Clinical trials: Preterm Birth
Premature Delivery
Feasibility Study and Predictive Value of the Uterine Cervix Polarimetric Imaging for the Management of the Threat of Premature Delivery.
Prematurity is the first cause of perinatal mortality and morbidity worldwide. The threat of premature delivery (TPD), the most important complication and the leading cause of hospitalization during pregnancy has multiple origins…
- Trial name
- NCT02859298
- Testing
- Uterine Cervix Polarimetric Imaging
- Where
- Belgium
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brugmann University Hospital
Preterm Birth
Brief Delay in Cord Clamping and Neurobehaviour in Preterms
RESEARCH HYPOTHESIS Brief delay(>30 sec to <60 sec ) in cord clamping as compared to early cord clamping (< 20 sec) leads to a better short term neurobehavioural outcome in preterm (34-36 wks) neonates when assessed by…
- Trial name
- NCT01753843
- Testing
- early cord clamping, Brief Delay in cord clamping
- Where
- India
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Lady Hardinge Medical College
Preterm Labor, Preterm Birth
Prematurity Risk Assessment Combined With Clinical Interventions for Improving Neonatal outcoMEs
This prospective, randomized, controlled study evaluates the safety and efficacy of a preterm birth (PTB) prevention strategy versus standard of care pregnancy management to reduce the incidence of adverse pregnancy outcomes.
- Trial name
- PRIME (NCT04301518)
- Testing
- Multimodal intervention strategy
- Where
- 18 sites in United States
- Volunteers
- 6,500 people, healthy volunteers welcome
- Sponsor
- Sera Prognostics, Inc.
Mercury Levels
Mercury Levels in Premature and LBW Infants Receiving Thimerosal-containing Vaccines
The goal of the study is to find out how much mercury is in the blood, urine, and stools of premature and low birth weight infants who have received standard childhood vaccines that are given to all infants in Argentina.
- Trial name
- NCT00138333
- Where
- Argentina
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Premature Birth
Theory of Mind in Preschool Children, School Children, Youths and Adults Born Preterm or Full-term
This study tests preschoolers, school children, youths and young adults, who were born preterm or full-term, in their theory of mind abilities.
- Trial name
- NCT02628015
- Where
- Germany
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- University of Bonn
Prematurity, Low Birth Weight
Paternal Involvement in Nursing Guidance and Breastfeeding Self-Efficacy in Mothers of High-Risk Newborns
This study aims to evaluate whether a structured nursing guidance program that increases fathers' participation in the care of hospitalized high-risk newborns improves maternal outcomes compared with routine nursing care.
- Conditions
- Prematurity, Low Birth Weight, Respiratory Distress Syndrome, Newborn, Neonatal Hyperbilirubinemia
- Trial name
- NCT07834008
- Testing
- step-by-step parent education, active father participation in breastfeeding support
- Where
- Taiwan
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University Shuang Ho Hospital
Prematurity
The Effect of Music on Preterm Infant's Brain Development
Studying the effect of music intervention on preterm infants' brain development by MRI and neurodevelopmental assessments
- Trial name
- NCT03689725
- Testing
- Music
- Where
- Switzerland
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Pediatric Clinical Research Platform
Infection, Candida
Early Diagnosis of Candidiasis in Premature Infants
This observational study evaluated the performance of new lab tests in detecting candida species fungal infections in extremely low birth weight (ELBW) infants quickly and accurately.
- Conditions
- Infection, Candida, Candidiasis, Infant, Newborn
- Trial name
- Candida (NCT00109525)
- Where
- 20 sites in United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- NICHD Neonatal Research Network
Premature Infant, Oxygen Therapy
SCO2T (Servo vs. Servo)
Most premature babies require oxygen therapy. There is uncertainty about what oxygen levels are the best. The oxygen levels in the blood are measured using a monitor called a saturation monitor and the oxygen the baby breathes is…
- Conditions
- Premature Infant, Oxygen Therapy, Hypoxia, Hyperoxia
- Trial name
- NCT04546568
- Testing
- Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - Leoni plus CLAC, Servo control (closed-loop automatic control of the inspiratory fraction of oxygen (FiO2)) - IntellO2 OAM
- Where
- United Kingdom
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Prematurity
The EveryPrem Project: Evaluating the INTER-NDA for Standardized Neurodevelopmental Screening at 2 Years of Age for Children Born Preterm.
Neurodevelopmental follow-up of infants at high-risk such as preterm born is necessary in order to early detect impairments and early start a supportive/therapeutic intervention.
