Clinical trials: Preventive Intervention
Tobacco, Prevention
Education Against Tobacco Randomized Trial
A two armed randomized trial is evaluating the effect of the medical-student-delivered school-based intervention Education Against Tobacco on the smoking behavior of adolescents in 7th grade of secondary school.
- Conditions
- Tobacco, Prevention, Adolescents, Schools
- Trial name
- NCT02697409
- Testing
- Education Against Tobacco intervention
- Where
- Germany
- Volunteers
- 20,000 people, healthy volunteers welcome
- Sponsor
- University of Giessen
Cancer
The SUNRISE Project is Dedicated to Enhancing Primary Cancer Prevention Among Adolescents in Europe by Leveraging Innovative Digital Tools and Methodologies. SmartCoach, Developed by Swiss Research Institute for Public Health and Addiction (ISGF), is a Mobile Phone-based Life-skills Training Program
SUNRISE aims to create a comprehensive, engaging, and sustainable digital health promotion program that not only addresses immediate health behaviours but also instills lifelong healthy habits among adolescents.
- Trial name
- SUNRISE_1 (NCT06922201)
- Testing
- SmartCoach
- Where
- 8 sites in Belgium, Cyprus and 6 more
- Volunteers
- 3,500 people, healthy volunteers welcome
- Sponsor
- Biobizkaia Health Research Institute
Dengue Fever
Safety of and Immune Response to a Dengue Virus Vaccine (rDEN4delta30-200,201) in Healthy Adults
Dengue fever, which is caused by dengue viruses, is a major health problem in tropical and subtropical regions of the world. The purpose of this study is to test the safety of and immune response to a new dengue virus vaccine in…
- Trial name
- NCT00270699
- Testing
- rDEN4delta30-200,201
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Kidney Stones, Urolithiasis, Hypocitraturia
Apple Cider Vinegar for the Prevention of Urinary Lithiasis (APUL)
The purpose of this study is to assess whether certain beverages can increase urinary citrate levels in healthy individuals with no history of kidney disease.
- Trial name
- APUL (NCT04073719)
- Testing
- Apple Cider Vinegar, Other Beverage
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- United States Naval Medical Center, San Diego
Omphalitis, Septicaemia
Efficacy of Umbilical Cord Cleansing With a Single Application of 4% Chlorhexidine for the Prevention of Newborn Infections in Uganda: a Randomized Controlled Trial
Background: Nearly all the yearly 3.3 million neonatal deaths occur in low and middle income countries. Infections, including those affecting the umbilical cord (omphalitis) are a significant factor in approximately a third of…
- Trial name
- NCT02606565
- Testing
- Intervention arm: 4% chlorhexidine
- Where
- Uganda
- Volunteers
- 4,760 people, healthy volunteers welcome
- Sponsor
- Makerere University
Sport Injury, Exercise Therapy
Comparison of Eccentric Training on Injury Prevention and Hamstring Strength in Football Players
To determine the effect of the eccentric exercise training on injury prevention and hamstring strength in football players.
- Trial name
- NCT05771792
- Testing
- ECCENTRIC EXERCISE, CONVENTIONAL EXERCISES PROGRAM
- Where
- Pakistan
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Riphah International University
HIV Prevention, HIV Pre-exposure Prophylaxis
Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP
The purpose of this project is to test a culturally-tailored, community-delivered long-acting injectable PrEP (lenacapavir) program for Latine gay and bisexual men (GBM) and transgender women (TGW).
- Conditions
- HIV Prevention, HIV Pre-exposure Prophylaxis, HIV Prevention Program, HIV Prevention and Care
- Trial name
- INCLUSION (NCT07218211)
- Testing
- Lenacapavir long-acting
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Duke University
Overdose
An Evaluation of a Social Network Intervention for Primary and Secondary Prevention of Opioid Overdoses
The purpose of this study is to pilot and implement a peer mentor intervention focused on overdose prevention and care. The intervention consists of 3 sessions.
- Trial name
- NCT04212364
- Testing
- Peer Education, Narcan Nasal Product
- Where
- United States
- Volunteers
- 614 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
DNA Methylation
DNA Methylation and Cancer Prevention: Duration and Intensity of Exercise
Specific aim 1. Using a fully crossed 2 (intensity) X 2 (duration) design, the investigators will demonstrate a dose-response relationship between volume of aerobic exercise and changes in DNA methylation over four months among…
- Trial name
- GEM (NCT02032628)
- Testing
- Exercise
- Where
- United States
- Volunteers
- 276 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Obesity-Related Malignant Neoplasm
A Food Security Intervention for the Prevention of Cancer in Low-income Families
This study is being done to see how produce delivery with or without nutritional education affects what people eat and if it can help improve diet and nutrition in low-income families and their ability to get enough healthy food.
