Clinical trials: Preventive Intervention
Major Depression in Remission
Online Cognitive Control Training for Remitted Depressed Patients
This study evaluates the effectiveness of an internet-delivered cognitive control training as a preventive intervention for remitted depressed patients.
- Trial name
- NCT03278756
- Testing
- Cognitive control training, Active control training
- Where
- Belgium
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Ghent
Malaria
Weekly Dosing of Malarone ® for Prevention of Malaria
The purpose of this study is to determine whether Malarone ®, which is a drug approved to prevent malaria when taken daily, will still effectively prevent malaria if taken weekly.
- Trial name
- MALWEEK (NCT00984256)
- Testing
- Atovaquone Proguanil, Procedure - malaria challenge
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- U.S. Army Medical Research and Development Command
Typhoid Fever
Dose Ranging Study to Determine the Safety, Reactogenicity and Immunogenicity of Typhoid Fever Vaccine (Ty800) in Healthy Adult Subjects
The purpose of this trial is to examine the safety and immunogenicity of Ty800 oral vaccine in healthy adult subjects.
- Trial name
- NCT00498654
- Testing
- Ty800 (Salmonella typhi) Oral Vaccine
- Where
- 5 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Avant Immunotherapeutics
Depression
Psychophysiological Correlates of Mindfulness Based Cognitive Therapy (MBCT) in Recurrent Depression
The study investigates cognitive attention, rumination and psychophysiological (EEG) processes in healthy subjects and remitted patients with at least three previous depressive episodes.
- Trial name
- MBCT & EEG (NCT00974077)
- Testing
- Mindfulness Based Cognitive Therapy, Waiting List Control
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University Hospital Tuebingen
Knee Pain Chronic, Knee Osteoarthritis
Prevention, Management and Rehabilitation of Knee Osteoarthritis at the Workplace
The goal of this intervention study is to assess the effect of blood flow restricted (BFR) exercise integrated into the daily work tasks among hospital workers with or at increased risk of chronic knee pain.
- Conditions
- Knee Pain Chronic, Knee Osteoarthritis, Knee Discomfort
- Trial name
- NCT05822401
- Testing
- Blood flow restriction (BFR), Usual care (control)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Research Centre for the Working Environment, Denmark
Infections, Papillomavirus
Human Papilloma Virus (HPV) Vaccine Efficacy Trial Against Cervical Pre-cancer in Young Adults With GlaxoSmithKline (GSK) Biologicals HPV-16/18
Human Papilloma virus (HPV) are viruses that cause a common infection of the skin and genitals in men and women. Several types of HPV infection are transmitted by sexual activity and, in women, can infect the cervix (part of the…
- Trial name
- NCT00122681
- Testing
- Cervarix™, Havrix™-based investigational formulation
- Where
- 138 sites in United States, Australia and 12 more
- Volunteers
- 18,729 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Obesity
Adapted Physical Activity Study
An uncontrolled, non-randomized, open-plan, multi-centre study of treatment and therapeutic education in endocrinology-diabetes-Nutrition that seeks to assess the interest of an adapted physical activity educator for the…
- Trial name
- APA (NCT03337412)
- Testing
- Adapted physical activity
- Where
- France
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Nantes University Hospital
Type 2 Diabetes
Chronotherapy with Low-dose Aspirin for Primary Prevention
Brief summary: Aspirin (ASA) has been shown to provide marked benefits in primary and secondary prevention of cardiovascular events.
- Trial name
- CARING (NCT00725127)
- Testing
- aspirin
- Where
- 19 sites in Spain
- Volunteers
- 3,200 people, healthy volunteers welcome
- Sponsor
- University of Vigo
Prevention of Zika Infection, Zika-Specific Immune Response
VRC 320: A Phase I, Randomized Clinical Trial to Evaluate the Safety and Immunogenicity of a Zika Virus DNA Vaccine, VRC-ZKADNA090-00-VP, Administered Via Needle and Syringe or Needle-free Injector, PharmaJet, inHealthy Adults
Background: People get Zika virus from infected mosquitos. They usually don t get very sick. But birth defects were reported in babies born to mothers who had Zika infection.
