Clinical trials: Prevention of Heart Disease
Atrial Fibrillation, Cardiovascular Disease
Atrial Fibrillation Clopidogrel Trial With Irbesartan for Prevention of Vascular Events (ACTIVE I)
The purpose of this study was to determine if Irbesartan compared to Placebo would reduce the risk of vascular events such as heart attack, stroke, non-cerebral thromboembolic event and death in patients with Atrial Fibrillation…
- Trial name
- ACTIVE I (NCT00249795)
- Testing
- Irbesartan
- Where
- 30 sites in United States, Argentina and 28 more
- Volunteers
- 9,016 people
- Sponsor
- Sanofi
Anemia, Iron Deficiencies
Postoperative Intravenous Ferric Derisomaltose for Prevention of Long-term Anemia After Cardiac Surgery
Postoperative anemia is highly prevalent among patients undergoing cardiac surgery and is associated with delayed functional recovery, increased morbidity, and impaired long-term outcomes.
- Conditions
- Anemia, Iron Deficiencies, Iron Deficiency Anemia, Cardiac Surgery
- Trial name
- NCT07238972
- Testing
- Ferric derisomaltose
- Where
- South Korea
- Volunteers
- 180 people
- Sponsor
- Yonsei University
Atrial Fibrillation
Xarelto on Prevention of Stroke and Noncentral Nervous System Systemic Embolism in Treatment-naïve Asian Patients With Non-valvular Atrial Fibrillation
The purpose of the study is to collect additional information of Xarelto treatment in routine clinical practice. Patients affected by atrial fibrillation and who will get Xarelto as a prophylactic treatment against stroke and…
- Trial name
- XaMINA (NCT03284762)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- 2 sites in South Korea, Taiwan
- Volunteers
- 1,216 people
- Sponsor
- Bayer
Cardiac Resynchronization, Biventricular Pacemakers, Artificial
Assessment of Ventricular Arrhythmia Risk After CRT-D Replacement for Patients With Primary Prevention Indication
Cardiac resynchronization therapy (CRT) has been shown to reduce heart failure (HF), hospitalizations and death in patients with left ventricular ejection fraction (LVEF) <35% and wide QRS.
- Conditions
- Cardiac Resynchronization, Biventricular Pacemakers, Artificial, Cardioverter-Defibrillators, Implantable, Device Replacement
- Trial name
- BioCONTINUE (NCT02323503)
- Testing
- CRT-D device replacement
- Where
- 37 sites in Belgium, France and 6 more
- Volunteers
- 289 people
- Sponsor
- Biotronik SE & Co. KG
Lipoprotein(a)
Heart CT Imaging to Detect Early Coronary Artery Disease in First-Degree Relatives With High or Low Lipoprotein(a) Identified Through Family Screening
Lipoprotein(a), or Lp(a), is a type of cholesterol that can increase the risk of heart and blood vessel disease. Many people are unaware they have high Lp(a), since it is not routinely measured and usually causes no symptoms on…
- Trial name
- IMAGE-LPA (NCT06995183)
- Where
- Netherlands
- Volunteers
- 150 people
- Sponsor
- E.S.stroes
Acute Ischemic Stroke, Atrial Fibrillation
Early Treatment of Atrial Fibrillation for Stroke Prevention Trial in Acute STROKE
This study will determine whether early, comprehensive, rhythm control therapy prevents adverse cardiovascular outcome in patients with acute ischemic stroke and atrial fibrillation compared to usual care.
- Trial name
- EAST-STROKE (NCT05293080)
- Testing
- Medical or interventional therapy for rhythm control in atrial fibrillation (antiarrhythmic drugs, ablation, electric cardio version), Usual care for atrial fibrillation
- Where
- Germany
- Volunteers
- 1,746 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiac Allograft Vasculopathy
A Study to Compare the Effectiveness of a Drug That Suppresses the Immune System Called Thymoglobulin® in Preventing the Development of a Disease That Affects the Majority of Heart Transplant Recipients Called Cardiac Allograft Vasculopathy (CAV)
The purpose of this study is to test the hypothesis that administering Thymoglobulin® induction therapy early after transplant prevents the development of cardiac allograft vasculopathy (CAV).
