Clinical trials: Prescription
Medication Therapy Management
A Collaborative Approach to Medication Reviews for Older Patients With Polypharmacy
In patients aged 65 years and older, polypathology is frequent and often associated with polypharmacy. This polypharmacy may be a source of iatrogeny due to pharmacokinetic interactions, enhanced sensitivity of older people to…
- Trial name
- BIMEDOC (NCT03909035)
- Testing
- Medication therapy management
- Where
- France
- Volunteers
- 697 people
- Sponsor
- University Hospital, Toulouse
Obesity, Physical Activity
Leisure Time Activity and Nutrition Program
The purpose of this investigation is to conduct an 8-week pilot study to examine the effects of two different leisure-time activity prescriptions on dietary intake, leisure-time activities, and weight loss in 26 adults receiving…
- Trial name
- LEAN (NCT00656045)
- Testing
- Dietary, Physical Activity, TV Watching
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Bacterial Infections
Evaluation of the Artificial Intelligence-based Prescription Support Software iAST® for the Choice of Empirical and Semi-targeted Antibiotic Treatment
Inadequate treatment of infections frequently leads to complications that cause new visits to the doctor, lengthen hospital stays and can lead to sepsis, even causing the death of affected patients.
- Trial name
- EVIAST (NCT06174519)
- Testing
- Medical device simulation
- Where
- Spain
- Volunteers
- 325 people
- Sponsor
- Pragmatech AI Solutions
Coronary Artery Disease
Effects of Omega-3 Fatty Acids on Platelets in Patients With Coronary Artery Disease With Hypertriglyceridemia
Omacor®/Lovaza® is an effective, and very safe mix of PO-3A, and the drug is currently approved by the Federal authorities for the drug management of post-infarction patients with high blood triglycerides.
- Trial name
- OMPA-CAD (NCT01086163)
- Testing
- Omacor, omega-3 fatty acids in CAD patients
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- HeartDrug Research LLC
Constipation, Bowel Dysfunction
Study Of Alvimopan Drug For Treatment Of Constipation Due To Prescription Pain Medication
A multicenter study to evaluate the effectiveness and safety of multiple dosage regimens of an investigational drug for the treatment of constipation due to prescription pain medication in subjects with cancer pain.
- Trial name
- NCT00101998
- Testing
- alvimopan
- Where
- 162 sites in United States, Argentina and 24 more
- Volunteers
- 233 people
- Sponsor
- Cubist Pharmaceuticals LLC, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)
Dementia
Study of Depakote for Behavioral and Psychological Symptoms in Dementia
This prospective, naturalistic, open label study will test the hypothesis that Depakote is correlated with a reduction in elevated Cohen-Mansfield Agitation Index (CMAI) verbal and physical agitation and aggression scales over a…
- Trial name
- NCT00197834
- Testing
- Depakote
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hearthstone Alzheimer Care
Rheumatoid Arthritis
IL-6 as a Biomarker for Personalized Treatment of PR
Several studies have shown the relevance of the IL6 level before treatment or after 6 months, as a predictive biomarker for the persistence of remission.
- Trial name
- REMISIX (NCT04779983)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Erosive Osteoarthritis of the Hand
Prescription-grade Crystalline Glucosamine Sulfate Therapy in Erosive Hand Osteoarthritis
The objective of this study is to evaluate the efficacy of prescription-grade Crystalline Glucosamine Sulfate (pCGS), as an add-on treatment to conventional therapy, compared to usual therapy alone, in patients with erosive…
- Trial name
- NCT05237596
- Testing
- Glucosamine Sulfate
- Where
- Italy
- Volunteers
- 123 people
- Sponsor
- University of Siena
Diabetic Kidney Disease, Type 2 Diabetes
Improving Kidney Care in Type 2 Diabetes: A Study of Pharmacist Prescribing Versus Usual Care
Type 2 diabetes is the leading cause of chronic kidney disease, which can result in serious complications such as kidney failure and heart disease.
- Conditions
- Diabetic Kidney Disease, Type 2 Diabetes, Chronic Kidney Disease
- Trial name
- RX4DKD (NCT07169422)
- Testing
- Usual care for diabetic kidney disease management without primary care provider., Pharmacist-led validated diabetic kidney disease decision support algorithm.
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Nova Scotia Health Authority
Prescription Opioid Dependence
Effective Treatment for Prescription Opioid Abuse
There has been an alarming increase in abuse of prescription opioids in recent years. This project aims to develop an effective outpatient treatment for prescription opioid (PO) abuse that combines an intensive behavioral therapy…
- Trial name
- NCT00719095
- Testing
- buprenorphine taper followed by naltrexone maintenance, Behavioral therapy
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Vermont Medical Center
SARS-CoV Infection, Antimicrobial Stewardship
Analysis of the Quality and Quantity of Antibiotic Prescriptions for Bacterial Respiratory Tract Superinfection in Patients Hospitalized in COVID-19 Wards
In this prospective observational study, a quantitative and qualitative analysis of antibiotic prescriptions for presumed respiratory tract (super)infection in patients hospitalized on COVID-19 wards will be made.
