Clinical trials: Primary PCI
Myocardial Infarction
Bivalirudin in Patients With Acute Myocardial Infarction (AMI) Undergoing Primary PCI
The purpose of this study is to demonstrate the benefit of bivalirudin in combination with clopidogrel with provisional GPIIb/IIIa inhibitor use, in reducing the bleeding complications associated with early invasive management of…
- Trial name
- NCT00093184
- Testing
- Angiomax (bivalirudin) anticoagulant
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Medicines Company
Myocardial Infarction
Relationship Between Primary Percutaneous Coronary Intervention, Door-to-balloon Times, and Mortality for Heart Attack Patients Across England
The degree to which elevated mortality associated with weekend or night-time hospital admissions reflects poorer quality of care ('off-hours effect') is a contentious issue.
- Trial name
- NCT02374190
- Testing
- Standard Hospital Care
- Where
- United Kingdom
- Volunteers
- 42,677 people
- Sponsor
- London School of Economics and Political Science
Myocardial Infarct, Remodeling, Left Ventricle
Heart Attack Blood Oxygen Therapy Trial
'Heart attack', known as acute ST-segment elevation myocardial infarction, is a leading cause of heart failure and death. A lack of blood and oxygen damages the heart muscle potentially causing heart failure and premature death.
- Trial name
- SSO2 Radial MI (NCT06662890)
- Testing
- Supersaturated oxygen
- Where
- United Kingdom
- Volunteers
- 56 people
- Sponsor
- NHS National Waiting Times Centre Board
Myocardial Infarction
Anti-inflammatory Effects of Intracoronary and Intravenous Abciximab Administration During Primary Percutaneous Coronary Intervention
Intracoronary abciximab administration during primary percutaneous coronary intervention (pPCI) could offer clinical advantages over the intravenous route.
- Trial name
- NCT01757457
- Testing
- Intracoronary administration of an abciximab bolus during primary PCI, Intravenous administration of an abciximab bolus during primary PCI
- Where
- Italy
- Volunteers
- 89 people
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Myocardial Infarction
Goodness of Clinical History During Stemi PCI
The purpose of this study is to confirm or confute the hypothesis that in patients treated with primary pci is not always possible to collect an adequate medical history, the investigators created a clinical registry in which the…
- Trial name
- GHOST (NCT01018706)
- Where
- Italy
- Volunteers
- 400 people
- Sponsor
- Umberto I Hospital, Frosinone Italy
Coronary Arteries
Ten-Year Outcomes of Stents Versus Coronary-Artery Bypass Grafting for Left Main Coronary Artery Disease
The purpose of this study is to evaluate long-term outcome of treatment(percutaneous coronary intervention or coronary-artery bypass graft) in unprotected left main coronary artery stenosis in Korea.
- Trial name
- MAIN COMPARE (NCT02791412)
- Testing
- percutaneous coronary intervention or coronary-artery bypass graft
- Where
- 12 sites in South Korea
- Volunteers
- 2,240 people
- Sponsor
- Seung-Jung Park
Myocardial Infarction
Diagnostic and Prognostic Utility of Pentraxin 3 in Patients With Acute STEMI Undergoing Primary PCI
A number of inflammatory markers have been recognized, among which the acute phase reactant C-reactive protein showed a positive correlation with the risk of coronary artery disease in both healthy individuals and those at high…
- Trial name
- NCT03476252
- Testing
- pentraxin 3
- Volunteers
- 100 people
- Sponsor
- Assiut University
Coronary Artery Disease
The Nordic Bifurcation Study III
Should we, or should we not, perform dilatation of the side branch through the main vessel stent, if there is acceptable blood flow in the side branch?
- Trial name
- BIF III (NCT00914199)
- Testing
- Percutaneous coronary intervention (PCI)
- Where
- Denmark
- Volunteers
- 477 people
- Sponsor
- Evald Hoej Christiansen
ST Elevation Myocardial Infarction
Outcome of Primary PCI in STEMI Addict Patients
The goal of this study is to Identify the in-hospital outcome of primary PCI in treatment of STEMI in addict patients in comparison to non-addict patients.
- Trial name
- NCT04090216
- Testing
- Primary Percutaneous Coronary Intervention
- Volunteers
- 176 people
- Sponsor
- Assiut University
STEMI - ST Elevation Myocardial Infarction
Noninvasive Artificial Venous Stasis for Reperfusion in STEMI
This prospective, randomized study was designed to evaluate whether the noninvasive artificial venous stasis / RE-START procedure, administered prior to primary percutaneous coronary intervention, increases the frequency of…
- Trial name
- RE-START (NCT07689591)
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Firat University
Myocardial Infarction, No Reflow Phenomenon
Validation of New Biomarkers for Predicting No-Reflow in STEMI Patients Undergoing Primary PCI
To evaluate the diagnostic value of the selected emerging biomarkers in predicting the no-reflow phenomenon among patients presenting with STEMI undergoing primary PCI.