- Trial name
- NCT07039630
- Testing
- Food Assistance Programs, Health Promotion and Education, Questionnaire Administration
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute
Cardiovascular Diseases
Meta-analysis of Randomized Controlled Trials on Vitamins and Mineral Supplementation for CVD Prevention and Treatment
The use of vitamin and mineral supplementation has historically been to treat and prevent micronutrient deficiencies. In recent years, however, and with their widespread use, the interest has shifted toward a possible role in the…
- Trial name
- NCT03442283
- Testing
- Vitamin mineral supplementation
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Baclofen Withdrawal Syndrome
Oral and IV Baclofen in Adult Volunteers
The primary objective of this study is to characterize baclofen pharmacokinetics following oral and intravenous administration in patients who are on chronic oral baclofen therapy.
- Trial name
- NCT01749319
- Testing
- Oral baclofen, Intervenous baclofen
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Osteoporosis
High Intensity Strength Training & Bone Mineral Density in Young Women
The current guidelines emphasize the prevention of bone loss, by building up bone mass in young age, as one of the most important measures to reduce the incidence of osteoporosis.
- Trial name
- NCT01482130
- Testing
- Heavy, explosive strength training, recommendations
- Where
- Norway
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Myopia
AI-Stratified Myopia Control for Children in Remote Areas
This cluster-randomized controlled trial aims to evaluate the effectiveness and cost-effectiveness of an artificial intelligence-based, risk-stratified, tiered intervention model for childhood myopia prevention and control in…
- Trial name
- NCT07825428
- Testing
- Routine Screening and Referral, AI-Guided Tiered Management
- Where
- 3 sites in China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Shanghai Eye Disease Prevention and Treatment Center
Overweight and Obesity
Prevention and Intervention of Overweight and Obesity in Preschool Children
Obesity is an important public health problem, which is directly related to the risk of childhood complications and the increase of incidence rate and mortality of adult complications.
- Trial name
- NCT06562465
- Testing
- dietary and exercise management, no dietary and exercise management
- Where
- 2 sites in China
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Chen Li
Bottle Feeding
GrowWell - Responsive Bottle Feeding
The overall goal of this research is use digital health to augment the clinical encounter with Women, Infants, and Children (WIC) clinicians and prevent rapid infant weight gain among children living in low-income households.
- Trial name
- NCT06319807
- Testing
- Digital Health Intervention, Safety Control
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Healthy Subjects, Sports Level 1
Effect of Blood Flow Restriction Training to Muscle Strength, Dynamic Stability, and ACL Injury Prevention
The goal of this randomized clinical trial study is to compare low-load blood flow restriction (LL-BFRt), sham LL-BFRt, and high-load eccentric training (HL-Et) in healthy level 1 sportsman.
- Trial name
- NCT05951036
- Testing
- Low-load Blood Flow Restriction training, High-load Eccentric training
- Where
- Indonesia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Udayana University
Sexually Transmitted Diseases, Safe Sex
P3 (Prepared, Protected, emPowered)
P3 (Prepared, Protected, emPowered) is an interactive smartphone app for HIV-uninfected YMSM and YTW that utilizes social networking and game-based mechanics as well as a comprehensive understanding of what constitutes "best…
- Conditions
- Sexually Transmitted Diseases, Safe Sex, Adherence, Medication
- Trial name
- P3 (NCT03320512)
- Testing
- P3, P3+, Control
- Where
- 9 sites in United States
- Volunteers
- 246 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Prevention of Surgical Site Infections
Tumescent Antibiotic Delivery Pharmacokinetics
Tumescent Antibiotic Delivery (TAD) is a technique for improving the prevention of surgical site infections (SSI). TAD involves the subcutaneous infiltration of tumescent local anesthesia (TLA) containing water soluble…
- Trial name
- NCT01046981
- Testing
- Tumescent Antibiotic Delivery of cefazolin with or without metronidazole, Intravenous Antibiotic Delivery
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Klein, Jeffrey A., M.D.
Postoperative Nausea and Vomiting, Post Operative Pain
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children
this study will aim to evaluate the effects of dexmedetomidine, dexamethasone and Ondansetron on the prevention of postoperative nausea and vomiting in children undergoing dental rehabilitation surgery.
- Conditions
- Postoperative Nausea and Vomiting, Post Operative Pain, Emergence Delirium
- Trial name
- NCT05124067
- Testing
- Dexamethasone, Ondansetron, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tanta University
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