Clinical trials: Preventive Intervention
Atrial Fibrillation, Stroke
Computerized Decision Support to Prevent Stroke in Atrial Fibrillation
Atrial fibrillation (AF) is the most preventable cause of stroke. However, despite widely available risk stratification tools, numerous options for oral anticoagulation, and evidence-based practice guidelines, anticoagulation for…
- Trial name
- AF-ALERT3 (NCT06355986)
- Testing
- Alert-based computerized decision support
- Where
- 2 sites in United States
- Volunteers
- 2,500 people
- Sponsor
- Brigham and Women's Hospital
Wound Infection, Amputation Wound
The Amputation Surgical Site Infection Trial (ASSIT)
Lower limb amputations are performed usually as a last resort in patients with acute and chronic limb ischaemia (CLI) caused by vascular disease, poorly controlled diabetes or, infection.
- Trial name
- ASSIT (NCT02018094)
- Testing
- Co-amoxiclav, Iodine, Metronidazole
- Where
- United Kingdom
- Volunteers
- 160 people
- Sponsor
- Hull University Teaching Hospitals NHS Trust
HIV, Pregnancy
Implementing a Comprehensive Prevention of Mother-to-Child Transmission of HIV Program for South African Couples
This study will test the effectiveness of a behavioral intervention to increase Prevention of Mother-to-Child Transmission of HIV (PMTCT) protocol uptake among South African HIV positive pregnant women.
- Trial name
- NCT02085356
- Testing
- Protect your family
- Where
- South Africa
- Volunteers
- 1,967 people
- Sponsor
- University of Miami
Hematologic Malignancy, Bone Marrow Transplant
Tocilizumab for the Prevention of Graft Failure and GVHD in Haplo-Cord Transplantation
The purpose of this study is to evaluate the safety of reducing and ultimately eliminating anti-thymocyte globulin (ATG) from the haplo-cord transplant conditioning regimen and replacing it with tocilizumab, an IL-6 receptor…
- Trial name
- NCT04395222
- Testing
- Tocilizumab, Fludarabine, Melphalan
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Weill Medical College of Cornell University
Atopic Dermatitis, Allergic Rhinitis
Prevention Allergic Disease of Infant With Probiotics During Pregnancy and Neonatal Period
The purpose of this study is to determine whether childhood atopic disease decrease or not after allowing allergic mothers intake of probiotic (Lactobacillus GG) in second trimester, followed by infant intake for 6 months after…
- Conditions
- Atopic Dermatitis, Allergic Rhinitis, Asthma
- Trial name
- NCT00325273
- Testing
- Lactobacillus rhamnosus GG
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
Venous Thromboses, Stent Stenosis
Aspirin® Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis in Patients With PTS
To show if a combination therapy of rivaroxaban plus Aspirin® is more efficient (superiority testing) as rivaroxaban alone in the prevention of early venous stent thrombosis in patients suffering from post-thrombotic syndrome in…
- Trial name
- ARIVA (NCT04128956)
- Testing
- Aspirin 100mg
- Where
- 6 sites in Austria, Germany and 1 more
- Volunteers
- 172 people
- Sponsor
- University of Zurich
Alzheimer's Disease
Alzheimer's Prevention Through Exercise
The purpose of this study is to learn about the possible benefits of aerobic exercise in controlling or reducing the amount of amyloid present in the brain, reducing changes in brain structure that may lead to Alzheimer's Disease…
- Trial name
- APEx (NCT02000583)
- Testing
- Aerobic Exercise, Standard of Care
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- University of Kansas Medical Center
Prevention of Falls
Strengthening Equilibrium and Educational Support in Preventing Falls in the Thermal Center
Preventing falls among people 65 years of age or older is a priority to promote healthy aging and reduce the number of hospitalizations, institutionalizations and years lived with disability.
- Trial name
- RESPECT (NCT03622554)
- Testing
- Adapted Physical Activity (APA), Therapeutic Patient Education (ETP)
- Where
- France
- Volunteers
- 269 people
- Sponsor
- University Hospital, Montpellier
Post-operative Nausea and Vomiting (PONV)
Efficacy and Safety Study of Aprepitant Injection for Prevention of Post-operative Nausea and Vomiting
A randomized, double-blind, placebo-controlled, multi-center phase III study to compare the efficacy and safety of aprepitant injection and placebo in the prevention of post-operative nausea and vomiting (PONV).,
- Trial name
- NCT06543966
- Testing
- Aprepitant Injection
- Volunteers
- 486 people
- Sponsor
- CSPC Zhongnuo Pharmaceutical (Shijiazhuang) Co., Ltd.
Upper Limb; Injury, Superficial, Multiple
Effectiveness of Laboral Kinesiotherapy in Prevention of Upper Limb Musculoskeletal Disorders
ABSTRACT Work-related musculoskeletal disorders are seen as a public health problem, and can often lead to temporary or permanent incapacity to work.
