Clinical trials: Preventive Intervention
Genital Herpes Simplex Type 2
A Clinical Trial in Healthy Volunteers and Volunteers With Recurrent Genital Herpes to Study the Safety, Tolerability, and Immune Responses After Vaccination With an Investigational Vaccine Designed to Prevent Genital Herpes Lesions
This exploratory trial will have three parts. Part A is a dose escalation part, Part B is an expanded safety and dose evaluation part, and Part C is a safety and immunogenicity evaluation part in individuals with recurrent HSV-2…
- Trial name
- NCT05432583
- Testing
- BNT163
- Where
- 6 sites in United States
- Volunteers
- 318 people, healthy volunteers welcome
- Sponsor
- BioNTech SE
Gingivitis, Gingivitis; Chronic
A Multicentre Randomised Controlled Trial Evaluating the Efficacy of the SMILE™ Module for Improving Short-term Periodontal Outcomes, Compliance, and Acceptability Among Clinical Dental Students
This multicentre randomised controlled trial aims to evaluate the efficacy and safety of the SMILETM (Siwak Method for Integrated Lifestyle Enhancement) module in improving short-term periodontal outcomes, oral hygiene behaviour…
- Trial name
- SMILE (NCT07702383)
- Testing
- SMILE Module, Conventional Toothbrushing Module
- Where
- 4 sites in Malaysia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Urinary Incontinence, Pelvic Organ Prolapse
Promoting Effective Recovery From Labor Urinary Incontinence (PERL)
The purpose of this study is to determine whether pushing during labor that is controlled by the woman results in less birth-related injury and less postpartum urinary incontinence (UI).
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse, Perinatal Laceration, Second Stage Labor
- Trial name
- PERL (NCT00506116)
- Testing
- Videotape, routine care, PME instruction, PME practice and record keeping (in diaries), Non-directed or directed,spontaneous or sustained pushing
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Smoking, Smoking Cessation
Project COMBAT: Combating Tobacco Use in the United States Army
The goal of this behavioral research study is to test a new multimedia anti-tobacco video game tailored to the U.S. Army. Researchers want to study how using the program affects tobacco use in soldiers, as compared to standard…
- Trial name
- NCT00948233
- Testing
- Video Game, Pamphlet, Surveys
- Volunteers
- healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Eating Disorders in Adolescence
The Peer-Delivered Body Project for Young Women in High School
This study will evaluate the impact of the Body Project (a dissonance-based program designed to address body image concerns and prevent eating disorders) on key eating disorder risk factors and relevant social and self-constructs…
- Trial name
- NCT04263155
- Testing
- The Body Project
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Acute Gastroenteritis, Norwalk Virus Infection
Norwalk Vaccine Study
The purpose of this study was to evaluate the efficacy of the Norwalk virus-like particle (VLP) vaccine as determined by the illness rate of viral acute gastroenteritis (AGE) during the inpatient stay.
- Trial name
- NCT00973284
- Testing
- Norwalk VLP vaccine, mannitol and sucrose, Norwalk virus
- Where
- 3 sites in United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Takeda
Dementia of the Alzheimer Type, Age-related Cognitive Decline
Dosage and Efficacy of Probucol-induced apoE to Negate Cognitive Deterioration
DEPEND is an open-label but dosage-masked trial of the retired cholesterol-lowering drug probucol as an agent to increase availability of apolipoprotein E (apoE) in the cerebrospinal fluid (CSF) of cognitively intact older…
- Conditions
- Dementia of the Alzheimer Type, Age-related Cognitive Decline, Mild Cognitive Impairment Due to Alzheimer Disease
- Trial name
- DEPEND (NCT02707458)
- Testing
- Probucol
- Where
- Canada
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Douglas Mental Health University Institute
Perinatal Depression, Perinatal Anxiety
Effectiveness and Implementation of a Personalized mHealth Intervention for the Universal Prevention of Maternal Perinatal Mental Disorders
This study is part of the ERC-funded e-Perinatal project and represents a large-scale hybrid type 1 effectiveness-implementation cluster randomized controlled trial.
- Trial name
- ePerinatal-RCT (NCT07613008)
- Testing
- The e-Perinatal intervention is a personalized mobile health (mHealth) program, Standard routine maternal care
- Where
- Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- University of Seville
Woman Aged 18 to 65
Prevention of Cystitis.
3436/5000 Urinary tract infections are a real public health issue. The frequency of these infections in France is estimated between 6 and 8 million in primary care (1) which represents 15% of antibiotics prescribed in primary…
- Trial name
- NCT03744338
- Testing
- questionnaire
- Where
- France
- Volunteers
- 773 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Urinary Retention Postoperative, Arthropathy of Knee
Prevention of Postoperative Urinary Retention With Treatment of Tamsulosin 5 Days Prior to Lower Limb Arthroplasty
Various studies have shown that the risk of suffering a urinary retention after knee or hip prosthesis surgery is 10-80%. The aim of the study is to reduce this riks.