- Conditions
- SARS-CoV Infection, Antimicrobial Stewardship, Respiratory Tract Infections, Antibiotic Resistance
- Trial name
- NCT04544072
- Where
- Belgium
- Volunteers
- 400 people
- Sponsor
- Universitair Ziekenhuis Brussel
Opioid Abuse, Overdose
Impact of Direct Outreach to Expand Access to Naloxone in the Context of Standing Orders
In the setting of naloxone standing orders, this study will assess if direct outreach with a web-based "Naloxone Navigator 1.0" to patients prescribed chronic opioid therapy (COT) changes opioid risk behaviors, increases naloxone…
- Conditions
- Opioid Abuse, Overdose, Risk Behavior
- Trial name
- NCT03241771
- Testing
- Naloxone Navigator 1.0
- Where
- United States
- Volunteers
- 325 people
- Sponsor
- Kaiser Permanente
Substance Use, Binge Drinking
iSTART: A Campus & Community Initiative for Services in Tec-health
The iSTART intervention is a 30-day substance prevention web-app whereby students complete five weekly interactive modules using a smart device or computer.
- Conditions
- Substance Use, Binge Drinking, Marijuana Use, Alcohol Drinking
- Trial name
- iSTART (NCT05362357)
- Testing
- iSTART Web-app
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- California State University, Northridge
Leiomyoma, Uterine, Leiomyoma
Prescription of Letrozole for Uterine Myoma
The PLUM Study is a randomized, double-blinded, 2-arm, parallel-group, placebo-controlled trial is designed to compare the efficacy of letrozole versus placebo on leiomyoma-related symptoms and quality of life as well as…
- Conditions
- Leiomyoma, Uterine, Leiomyoma, Fibroid, Fibroid Uterus
- Trial name
- PLUM (NCT06143631)
- Testing
- Letrozole 2.5mg
- Where
- 5 sites in United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Myocardial Infarction, Coronary Artery Bypass
Improving Cardiac Rehabilitation Exercise Using Target Heart Rate Trial
The goal of this clinical trial is to compare two types of exercise prescriptions in cardiac rehabilitation eligible older adults (60 years or older) with heart disease.
- Conditions
- Myocardial Infarction, Coronary Artery Bypass, Percutaneous Coronary Intervention, Heart Failure
- Trial name
- PACE SETTER (NCT05925634)
- Testing
- RPE (usual care), GXT+THHR (intervention)
- Where
- 2 sites in United States
- Volunteers
- 320 people
- Sponsor
- Baystate Medical Center
Opioid Use, Acute Pain
Appropriate Opioid Quantities for Acute Pain - Pharmacist Study
Prescription opioids contribute to opioid related deaths, overdose and addiction. Unused prescribed opioids are not routinely being stored or disposed of appropriately and their availability is associated with harms.
- Trial name
- NCT04484610
- Testing
- Pharmacist Practice Change to Dispense Appropriate Opioid Quantities for Acute Pain
- Where
- Canada
- Volunteers
- 205 people
- Sponsor
- Centre for Addiction and Mental Health
Postoperative Pain, Opioid Use
STandard Versus No Opioid Prescription After Prolapse and Anti-INcontinence Surgery Trial
Overprescribing opioids is considered a major contributor to the opioid crisis. Hill et al. demonstrated that within a general surgery practice, over 70% of the prescribed opioid pills were never taken.
- Conditions
- Postoperative Pain, Opioid Use, Prolapse; Female, Incontinence
- Trial name
- STOP-PAIN (NCT04491617)
- Testing
- Standard opioid prescribing, Restrictive opioid prescribing
- Where
- United States
- Volunteers
- 129 people
- Sponsor
- The Cleveland Clinic
Opioid Overdose
Improving Availability of Intranasal Naloxone
While there is a lifesaving medication called naloxone that can reverse the deadly effects of opioid overdose, patients often fail to fill the prescription at the pharmacy when it is prescribed.
- Trial name
- NCT05877118
- Testing
- Enhanced Overdose Education (EOE), Standard education
- Where
- 2 sites in United States
- Volunteers
- 84 people
- Sponsor
- Hartford Hospital
Peptic Ulcer, Ulcer Complications
Peptic Ulcer Disease in Ischemic Heart Patients Taking Aspirin and Clopidogrel With or Without Proton Pump Inhibitor
Studies showed that combined use of clopidogrel and aspirin had a 25 % reduction of risk on myocardial infarction and stroke in patients who undergone percutaneous coronary intervention (PCI) when compared with use of aspirin…
- Trial name
- NCT00854776
- Testing
- lansoprazole, aluminum hydroxide 334 mg and Mg hydroxide 166 mg
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Tobacco Dependence
Prolonged Smoking Cessation Using Prescription Step Care
Smoking is the number one preventable cause of morbidity and mortality in this nation. Unfortunately, more than 50% of those who quit following a smoking cessation intervention typically relapse within two weeks, with…
- Trial name
- NCT00170079
- Testing
- Smoking Cessation Intervention
- Where
- 2 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
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