Clinical trials: Prevention of Colorectal Cancer
Colon Cancer
Xian-Lian-Jie-Du Optimization Decoction As an Adjuvant Treatment for Prevention of Recurrence of Colon Cancer
This study is designed as a multi-center, randomized, double-blind, placebo-controlled trial. Subjects in the intervention group will be treated with XLJDOD compound granule.
- Trial name
- NCT05709249
- Testing
- XLJDOD compound granule
- Where
- China
- Volunteers
- 730 people
- Sponsor
- Jiangsu Famous Medical Technology Co., Ltd.
Colorectal Cancer
The Role of Coenzyme Q10 in the Prophylaxis of Oxaliplatin Induced Peripheral Neuropathy in Patients With Colorectal Cancer
This study aims to evaluate the possible beneficial role of coenzyme Q10 against oxaliplatin-induced peripheral neuropathy in patients with colorectal cancer.
- Trial name
- NCT06856447
- Testing
- Coenzyme Q10, Oxaliplatin, 5-Fluorouracil (5-FU)
- Where
- Egypt
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- toqa saad mohammed mohammed
Cognitive Function
Ca:Mg Ratio and Cognitive Function
Between 2000 and 2015, mortality due to Alzheimer's disease (AD) increased by 123%. No drugs have yet been approved to stop or slow the progression of AD.
- Trial name
- NCT04196023
- Testing
- Magnesium glycinate
- Volunteers
- 129 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Colorectal Serrated Adenomas, Colorectal Tubular Adenomas
Minimizing the Risk of Metachronous Adenomas of the Colorectum With Green Tea Extract -MIRACLE-
This is a randomized, placebo controlled, multicentric trial to investigate the effect of diet supplementation with green tea extract containing 300mg epigallocatechin gallate (EGCG), the major polyphenol of green tea, on the…
- Conditions
- Colorectal Serrated Adenomas, Colorectal Tubular Adenomas, Colorectal Villous Adenomas, Colorectal Tubulovillous Adenomas
- Trial name
- MIRACLE (NCT01360320)
- Testing
- Green tea extract of Camellia Sinensis
- Where
- 21 sites in Germany
- Volunteers
- 1,001 people
- Sponsor
- Martin-Luther-Universität Halle-Wittenberg
Colorectal Cancer, Polyps
Aspirin/Folate Prevention of Large Bowel Polyps
This is a randomized controlled trial of aspirin and/or folate supplementation for the prevention of the recurrence of neoplastic polyps (adenomas) of the large bowel.
- Conditions
- Colorectal Cancer, Polyps, Adenomas
- Trial name
- NCT00272324
- Testing
- Aspirin, Folate
- Where
- 9 sites in United States, Canada
- Volunteers
- 1,121 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Neoplasms, Colorectal
Green Tea Extracts for the Prevention of Colorectal Adenomas and Colorectal Cancer
Experimental studies have shown the chemopreventive properties of green tea extract (GTE) on colorectal cancer. And colorectal adenomas are precursors to colorectal cancers.
- Trial name
- NCT02321969
- Testing
- GTE (green tea extract)
- Volunteers
- 176 people
- Sponsor
- Seoul National University Hospital
Febrile Neutropenia, Stage 0 Breast Cancer
S1415CD, Trial Assessing CSF Prescribing Effectiveness and Risk (TrACER)
This randomized clinical trial studies prophylactic colony stimulating factor management in patients with breast, colorectal or non-small cell lung cancer receiving chemotherapy and with risk of developing febrile neutropenia.
- Conditions
- Febrile Neutropenia, Stage 0 Breast Cancer, Stage 0 Colorectal Cancer, Stage 0 Non-Small Cell Lung Cancer
- Trial name
- TrACER (NCT02728596)
- Testing
- Preventive Intervention, Quality-of-Life Assessment, Questionnaire Administration
- Where
- 160 sites in United States, Puerto Rico
- Volunteers
- 3,665 people
- Sponsor
- SWOG Cancer Research Network
Anus Neoplasms, Rectal Neoplasms
Alkagin Paste in the Prevention of Radiation Dermatitis
The purpose of this study is to determine whether Alkagin paste is effective at preventing radiodermatitis in patients receiving external beam radiation therapy to the perineal area.
- Conditions
- Anus Neoplasms, Rectal Neoplasms, Urogenital Neoplasms
- Trial name
- NCT01408407
- Testing
- Aveeno cream, Alkagin paste
- Where
- Canada
- Volunteers
- 2 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Colorectal Adenoma, Colorectal Cancer Control and Prevention
6-year Follow-up Data After the Berberine Intervention Trial
Colorectal cancer (CRC) is a common malignancy of the digestive tract, which constitutes a major public health burden. Almost 90% of CRC cases progress from precursor adenomatous polyps through adenoma-carcinoma sequence.
- Conditions
- Colorectal Adenoma, Colorectal Cancer Control and Prevention, Colorectal Polyps
- Trial name
- NCT06629051
- Testing
- Berberine Hydrochloride
- Where
- China
- Volunteers
- 891 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Parastomal Hernia, Rectal Adenocarcinoma
Chimney Trial of Parastomal Hernia Prevention
Chimney trial is designed to compare the effectiveness and safety of specifically designated polyvinylidene fluoride mesh (PVDF, Dynamesh IPST) to controls in a multi center, randomized setting.