- Conditions
- Urinary Retention Postoperative, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT03808155
- Testing
- Tamsulosin
- Where
- Switzerland
- Volunteers
- 170 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Graubünden
Secondary Caries
Effect of Bioactive Restorative Materials on Secondary Caries Prevention
This manuscript presents a 24-month randomised clinical trial evaluating the effectiveness of bioactive restorative materials in preventing secondary caries compared with conventional composite restorations.
- Trial name
- BARM (NCT07619378)
- Testing
- Fuji IX GP Glass Ionomer Cement, Beautifil II Giomer, Cention N
- Where
- Saudi Arabia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Jouf University
Accidental Falls
FallSensing Clinical Tool for Fall Risk Prevention in Community-dwelling Adults Aged 50 Years or Over
Fall prevention programs should include strength and balance training, home hazard assessment and intervention, vision assessment and referral and also medication review with modification/withdrawal.
- Trial name
- NCT03591185
- Testing
- FallSensing Clinical Tool
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Anabela Correia Martins
HIV/AIDS
Assessing the Impact of an Educational HIV Prevention Intervention in Zambia
In Zambia, 13% of the 15 to 49 year old population lives with HIV. The highest number of new HIV infections is among young people.
- Trial name
- NCT03316040
- Testing
- JIC
- Where
- 3 sites in United States, Zambia
- Volunteers
- 8,270 people, healthy volunteers welcome
- Sponsor
- Columbia University
Malaria
MULTIple Doses of IPTi Proposal: a Lifesaving High Yield Intervention
As efforts to control malaria are stalling, and the disease is particularly severe in children under the age of two, it is imperative for countries in sub-Saharan Africa, with areas of moderate-to-high transmissions, to implement…
- Trial name
- MULTIPLY (NCT05085340)
- Testing
- Intermittent preventive treatment of malaria in infants (IPTi) with sulfadoxine-pyrimethamine (SP)
- Where
- 3 sites in Mozambique, Sierra Leone and 1 more
- Volunteers
- 94,252 people, healthy volunteers welcome
- Sponsor
- Barcelona Institute for Global Health
Colorectal Cancer
Lifestyle Intervention Among Participants of the French Colorectal Cancer Screening Program
The investigators propose a randomized controlled trial to develop and evaluate the impact of promoting advice on diet and lifestyle recommendations for cancer prevention at colorectal cancer screening among individuals who may…
- Trial name
- LIFE-SCREEN (NCT04257526)
- Testing
- Diet and lifestyle advice following a positive FIT test and diagnostic colonoscopy.
- Where
- France
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- International Agency for Research on Cancer
HIV Prevention
An Exploratory Study of Potential Sources of Efficacy Dilution in the VOICE Trial (MTN-003)
This study is primarily exploratory and is designed to both identify factors that may have affected participant adherence to study product in VOICE, and describe how sexual behaviors, such as anal sex, may have had an effect on…
- Trial name
- NCT02358616
- Where
- 5 sites in South Africa, Uganda and 1 more
- Volunteers
- 219 people, healthy volunteers welcome
- Sponsor
- Microbicide Trials Network
Congenital Syphilis
Evaluation of Antimicrobial Prophylaxis to Prevent Syphilis in Pregnancy in Patients at Risk in Rio de Janeiro, Brazil
The goal of this clinical trial is to learn if benzathine penicillin works to prevent maternal syphilis. It will also learn about the safety of benzathine penicillin.
- Trial name
- PRESERvE (NCT07189208)
- Testing
- Benzathine penicillin 2.4 million units, Counseling and intensified testing.
- Where
- 4 sites in Brazil
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Eating Disorder
Implementation Support for Prevention Program Delivery by College Peer Educators
This project will evaluate 3 approaches of implementation support for university peer leaders who will deliver a prevention program with a particularly strong evidence-base compared to changes observed in outcomes in response to…
- Trial name
- PI (NCT03409809)
- Testing
- Training, Training and Technical Assistance, Training, Tech. Assistance, Quality Assurance/Improvement
- Where
- 4 sites in United States
- Volunteers
- 2,261 people, healthy volunteers welcome
- Sponsor
- Oregon Research Institute
Active Aging Individuals Aged 65 and Over, Aging
Italian Validation of the dNA Scale and Its Correlation With Neurocognitive Variables
The goal of this experimental multicentric intervention study is to validate, in Italian, the dynamic Neurocognitive Adaptation (dNA) Scale, which has already been validated in English, among a healthy elderly population (aged 65…
- Conditions
- Active Aging Individuals Aged 65 and Over, Aging, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- NCT07533084
- Where
- 8 sites in Italy
- Volunteers
- 265 people, healthy volunteers welcome
- Sponsor
- Neuromed IRCCS
White Spot Lesion
Comparing Fluoride Varnish and Sealant to Prevent White Spots in Orthodontic Patients
The purpose of the study is o compare the efficacy of CPP-ACP MI Varnish and ProSeal sealant in preventing white spot lesion (WSL) formation in orthodontic patients.
- Trial name
- NCT04560478
- Testing
- Pro Seal Sealant, MI Varnish
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.