Clinical trials: Prescription
Opioid-Use Disorder, Opioid Overdose
Extended-release Injectable Buprenorphine for Individuals at High Risk of Overdose
This pilot study will evaluate the feasibility and clinical utility of extended-release injectable buprenorphine (XR-BUP) for the treatment of opioid use disorder (OUD) among individuals at high-risk for overdose (OD).
- Trial name
- FASTER-BUP (NCT04815590)
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- BC Centre on Substance Use
Chronic Pain
Effect of Egoscue Corrective Exercise Prescription on Acute and Short-term Chronic Knee and Hip Pain
The primary purpose of this experimental study was to determine the acute effect following one treatment and the short-term effect after a two-week program of Egoscue corrective exercises on chronic knee and hip pain.
- Trial name
- NCT02374034
- Testing
- Corrective exercise
- Volunteers
- 40 people
- Sponsor
- Brigham Young University
HIV Infections
Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement Study
Through the proposed Substance Checking Outreach and Pre-Exposure Prophylaxis (PrEP) Engagement (SCOPE) study, the investigators will design and evaluate an overdose prevention and HIV prevention study among people who use drugs…
- Trial name
- SCOPE (NCT05977881)
- Testing
- CHECKIT!
- Where
- United States
- Volunteers
- 493 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetic Peripheral Neuropathy, Diabetes
A Study of Xuebi Formula for Diabetic Peripheral Neuropathy(Qi-deficiency and Blood-stasis)
A Randomized, Parallel-controlled, Clinical Study to Evaluate the Efficacy of Xuebi Prescription Compared With Placebo in the Treatment of Diabetic Peripheral Neuropathy(Qi Deficiency and Blood Stasis)
- Conditions
- Diabetic Peripheral Neuropathy, Diabetes, Chinese Herbs
- Trial name
- XB (NCT02039544)
- Testing
- Xuebi formula
- Volunteers
- 60 people
- Sponsor
- Guang'anmen Hospital of China Academy of Chinese Medical Sciences
Hypercholesterolemia
Evaluating the Efficacy of AI-Guided (GenAIS TM) vs. Standard Physician-Guided Dietary Supplement Prescriptions for Lowering LDL Cholesterol in Hypercholesterolemic Patients
The trial compared AI-guided and standard physician-guided dietary supplement (DS) prescriptions for lowering LDL cholesterol (LDL-C) in hypercholesterolemic patients.
- Trial name
- NCT06448234
- Testing
- Standart supplementation therapy group, AI-guided supplementation therapy group
- Where
- Russia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- S.LAB (SOLOWAYS)
Drug Overdose
Pharmacokinetics and Pharmacodynamics of a New Formulation of Nasal Naloxone for Prehospital Use
Overdose with potential deadly outcome is a serious problem among opioid abusers, not least in Norway. The annual death toll from overdose is about 250, higher than road traffic accidents.
- Trial name
- OPI-14-001 (NCT02307721)
- Testing
- Intranasal naloxone, Intramuscular naloxone, Remifentanil
- Where
- Norway
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus, Type 2
High-intensity Interval Training Prescriptions to Reduce the Risk of Complications Linked to Type 2 Diabetes: the Role of Interval Length on Clinical Benefits and on Physiological Mechanisms
Type 2 diabetes (T2D) prevalence has steadily been rising in the past decades and its complications, including cardiovascular diseases (CVD), are a major public health concern.
- Trial name
- NCT04986345
- Testing
- High-intensity interval training (HIIT)-4, High-intensity interval training (HIIT)-10, Rest
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- Université de Sherbrooke
Epilepsy
A Study on Telemedicine Applied to Actual Outpatient Clinic for Epilepsy
This is an observational study to confirm the non-inferior effectiveness on health outcomes of tele-counseling or tele-prescription, which was the first outpatient system applied to the actual medical sites in Korea during the…
- Trial name
- NCT05418257
- Testing
- (exposure) telemedicine
- Where
- South Korea
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Refractive Error Correction, Visual Acuity
Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome
This study seeks to determine whether glasses prescriptions determined from computer analysis of detailed images of the eyes provide better vision outcomes for children with Down syndrome than prescriptions determined using…
- Trial name
- NCT07490444
- Testing
- Metric-optimized spectacles, Routine Clinical Spectacles
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ohio State University
Infection Due to Resistant Bacteria, Multi-antibiotic Resistance
Resistant Bacteria in Children in France
This study is observational, multicenter and prospective study for surveillance of the use of new antibiotics in pediatrics for treated pediatrics infections due to multi-resistant bacteria
- Conditions
- Infection Due to Resistant Bacteria, Multi-antibiotic Resistance, Antibiotic Prescription, Risk Factors
- Trial name
- BREF (NCT06036628)
- Where
- France
- Volunteers
- 306 people
- Sponsor
- Association Clinique Thérapeutique Infantile du val de Marne
End-Of-Life, Inappropriate Prescribing
Effectiveness of a Person-centred Prescription Model at the End of Life
This study's main objective is to investigate whether the application of an adapted person-centred prescription model during a hospital stay would reduce the use of inappropriate or futile regular medications in older people at…
- Conditions
- End-Of-Life, Inappropriate Prescribing, Deprescriptions, Palliative Medicine
- Trial name
- NCT05454644
- Testing
- Person-Centred Prescription Model
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Matia Foundation
Opioid Use, Opioid-Related Disorders
Addressing Origins of the Opioid Epidemic by Improving Prescribing for Opioid-Naive Patients
Risk of long-term opioid dependence increases with initial opioid dose/duration, but despite recent Centers for Disease Control and Prevention (CDC)-endorsed minimum doses for initial opioid prescription, primary care providers…
- Conditions
- Opioid Use, Opioid-Related Disorders, Opioid Abuse, Prescription Drug Abuse and Dependency
- Trial name
- NCT03377855
- Testing
- Default Prescribing Change
- Where
- 2 sites in United States
- Volunteers
- 948 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Sepsis Abdominal, Gastrointestinal Dysfunction
Efficacy of Fuzheng Tongfu Jiedu Prescription for Treating Gastrointestinal Dysfunction Associated With Sepsis
This study is a single-center, randomized, double-blind, placebo-controlled trial.