- Trial name
- VaBiNoR (NCT07132489)
- Testing
- HbA1c/C-peptide ratio Albumin-bilirubin (ALBI) score. Neutrophil/HDL ratio
- Volunteers
- 114 people
- Sponsor
- Assiut University
Acute Kidney Injury
Serum Cystatin C for Early Detection of Acute Kidney Injury After Primary Percutaneous Coronary Intervention
This study aims to evaluate whether the serum levels of Cystatin C (CysC) can be used as early biomarkers for the identification of patients who are prone to AKI after cardiac interventional surgeries as primary percutaneous…
- Trial name
- NCT06459362
- Testing
- Serum cystatin C
- Volunteers
- 45 people
- Sponsor
- Assiut University
Left Main Coronary Artery Stenosis
Ultrathin-strut Biodegradable Polymer Sirolimus-eluting Stents With P2Y12 Inhibitor-based Single Antiplatelet Therapy vs. Conventional DAPT for Unprotected Left Main Coronary Artery Disease (ULTIMATE-LM)
The management of patients with unprotected left main coronary artery (LMCA) disease undergoing percutaneous coronary intervention (PCI) in contemporary interventional cardiology practice remains matter of intense debate.
- Trial name
- ULTIMATE-LM (NCT05650411)
- Testing
- LMCA PCI with Supraflex Cruz ultrathin-strut biodegradable polymer sirolimus-eluting stent (Sahajanand Medical Technologies Ltd., Surat, India)., P2Y12 inhibitor-based SAPT after short DAPT, Conventional DAPT
- Where
- Switzerland
- Volunteers
- 828 people
- Sponsor
- IGLESIAS Juan Fernando
ST Elevation (STEMI) Myocardial Infarction
PICSO in Patients With STEMI Treated by Primary Percutaneous Coronary Intervention
A prospective multi-center study in which patients with an acute heart attack (in the left anterior descending artery) with ECG changes (ST segment elevation) receive angioplasty followed by stent placement and 90 minutes of…
- Trial name
- pRAMSES (NCT01493037)
- Testing
- PICSO (Pressure-controlled Intermittent Coronary Occlusion
- Where
- 2 sites in Netherlands
- Volunteers
- 30 people
- Sponsor
- Miracor Medical SA
Primary PCI - STEMI
STEMI Treated With Primary Angioplasty and Intravenous Lovenox or Unfractionated Heparin (UFH)
Randomized evaluation of enoxaparin (0.5mg/kg IV) versus UFH (50-70IU/kg with GPIIb/IIIa inhibitors; 70-100IU without GPIIb/IIIa inhibitors).
- Trial name
- ATOLL (NCT00718471)
- Testing
- Enoxaparin, UFH (unfractionated heparin)
- Where
- France
- Volunteers
- 910 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiovascular Diseases
Effect of Trimetazidine During the Primary PCI on Cardiac Function in Patients With ST-elevation Myocardial Infarction
Giving preoperative loading dose of 60mg of trimetazidine can safely and effectively reduce the PCI-related myocardial damage for the patients undergoing selective PCI.
- Trial name
- NCT02826616
- Testing
- Trimetazidine
- Where
- China
- Volunteers
- 240 people
- Sponsor
- Chinese PLA General Hospital
Myocardial Infarction
Effect of Diabetes and Hepatic Enzymes Mutation on Clopidogrel VS Ticagrelor Activity in Myocardial Infarction (MI) Patients Undergoing Primary Percutaneous Coronary Intervention (PCI)
In this study the combined effect of diabetes mellitus and cyp2c19 polymorphism on platelet aggregation inhibitory activity of the highest traditionally used loading dose 600 mg clopidogrel and ticagrelor 180 mg loading dose will…
- Trial name
- NCT03613857
- Testing
- Clopidogrel, Ticagrelor 90mg
- Where
- Egypt
- Volunteers
- 1,022 people
- Sponsor
- Cairo University
Acute Myocardial Infarction
PAclitaxel-eluting Balloon in Primary PCI in Amsterdam; Pilot Study
This clinical evaluation will study the feasibility and safety of a CE-marked paclitaxel-eluting balloon in primary PCI in patients with a STEMI.
- Trial name
- PAPPA-pilot (NCT01274728)
- Testing
- Percutaneous coronary intervention
- Where
- Netherlands
- Volunteers
- 100 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Acute Myocardial Infarction
Myocardial Protection With Adenosine During Primary Percutaneous Coronary Intervention in Pts With STEMI
OBJECTIVE: to evaluate the safety and efficacy of a brief intracoronary infusion of ADO applied at the time of reperfusion to limit infarct size and LV remodelling in patients with ACSST submitted to primary ACTP.
- Trial name
- PROMISE (NCT00781404)
- Testing
- Adenosine
- Where
- Spain
- Volunteers
- 201 people
- Sponsor
- David Garcia-Dorado
Myocardial Infarction
The Time Delay Correlated With LV Functions and Heart Failure Incidence in STEMI?!
To find out if the time delays between the first medical contacts till the device has an impact on LV functions estimated by transthoracic Echocardiography and if it's correlated to heart failure incidence in non-diabetic…
- Trial name
- NCT05097755
- Volunteers
- 345 people
- Sponsor
- mustafa Zayan Abdelsayed Mohamed