Clinical trials: Primary Motor Cortex
Sports Fatigue
Effects of Dual-site Anodal Transcranial Direct Current Stimulation on Attention, Decision-making and Working Memory During Sports Fatigue in Elite Soccer Athletes
Investigation of the effects of dual-site anodal transcranial direct current stimulation over the dorsolateral prefrontal cortex or primary motor cortex on attention, decision-making and working memory during sports fatigue in…
- Trial name
- NCT06594978
- Testing
- dual-site anodal tDCS over the M1, dual-site anodal tDCS over the DLPFC
- Where
- China
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Beijing Sport University
Ultrasound in MRI
Effects of Transcranial Focused Ultrasound on Human Primary Motor Cortex Using 7T fMRI
Transcranial focused ultrasound (tFUS) is a form of neuromodulation that uses a single element transducer to produce highly focused low-intensity acoustic energy that can be used to affect cortical excitability in humans.
- Trial name
- NCT03634631
- Testing
- Focused Ultrasound
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Parkinsons Disease (PD)
Neuroimaging of Parkinson's
Parkinson's Disease (PD) is a neurodegenerative disorder caused by dysfunction in both subcortical structures and the cortex. The investigators recently discovered a new brain system called the Somato-Cognitive Action Network…
- Trial name
- NCT07024875
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Stroke
Study of Neurophysiological Markers of Motor Recovery in Post-stroke Patients.
The aim of the study was to explore potential pathways for recovery and adaptation of neural pathways after stroke by examining electrical activity of the brain cortex and cortico-spinal excitability using transcranial magnetic…
- Trial name
- NCT06386627
- Testing
- Stimulus response task, Transcranial magnetic stimulation
- Where
- Russia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Skolkovo Institute of Science and Technology
Congenital Hemiparesis
Comparing the Location of the Motor Cortex in Children Using Two Methods
Hypothesis: In typically developing children (TDC), use of conventional EEG landmarks to determine the brain area that controls hand function will not differ from TMS-guided determination of individual motor hotspots.
- Trial name
- NCT02015338
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Minnesota
Brain Tumors
Presurgical Planning With Functional MRI (fMRI) Mapping of Motor Cortex in Patients With Cerebral Tumors
The purpose of this study is to determine if functional MRI is precise enough to provide information about the location of brain functions in patients who have brain tumors.
- Trial name
- NCT00724737
- Testing
- Presurgical MRI, functional MRI (fMRI) of the brain
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Tourette's Syndrome, Chronic Motor Tic Disorder
Brain Activation in Vocal and Motor Tics
This study will investigate the brain areas that are activated by vocal and motor tics in patients with Tourette's syndrome and other tic disorders. Tics are involuntary repetitive movements similar to voluntary movements.
- Conditions
- Tourette's Syndrome, Chronic Motor Tic Disorder, Chronic Motor Vocal Disorder
- Trial name
- NCT00026000
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Dystonic Disorders
Brain Inhibition of Muscle Movement in Normal Volunteers
This study will use transcranial magnetic stimulation, or TMS (described below), to examine how the brain controls muscle movement to prevent unwanted movements in surrounding muscles.
- Trial name
- NCT00047957
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Movement Disorder, Healthy
Study of Brain Control of Movement
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017979
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Amniotic Band Syndrome, Upper Extremity Deformities, Congenital
The Influence of 3D Printed Prostheses on Neural Activation Patterns
The neural basis underlying motor performance in children using a prosthesis has been severely understudied resulting in minimal empirical evidence.
- Trial name
- NCT04110730
- Testing
- 3D Printed Upper-limb Prosthesis, Home Intervention
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Nebraska
Motor Activity
Investigating Motor Cortex Processing for Pain Modulation
The purpose of this study is to investigate the effects of different types of interventions (motor learning, somatosensory learning, observation task, mental imagery and tDCS) on the perception of pain and motor cortex…
- Trial name
- NCT01404039
- Testing
- Motor Learning, Somatosensory Learning, Observational Task
- Where
- United States
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Spaulding Rehabilitation Hospital
Cerebrovascular Accident
Role of the Intact Hemisphere in Recovery of Motor Function After Stroke
The purpose of this study is to better understand the role of the motor part of the brain in the recovery of motor function after stroke. The motor deficits that follow a stroke are compensated for over several months.
- Trial name
- NCT00028184
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Stroke
The Modulatory Effect of Low-intensity Priming Intermittent Theta Burst Stimulation on Motor Cortex Poststroke: a Concurrent TMS-EEG Study
Background: The optimization of the intensity of priming theta burst stimulation increases the probability of success in a randomized controlled trial.
- Trial name
- NCT06241508
- Testing
- Transcranial magnetic stimulation
- Where
- Hong Kong
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The Hong Kong Polytechnic University
Migraine Disorders
Effects of the Visual Stimulation on the Motor and Visual Cortex in Migraneurs With and Without Aura
The aim of this study is to investigate the motor and visual cortex excitability in response to visual stimulation of migraineurs with and without aura compared to healthy individuals.
- Trial name
- NCT02564822
- Testing
- Visual Stimulation
- Where
- Brazil
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Pernambuco
Healthy Young Adults
iTBS Effect on M1 Plasticity, Blood Glucose, and Cardiovascular Response
Transcranial magnetic stimulation is a medical device that can alter motor cortical (M1) excitability through the scalp via various protocols.
- Trial name
- NCT06043076
- Testing
- TMS
- Where
- Malaysia
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Paraplegia, Spinal, Myelomeningocele
Brain Function and White Matter Changes in Congenital, Acute and Chronic Spinal Cord Lesions
The purpose of this study is to use functional MRI (fMRI) and magnetic resonance (MR) diffusion tensor imaging (DTI) to investigate brain activation and white matter changes in patients with congenital (birth defect of the spinal…
- Trial name
- NCT01208584
- Testing
- fMRI, DTI
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Healthy
Safety, Parameterization, and Mechanism of Transcranial Focused Ultrasound
Through the BrainBox Initiative, investigators propose to study the effects of motor tFUS on Motor Evoked Potentials (MEPs) and GABA and Glutamate Concentrations in the Brain.
- Trial name
- NCT05792020
- Testing
- Focused Ultrasound Stimulation
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Healthy Control Subjects
Impact of Spaced iTBS on Plasticity in the Motor Cortex
The goal of this clinical trial is to explore the effects of non-invasive brain stimulation protocols using intermittent theta-burst stimulation (iTBS) on brain plasticity in healthy, right-handed individuals aged 18 to 50 years.
- Trial name
- STEP-MC (NCT06735794)
- Testing
- Compressed iTBS, Spaced iTBS
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Centre for Addiction and Mental Health
Movement Disorder, Healthy
Brain Excitability During Self-Paced Voluntary Movements
This study will use transcranial magnetic stimulation to examine how the brain controls movement by sending messages to the spinal cord and muscles and what goes wrong with this process in disease.
- Trial name
- NCT00017966
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cortical Excitability, Psychiatric Disorder
Effects of L-theanine on Motor Cortex Excitability in Healthy Subjects: A Paired-Pulse TMS Study
Major depressive disorder (MDD) is a serious mental illness and the leading cause of disability worldwide. New pharmacotherapeutic agents with complementary neurobiological mechanism and better side effect profile are of great…
- Trial name
- NCT04749745
- Testing
- L-theanine
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Butler Hospital