Clinical trials: Preterm Infants
Retinopathy of Prematurity
A Study Investigating Whether Low Dose Eyedrops for Pupil Dilation is as Effective and Safe as Standard Dose Eyedrops in Examination for Retinopathy of Prematurity.
A prospective, randomized controlled study was conducted from August, 2022 to March, 2023 in the neonatal intensive care unit in Queen Mary Hospital, Hong Kong.
- Trial name
- NCT06288321
- Testing
- Microdrop Mydrin-P, Standard Mydrin-P
- Where
- Hong Kong
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Preterm Birth, Very Low Birth Weight Infant
Assessment of Body Composition in Premature Children Submitted to an Early Stimulation Program
This is a cross-sectional study of a randomized clinical trial to investigate nutritional aspects of pre-scholar aged children born preterm submitted to an early stimulation program versus conventional care program.
- Conditions
- Preterm Birth, Very Low Birth Weight Infant, Early Intervention, Parent-Child Relations
- Trial name
- NCT05399667
- Testing
- Early stimulation, Conventional care
- Where
- Brazil
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Hospital de Clinicas de Porto Alegre
Premature Infants, Parent-Child Relations
Implementation of an Evidence Based Parentally Administered Intervention for Preterm Infants
Early developmentally-based behavioral intervention has well-established positive effects and is recommended as the standard of care to support early brain maturation, health, and development.
- Trial name
- NCT04555590
- Testing
- H-HOPE Intervention
- Where
- 4 sites in United States
- Volunteers
- 1,882 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Mother, Premature
The Effect of the Mobile Application Developed for Home Care of Preterm
mobile application will be developed to support the post-discharge home care of mothers of premature babies. With the developed mobile application, the effect of the education given to the mothers on the knowledge and skills of…
- Conditions
- Mother, Premature, Education, Home Care
- Trial name
- NCT05438056
- Testing
- education with mobile application
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Ankara University
Necrotizing Enterocolitis, Allergy
Investigation of Allergen Sensitization in Newborn Babies Diagnosed With Necrotizing Enterocolitis.
To evaluate the frequency of allergy between 12 and 24 months of age in infants who were treated in the neonatal clinic and had NEC.
- Conditions
- Necrotizing Enterocolitis, Allergy, Preterm
- Trial name
- AlisNEC (NCT07562009)
- Testing
- skin prick test
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Retinopathy of Prematurity
Clinical and Genetic Analysis of ROP
Retinopathy of Prematurity (ROP) is a vascular disease affecting the retinas (back of the eye) of low birth weight infants. Although it can be treated effectively if diagnosed early, it continues to be a leading cause of…
- Trial name
- (ROP) (NCT04420156)
- Testing
- No intervention administered.
- Where
- 5 sites in United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Preterm, Feeding Behavior
Feeding Readiness and Oral Feeding Success in Preterm Infants
To examine the effects of sensorimotor interventions applied to in preterm infants on readiness for feeding and oral feeding success.
- Conditions
- Preterm, Feeding Behavior, Enteral Feeding Intolerance
- Trial name
- NCT04946045
- Testing
- Sensorimotor Interventions (Tactile/Kinesthetic Stimulation+Nonnutritive Sucking)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Preterm Infant
Visual Stimulation of Preterm Infants
Introduction: Prematurity rate has increased and is a risk factor for developmental delay. Preterm infants with low visual tracking might present deficits in cognition, language, and fine motor function in future ages.
- Trial name
- NCT03302000
- Testing
- Early Visual Stimulation, standard care
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Santa Catarina
Respiratory Distress, Transient Tachypnea of the Newborn
Effect of Supine or Prone Position After Caesarean Birth
Respiratory Distress is a frequent clinical diagnosis of babies delivered by elective Caesarean birth. There has been no study comparing the efficacy of immediately positioning a newly born infant prone vs.
- Conditions
- Respiratory Distress, Transient Tachypnea of the Newborn, Delayed Transition of the Newborn, Persistent Pulmonary Hypertension
- Trial name
- NCT01310153
- Testing
- prone positioning, Supine
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Montefiore Medical Center
Non-nutritive Sucking
Effect of Non-nutritive Sucking on Feeding Intolerance
The design of this study is an experimental research design, and the research subjects who meet the conditions of acceptance will be used as randomized controlled trials.