- Trial name
- NCT02996461
- Testing
- VRC-ZKADNA090-00-VP
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Hiv, Adolescent Behavior
A Pragmatic Trial of An Adaptive eHealth HIV Prevention Program for Diverse Adolescent MSM
This pragmatic trial of an HIV prevention program focuses on HIV risk-reduction in men who have sex with men (MSM) ages 13-18. The design is a three-tiered, internet-based HIV prevention intervention series that uses a sequential…
- Conditions
- Hiv, Adolescent Behavior, Sex, Safe
- Trial name
- SMART (NCT03511131)
- Testing
- Queer Sex Ed, Keep It Up, Keep It Up-Control
- Where
- United States
- Volunteers
- 1,306 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Early Childhood Caries, Dental Caries
Great Beginnings for Healthy Native Smiles: An Early Childhood Caries Prevention Project
The purpose of this study is to determine whether a bundled best practices oral health intervention utilizing motivational interviewing versus a didactic maternal and child healthy lifestyle intervention will reduce childrens'…
- Trial name
- NCT04556175
- Testing
- Oral Health, Healthy Lifestyle
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Northern Arizona University
Diabetes
Post Trial Analysis of a Primary Prevention Study in Asian Indians
An extended follow-up study of NCT00819455 conducted 5 years post randomization. In this study we estimate the incidence of type 2 diabetes among participants enrolled in the diabetes prevention programme.
- Trial name
- NCT02848547
- Testing
- Text Messaging via Short Message Service
- Volunteers
- 537 people, healthy volunteers welcome
- Sponsor
- India Diabetes Research Foundation & Dr. A. Ramachandran's Diabetes Hospitals
HIV/AIDS and Infections, Sexually Transmitted Diseases
Puerto Rico Cuidalos Parent-adolescent Program
Latino adolescents are at high risk for HIV/AIDS, other sexually transmitted infections (STIs), and unintended pregnancies. Puerto Rican adolescents, in particular, experience disparities in these areas, yet few adolescent and…
- Conditions
- HIV/AIDS and Infections, Sexually Transmitted Diseases, Pregnancy Prevention
- Trial name
- NCT03063385
- Testing
- Parental Communication intervention, Health promotion control condition
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Prevention of Pneumonic Plague Resulting From Aerosol Exposure to Yersinia Pestis
Immunogenicity, Safety, and Tolerability of rF1V-1018 Vaccine in Adults 18 to 55 Years of Age
This study will evaluate the immunogenicity, safety, and tolerability of rF1V-1018 vaccine
- Trial name
- NCT07207408
- Testing
- rF1V-1018
- Where
- 4 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Dynavax Technologies Corporation
Eating Disorders in Adolescence
The Peer-Delivered "Mind. Body. Voice." Program for High School Women (Mbv) - Remote
This study will evaluate the impact of a program (called mind. body. voice. or "mbv") that was collaboratively designed by youth, educators, and researchers, informed by the Body Project (Becker et al., 2013; Stice et al., 2019)…
- Trial name
- NCT04591912
- Testing
- mind. body. voice
- Where
- United States
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Male Circumcision, HIV Prevention
Cohort Field Study to Assess the Safety and Efficacy of the PrePex Device for Non-Surgical Circumcision When Performed by Nurses
A range of observational and epidemiological studies have shown that the lifetime risk of HIV infection can be reduced by 70% through male circumcision.
- Trial name
- NCT01434628
- Testing
- PrePex™ device
- Where
- Rwanda
- Volunteers
- 590 people, healthy volunteers welcome
- Sponsor
- Ministry of Health, Rwanda
Mental Health Wellness 1
Health Promotion on Young Adults With High Risk Disability for Mental Health
1. The positive outcomes reported by participants in experimental group after two weeks of interventions will be significantly better than before interventions. 2.
- Trial name
- HPMI (NCT01740167)
- Testing
- health promotion lifestyle program
- Where
- Taiwan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- China Medical University Hospital
Immunization Coverage, Vaccination
Increasing Measles Vaccination Coverage Through Supplementation With an SQ-LNS Incentive in Children Aged 6-23 Months
Provision of SQ-LNS also holds promise in incentivizing vaccination as well as other health services. The investigators will estimate 1) the effectiveness of a SQ-LNS mass supplementation program added to routine immunization…
- Conditions
- Immunization Coverage, Vaccination, Nutrition
- Trial name
- NCT06387511
- Testing
- Small-quantity lipid-based nutrition supplements (SQ-LNS) NutriVax, Sensitization on vaccination and on Infant and Young Child Feeding (IYCF) practices
- Where
- Nigeria
- Volunteers
- 3,814 people, healthy volunteers welcome
- Sponsor
- Alliance for International Medical Action
HIV
HIV Prevention and Care Interventions for Youth in Uganda
Several studies show that Adolescents and Young Adults (AYA) have poor outcomes along the entire Human Immunodeficiency Virus (HIV) prevention and care cascades compared to adults.
- Trial name
- HIPCY (NCT06474364)
- Testing
- Long-acting Cabotegravir injection, SEARCH-YOUTH
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- MU-JHU CARE
Carious and Non-carious Lesions of the Teeth
Comparative Evaluation of Dental Disease Prevention Programs
Relevance. The dental health of the Chapaevsk children's population and the risk factors for dental caries and periodontal disease were well studied in 1995-2009.
- Trial name
- NCT05767281
- Testing
- prevention program
- Where
- Russia
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Samara State Medical University
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