Clinical trials: Processes, Metabolic
Vitamin D Deficiency, Pre-Eclampsia
Vitamin D in Pregnancy
Danish pregnant women are recommended ad daily vitamin D supplement of 10 µg. Despite the fact that 9 out of 10 women take vitamin D supplements, more than 40% of pregnant women are vitamin D deficient, putting them at an…
- Conditions
- Vitamin D Deficiency, Pre-Eclampsia, Fetal Growth Retardation, Gestational Diabetes
- Trial name
- GRAVITD (NCT04291313)
- Testing
- Vitamin D3 (90µg), Vitamin D3 (10µg)
- Where
- 2 sites in Denmark
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Aging, Frailty
Metabolic Dysregulation as Biomarker of Frailty: Role of the Mitochondrial Dysfunction
The goal of this observational study is to evaluate the presence of mitochondrial dysfunction related to oxidative stress and its possible role in frailty, with and without multimorbidity, and to identify possible frailty…
- Conditions
- Aging, Frailty, Mitochondrial Dysfunction, Chronic Disease
- Trial name
- FRAMITO (NCT06433427)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University Hospital of Ferrara
Metabolic Syndrome, Diabetes
Cardiovascular-Kidney-Metabolic Syndrome in Shanghai Zicitizens
The main purpose of this study is to conduct follow-up assessments and update the cardiorenal outcomes among the STONE cohort that was established during 2016-2017.
- Conditions
- Metabolic Syndrome, Diabetes, Obesity and Overweight, Hypertension
- Trial name
- NCT07043166
- Where
- China
- Volunteers
- 4,094 people, healthy volunteers welcome
- Sponsor
- Shanghai Changzheng Hospital
Chronic Obstructive Pulmonary Disease (COPD)
TD-4208 Absorption, Distribution, Metabolism and Excretion (ADME) Study in Healthy Male Subjects
The purpose of this study is to evaluate the absorption, distribution, metabolism and excretion of an investigational medication used to treat chronic obstructive pulmonary disease (COPD).
- Trial name
- NCT02772159
- Testing
- TD-4208
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Mylan Inc.
Conditions Influencing Health Status, Body Weight
Body Composition, Nutritional and Cardiovascular Status and Lifestyle Factors of Adults Who Are on Plant-Based Diet
There is an objective lack of data on the body composition, nutritional status, cardiovascular status and lifestyle of adults on a plant-based diet (PBD).
- Conditions
- Conditions Influencing Health Status, Body Weight, Lipid Metabolism Disorders, Uricemia
- Trial name
- SuppWFPBD (NCT03976479)
- Testing
- Body composition, questionnaires, biochemistry and blood pressure results
- Where
- Slovenia
- Volunteers
- 166 people, healthy volunteers welcome
- Sponsor
- Boštjan Jakše
Mild Dehydration
The Effect of Acute Mild Dehydration on Blood Pressure Control
The goal of this project is determine how acute mild dehydration impacts blood pressure control at rest and during static exercise.
- Trial name
- NCT03560869
- Testing
- Normal hydration, Dehydration
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Delaware
Renal Insufficiency, Chronic, Renal Osteodystrophy
Kidney Yin/Yang Replenishment on Patients With Renal Osteodystrophy
Patients with serious chronic renal insufficiency usually develop secondary osteoporosis or bone loss, especially those with chronic dialysis, and the degree of bone loss is corrected with decrease of renal function.
- Trial name
- NCT01665651
- Testing
- Yougui granules, Zuogui granules
- Where
- 3 sites in China
- Volunteers
- healthy volunteers welcome
- Sponsor
- Bing Shu
Cardiovascular Diseases, Cardiovascular Risk Factor
Cardiovascular Health Awareness Program (CHAP) in Subsidized Social Housing
This project aims to improve the cardiovascular health of seniors living in subsidized housing by implementing the successful community-based Cardiovascular Health Awareness Program (CHAP).
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Diabetes Mellitus
- Trial name
- NCT03549845
- Testing
- Cardiovascular Health Awareness Program
- Where
- Canada
- Volunteers
- 2,742 people, healthy volunteers welcome
- Sponsor
- McMaster University
Hyperlipidemia, Atrial Fibrillation
Impact of MayoExpertAdvisor on Provider Adherence
This study evaluates the efficacy of MayoExpertAdvisor (MEA), a knowledge delivery tool, to improve adherence to best practices for patients with hyperlipidemia, atrial fibrillation and heart failure.
