Patients undergoing cardiac surgery often complain of anxiety before a major operation and the resulting stress. This circumstance is a risk factor for mental problems that may occur after the operation (e.g., delirium or memory…
- Conditions
- Preoperative Stress, Postoperative Cognitive Dysfunction, Postoperative Delirium
- Trial name
- DESTRESS-SURG (NCT05036538)
- Testing
- Intervention with natural sounds administered via headphones, Intervention with natural sounds and binaural beats administered via headphones, Intervention with natural sounds and virtual reality administered via headphones and head mounted display
- Where
- Germany
- Volunteers
- 125 people
- Sponsor
- Heart and Brain Research Group, Germany
Postoperative Cognitive Dysfunction
Evaluation of the Effect of Preoperative Intravenous Amantadine Sulfate on the Postoperative Early Cognitive Functions in a Elderly Patient With Laparoscopic Radical Prostatectomy
Evaluation of the effect of preoperative intravenous administration of amantadine sulfate on the prevention of the development of early cognitive dysfunction in elderly patients undergoing laparoscopic radical prostatectomy
- Trial name
- NCT03988010
- Testing
- Amantadine Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- TC Erciyes University
Gynecologic Cancer, Frailty
Cognitive and Physical Frailty as Predictors of Decision Satisfaction in Geriatric Gynecologic Oncology
This prospective observational study aims to evaluate the association between preoperative cognitive function, measured by the Montreal Cognitive Assessment (MoCA), and physical frailty, assessed using the Clinical Frailty Scale…
- Conditions
- Gynecologic Cancer, Frailty, Cognitive Impairment, Geriatric Oncology
- Trial name
- GYNCOGFRAIL (NCT07085000)
- Testing
- No Intervention - Observational Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Izmir City Hospital
Mild Cognitive Impairment
Preoperative Cognitive Screening of Surgical Patients 65 Years of Age or Older
The overall objectives of this study are to improve outcomes of surgical patients 65 years of age or older through risk stratification based on preoperative screening of cognition / mental function.
- Trial name
- NCT02570451
- Testing
- Patient Survey, Mini Cog, Independent Activities of Daily Living Score Sheet
- Where
- United States
- Volunteers
- 711 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Delirium in Old Age, Neurocognitive Disorders
Preoperative Cognitive Impairment Predicts Postoperative Delirium
Preoperative cognitive impairment (PCI) may increase the incidence of postoperative delirium (POD), yet screening for cognitive impairment is rarely performed.
- Conditions
- Delirium in Old Age, Neurocognitive Disorders, Cognitive Impairment
- Trial name
- NCT05798767
- Testing
- Neuropsychological tests
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Henan Provincial People's Hospital
Postoperative Cognitive Dysfunction, Preoperative Anxiety
Correlation of Preoperative Anxiety With Early Postoperative Cognitive Dysfunction in Breast Cancer Patients
Breast cancer is the most common type of cancer in women. Anxiety and depression often accompany the treatment phase of oncology patients.
- Trial name
- NCT04701801
- Testing
- MoCA test
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people
- Sponsor
- Dr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital
Gastroesophageal Cancer (GC), Postoperative Delirium (POD)
Cognitive Impact Associated With Surgery For Gastric Or Esophageal Cancer
The primary objective of this observational study is to investigate the incidence of Post Operative Delirium (POD) after gastroesophageal cancer surgery.
- Conditions
- Gastroesophageal Cancer (GC), Postoperative Delirium (POD), Quality of Life (QOL), Frailty
- Trial name
- CASE (NCT06687291)
- Where
- Sweden
- Volunteers
- 130 people
- Sponsor
- Karolinska Institutet
POCD - Postoperative Cognitive Dysfunction, Mechanical Bowel Preparation
Investigation of the Effect of Preoperative Bowel Cleansing on Postoperative Cognitive Impairment
Cognitive impairment has been reported up to 54 % after colorectal surgeries. Mechanical bowel cleansing means that a system called the second brain in the body, which includes a wide variety of genetic and neuronal structures…
- Trial name
- NCT05942404
- Testing
- mechanical bowel preparation
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- TC Erciyes University
Cognitive Impairment
Preoperative Survey
This study will examine preoperative concerns in older adults through the use of a self-administered questionnaire. The development of this questionnaire will involve adapting survey questions from previously validated studies…
- Trial name
- NCT05653154
- Where
- 2 sites in Canada
- Volunteers
- 264 people
- Sponsor
- University Health Network, Toronto
Cognitive Decline
Preoperative Cognitive Reserve in Older Surgical Patients: A Feasibility Study
Investigators will evaluate feasibility of using a custom 6-game Lumosity brain exercise experience in busy clinical areas to obtain a quick, quantitative measure of cognitive reserve (first gameplay performance [FGP]) in older…
- Trial name
- NCT06245005
- Testing
- Brain exercise gameplay on a portable electronic device
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Ohio State University