- Trial name
- NCT04047056
- Testing
- Labor Kinesiotherapy
- Where
- Brazil
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Atrial Fibrillation, Atrial Appendage
Assessment of Dual Antiplatelet Therapy Versus Rivaroxaban In Atrial Fibrillation Patients Treated With Left Atrial Appendage Closure
Evaluation of 2 doses of rivaroxaban (10 and 15 mg) compared to dual anti platelet therapy (aspirin+clopidogrel) after left atrial appendage closure.
- Conditions
- Atrial Fibrillation, Atrial Appendage, Hemorrhage
- Trial name
- ADRIFT (NCT03273322)
- Testing
- Rivaroxaban 10 mg qd, Rivaroxaban 15 mg qd, DAPT
- Where
- France
- Volunteers
- 105 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immunoglobulin Prophylaxis, Cytomegalovirus Infections
Immunoglobiulin-specific Prophylaxis of Citomegalovirus Infections in Immunocompromised Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation
Human cytomegalovirus (CMV) is a globally prevalent, human-specific herpesvirus characterised by a lifelong latency after primary infection, an often asymptomatic reactivation and affecting up to 100% of adults based on region…
- Conditions
- Immunoglobulin Prophylaxis, Cytomegalovirus Infections, Allogeneic Hematopoietic Stem Cell Transplantation, Transplant-Related Disorder
- Trial name
- NCT07013370
- Testing
- Anti-CMV immunoglobulins [Megalotect (R)]
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Antonello Di Paolo, M.D., Ph.D.
Prevention of Sudden Death
Training Mothers of Infants in Infant Cardiopulmonary Resuscitation (CPR)
This research will be a prospective, cohort study to determine if mothers of infants/newborns are more willing to complete CPR training using a 22-minute instructional DVD and infant manikin versus traditional four hour didactic…
- Trial name
- NCT00570869
- Testing
- CPR Anytime
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Lehigh Valley Hospital
Stroke
SMART (School-aged Children Making Healthy Choices And Recognizing sTroke)
A stroke awareness program for school-aged children to learn the signs/symptoms of stroke, teach their parents and make healthy life-style choices.
- Trial name
- SMART (NCT02346266)
- Testing
- SMART Education
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Los Amigos Research and Education Institute
Peri-implant Mucositis
Effects of a 0.03% CHX Mouth Rinse in Peri-implant Mucositis
Aim: To evaluate the efficacy of a 0.03% chlorhexidine (CHX) and 0.05% cetyl pyridinium chloride (CPC) mouth rinse, as an adjunct to professionally and patient-administered mechanical plaque removal, in the treatment of…
- Trial name
- NCT03533166
- Testing
- Chlorhexidine
- Where
- Spain
- Volunteers
- 54 people
- Sponsor
- Universidad Complutense de Madrid
Cardiac Disease, Vascular Diseases
Fighting Social Inequality in Cardiovascular Health I
This study attempts to reduce social inequality in cardiovascular health by performing an interventional screening trial on how best to decrease cardiovascular disease (CVD) among people with low social status
- Trial name
- FISICH-I (NCT03946956)
- Testing
- Prebooking, Pictured invitation
- Where
- 5 sites in Denmark
- Volunteers
- 5,000 people
- Sponsor
- Odense University Hospital
Anemia During Pregnancy
The Effect Of Pumpkin Seed Extract Capsules On Nutritional Status and Haemoglobin Level in Pregnant Women.
The goal of this to measure the effect of supplementation of Yellow Pumpkin Seed Extract Capsules in pregnant women on hemoglobin levels and nutritional status of pregnant women.
- Trial name
- NCT05657821
- Testing
- Pumpkin seeds extract capsules
- Where
- Indonesia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Dr. Rosdiana Syakur
Fall
The Effectiveness of Remote Fall Prevention Program vs. Face-to-Face
Falls are a serious problem in the elderly leading to injuries, morbidity, and consequently a heavy impact on the individual suffering, and society at large.
- Trial name
- NCT05018455
- Testing
- Fall prevention program training based on Otago principles
- Where
- 2 sites in Israel
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Malaria
Seasonal Intermittent Preventive Treatment With Sulfadoxine-Pyrimethamine in Children in Mali
Recent, randomized controlled trials conducted in areas of perennial malaria transmission have shown that intermittent preventive treatment (IPT) given at the time of vaccination reduced the incidence of the first episode of…
- Trial name
- NCT00623155
- Testing
- Seasonal IPT in children - Sulfadoxine-pyrimethamine
- Where
- Mali
- Volunteers
- 262 people, healthy volunteers welcome
- Sponsor
- University of Bamako
Asthma, Care Management, Patient
Digital Prevention of Asthma
Asthma self-management is dependent on support and education. To facilitate self-management have we developed and CE-mark a novel digital self-management system called Asthmatuner (Medituner AB, Sweden).The primary aim of this…
- Trial name
- AsthmaTuner (NCT04132778)
- Testing
- AsthmaTuner
- Where
- 2 sites in Sweden
- Volunteers
- 331 people
- Sponsor
- Karolinska Institutet
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