- Trial name
- EveryPrem (NCT05065385)
- Testing
- INTER-NDA
- Where
- Switzerland
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Giancarlo Natalucci
Premature Birth
Three Interacting Single Nucleotide Polymorphisms (SNPs) and the Risk of Preterm Birth in Black Families
A multilocus interaction of three pro-inflammatory cytokine single nucleotide polymorphisms (SNPs), -3448 Tumor Necrosis Factor-α, -7227 Interleukin 6, and 33314 Interleukin 6R was reported by Menon and associates in 2006.
- Trial name
- NCT00675753
- Testing
- Blood spot specimens will be drawn
- Where
- 2 sites in United States
- Volunteers
- 258 people, healthy volunteers welcome
- Sponsor
- University of Miami
Length of Pregnancy Prolongation in Hours
Antibiotics and the Prolongation of Pregnancy in Preterm Labor With an Advanced Cervical Exam
Preterm birth remains a major health concern affecting up to 12% of all live births prior to 37 weeks gestation. As preterm birth can often be associated with infection our proposal is to evaluate in a randomized fashion…
- Trial name
- NCT00589329
- Testing
- erythromycin and metronidazole (antibiotics)
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MetroHealth Medical Center
Prematurity
Effect of Osteopathic Manipulative Treatment on Length of Stay in Preterms
The use of osteopathic manipulative treatment (OMT) in preterm infants has been documented and results from previous studies suggest the association between OMT and length of stay (LOS) reduction, as well as significant…
- Trial name
- NCT01544257
- Testing
- osteopathic manipulative treatment, Usual care
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- European Institute for Evidence Based Osteopathic Medicine
Upper Extremity Dysfunction
Movement Enhancing Device for Children
The purpose of this study is to assess: 1) how infants move their bodies to explore, play, and solve problems, 2) if this is different in a high-risk group of infants, and 3) if these abilities can be advanced in a high-risk…
- Trial name
- NCT01959581
- Testing
- Movement Enhancing Device
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Preterm, Breastfeeding
Breastfeeding and Bottle Feeding: Impact on Preterm Infants' Physiology and Feeding Performance
The goal of this clinical trial is to evaluate the effect of breastfeeding on the infant's test weight and physiological characteristics (oxygen saturation and heart rate) in preterm infants in the Neonatal Intensive Care Unit…
- Conditions
- Preterm, Breastfeeding, Bottlefeeding, Premature
- Trial name
- NCT05651035
- Testing
- oral feeding
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Preterm Birth, Pregnancy
An Electronic Medical Record Alert of Progesterone
Progesterone can be given to women at risk for preterm birth, and is advocated by many guidelines as progesterone has been shown to markedly decrease preterm birth, death in newborns, and disability.
- Trial name
- NCT03219489
- Testing
- Electronic medical record alert
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hypertension, Premature Birth
Trial of Exercise to Prevent HypeRtension in Young Adults
TEPHRA investigates the effect of exercise on blood pressure and other cardiovascular factors in young adults with different birth histories.
- Trial name
- TEPHRA (NCT02723552)
- Testing
- Aerobic Exercise
- Where
- United Kingdom
- Volunteers
- 203 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Preterm Infants, Term Infants
The Intestinal Innate Immune System in Newborns. Development and Inflammation in Health and Disease
The goal of this observational study is to determine the normal development of the human intestinal immune system in premature and mature neonatal life and to determine the pathophysiology behind life-threatening gastrointestinal…
- Conditions
- Preterm Infants, Term Infants, Necrotising Enterocolitis, Atresia; Bowel
- Trial name
- INTINE (NCT06092463)
- Where
- 2 sites in Denmark
- Volunteers
- 275 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stress, Psychological
Investigation of Different Relaxation Techniques in Eliciting a Relaxation Response
While the stress response, characterised by an increase in heart rate, blood pressure, and cortisol, has evolved to ensure the survival of the organism in face of danger, chronic stress due to psychological stressors can be…
- Trial name
- NCT03592147
- Testing
- Guided Imagery Relaxation Tape, Music Listening, Relaxation Lighting
- Where
- United Kingdom
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University College, London
Malaria, Sexually Transmitted Diseases
Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth
The purpose of this study is to examine whether treatment of pregnant Malawian women with repeated doses of sulfadoxine-pyrimethamine and azithromycin antibiotics will prevent preterm deliveries and result in other health…
- Conditions
- Malaria, Sexually Transmitted Diseases, Preterm Birth, Pregnancy
- Trial name
- NCT00131235
- Testing
- Sulfadoxine-pyrimethamine treatment twice during pregnancy, Sulfadoxine-pyrimethamine at 4-week intervals, Sulfadoxine-pyrimethamine every 4 weeks + azithromycin twice
- Where
- Malawi
- Volunteers
- 1,320 people, healthy volunteers welcome
- Sponsor
- Tampere University
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