- Trial name
- NCT06065839
- Testing
- non-nutritive sucking 5 minutes, non-nutritive sucking 15 minutes
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Preterm and Term Infants
Relationship of Gestational Age and Urine Concentration of S100B in Preterm and Term Infants in the First Week of Life
S100B, a calcium-binding protein, is found predominantly in the central nervous system (CNS) and is increased in CSF and blood after CNS injury. There are two objectives to this study.
- Trial name
- NCT00747864
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- University of Utah
Breastfeeding, Preterm Infant
The Effect of the SNS-Based Feeding on Transition to Exclusive Breastfeeding in Preterm Infants
This study investigated the effect of the Supplemental Nursing System (SNS)-based feeding on the time to transition to exclusive breastfeeding, sucking success, and the time to discharge in preterm infants
- Conditions
- Breastfeeding, Preterm Infant, Sucking Behavior
- Trial name
- NCT05815706
- Testing
- MEDELA Supplemental nursing system
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Sleep Problem, Neurobehavioral Manifestations
NapBiome: Targeting Gut Microbiota and Sleep Rhythm to Improve Developmental and Behavioral Outcomes in Early Childhood
The gut-brain axis plays a crucial role in the regulation and development of psychological and physical processes. The first year of life is a critical period for the development of the gut microbiome, which parallels important…
- Trial name
- NapBiome (NCT06396689)
- Testing
- Synbiotic
- Where
- 2 sites in Switzerland
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Petra Zimmermann
Parents of Premature Infants, Intelligent Intervention
Effects of Intelligent Parent-child Bonding Intervention on the Physical, Psychological and Social Health of Parents of Premature Infants During Hospitalization and Return Home
The study purpose is to construct and validate the effects of "intelligent parent-child bonding intervention" on the physical, psychological and social health of parents of premature infants.
- Conditions
- Parents of Premature Infants, Intelligent Intervention, Parent-child Connection
- Trial name
- NCT06987227
- Testing
- Intelligent intervention to enhance parent-child connection, Routine care
- Where
- Taiwan
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Preterm Birth
The GROWNDUP Study of Late Preterm Births
This pilot study will examine the feasibility of conducting a large randomized clinical trial (RCT) to examine the role of a novel, specialized follow-up clinic in preventing complications among late preterm infants (LPTB), born…
- Trial name
- GROWNDUP (NCT01747603)
- Testing
- Specialized LPTB clinic
- Where
- 2 sites in Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- McMaster University
Prematurity; Extreme, Feeding Patterns
To Determine the Best Feeding Practice in Preterm Infants on Non-invasive Ventilation.
To evaluate the duration to reach full feeds by comparing continuous gavage feeds versus bolus feeds in preterm infants who are on non-invasive respiratory support (RAM cannula - short binasal prongs).
- Conditions
- Prematurity; Extreme, Feeding Patterns, Ventilator Lung; Newborn
- Trial name
- NCT05824377
- Testing
- Continuous Feeds, Intermittent Bolus Feeds
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Rajeev Kumar
Cerebral Palsy, Prematurity
Best Practices Fo Early Diagnosis of Cerebral Palsy
In this research, the investigators are using an implementation science approach to enhance the uptake of a clinical practice guideline for earlier diagnosis of cerebral palsy (i.e.
- Trial name
- CP (NCT06537622)
- Testing
- Implementation group, Standard of care
- Where
- Canada
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- St. Justine's Hospital
Oral Colostrum Administration in Very Low Birth Weight Premature Infants
Analysis of the Effects of Oral Colostrum Administration in Premature Infants on the Breastfeeding
In the literature, it is emphasized that oral colostrum administration in very low birth weight infants supported the immune development of the premature newborn, contributed to the development of oral microbiota and reduced the…
- Trial name
- Oral colostrum (NCT04454502)
- Testing
- Oral colostrum administration
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Preterm Infants
Socio-Emotional Development in Preterm Infants
With advances in medicine and medical technology, premature infants born as early as 24 weeks of gestation and with birth weight less than 1000 grams are surviving today. Preterms are born with immature biological systems.
- Trial name
- NCT00917475
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Procedural Pain, Pre-Term
Multimodal Approach to the Ontogenesis of Nociception in Very Preterm and Term Infants
The management of pain related to venipuncture remains insufficient in very preterm infants (VPI. The separation between the mother (father) and her(his) child can aggravate the short-term painful experience of the newborn.
- Conditions
- Procedural Pain, Pre-Term, Venipuncture
- Trial name
- NOCI-Prem (NCT05404594)
- Testing
- Maternal vocal contact
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France