Clinical trials: Preterm Infants
Premature Birth, Parenteral Nutrition
Physiotherapy to Improve Feeding Skills in Preterm Infants
INTRODUCTION: Suction problems are very common in premature children due to a lack of maturation and orofacial control, the manifestation of a low muscle tone and the incoordination during sucking-swallow-breathe.
- Conditions
- Premature Birth, Parenteral Nutrition, Motor Disorders, Neurodevelopmental Disorders
- Trial name
- NCT05619224
- Testing
- Neurodevelopmental stimulation + Oral stimulation, Oral stimulation
- Where
- Spain
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Universidad de Almeria
Prematurity, RSV
The Impact of a Short Intervention During RSV Prophylaxis on Influenza Vaccination Rate.
Premature infants (born before 34 wk) are routinely vaccinated against RSV but vaccination rate against influenza are low in spite of national programs.
- Conditions
- Prematurity, RSV, Influenza, Upper Respiratory Tract Infection
- Trial name
- NCT01985620
- Testing
- Educational intervention
- Where
- Israel
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Breastfeeding Mothers of Infants Hospitalized
The "Pooling" Expressed Breast Milk: A Method for Improving the Nutritional Intake of Premature Infants
The investigators compared a pooled mother's expressed breastmilk for 24 hours with individual pump session collection of milk to provide a more consistent caloric product without increasing bacterial contamination.
- Trial name
- POOL-BM (NCT02994823)
- Where
- France
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Oxygen Saturation, Heart Rate
The Effect of Elastic Sac on Feeding
The study will be conducted using the crossover randomized controlled method. Preterm infants who began oral feeding from the neonatal intensive care unit will be divided into two groups through randomization in the computer…
- Conditions
- Oxygen Saturation, Heart Rate, Nutritional Status
- Trial name
- NCT05154357
- Testing
- Elastic Sac, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Death, Nosocomial Infection
Prophylactic Probiotics in Premature Infants
This study tries to determine whether the oral administration of a specific probiotic (good bacteria) in premature infants hospitalized in a neonatal intensive care unit may prevent infections and the development of a severe…
- Trial name
- C3P (NCT00727363)
- Testing
- Lactobacillus reuteri
- Where
- 8 sites in Colombia
- Volunteers
- 751 people, healthy volunteers welcome
- Sponsor
- Colombian Neonatal Research Network
Retinopathy of Prematurity, ROP
Automated Screening Device to Detect MTMROP
The purpose of the study is to evaluate the i-ROP DL system for autonomous ROP screening. To demonstrate the sensitivity and specificity of the i-ROP DL system on images obtained by healthcare providers in the neonatal intensive…
- Trial name
- NCT06517836
- Testing
- iROP DL
- Where
- United States
- Volunteers
- 1,284 people, healthy volunteers welcome
- Sponsor
- Siloam Vision
Breast Milk Expression, Premature Birth of Newborn
How Effect Olive Oil and Eoprotin on Immunological Parameters and Growth
This study aims to compare immunologic parameters of 60 patients who are 1-28 days-aged, below 1500-gram body weight, born before 32 weeks of gestational age and fed with eoprotin or olive-oil fortified breast milk.
- Trial name
- RDS (NCT02832011)
- Testing
- olive oil, Eoprotin
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- nihat demir
Tissue Oxygenation
The Correlation Between Tissue Oxygenations Using NIRS and Clinical Outcomes in Very Preterm Infants.
With the development of neonatal critical medicine, the survival rate of premature infants has gradually increased, and the incidence of late complications has significantly decreased, but preterm delivery is still the main cause…
- Trial name
- TCBTOUNACOIVPI (NCT06483867)
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The First Hospital of Jilin University
Neonatal Hypoglycemia
Immediate Skin-To-Skin Contact and Early Breastfeeding During Caesarean Section
Background: Neonatal hypoglycemia is a prevalent and serious condition among late preterm and term infants, which can lead to severe neurodevelopmental consequences if not managed properly.
- Trial name
- NCT06543160
- Testing
- Immediate SSC and early breastfeeding during CS, Delayed SSC and breastfeeding after CS, Routine newborn care
- Where
- China
- Volunteers
- 336 people, healthy volunteers welcome
- Sponsor
- Qingdao Municipal Hospital
Cerebral Palsy, General Movement Assessment
This Study Aims to Evaluate the Validity of Family-led Recordings for General Movement Assessment (GMA) Compared to Provider-led Recording in Neonates Born Under 29weeks
This study aims to evaluate the validity of family-led recordings for General Movements Assessment (GMA) compared to provider-led recordings in neonates born <29 weeks.
