Clinical trials: Primary Parkinsonism
Parkinson's Syndrome
A Cross-Over, Multi-Center Trial to Evaluate the Diagnostic Efficacy and Safety of [123I]NAV5001 as an Imaging Agent to Aid in the Diagnosis of Parkinsonian Syndromes
This is a phase 3, open-label, multiple-center, randomized cross-over study to assess the safety and efficacy of [123I]NAV5001 SPECT imaging in aiding in the differentiaion of parkinsonian syndromes from non-parkinsonian tremor.
- Trial name
- NCT01950468
- Testing
- NAV5001, DaTscan
- Where
- 2 sites in United States
- Sponsor
- Navidea Biopharmaceuticals
Parkinson's Disease
Effects of Combined rTMS and Treadmill Training in People With Parkinson's Disease
The purpose of this study is to investigate whether the beneficial effect of treadmill training on people with Parkinson's disease can be enhanced by high- and low-frequency repetitive transcranial magnetic stimulation (rTMS).
- Trial name
- NCT02701647
- Testing
- Repetitive transcranial magnetic stimulation (rTMS), Treadmill training
- Where
- Hong Kong
- Volunteers
- 51 people
- Sponsor
- The Hong Kong Polytechnic University
Neurologic Diseases, Arthropathy of Knee
Experience of Use and Biopsychosocial Effects of Robotic and Virtual Reality Devices in Neuromotor Rehabilitation
The implementation of virtual reality (VR) and robotic devices in neuromotor rehabilitation has so far provided promising evidence in terms of efficacy throughout different clinical populations.
- Conditions
- Neurologic Diseases, Arthropathy of Knee, Arthropathy of Hip
- Trial name
- NCT05399043
- Testing
- Multidisciplinary Conventional Neuromotor Rehabilitation, Technology-based Rehabilitation
- Where
- Italy
- Volunteers
- 84 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Parkinson's Disease
Cholinergic Augmentation in Frequently Falling Subjects With Parkinson's Disease
The purpose of this study is to find out if a medication that increases levels of a brain chemical called acetylcholine will improve balance and reduce falls in patients with parkinson's disease who have the problem of very poor…
- Trial name
- NCT00912808
- Testing
- Donepezil
- Volunteers
- 23 people
- Sponsor
- Oregon Health and Science University
Parkinson Disease
Can tDCS Enhance Efficacy of Rehabilitative Intervention for Freezing of Gait in Parkinson's Disease?
Freezing of gait in Parkinson's disease (PD) is a major cause of disability and falls and responds often incompletely to conventional therapy. The pathogenesis remains largely unknown and therapeutic alternatives are needed.
- Trial name
- NCT02205216
- Testing
- Active tDCS, Rehabilitation Therapy
- Where
- Switzerland
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Parkinson Disease, Medication
Behavioural Profiling of Disease-related Cognitive and Motor Impairment in PD
In this project, patients with Parkinson's Disease (PD) will be characterized by measuring cognitive and motor function and relation to effect of Levodopa.
- Conditions
- Parkinson Disease, Medication, UPDRS, Motor Function
- Trial name
- NCT06275633
- Testing
- Levodopa
- Where
- Denmark
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Glymphatic System, Parkinson's Disease (PD)
Research on the Brain Glymphatic System of Parkinson's Disease Patients Based on DTI Technology
Synopsis：The brain glymphatic system is a newly discovered anatomical system for removing waste products and maintaining homeostasis in the brain, and its damage is closely related to a variety of neurological diseases.
- Conditions
- Glymphatic System, Parkinson's Disease (PD), DTI
- Trial name
- NCT06858176
- Testing
- No intervention was implemented in this observational study
- Volunteers
- 150 people
- Sponsor
- The First People's Hospital of Yunnan
Parkinson Disease
The Effect of Exercise Intervention on Posture, Trunk Flexibility and Spine Function in Patients With Parkinson's Disease
The primary goal of this clinical trail is to compare the effect of a five-week specific motor interventions on the postural alignment, trunk range of motion and spine function in patients with Parkinson's disease.
- Trial name
- NCT06536478
- Testing
- exercise, education
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Parkinson's Disease, Parkinsonism
Molecular Analysis of Human Neural Stem Cells
The aim of this study is to develop and optimize methods to isolate, propagate and differentiate adult human neural stem cells from patients with degenerative neurological disorders like Parkinson's disease.
- Trial name
- NCT01329926
- Testing
- Harvesting of neural stem cells
- Where
- United States
- Sponsor
- NeuroGeneration
Parkinson Disease
Efficacy of Nano-PSO in Parkinson's Disease.
The present research aims to carry out a double-blind, placebo-controlled clinical trial to study the efficacy of a new antioxidant.
