Clinical trials: Priming
Stroke
Exercise Primed Stroke Rehabilitation
Stroke is a leading cause of disability in the U.S. and many Veteran stroke survivors live with severe disability. Despite recent advances in rehabilitation treatments many stroke survivors have persistent physical and mental…
- Trial name
- NCT04877444
- Testing
- Duck Duck Punch, Aerobic exercise, Lower extremity stretching
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- VA Office of Research and Development
Prophylaxis of Avian Influenza Vaccine
Safety and Immunogenicity of Two Doses of H5N1 Influenza Vaccine in Adults Unprimed and Primed With Adjuvanted or Non-adjuvanted Influenza Vaccines
Valuate the immune response and reactogenicity of H5N1 vaccination in a primed population (H5N3 adjuvanted or non-adjuvanted vaccine) compared to immunologically naïve subjects
- Trial name
- NCT00478816
- Testing
- Fluad H5N1 Pandemic Influenza Vaccine
- Where
- United Kingdom
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Novartis Vaccines
Postoperative Pulmonary Complications
An Anesthesia-Centered Bundle to Reduce Postoperative Pulmonary Complications: The PRIME-AIR Study
Postoperative pulmonary complications (PPCs) are a major cause of morbidity and mortality in surgical patients. National estimates suggest 1,062,000 PPCs per year, with 46,200 deaths, and 4.8 million additional days of…
- Trial name
- PRIME-AIR (NCT04108130)
- Testing
- Preoperative Education, Intraoperative PEEP (Positive End-Expiratory Pressure) Individualization, Individualization of Neuromuscular Blockade
- Where
- 16 sites in United States
- Volunteers
- 794 people
- Sponsor
- Columbia University
Dengue
A Phase-I Study of a Nanoparticle-based Peptide Vaccine Against Dengue Virus
This trial aims to test the safety of 2 doses of a T-cell priming specific cocktail of Dengue viruses peptides representing all 4 DENV serotypes and mounted on a gold nanoparticle.
- Trial name
- NCT04935801
- Testing
- LD vehicle-GNP, LD PepGNP-Dengue, HD vehicle-GNP
- Where
- Switzerland
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Gylden Pharma Ltd
Endothelial Dysfunction, Hemolysis
Optimization of Prime Fluid Strategy to Preserve Microcirculatory Perfusion During Cardiac Surgery With Cardiopulmonary Bypass, Part II
Acute microcirculatory perfusion disturbances is common in critical illness and associated with increased morbidity and mortality.
- Conditions
- Endothelial Dysfunction, Hemolysis, Fluid Overload
- Trial name
- PRIME part II (NCT05647200)
- Testing
- Treatment: additional albumin during cardiopulmonary bypass, control: additional ringers during cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 64 people
- Sponsor
- Amsterdam UMC, location VUmc
Malaria, Falciparum, Malaria
Sporozoite Challenge of Polyprotein Vaccinees
This study examines the ability of two new malaria vaccines (FP9-PP and MVA-PP) to prevent the development of malaria infection after controlled exposure to the parasite.
- Trial name
- NCT00375128
- Testing
- FP9-PP (FP9 polyprotein), MVA-PP (Modified Virus Ankara polyprotein)
- Where
- 2 sites in United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- European Vaccine Initiative
Misoprostol Allergy
Misoprostol for Cervical Priming Before Office Hysteroscopy
The objective of the present study is to evaluate the appropriate route of administration of misoprostol, either oral or vaginal, for cervical priming to facilitate the procedure of office hysteroscopy and reduce patient…
- Trial name
- NCT03276000
- Testing
- office hysteroscopy
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Kasr El Aini Hospital
Acellular Pertussis, Tetanus
Immunogenicity, Antibody Persistence and Safety of GSK Biologicals' DTPa (INFANRIX) and dTpa (BOOSTRIX) Vaccines.
To evaluate the immunogenicity, persistence of antibodies and reactogenicity of GSK Biologicals' DTPa (INFANRIX) and dTpa (BOOSTRIX), when administered to subjects 18-20 months old, compared with not giving a booster DTP vaccine…
- Conditions
- Acellular Pertussis, Tetanus, Diphtheria
- Trial name
- NCT00544271
- Testing
- INFANRIX, BOOSTRIX, HAVRIX
- Where
- Australia
- Volunteers
- 720 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Zika Virus Infection
A Phase 1, First-in-human, Double-blinded, Randomized, Placebo-controlled Trial of a Zika Virus Purified Inactivated Vaccine (ZPIV) With Alum Adjuvant in Healthy Flavivirus-naive and Flavivirus-Primed Subjects.
Phase 1 study to evaluate two doses of Alum Adjuvanted Zika Virus Purified Inactivated Vaccine (ZPIV) administered 28 days apart. The study will enroll 75 flavivirus naïve healthy adult subjects into 3 equal groups sequentially.