- Trial name
- NCT01157949
- Testing
- Thymoglobulin
- Where
- United States
- Sponsor
- Cedars-Sinai Medical Center
Atrial Fibrillation (AF), Cardiac Events
Prevention of Atrial Fibrillation After Cardiac Surgery by Pericardiotomy
PRINCE-CH is a multicentre, randomized controlled trial which evaluates the effectiveness and safety of posterior pericardiotomy in preventing POAF after cardiac surgery in Chinese population.
- Conditions
- Atrial Fibrillation (AF), Cardiac Events, Pericardial Effusion
- Trial name
- PRINCE-CH (NCT06728826)
- Testing
- Posterior pericardiotomy
- Where
- China
- Volunteers
- 650 people
- Sponsor
- Changhai Hospital
Atrial Fibrillation
SmartWATCHes for Detection of Atrial Fibrillation
In this trial the Preventives Heartbeats algorithm will be tested in two wearable devices for its specificity and sensitivity to distinguish between AF and SR.
- Trial name
- WATCHAF (NCT02956343)
- Testing
- Five minutes pulse wave recording
- Where
- 2 sites in Germany, Switzerland
- Volunteers
- 651 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Cardiac Surgery Associated - Acute Kidney Injury, AKI - Acute Kidney Injury
Safety & Efficacy of RenalGuard® Therapy in the Prevention of Cardiac Surgery Associated Acute Kidney Injury
The goal of this clinical trial is to assess the effect of RenalGuard Therapy in reducing the rates of Acute Kidney Injury (AKI) within 72 hours after cardiac surgery in patients at risk of developing Cardiac Surgery Associated…
- Trial name
- SAFEGUARD (NCT07123935)
- Testing
- RenalGuard® Therapy, Standard of Care (SOC)
- Where
- 2 sites in Malaysia
- Volunteers
- 300 people
- Sponsor
- CardioRenal Systems, Inc.
Ischemic Stroke, Cryptogenic, Transient Ischemic Attack
Smartwatches for Detection of Atrial Fibrillation (AFib) in Secondary Prevention of Cryptogenic Stroke
Scientific Background: In secondary prevention of ischemic stroke, detection of atrial fibrillation (AFib) and subsequent anticoagulation therapy reduce the risk of recurrent stroke by approximately 60%.
- Conditions
- Ischemic Stroke, Cryptogenic, Transient Ischemic Attack, Atrial Fibrillation
- Trial name
- WATCH AFib (NCT06005233)
- Testing
- Smartwatch
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Technical University of Munich
Heart Failure, Atrial Fibrillation (AF)
Bachmann Bundle Pacing for Prevention of New-Onset Atrial Fibrillation in Patients With Heart Failure
This is a multi-center, prospective, single-blind, randomized controlled clinical trial to evaluate the efficacy and safety of Bachmann bundle pacing (BBP) in preventing new-onset atrial fibrillation (AF) in patients with chronic…
- Conditions
- Heart Failure, Atrial Fibrillation (AF), Cardiac Insufficiency
- Trial name
- NCT07547449
- Testing
- Bachmann Bundle Pacing, Right Atrial Appendage Pacing
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Acute Kidney Injury
Post-Cardiac Surgery Acute Kidney Injury Prevention by Administration of Proton Pump Inhibitor (P2 Trial)
The central hypothesis of this research study is that perioperative administration of the proton pump inhibitor (PPI) pantoprazole could reduce the development of acute kidney injury (AKI) following cardiac surgery by activation…
- Trial name
- P2 AKI PPI (NCT06706258)
- Testing
- Protonix (Pantoprazole) 40 mg q 12 hrs for 3 days, Pepcid (Famotidine) 20 mg q 12 hrs for 3 days
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- The University of Texas Health Science Center, Houston
Coronary Heart Disease
Pharmaceutical Follow-up of Coronary Heart Disease (CHD) Patients
Objectives To explore the impact of a clinical pharmacist-led 12 month lasting follow-up program for patients with established coronary heart disease (CHD) discharged from the North Norway University Hospital.
