Clinical trials: Preterm
Prematurity
Are Newborns Conscious of the Placebo Effect? Result From an RCT in Osteopathy
Results from previous studies suggest the association between Osteopathic Manipulative Treatment (OMT) and length of stay (LOS) reduction in a population of preterm infants.
- Trial name
- NCT01852500
- Testing
- Standard care
- Where
- Italy
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Preterm Rupture of Membranes
Trace Elements and Heavy Metals at PPROM
Objectives: To evaluate maternal serum trace elements and heavy metals namely, aluminum (Al), chromium (Cr), manganese (Mn), cobalt (Co), nickel (Ni), copper (Cu), zinc (Zn), arsenic (As), molybdenum (Mo), cadmium (Cd), tin (Sn)…
- Trial name
- metals&PROM (NCT04077944)
- Testing
- maternal serum concentration of trace elements and heavy metals levels
- Where
- Turkey (Türkiye)
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Cengiz Gokcek Women's and Children's Hospital
Premature Rupture of Membranes
FOLCROM Trial: Foley Catheter in Rupture of Membranes
Multicenter randomized clinical trial comparing oxytocin versus oxytocin and foley catheter for induction in women who present with premature rupture of membranes who are not in labor.
- Trial name
- FOLCROM (NCT01973036)
- Testing
- Foley Catheter, Oxytocin
- Where
- 5 sites in United States
- Volunteers
- 201 people, healthy volunteers welcome
- Sponsor
- Geisinger Clinic
Pain
The Effect of Non-nutritive Sucking on Pain During Examination for Retinopathy of Prematurity
Aim: The aim of the study is to determine the effect of non-nutritive sucking on pain during examination for retinopathy of prematurity. Method: The study is conducted as a randomized controlled trial.
- Trial name
- NCT04463927
- Testing
- non-nutritive sucking
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Adiyaman University Research Hospital
Pulmonary Hypertension, Bronchopulmonary Dysplasia
The Role of Transthoracic Echocardiography in Diagnosis of Pulmonary Hypertension of Infants With Bronchopulmonary Dysplasia
Pulmonary hypertension may develop in premature newborn infants due to impaired lung development. The diagnosis of this disease can actually be made with interventional methods.
- Trial name
- NCT05082272
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Healthy
Brain Structure and Development in Pre-Term and Full-Term Infants
The purpose of this study is to see how full-term and pre-term infants' brains relate to their movement and development throughout the first two years of life.
- Trial name
- NCT00679471
- Where
- 2 sites in United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Christiana Care Health Services
Premature Birth
The Impact of NICU Music Therapy for Preterm Infants and Caregivers
This study aims to provide initial evidence for the use of music therapy in the NICU in a UK context. In other countries, such as the US and the Netherlands, music therapy is routinely provided in the NICU and research has…
- Trial name
- NCT06844396
- Testing
- Music Therapy
- Where
- United Kingdom
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Anglia Ruskin University
Fetal Infection, Fetal Inflammatory Response Syndrome
IL-6 and Lactates in Cord Blood and Neonatal Outcomes
The goal of this observational study or clinical trial is to evaluate interleukin-6 (IL-6) and lactate levels in maternal and cord blood to identify early signs of fetal inflammation or infection.
- Conditions
- Fetal Infection, Fetal Inflammatory Response Syndrome, Chorioamnionitis, Chorioamnionitis Affecting Fetus or Newborn
- Trial name
- ECCO-IL6 (NCT07211503)
- Testing
- blood sampling
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Premature Birth, Psychological Stress
Parental Stress and Attachment in Preterm Infants
Introduction: Advances in neonatology mean a significant reduction in mortality in premature infants as well as an increase in the risk of morbidity in the medium, short and long term.
- Conditions
- Premature Birth, Psychological Stress, Physiological Stress
- Trial name
- NCT06813560
- Testing
- hair cortisol, salivary cortisol, salivary Oxytocin
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cardenal Herrera University
Preterm Birth, Neurodevelopment
Preterm Birth Cohort Study in Guangzhou
The Preterm Birth Cohort Study in Guangzhou (PBCSG) aims to explore the impact of genetic and environmental factors including life styles on preterm birth, to examine the interaction effect between these factors, and to follow up…
- Conditions
- Preterm Birth, Neurodevelopment, Immune Development, Host and Microbiome
- Trial name
- PBCSG (NCT03668327)
- Where
- China
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Exosomes, Newborn
Exosome microRNAs as Potential Biomarkers of Metabolic Bone Disease of Prematurity
Metabolic bone disease of prematurity (MBDP) is caused by insufficient content of calcium, phosphorus, and organic protein matrix in preterm infants or bone metabolism disorder, which is one of the complications affecting the…
- Conditions
- Exosomes, Newborn, Bone Diseases, Metabolic
- Trial name
- NCT06368154
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hunan Children's Hospital
Very Preterm Infants
Feeding the Preterm Gut Microbiota - Impact of Infant-feeding on Preterm Gut Microbiota Development
Preterm infants are especially vulnerable to gut microbiota disruption and dysbiosis since their early gut microbiota is less abundant and diverse.