- Trial name
- NCT02963909
- Testing
- IXIARO, YF Vax 17D Strain, Zika Virus Purified Inactivated Vaccine (ZPIV)
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma
Photoradiation With Verteporfin to Facilitate Immunologic Activity of Pembrolizumab in Unresectable, Locally Advanced or Metastatic Pancreatic Cancer
This phase II trial tests how well photoradiation with verteporfin and pembrolizumab plus standard of care chemotherapy works in treating patients with pancreatic cancer that cannot be removed by surgery (unresectable), that has…
- Conditions
- Locally Advanced Pancreatic Adenocarcinoma, Metastatic Pancreatic Adenocarcinoma, Stage II Pancreatic Cancer AJCC v8, Stage III Pancreatic Cancer AJCC v8
- Trial name
- NCT06381154
- Testing
- Biopsy, Biospecimen Collection, Computed Tomography
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Mayo Clinic
Neuroendocrine Tumor of Pancreas, Multiple Endocrine Neoplasia Type 1
Precision Radiotherapy Using MR-linac for Pancreatic Neuroendocrine Tumours in MEN1 Patients
Patients with the Multiple Endocrine Neoplasia type 1 (MEN1) syndrome are genetically predisposed for developping multiple pancreatic neuro-endocrine tumours (pNET).
- Trial name
- PRIME (NCT05037461)
- Testing
- High-dose-high precision MR-guided radiotherapy
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- J.M. de Laat
Stroke, Upper Extremity Hemiparesis
Bilateral Priming for Upper Extremity Hemiparesis in Older Adults
This study will compare bilateral priming followed by task specific training to health care education followed by the same task specific training protocol.
- Trial name
- NCT02277028
- Testing
- priming and task specific training
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Rush University Medical Center
Meniscus Tear
PRedIcting MEniscal Tears Outcomes After Physical Therapy Treatment
The aim of this multicenter non-controlled study is to develop a multivariable prediction model of pain/disability improvements in patients with meniscal tears, after a physical therapy treatment based on therapeutic exercise and…
- Trial name
- PRIME (NCT05909865)
- Testing
- Therapeutic resistance exercise, Education
- Where
- Spain
- Volunteers
- 386 people
- Sponsor
- Hospital Universitario Fundación Alcorcón
B-ALL
a Clinical Research of CD19 and CD22 Targeted Prime CAR-T Cell in Relapsed/Refractory B-ALL
This is a single arm study to evaluate the efficacy and safety of CD19 and CD22 targeted prime CAR-T cells therapy for patients with relapsed/refractory B -ALL
- Trial name
- NCT04781634
- Testing
- CD19 and CD22 targeted prime CAR-T cells
- Where
- China
- Volunteers
- 40 people
- Sponsor
- Chongqing Precision Biotech Co., Ltd
Hepatitis C Infection
A Study to Assess the Safety of Hep C Vaccine Candidates in HIV Seropositive Individuals
This study is aimed at assessing the safety of candidate Hepatitis C (Hep C) vaccines AdCh3NSmut1 and MVA-NSmut when administered to Human Immunodeficiency Virus (HIV) seropositive individuals.
- Trial name
- NCT02568332
- Testing
- AdCh3NSmut1, MVA-NSmut
- Where
- 2 sites in Ireland, Switzerland
- Volunteers
- 20 people
- Sponsor
- University of Oxford
Colorectal Cancer
The PRIME-CRC Trial to Promote CRC Screening in Rural Communities
The investigators will expand an existing, patient-centered, health literacy strategy to promote longer-term adherence to colorectal cancer (CRC) screening in resource-limited, rural health clinics via colonoscopy or annual fecal…
- Trial name
- NCT04313114
- Testing
- health literacy appropriate education and demonstration, shared decision making, automated call reminders or automated texts
- Where
- 3 sites in United States
- Volunteers
- 804 people, healthy volunteers welcome
- Sponsor
- Louisiana State University Health Sciences Center Shreveport
HIV Infections
A Study of the Safety and Effectiveness of an HIV Vaccine for HIV-Positive Patients Receiving Anti-HIV Drugs for at Least 2 Years
The purpose of this study is to see if 2 study vaccines, ALVAC-HIV (vCP1452) and gp160 MN/LAI-2, are safe and effective in boosting the body's attacks on HIV in HIV-positive patients.
- Trial name
- NCT00006509
- Testing
- ALVAC(2)120(B,MN)GNP (vCP1452), gp160 MN/LAI-2
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Unconscious (Psychology)
Memory Priming in General Anesthesia
Memory priming under general anesthesia is a phenomenon of incredible interest in the study of consciousness and unconscious cognitive processing, and for clinical practice.
- Trial name
- NCT03727464
- Testing
- Abstract priming, Concrete priming, Controls
- Where
- Italy
- Volunteers
- 102 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Malaria
A Phase I Study to Assess the Safety and Immunogenicity of ChAd63 ME-TRAP - MVA ME-TRAP Heterologous Prime-boost Vaccination Co-administered With EPI Vaccines in Gambian Infants
Two vaccines, ChAd63 ME-TRAP and MVA ME-TRAP, are being tested to see if they will form a safe and effective vaccination strategy against malaria.
- Trial name
- VAC058 (NCT02083887)
- Testing
- ChAd63 ME-TRAP / MVA ME-TRAP
- Where
- The Gambia
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pneumonia, Pneumococcal
Dose-Finding Study of S.Pneumoniae Whole Cell Vaccine Adsorbed to Alum (PATH-wSP) in Healthy Kenyan Adults and Toddlers
The purpose of this study is to assess the safety and tolerability of PATH-wSP, administered intramuscularly to healthy Kenyan adults and toddlers who have been primed with a pneumococcal conjugate vaccine (PCV).
- Trial name
- NCT02097472
- Testing
- PATH-wSP, Synflorix, Pentavac
- Where
- Kenya
- Volunteers
- 304 people, healthy volunteers welcome
- Sponsor
- PATH