Clinical trials: Preterm Labor With Preterm Delivery, open to volunteers
Previable Labour With Intact Membranes
A Combination of Antibiotics to Decrease Neonatal Morbidity and Mortality for Previable Threatened Labor
The purpose of this study is to determine whether a combination of antibiotics (cephalosporin 3rd generation, clarithromycin, metronidazole) are effective to prolong pregnancies complicated with previable threatened labour with…
- Trial name
- ECHEC-MAT (NCT06572761)
- Testing
- Combination of antibiotics, Emergency cerclage, Vaginal progesterone
- Where
- France
- Volunteers
- 350 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Vulvodynia, Mycoses
Prospective Data Bank Creation to Study Vaginal Conditions
The purpose of this study is to identify and elucidate the pattern and perhaps role of atypical proteins, cytokines and vaginal microbial flora in the pathogenic mechanisms involved in the development of vulvodynia, recurrent…
- Conditions
- Vulvodynia, Mycoses, Bacterial Vaginosis, Preterm Labor
- Trial name
- CRIPB-13-002 (NCT01829204)
- Where
- United States
- Volunteers
- 550 people, healthy volunteers welcome
- Sponsor
- Texas Tech University Health Sciences Center
Preterm
Cerclage Plus Progesterone vs Progesterone Alone in Twin Short Cervix
This study aims to compare the effectiveness of cervical cerclage combined with progesterone versus progesterone alone in preventing preterm birth among women with twin pregnancies and a short cervix (cervical length ≤ 30 mm).
- Trial name
- VNTWINC (NCT07372495)
- Testing
- Cervical cerclage, Progesterone
- Where
- 6 sites in Vietnam
- Volunteers
- 260 people
- Sponsor
- National Hospital of Obstetrics and Gynecology
Doula Support, Postpartum
The Goal is to Examine the Impact of Doula-delivered, Nurse-coordinated Postpartum Care Among Individuals With Preterm Births <34 Weeks' Gestation Requiring NICU Admission.
The primary objective of this research is to conduct a randomized clinical trial to examine the impact of nurse-coordinated, doula-delivered postpartum support (intervention arm) on postpartum health care utilization, health…
- Conditions
- Doula Support, Postpartum, Postpartum Depression (PPD), Postpartum Anemia
- Trial name
- NEST (NCT07787845)
- Testing
- Doula-delivered, Nurse-coordinated postpartum support
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- University of South Carolina
Preterm Birth
Cerclage for the Reduction of Extreme Preterm Birth in Twin Pregnancies With a Short Cervix or Dilatation
The goal of this clinical trial is to assess the effectiveness of a cerclage in women with a twin pregnancy with a midpregnancy short cervix or cervical dilatation compared to standard treatment (no cerclage) in the prevention of…
- Trial name
- TWIN Cerclage (NCT05968794)
- Testing
- Vaginal cerclage
- Where
- 13 sites in Belgium, Netherlands
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Preterm Birth, Preeclampsia
The ROOT Study: Scaling the 'Standard of Care Plus' Obstetric Nutrition Model to Optimize Maternal and Infant Health
The 'Standard of Care Plus' ('PLUS') model in the ROOT Study consists of analyzing select micronutrient and gene variants of pregnant females to construct trimester-specific and personalized nutrition and lifestyle…
- Conditions
- Preterm Birth, Preeclampsia, Gestational Diabetes Mellitus (GDM), Small for Gestational Age (SGA)
- Trial name
- ROOT (NCT07559773)
- Testing
- 'Standard of Care PLUS'
- Volunteers
- 500 people
- Sponsor
- GrowBaby Life Project
Prematurity; Extreme, Prematurity; Decision Support
Health-Related Quality-of-Life and Household Financial and Wellbeing Impacts of Prematurity and Necrotising Enterocolitis (NEC).
PREM-IMPACT is a UK-based observational study exploring how caring for a very premature baby-particularly one affected by necrotising enterocolitis (NEC)-impacts families over the first year after hospital discharge.
- Conditions
- Prematurity; Extreme, Prematurity; Decision Support, Necrotising Enterocolitis, Preterm
- Trial name
- PREM-IMPACT (NCT07192393)
- Where
- 7 sites in United Kingdom
- Volunteers
- 90 people
- Sponsor
- Imperial College London
Preterm Birth
Music Intervention for Preterm Birth
This study will test a music intervention (MI) versus a sham control (SC) arm which only includes a verbal intervention, to determine if the effects of the music intervention will reduce the biological impact of chronic stress…
- Trial name
- NCT05945264
- Testing
- Music Intervention (MI)
- Where
- 2 sites in United States
- Volunteers
- 142 people
- Sponsor
- Columbia University
Motor Disorders, Neurodevelopmental Disorders
Neuromotor Development and Motor Related Health Care in Children with a High Risk Neonatal Period
The overall aim of the study is to evaluate the prevalence of motor- and neurological disorders (cerebral pares and other less severe motor disorders) in Swedish infants with a high-risk neonatal period and to elucidate whether…
- Conditions
- Motor Disorders, Neurodevelopmental Disorders, Premature Birth, Hypoxic-Ischemic Encephalopathy
- Trial name
- NCT06645717
- Volunteers
- 2,900 people
- Sponsor
- Karolinska Institutet
Pregnant With Complication, Preeclampsia
Developing & Evaluating Models for Early Predicting Obstetrical Diseases in Pregnant Women by Non-invasive Prenatal Test
This is Observational study, aiming to investigate the potentiality of cffDNA and cfRNA by a non-invasive test, in combination with clinical characteristics, to establish models for early screening and predicting high-risk…
- Conditions
- Pregnant With Complication, Preeclampsia, Preterm Birth, Gestational Diabetes
- Trial name
- NCT06385366
- Where
- Vietnam
- Volunteers
- 1,105 people
- Sponsor
- Gene Solutions
Intraventricular Hemorrhage, Premature Birth
Intranasal Fresh Mother's Own Milk to Prevent Intraventricular Hemorrhage in Extremely Preterm Infants
Babies born very prematurely are at risk of intraventricular hemorrhage (IVH), which is bleeding in or around the fluid-filled spaces of the brain. Most IVH occurs during the first week after birth.
- Trial name
- iF-MOM-IVH (NCT07812922)
- Testing
- Intranasal Fresh Mother's Own Milk (iF-MOM)
- Volunteers
- 67 people
- Sponsor
- University of Manitoba
Respiratory Distress Syndrome, Premature Birth
nCPAP Versus High-Flow Nasal Cannula in Preterm Infants With RDS
This randomized controlled trial aims to compare the efficacy and safety of nasal continuous positive airway pressure versus high-flow nasal cannula as initial non-invasive respiratory support in preterm infants with respiratory…
- Trial name
- NCT07869719
- Testing
- Non-invasive respiratory support
- Volunteers
- 94 people
- Sponsor
- Assiut University