Clinical trials: Primary Infertility
Primary Hypothyroidism, Acupuncture
Effect of Acupuncture and Low Caloric Diet on Primary Hypothyroidism and Irregular Menstruation in Infertile Women
the goal of this randomize clinical trial is to compare in 60 infertile women with hypothyroidism. selected from national Nutritional institute out clinic.
- Conditions
- Primary Hypothyroidism, Acupuncture, Irregular Menstruation, PCO
- Trial name
- NCT05804149
- Testing
- acupuncture, Thyroxine, low caloric diet
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Infertility, Female, Premature Ovarian Failure
Is There A Role For Mechanical Stimulation In Ovarian Follicular Activation?
Premature ovarian failure (POI) is a loss of normal function before age 40, leading to infertility and hypoestrogenism. About 1% of women younger than 40 years old and 0.1% before 30 are affected.
- Conditions
- Infertility, Female, Premature Ovarian Failure, IVF
- Trial name
- NCT04390308
- Testing
- Ovarian puncture, Hormonal blood Test, Transvaginal ultrasound
- Where
- United Arab Emirates
- Volunteers
- 70 people
- Sponsor
- ART Fertility Clinics LLC
Infertility, Female
Primary Efficacy Evaluation of Traditional Chinese Medicine in Treating Older Infertile Women
This study is a preliminary evaluation of the efficacy of traditional Chinese medicine in the treatment of elderly infertile women.
- Trial name
- NCT03973528
- Testing
- traditional Chinese medicine: tonifying kidney Wan
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- Chang Gung Memorial Hospital
Diminished Ovarian Reserve, Premature Ovarian Insufficiency
Autologous Platelet-rich Plasma (PRP) Infusion to Improve Outcomes in Women With Ovarian Insufficiency: a Pilot Study
The investigators propose a pilot study to determine if autologous platelet-rich plasma (PRP) improves ovarian reserves and In-vitro fertilisation (IVF) outcomes in women with diminished ovarian reserve / premature ovarian…
- Conditions
- Diminished Ovarian Reserve, Premature Ovarian Insufficiency, Fertility Issues, IVF
- Trial name
- NCT05385848
- Testing
- Autologous Platelet-rich Plasma (PRP) Injection
- Where
- Singapore
- Volunteers
- 30 people
- Sponsor
- KK Women's and Children's Hospital
Primary Uterine Infertility
Uterine Transplantation for the Treatment of Uterine Factor Infertility
This feasibility study aims to enroll ten subjects who will undergo deceased donor uterine transplantation at Cleveland Clinic. We estimate that fifty to one hundred patients with uterine factor infertility will need to be…
- Trial name
- NCT02573415
- Testing
- Uterus Transplant
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- The Cleveland Clinic
Female Infertility Due to Diminished Ovarian Reserve
Human Growth Hormone Pre-treatment for 6 Weeks Prior to Ovulation Induction for IVF
Synthetic human growth hormone (HGH) has been available for more than a decade for specific indication in children and adults. Past Randomized Control Trials (RCT)s of HGH (under off-label use) for improving ovarian function have…
- Trial name
- NCT02179255
- Testing
- Human Growth Hormone, Follicle Stimulating Hormone
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Center for Human Reproduction
Primary Infertility, Secondary Infertility
Minimal Stimulation Protocol Using Aromek(Letrozole) and Follitrope(recFSH) Combined With INVOCell-Low Cost IVF
The purpose of this study to evaluate a low cost minimal stimulation protocol combined with Intravaginal Culturing, to make IVF affordable and available across the large infertile/subfertile population
- Conditions
- Primary Infertility, Secondary Infertility, Low Responders, Mild to Moderate Male Factor Infertility
- Trial name
- MSP-INVO IVF (NCT01058252)
- Testing
- INVOCell, Letrozole 2.5 mg, recFSH 75 IU, STEP-3: LH Suppression & Monitoring, STEP-4: HCG Timing
- Where
- 2 sites in Pakistan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Galaxy Pharma (Pvt) Limited
Anti-Müllerian Hormone, Polycystic Ovarian Syndrome
Clinical Application of Serum Anti-Müllerian Hormone (AMH) Measurements
This study aims to assess the association of Anti-Müllerian hormone (AMH) with polycystic ovarian syndrome, premature ovarian insufficiency and fertility. The main objectives include the following: 1.
- Conditions
- Anti-Müllerian Hormone, Polycystic Ovarian Syndrome, Premature Ovarian Insufficiency, Fertility Issues
- Trial name
- NCT05858307
- Where
- Hong Kong
- Volunteers
- 300 people
- Sponsor
- Chinese University of Hong Kong
Primary Ovarian Insufficiency, Female Infertility Due to Diminished Ovarian Reserve
Effect of Testosterone Treatment on Embryo Quality
The purpose of this study is to determine the effect of treatment with trans-dermal testosterone cream compared to placebo on measures of ovarian reserve, oocyte and embryo quality, and pregnancy rates among women with evidence…
- Trial name
- NCT01662466
- Testing
- Testosterone cream (0.5mg per gram), DHEA
- Where
- 2 sites in United States
- Volunteers
- 180 people
- Sponsor
- Center for Human Reproduction
Primary Uterine Infertility
Uterus Transplantation From Live Donor
Uterus transplantation, as a possible future treatment for uterine factor infertility, has been developed in animal species during the last decade.