- Trial name
- NCT05142085
- Testing
- nano-PSO
- Where
- Mexico
- Volunteers
- 170 people
- Sponsor
- Distribuidora Biolife SA de CV
Parkinson Disease
PROGENI (Parkinson's Research: The Organized Genetics Initiative) Family Study of LRRK2 (Leucine-rich Repeat Kinase 2)
The PROGENI Family Study is part of a larger consortium that is studying a gene shown to be important in Parkinson's disease, called LRRK2. People who have a defect in the LRRK2 gene will often develop Parkinson's disease.
- Trial name
- PROGENI (NCT01536821)
- Where
- 10 sites in United States, Canada
- Volunteers
- 81 people
- Sponsor
- Indiana University
Parkinson Disease
PARKINSON BRASIL - Database on Motor and Non-Motor Aspects of Parkinson's Disease in Brazil
This is an observational, cross-sectional study with a control group, with the general objective of developing and evaluating a national database, unprecedented in Brazil, containing clinical, epidemiological, motor, and…
- Trial name
- NCT06536348
- Where
- 5 sites in Brazil
- Volunteers
- 958 people, healthy volunteers welcome
- Sponsor
- Federal University of Uberlandia
Parkinson Disease
Asymmetric DBS for PD : A Multicenter, Prospective, Single Arm, Open Label Study
Deep brain stimulation (DBS) is an efficacious neurosurgical treatment for moderate-to-late stage Parkinson's disease (PD). The subthalamic nucleus (STN) and globus pallidus interna (GPi) are two targets extensively studied and…
- Trial name
- ADP (NCT04616521)
- Testing
- Deep brain stimulation
- Volunteers
- 1,000 people
- Sponsor
- Ruijin Hospital
Parkinson's Disease
National Institute of Neurological Disorders and Stroke (NINDS) Parkinson's Disease Neuroprotection Trial
The goal of this study is to assess the impact of minocycline and creatine on the progression of Parkinson's disease, in order to determine whether it is reasonable to proceed with further study of either of these agents.
- Trial name
- NCT00063193
- Testing
- minocycline, creatine
- Where
- United States
- Volunteers
- 195 people
- Sponsor
- University of Rochester
Parkinson's
Nurse Management of Neuromodulation Therapy
The central hypothesis is that the use of a DBS (Deep Brain Stimulation) clinical decision support system for individual patient management will enable considerable time savings compared to standard care.
- Trial name
- DBS (NCT02177149)
- Testing
- Standard of Care, DBS using Clinical Support System.
- Sponsor
- Medical College of Wisconsin
Parkinson's Disease
A Study of KW-6356 in Subjects With Early Parkinson's Disease
The primary objective is to evaluate the effect of KW-6356 on motor symptoms in Parkinson's disease and the primary endpoint is the change from baseline in the MDS-UPDRS part III score between KW-6356 and placebo in subjects with…
- Trial name
- NCT02939391
- Testing
- KW-6356
- Where
- 7 sites in Japan
- Volunteers
- 175 people
- Sponsor
- Kyowa Kirin Co., Ltd.
Exercise, Parkinson Disease
Comparing the Effects of Instability Resistance Training Versus Aerobic Training on Cognitive and Motor Improvements Found in Parkinson's Disease Participants
This study will be looking at the effects that instability resistance training and aerobic training, individually, have on the improvement of various motor and cognitive impairments present in individuals with Parkinson' disease.
- Trial name
- NCT03711955
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Sun Life Financial Movement Disorders Research and Rehabilitation Centre
Parkinson's Disease and Parkinsonism
Saliva and Extracellular Vesicles for Parkinson's Disease
Rehabilitation is crucial in the treatment of people with Parkinson's disease (PD) as it can ameliorate motor and non-motor impairments, improving their clinical profile and quality of life.
- Trial name
- RaSPiD (NCT05320250)
- Testing
- Single saliva collection, Saliva collection, longitudinal
- Where
- 4 sites in Italy
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Parkinson Disease, Huntington Disease
Group Drum-Based Music Therapy Intervention for Parkinson's Disease/Huntington's Disease
Participants in this study (18-89 years) with Parkinson's disease or Huntington's disease receive drum classes twice a week for 12 weeks (24 lessons).
- Trial name
- NCT05157074
- Testing
- Group Drumming Music Therapy
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
PARKINSON DISEASE (Disorder), Aged 65 Years or Older
Multidimensional Assessment of Fatigability in Older Adults Living in Southern Switzerland and Elderly With Parkinson's Disease
With our study, the investigators aim to assess the impact of the fatigue experienced during daily life activities (tiredness) and whether there is a relationship with muscle fatigue during an exercise task.
- Trial name
- LifeLike (NCT07485218)
- Where
- 5 sites in Italy, Switzerland
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Applied Sciences and Arts of Southern Switzerland
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