- Trial name
- FEEDMI (NCT03663556)
- Testing
- Infant-feeding
- Where
- 2 sites in Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Language Delay, Language Development
Combined Oral Motor Stimulation and Language on Preterm Infant Feeding
This is a randomized controlled trial to study an oromotor stimulation in combination with a reading curriculum in the NICU among preterm infants using oral muscle exercises, Language Environment Analysis (LENA) recordings…
- Conditions
- Language Delay, Language Development, Feeding; Difficult, Newborn, Mother-Infant Interaction
- Trial name
- NCT05861531
- Testing
- Oromotor stimulation, Reading curriculum, LENA recording
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Women and Infants Hospital of Rhode Island
Premature
Effect of Docosahexaenoic Acid (DHA)-Enriched Human Milk in Premature Newborns
Several recent publications showed a reduction in the level of DHA and/or an increase in the arachidonic acid (AA)/DHA ratio in the milk of mother.
- Trial name
- DHARMA (NCT01062373)
- Testing
- Supplementation of lactating mothers who has delivered prematurely with DHA
- Where
- France
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Anemia, Iron Deficiency
Effect of Timing of Umbilical Cord Clamping on Anaemia at 8 and 12 Months and Later Neurodevelopment
The investigators plan a study to randomize 540 children in Nepal to early (≤30 seconds) or late (≥180 seconds) clamping of the umbilical cord at birth.
- Conditions
- Anemia, Iron Deficiency, Neonatal Jaundice
- Trial name
- NCT02222805
- Testing
- Early (≤30 seconds) cord clamping, Delayed (≤180 seconds) cord clamping
- Where
- Nepal
- Volunteers
- 540 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Preterm Birth, Breastfeeding
Phone Breastfeeding Support for Premature Babies
It was observed that premature babies had the risk of insufficient milk intake and a lower rate of breastfeeding compared to term babies.
- Trial name
- NCT04883866
- Testing
- Telephone Breastfeeding Support Program, Sending a breastfeeding guide for premature babies to the phone of mothers in addition to the routine discharge procedure
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Akdeniz University
Preterm Birth
Direct Measurements of Cervical Remodeling for Predicting Preterm Birth
Racism and health care system distrust are potent stressors and may be associated with preterm birth (PTB). Additionally, cervical shortening is a common pathway leading to PTB.
- Trial name
- NCT01175551
- Where
- 2 sites in United States
- Volunteers
- 1,207 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Preterm Premature Rupture of Membranes
The Relation Between Serum Ascorbic Acid Concentration and Preterm Premature Rupture of Membranes
To study the association between maternal serum vitamin C concentration in women with preterm premature rupture of membranes (PPROM) and women without PPROM.
- Trial name
- NCT02635451
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ain Shams Maternity Hospital
Preterm Birth, Preterm Labor
To Optimize Antenatal Management of Women With Pre Term Labor Using Amniocentesis
Implementation of prediction models of risk of spontaneous delivery within 7 days or of intra-amniotic infection in women with preterm labor and intact membranes
- Conditions
- Preterm Birth, Preterm Labor, Intra-amniotic Infection, Amniocentesis Affecting Fetus or Newborn
- Trial name
- OPTIM-PTL (NCT04831086)
- Testing
- Steroid Drug, Tocolytic Agents
- Where
- Spain
- Volunteers
- 247 people, healthy volunteers welcome
- Sponsor
- Fundacion Clinic per a la Recerca Biomédica
Prematurity, Very Preterm Maturity of Infant
Sleep in SNOO Smart Sleeper Bassinet in Preterm Infants
The goal of this clinical trial is to compare sleeping in a SNOO Smart Sleeper bassinet (SNOO) with sleeping in traditional bassinet conditions in premature infants. The main questions it aims to answer are: 1.
- Trial name
- NCT05711927
- Testing
- SNOO Smart Sleeper, Traditional bassinet
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Columbia University