- Trial name
- utx (NCT01844362)
- Testing
- uterine transplantation
- Where
- Sweden
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Sahlgrenska University Hospital
Premature Ovarian Insufficiency, Infertility, Female
Ovarian PRP (Platelet Rich Plasma) Injection for Follicular Activation
The primary objective is to investigate the efficacy, defined as an increase in oocyte numbers upon ovarian stimulation, and safety of a single intra-ovarian PRP injection vs.
- Conditions
- Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP
- Trial name
- OPIF (NCT05279560)
- Testing
- autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection
- Where
- Germany
- Volunteers
- 114 people
- Sponsor
- University of Luebeck
Hysteroscopy
Verbal Analgesia Versus Standard Care for Pain Control in Women With Primary Infertility Undergoing Office Hysteroscopy
Office hysteroscopy is a cornerstone in the diagnostic evaluation of infertile women, enabling direct visualization of the uterine cavity for identifying intrauterine pathology.
- Trial name
- NCT07325994
- Testing
- verbal analgesia, standard care
- Where
- Egypt
- Volunteers
- 92 people
- Sponsor
- Cairo University
Infertility, Female, Premature Ovarian Failure
Second Step Protocol in Poor Ovarian Responder (POR)
Reduced ovarian reserve and the consequent poor ovarian response are very recurent in infertile patients, indeed a percentage of 10%-24% of couples addressed to infertility program may be classified as Poor Ovarian Responder…
- Conditions
- Infertility, Female, Premature Ovarian Failure, Fertility Disorders
- Trial name
- POR (NCT03480412)
- Testing
- Follicular Phase, Luteal Phase
- Where
- Italy
- Volunteers
- 50 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Primary or Secondary Infertility
Impact of Local Biopsy to the Endometrium Prior to Controlled Ovarian Stimulation on Clinical Pregnancy
In vitro fertilization (IVF) is the only available solution for many couples with various forms of infertility. The embryo implantation step in the IVF procedure is a complex multistage process and represents the majority of the…
- Trial name
- NIDABRECHE (NCT01064193)
- Testing
- biopsy, IVF
- Where
- 3 sites in France
- Volunteers
- 190 people
- Sponsor
- University Hospital, Bordeaux
Stress Reduction
The Impact of a Self-help Coping App on Distress Levels in Men Experiencing Infertility
The purpose of this study is to determine if the use of a new app, FertiStrong, is associated with decreased levels of anxiety and depression in men who have infertility or whose partner has infertility.
- Trial name
- NCT03519607
- Testing
- FertiStrong App
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fertility Centers of Illinois
Primary Infertility
Endometrial Injury and Single Embryo Transfer
Endometrial injury increases clinical pregnancy rate in normoresponder patients undergoing long agonist protocol intracytoplasmic sperm injection cycles with single embryo transfer.
- Trial name
- NCT01851876
- Testing
- Endometrial injury
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Karadeniz Technical University
Autoimmune Disease, Infertility
Steroid Therapy in Autoimmune Premature Ovarian Failure
No therapy for infertile patients with premature ovarian failure has been proven effective. Some anecdotal reports have suggested that high dose, long term prednisone (steroid) therapy may be useful in treating autoimmune ovarian…
- Conditions
- Autoimmune Disease, Infertility, Premature Ovarian Failure
- Trial name
- NCT00001306
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infertility, Male Infertility
"System Medicine" Approach for Prevention Strategies for Comorbidities in Infertile Men
By applying a "system medicine" approach, the project aims to identify new biomarkers and/or prognostic tools aimed at developing personalized strategies to prevent the onset of comorbidities in infertile men.
- Trial name
- NCT06183255
- Testing
- Observation and evaluation of clinical parameters in the two cohorts
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- IRCCS San Raffaele
Primary Ovarian Insufficiency, Infertility
Parental Project and Premature Ovarian Insufficiency
One of the main repercussions of POI is infertility. When the diagnosis of POI is announced, the question of fertility is addressed and the patient is often directed towards egg donation or adoption when she has a parental…
- Trial name
- ParentIOP (NCT05310617)
- Testing
- Survey
- Where
- France
- Volunteers
- 324 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fertility Issues
Assessing the Fertility Status of Men With Spinal Muscular Atrophy (SMA)
This study will aim to assess the fertility status of men with Spinal Muscular Atrophy (SMA) not on disease-modifying therapies. Participants will: 1.
- Trial name
- NCT06194539
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Bar-Chama, Natan, M.D.