- Conditions
- Sepsis Abdominal, Gastrointestinal Dysfunction, Traditional Chinese Medicine
- Trial name
- FZTFJD (NCT06933238)
- Testing
- Fuzheng Tongfu Jiedu prescription (FZTFJD)
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Dongzhimen Hospital, Beijing
Inflammatory Bowel Diseases
A Multimodal Wearable Device-based Study to Evaluate the Efficacy of an Exercise Prescription Intervention in IBD
This project is a multimodal wearable device-based evaluation of the efficacy of an exercise prescription intervention for inflammatory bowel disease in a This is a single-center, randomized controlled clinical study to evaluate…
- Trial name
- NCT06427135
- Testing
- Exercise interventions
- Volunteers
- 56 people
- Sponsor
- Ping An
Opioid-use Disorder, Opioid Dependence
Young Houston Emergency Opioid Engagement System
The Houston Emergency Response Opioid Engagement System for Youths and Adolescents (Young HEROES) is a community-based research program integrating assertive outreach, medication for opioid use disorder (MOUD), behavioral…
- Conditions
- Opioid-use Disorder, Opioid Dependence, Opioid Overdose, Opioid Use
- Trial name
- YHEROES (NCT04811014)
- Testing
- Buprenorphine, Naloxone Drug Combination, Individual Counseling, Peer Recovery Support Services
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- The University of Texas Health Science Center, Houston
Nursing Home Residents, Older People
Improved Prescribing for Older Nursing Home Patients
Research aim: To investigate the effect of training health care professionals in medication assessments on the medication use of nursing home residents with a limited life expectancy (< 1.5-2 years).
- Conditions
- Nursing Home Residents, Older People, Prescribing, Advance Care Planning
- Trial name
- IMPETUS (NCT06731361)
- Testing
- Systematic multidisciplinary medication review + ACP (SMMR+)
- Where
- 7 sites in Netherlands
- Volunteers
- 450 people
- Sponsor
- Amsterdam UMC, location VUmc
Overdose
Evaluation of a Medication Health Center to Promote Opioid Safety
This study will assess the impact of an opioid safety clinic intervention for patients prescribed chronic opioid therapy. Outcomes are visits to the clinic, naloxone dispensings, Prescription Drug Monitoring reviews, and Urine…
- Trial name
- NCT06456294
- Testing
- MHC Outreach Intervention
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Kaiser Permanente
Prescription Opiate/Medication Dependence
CURE Addiction Center of Excellence: Brain Mechanisms of Relapse and Recovery
The proposed project will use fMRI and specific probes of reward and inhibition as biomarkers predicting drug use during and after treatment in 72 subjects addicted to prescription opioids/medications.
- Trial name
- fMRI CURE (NCT01587196)
- Testing
- Vivitrol
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Pennsylvania
Peritoneal Dialysis, Quality of Life
Designer Dialysis Peritoneal Dialysis
This study aims to use modified peritoneal dialysis prescriptions to achieve adequate clearance and volume removal while decreasing the number of exchanges or time spent on dialysis, evaluating maintenance of residual renal…
- Trial name
- NCT03100188
- Testing
- modified PD prescription
- Volunteers
- 7 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Cancer
The ICT Based Prescription of Physical Activity for Oncology Patients at Their Home
Study evaluating the efficacy of ICT-based prescription of physical activity in oncology patients
- Trial name
- EASYDOM (NCT07021196)
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Federico II University
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