- Conditions
- Hyperlipidemia, Atrial Fibrillation, Heart Failure
- Trial name
- MEA Research (NCT02742545)
- Testing
- MayoExpertAdvisor
- Where
- United States
- Volunteers
- 2,248 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Reproductive Effects, Pregnancy
Vitamin D and Pregnancy: Camden Study
Vitamin D is present in food either naturally or by fortification and included in nutritional supplements. It is also synthesized photochemically by the skin from ultraviolet B radiation.
- Trial name
- NCT02032459
- Where
- United States
- Volunteers
- 1,141 people, healthy volunteers welcome
- Sponsor
- Rowan University
Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease
NAFLD in Adolescents and Young Adults With PCOS
This project focuses on an at-risk adolescent and young adult population who may gain long-term health benefits from detection of risk factors at a young age.
- Conditions
- Polycystic Ovary Syndrome, Non-Alcoholic Fatty Liver Disease, Metabolic Syndrome
- Trial name
- NCT02506946
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Columbia University
Infarction, Stroke
Polymorphisms in the Vitamin D System and Health
Polymorphisms in the vitamin D system appear to affect the serum 25(OH)D levels. If so one would expect these polymorphisms to be associated with vitamin D related conditions and diseases, which will be tested in the present…
- Conditions
- Infarction, Stroke, Diabetes, Fracture
- Trial name
- NCT01395303
- Where
- Norway
- Volunteers
- 9,700 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Sepsis
Lactate Metabolism After an Endotoxin Challenge in Healthy Humans
Sepsis is characterized by hyperlactatemia, the severity of which is proportionate with sepsis severity. The pathophysiological mechanisms (increased lactate production vs decreased lactate utilization; tissues involved in…
- Trial name
- NCT01647997
- Testing
- bacterial endotoxin challenge
- Where
- Switzerland
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Cognitive Change, Mood
Cognitive, Mood, Anti-Inflammatory and Metabolic Effects of Chronic Oyster Mushroom Intervention in Older Adults
The Pleurotus oyster species is a common edible mushroom rich in phytochemicals such as proteins, phenolic compounds, dietary fibre and is also particularly rich in ergothioneine, a bioactive known for its neurocognitive…
- Conditions
- Cognitive Change, Mood, Metabolism, Inflammatory Response
- Trial name
- OYSCOG (NCT06846827)
- Testing
- Oyster mushroom, Maltodextrin
- Where
- United Kingdom
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Reading
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Dehydration, Hyperhydration
Effects of Hydration Changes on Neuromuscular Function of Athletes
Greater muscular strength and power are relevant qualities for athletic success and decreased injury rate. It is known that dehydration impairs muscular strength and power, although the explanation for this association is not…
- Trial name
- H2OAthletes (NCT05380089)
- Testing
- Increasing water intake
- Where
- Portugal
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Faculdade de Motricidade Humana
Osteoporosis, Vascular Calcification
Effect of Vitamin K on Age-Related Bone Loss and Vascular Calcification
The purpose of this study is to determine if supplemental vitamin K will reduce age-related bone loss in elderly men and women above that achieved by supplementation.
- Conditions
- Osteoporosis, Vascular Calcification, Inflammation
- Trial name
- NCT00183001
- Testing
- Vitamin K
- Where
- United States
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Weight Loss, Inflammation
Effect of Very-low Calorie Diet and Synbiotic Supplementation in Gut Microbiota (Pronokal Method)
The present study aimed to investigate the changes produced in gut microbiota by a very-low-calorie-ketogenic diet followed by a low calorie diet, whether the use of synbiotics is able to modulate gut microbiota diversity and…
- Trial name
- Pronokal (NCT03530501)
- Testing
- Diet, Synbiotic1, Synbiotic2
- Where
- Spain
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud
Physical Inactivity, Obesity, Childhood
Children With High Genetic Susceptibility Benefit More From Short-term Physical Activity Interventions
Sharp increase in childhood obesity has been regarded as one of the most serious but preventable global public health challenges.
- Trial name
- NCT06583421
- Testing
- 4-week MVPA intervention
- Where
- China
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- China Medical University, China
Hookworm Infection, Hookworm Disease
Na-GST-1/Alhydrogel With or Without CpG 10104 in Gabonese Adults
Na-GST-1 is a protein expressed during the adult stage of the Necator americanus hookworm life cycle that is thought to play a role in the parasite's degradation of host hemoglobin for use as an energy source.
- Trial name
- NCT03373214
- Testing
- Na-GST-1, CPG 10104
- Where
- Gabon
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
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