- Conditions
- Cerebral Palsy, General Movement Assessment, Prematurity
- Trial name
- NCT07141654
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders
Multi-observational Study for the Early Identification of Autism Spectrum Disorder (ASD) and Other Neurodevelopmental Disorders (NDD) in At-risk Populations
Autism spectrum disorder (ASD) is a neurodevelopmental disorder (NDD) that affects about 78 million people worldwide. Its prevalence and degree of impact on individuals and families place it among disorders of global importance.
- Trial name
- BABY@NET (NCT06915805)
- Where
- 5 sites in Italy
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- Istituto Superiore di Sanità
Neonatal Hypothermia, Brown Adipose Tissue
Investigation of the Mechanisms of the Tendency to Hypothermia in Newborns and Premature Neonates
Newborns have thermoregulatory mechanisms that differ from those of adults. Instead of producing heat through shivering, newborns primarily rely on non-shivering thermogenesis by the brown adipose tissue.
- Conditions
- Neonatal Hypothermia, Brown Adipose Tissue, Preterm and Term Infants, Neonate
- Trial name
- NCT06803069
- Where
- 2 sites in Hungary
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Pecs
Caregiver Feeling
Feeling of Caregivers After a Palliative Management of Extreme Premature Babies in Delivery Room.
Introduction : The birth of a child is usually a happy event that caregivers working in delivery rooms share with families. Unfortunately, newborns sometimes need palliative care as soon as birth occurs.
- Trial name
- NCT06458114
- Testing
- Assessment of caregiver feeling
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- CHU de Reims
Premature Infants, Necrotizing Enterocolitis
PREMAPROB. Probiotics to Prevent Necrotizing Enterocolitis
The main objective of this study is to assess the impact of two different doses of a mixture of probiotics from two strains isolated in human milk on the incidence of severe necrotizing enterocolitis (NEC) and death among preterm…
- Trial name
- NCT06501404
- Testing
- High dose group, Low dose group
- Where
- Spain
- Volunteers
- 583 people, healthy volunteers welcome
- Sponsor
- José Antonio Hurtado Suazo
Preterm Infants, Metabolic Bone Disease
Calciuric Effect and Cyclic Parenteral Nutrition in Preterm Infants
The aim of our work is to study the effect of total parenteral nutrition (TPN) cycling in preterm infants on hypercalcuria (excessive calcium excretion in urine).
- Trial name
- NCT00711763
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
Pain, Acute, Preterm Infant
Olfactive Stimulation Interventions With Mothers' Milk on Preterm Pain Response
Repeated and untreated pain can lead to long-term consequences in preterm infants, such as pain hypersensitivity and impaired motor and intellectual development.
- Conditions
- Pain, Acute, Preterm Infant, Breast Milk
- Trial name
- NCT04062513
- Testing
- Olfactive stimulation intervention with familiarization, Olfactive stimulation intervention, Standard care
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Premature Infant
Effect of a Mixture of New Probiotic Strains in Preterm Infants
An interventional, randomized, double-blind, placebo-controlled study will be conducted to investigate the effect of a new probiotic strain Lactobacillus PS11603 \& Bifidobacterium PS10402 in premature infants from 28 weeks + 0…
- Trial name
- PREBIOMA (NCT03701906)
- Testing
- Lactobacillus PS11603 & Bifidobacterium PS10402
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ProbiSearch SL
Infant, Premature, Diseases
Measurement of Neonatal Microvascular Hemodynamics Using Non-invasive Optical Technologies
Alterations to microvascular blood flow in premature infants, are known to contribute to several major disease entities. The optically-measured tissue blood flow, to determine tissue perfusion that can be use to detect blood loss.
- Trial name
- NCT01982357
- Testing
- Laser Speckle Imaging and Diffuse Optical Spectroscopy
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Growth Failure, Atopy
The PREWEAN Study. Weaning of Preterm Infants During the First Year of Life.
In this Austrian observational study preterm infants born with a birth weight <1500 g and a gestational age <32 weeks will be investigated at the neonatal outpatient clinic.
- Conditions
- Growth Failure, Atopy, Adiposity, Cognitive Impairment
- Trial name
- PREWEAN (NCT02936219)
- Where
- Austria
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Enterocolitis, Necrotizing, Infant, Premature
Role of Urinary Claudin-2, Caveolin-1, and EGF as Diagnostic Biomarkers of Necrotizing Enterocolitis in Preterm Neonates
Our study aims to determine the differences in the concentration of urinary claudin-2, caveolin-1, and epidermal growth factor (EGF) as non-invasive biomarkers in the diagnosis of Necrotizing Enterocolitis (NEC).
- Trial name
- NCT05335577
- Testing
- Urinary Claudin-2, Urinary Caveolin-1, Urinary EGF
- Where
- Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya