Clinical trials: Primary Parkinsonism
Parkinson's Disease
A Trial To Assess Switching From Ropinirole, Pramipexole Or Cabergoline To The Rotigotine Transdermal System In Idiopathic Parkinson's Disease
The purpose of this trial is to assess whether it is possible for subjects with idiopathic Parkinson's Disease to switch from ropinirole, pramipexole and cabergoline to rotigotine transdermal system (SPM 962) overnight without…
- Trial name
- NCT00242008
- Testing
- Rotigotine
- Where
- United States
- Sponsor
- UCB Pharma
Advanced Idiopathic Parkinson's Disease
Sleep Efficiency Assessed by Polysomnography (PSG Sleep Lab Testing) in Advanced Parkinson's Disease
This is a phase 4 study to evaluate with Polysomnography (PSG) and subjective measures the effect of Rotigotine on sleep efficiency, maintenance, insomnia, nocturnal akinesia and night-time movement in bed, in patients with…
- Trial name
- REFRESH-PD (NCT01519882)
- Testing
- Rotigotine
- Where
- United Kingdom
- Volunteers
- 1 people
- Sponsor
- UCB Pharma SA
PARKINSON DISEASE (Disorder)
A Study to Evaluate the Efficacy, PK, Safety, and Tolerability of VIM0423 in Adults With Parkinson's Disease Tremor Insufficiently Responsive to Dopaminergic Therapy
Vista PD is a randomized, placebo-controlled, multicenter study to evaluate the efficacy, PK, safety, and tolerability of VIM0423 in adults with Parkinson's disease tremor insufficiently responsive to dopaminergic therapy.
- Trial name
- Vista PD (NCT07804615)
- Testing
- VIM0423
- Where
- 30 sites in United States, Canada
- Volunteers
- 80 people
- Sponsor
- Vima Therapeutics
Parkinson's Disease
Effect on Parkinson's Disease After Therapeutic Induction of CranioSacral Integrated Therapy
We are studying \& researching the effect of CranioSacral Integrative therapy on Parkinson's Diseased Patients for 3 months. With a therapeutic induction via manual CranioSacral integrative therapy for 90 minutes per session with…
- Trial name
- NCT01989013
- Testing
- biweekly intervention
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Zia, Al Raza
Parkinson Disease
Quasi-experimental Study With a Control Group to Evaluate a Psychoeducational Intervention in Parkinson's Disease Patients and Carers
The aim of this study is to evaluate the effects of a psychoeducational multidisciplinary intervention focusing on improving coping skills, the psychosocial adaptation to Parkinson's disease and the quality of life in patents and…
- Trial name
- ReNACE-PD01 (NCT03129425)
- Testing
- ReNACE Psychoeducational Intervention, General Educational Program
- Where
- Spain
- Volunteers
- 140 people
- Sponsor
- Clinica Universidad de Navarra, Universidad de Navarra
Parkinson's Disease
BradyXplore Phase II: Bradykinesia Feature Extraction System
Study objectives are to improve motion sensor algorithms for measuring bradykinesia in the clinic and the home, evaluate test-retest reliability of motion sensor algorithms for measuring bradykinesia compared to clinician raters…
- Trial name
- NCT02358876
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Great Lakes NeuroTechnologies Inc.
Parkinson Disease, Orthostatic Hypotension
Blood Pressure Effects on Cognition and Brain Blood Flow in PD
Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide. Besides causing symptoms that impair movement, PD also causes non-motor symptoms, such as problems thinking and orthostatic hypotension…
- Conditions
- Parkinson Disease, Orthostatic Hypotension, Dysautonomia
- Trial name
- NCT05400174
- Testing
- Tilt table (upright position)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, San Diego
Parkinson's Disease, Deep Brain Stimulation
Can Subthalamic Stimulation Using Directional Electrodes Improve Postoperative Management in Parkinson's Disease
The primary objective of the study is to determine if subthalamic nucleus (STN) deep brain stimulation (DBS) using the Vercise directional leads improves neuropsychiatric state and neuropsychiatric fluctuations 12 months after…
- Trial name
- Steeropt (NCT04578678)
- Testing
- Steering
- Where
- 4 sites in France, Germany and 1 more
- Volunteers
- 105 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Parkinson Disease
Effects of Inspiratory Muscle Training on Parkinson's Disease
Parkinson's disease (PD) is a neurodegenerative movement disorder that provoke motors and non-motors symptoms causing further dependence and disability.
- Trial name
- IMT_PD (NCT06912997)
- Testing
- Exercise
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Universidade Federal Fluminense
Parkinson Disease
EEG Recordings and Analysis in Parkinson's Patients: Towards Adaptive Deep Brain Stimulation by Machine Learning
The objective of this protocol is to obtain on Parkinson's disease more accessible therapeutic targets than deep brain stimulation (HFS-STN), the neurosurgical treatment for this pathology.
- Trial name
- ElectroPARK (NCT05284526)
- Testing
- electroencephalogram (EEG) of control and parkinsonian subjects during the preparation and execution of movements
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Parkinson Disease
Words Generation in Compulsives Gamblers and Parkinson's Disease Patients
The pathophysiology of compulsive disorders as gambling could be close to behavior problems encountered in Parkinson's disease associated with a hyperactivity of the motivational system.
- Trial name
- FLUENCE (NCT01888276)
- Testing
- evaluation of word generation and of motivation
- Where
- France
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University Hospital, Toulouse
Follow up, Parkinson Disease
Two-year Follow-up to High-intensity Multi-component Agility Intervention That Improves Clinical and Motor Symptoms of Parkinson's Disease
Individualization of exercise is recommended but rarely performed in patients with Parkinson's disease (PD). Unusually High Intensity and Individual Sensor Motor with Visuomotor Mobility Trainer The clinical symptoms, mobility…
- Conditions
- Follow up, Parkinson Disease, Rehabilitation
- Trial name
- NCT03193489
- Testing
- Follow-up, Post-treatment control, Control Parkinson group
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- Somogy Megyei Kaposi Mór Teaching Hospital
PARKINSON DISEASE (Disorder), Rigidity
Spinal Mobility, Rigidity, and Kinesiophobia in PD and TMD
Axial rigidity and loss of spinal mobility commonly observed in Parkinson's disease (PD) lead to postural deformities and substantial reductions in trunk flexibility.
- Conditions
- PARKINSON DISEASE (Disorder), Rigidity, Temporomandibular Disorders (TMDs), Mobility
- Trial name
- NCT07850674
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Parkinson's Disease
A US Study That Observes How Parkinson's Disease Changes Over Time in Patients Who Still Have Movement Symptoms Despite Taking Parkinson's Medications
This is an observational study in which data are collected and studied from Parkinson's disease patients who have movement symptoms despite taking standard Parkinson's medications.
- Trial name
- NCT07330258
- Testing
- Standard of Care
- Where
- 27 sites in United States
- Volunteers
- 300 people
- Sponsor
- Bayer
Parkinson's Disease
Pharmacokinetic Profile of Neupro Patch Administrated at 2 mg, 4 mg, 6 mg and 8 mg/Day Weekly in Patients With Early-stage Parkinson's Disease
To study the profile of Neupro patch administrated at 2 mg, 4 mg, 6 mg and 8 mg/day weekly in patients with early-stage Parkinson's disease
- Trial name
- NCT02728947
- Testing
- ROTIGOTINE
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Luye Pharma Group Ltd.
Parkinson Disease
Safety and Efficacy Study of CEP-1347 in the Treatment of Parkinson's Disease
The purpose of this study is to establish safety for CEP-1347 and to determine an efficacious dose in the treatment of Parkinson's disease.
- Trial name
- NCT00040404
- Testing
- CEP-1347 10mg, CEP1347 25mg, CEP-1347 50mg
- Where
- 66 sites in United States, Canada and 1 more
- Volunteers
- 806 people
- Sponsor
- Cephalon
Alzheimer Disease, Parkinson Disease
An Exploratory Study to Confirm Efficacy of Modified Deep Cervical Lymphovenous Anastomosis (LVA) in Alzheimer's Disease/ Parkinson's Disease
Alzheimer's disease (AD) and Parkinson's disease (PD) are characterized by pathological protein accumulation in the brain-Aβ/tau in AD and α-synuclein in PD.
- Trial name
- SOLVEN (NCT06852352)
- Testing
- Modified deep cervical Lymphatic-Venous Anastomosis
- Where
- China
- Volunteers
- 160 people
- Sponsor
- Zhejiang Provincial People's Hospital
Parkinson's Disease (PD)
Comparison of Two Different Dual-Task Training Methods in Patients With Parkinson's Disease
The aim of this study is to compare the effectiveness of motor-motor dual-task training and cognitive-motor dual-task training in patients with Parkinson's disease.The main questions it aims to answer are: Whether there is a…
- Trial name
- NCT07641569
- Testing
- Single Task Exercise Training, Motor-Motor Dual Task Exercise Training, Cognitive-Motor Dual Task Exercise Training
- Where
- Turkey (Türkiye)
- Volunteers
- 39 people
- Sponsor
- Saglik Bilimleri Universitesi
Parkinson's Disease (PD), Healthy Control Subjects
This Protocol is a Sub-study Under the PPMI Program. It is a Longitudinal, Single-center Study to Assess the Performance of [18F]AV-133 Imaging Using High and Standard Resolution PET in Individuals Enrolled With Parkinson's Disease (PD) for up to 12 Months.
The study is a longitudinal, single-center study to assess progression of [18F]AV-133 imaging in PD participants. Participants will be followed for up to 12 months.
- Trial name
- NCT07830654
- Testing
- [18F]AV-133
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Michael J. Fox Foundation for Parkinson's Research
Parkinson Disease
Effects Of tDCS With Physical Therapy On Rehabilitation In Parkinson's Disease
The present study aims to investigate the effect of transcranial direct current stimulation (tDCS) associated with physiotherapy in parkinson´s rehabilitation.
- Trial name
- NCT01877148
- Testing
- tDCS, Physiotherapy
- Where
- Brazil
- Volunteers
- 12 people
- Sponsor
- Universidade Federal de Pernambuco
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