- Trial name
- NCT01115608
- Testing
- Pharmacist follow-up
- Where
- Norway
- Volunteers
- 102 people
- Sponsor
- Hospital Pharmacy of North Norway Trust
Stroke, Ischemic, Atrial Fibrillation
Wearable Devices for Secondary Prevention of Ischemic Stroke
Ischemic stroke is an important cause of death and disability in Western countries. Different risk factors have been identified such as hypertension, diabetes, dyslipidemia, smoke, atrial fibrillation, obesity, and sedentary.
- Trial name
- NCT04282993
- Testing
- Wearable devices for identifying and measuring risk factors for ischemic stroke, Standard of care monitoring
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Campus Bio-Medico University
Complication of Coronary Artery Bypass Graft, Atrial Fibrillation
Atrial Fibrillation Prevention in Post Coronary Artery Bypass Graft Surgery With Cryoablation for Ganglionic Plexi
Atrial fibrillation after coronary artery bypass graft is a common complication. The investigators have thought that the mechanism of temporarily postoperative atrial fibrillation is closely related to the autonomic nervous…
- Trial name
- NCT02035163
- Testing
- Two sites cryoablation
- Where
- South Korea
- Sponsor
- Yong Seog Oh
Stroke, Prevention and Control
An Observational Cross-sectional Study Evaluating the Use of Re-sources and the Sociodemographic and Clinical Characteristics of Patients Diagnosed With Non-valvular Atrial Fibrillation With a Risk of Stroke or Systemic Embolism on Anticoagulant Therapy and Treated in Primary Care Centers
This is a retrospective observational study to describe the sociodemographic and clinical characteristics of patients diagnosed with non-valvular atrial fibrillation (NVAF) at risk of stroke or systemic embolism, who at least…
- Conditions
- Stroke, Prevention and Control, Atrial Fibrillation
- Trial name
- BRONCE-AP (NCT02559232)
- Testing
- Direct Oral Anticoagulant (DOAC)
- Where
- Spain
- Volunteers
- 247 people
- Sponsor
- Bayer
Atrial Fibrillation
Observational Study to Assess Sociodemographic and Clinical Features of Patients Treated With Rivaroxaban in Routine Clinical Practice of Hematologists, Cardiologists and Internists of Spain
Depict demographic and clinical features of patients with atrial fibrillation treated with rivaroxaban to prevent stroke and pulmonary embolism in routine clinical practice
- Trial name
- HEROIC (NCT02262676)
- Testing
- Rivaroxaban (Xarelto, BAY59-7939)
- Where
- Spain
- Volunteers
- 2,251 people
- Sponsor
- Bayer
Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS)
Aspirin for the Prevention of Ischemic Complications in Giant Cell Arteritis
The ASPIRE-GCA Pilot trial will assess the feasibility of a future randomized controlled trial (RCT) evaluating the efficacy of low-dose ASA in preventing ischemic complications in patients with Giant Cell Arteritis (GCA).
- Conditions
- Giant Cell Arteritis (GCA), Acute Coronary Syndrome (ACS), Ishemic and Thrombotic Complications
- Trial name
- ASPIRE-GCA (NCT07908082)
- Testing
- Acetyl Salicylic Acid (ASA)
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression
PRE-EMPT: Prospective RandomizEd Evaluation and Management of Premature aTherosclerosis
Heart disease is the leading cause of death for men, women, and people of most racial and ethnic groups in the United States. This clinical trial will test if screening and early treatment of mild heart disease works.
- Conditions
- Coronary Artery Disease Risk Factors Multiple, Coronary Artery Disease Progression, Prevention & Control, Premature Atherosclerosis
- Trial name
- PRE-EMPT (NCT07232069)
- Testing
- Rosuvastatin 20 Mg Oral Tablet, Colchicine 0.5 MG Oral Tablet Once Daily
- Where
- 23 sites in United States
- Volunteers
- 1,500 people
- Sponsor
- Duke University