- Conditions
- Parastomal Hernia, Rectal Adenocarcinoma, Abdominoperineal Resection
- Trial name
- NCT03799939
- Testing
- Intervention group
- Where
- 7 sites in Finland, Sweden
- Volunteers
- 141 people
- Sponsor
- University of Oulu
Colorectal Cancer Prevention, Colorectal Adenoma
BILe Acid-gut Microbiome Axis MODification Through Diet Education for Colorectal Cancer Prevention
This research study is a prospective, single-arm clinical trial to assess the effect of a dietary intervention for more plant-based and less animal-based food intake on secondary bile acid production, gut microbiota, circulating…
- Trial name
- BILMOD (NCT07162337)
- Testing
- Increased Plant-Based Diet and Decreased Animal-Based Diet
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Massachusetts General Hospital
Salpingectomy, Colorectal Surgery
Preventing Ovarian Cancer Through Oportunistic Salpingectomy at the Time of Colorectal Surgery
This study aims to evaluate the feasibility, safety and cost-effectiveness of opportunistic salpingectomy (OS-the removal of the fallopian tubes) at the time of colorectal surgery to prevent ovarian cancer.
- Trial name
- NCT05300711
- Testing
- Bilateral salpingectomy, Colorectal surgery
- Where
- 2 sites in Canada
- Volunteers
- 240 people
- Sponsor
- University of British Columbia
Colorectal Cancer Screening
Optimizing Participation In Colorectal Cancer Screening By Direct Invitation Of Non Responders By General Practitionners
The goal of this randomized trial is to assess the effectiveness of a targeted telephone reminder strategy, implemented by the patient's general practitioner, in enhancing participation in colorectal cancer screening among…
- Trial name
- OPTIDEC COLO (NCT07639554)
- Testing
- Intervention
- Where
- France
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- MSPU des 3 Provinces
Breast Cancer, Colorectal Cancer
Improving Cancer Screening and Prevention During the COVID-19 Pandemic in Underserved Populations of Rhode Island
Lifespan Cancer Institute serves over 50% of cancer patients in the state. Rhode Island is known for strong medical care and high rates of cancer screening with mammography and colonoscopy.
- Conditions
- Breast Cancer, Colorectal Cancer, Covid19
- Trial name
- NCT04587258
- Testing
- Informational videos and social media campaigns encouraging cancer screening.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rhode Island Hospital
Colorectal Cancer
Text-based Colorectal Cancer Prevention Pilot
In this project, we intend to conduct a randomized pilot trial of a structured behavioral intervention, grounded in the Theory of Planned Behavior and Self-Determination Theory, to promote adherence of patients aged 45 - 75 to…
- Trial name
- NCT05004376
- Testing
- Text Messaging
- Where
- United States
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Rectal Cancer
Antibiotic Prophylaxis in Rectal Cancer Surgery: Oral With Intravenous Versus Intravenous Antibiotics.
This is a randomized, controlled, parallel study to determine the efficiency of oral antibiotics in reduction of surgical site infection (SSI) in rectal cancer surgery.
- Trial name
- NCT03436719
- Testing
- Oral antibiotic, Intravenous antibiotic, Mechanical Bowel Preparation
- Where
- Russia
- Volunteers
- 280 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Deep Vein Thrombosis, Pulmonary Embolus, Colon Cancer
VTE Incidence After Curative Colon Cancer Surgery in an ERAS Program
Based on data on a cohort of 2,141 patients undergoing elective colonic cancer resection in an ERAS program, the incidence of postoperative thromboembolic events is estimated in patients no receiving prolonged thromboembolic…
- Trial name
- NCT06009484
- Testing
- Colon resection
- Volunteers
- 2,141 people
- Sponsor
- Nordsjaellands Hospital
Colorectal Cancer Prevention, Colorectal Cancer (Diagnosis)
Study Comparing the Quality of Colon Cleanliness With Prepackaged LRD (Low-residue Diet) vs. Guided (POG).
Low-residue diet (LRD) in patient improves the quality of the colon cleanliness and thus the adenoma detection rate (ADR). This is a key criterion in colonoscopy screening for colorectal cancer (CRC).
- Conditions
- Colorectal Cancer Prevention, Colorectal Cancer (Diagnosis), Colorectal Adenocarcinoma
- Trial name
- POG (NCT07361575)
- Testing
- Colonoscopy, Questionnaires, Pre-colonoscopy diet according to the investigator's oral instructions
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Clinique Paris-Bercy
Colorectal Cancer
Colorectal Cancer Control in Appalachian Churches
The purpose of this project is to conduct a community-based intervention and evaluate the independent and combined effects of two intervention strategies on primary and secondary prevention of colorectal cancer (CRC) among…
- Trial name
- NCT00137683
- Testing
- one-on-one education, group education, small media
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Centers for Disease Control and Prevention
Peritoneal Metastases From Colorectal Cancer
Adjuvant Pressurized Intraperitoneal Aerosol Chemotherapy to Prevent Colorectal Peritoneal Metastases (ProphyPIPAC)
The objective of this clinical trial is to demonstrate the feasibility and safety of pressurized intraperitoneal aerosol chemotherapy (PIPAC) for the prevention of peritoneal metastases after curative-intent surgery for high-risk…
- Trial name
- ProphyPIPAC (NCT06091683)
- Testing
- Pressurized intraperitoneal aerosol chemotherapy (PIPAC)
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano