Clinical trials: Processes, Metabolic
Hyperlipidemia, Hypertension
Renal Hemodynamic Effects of the HMG-CoA Reductase Inhibitors in Normal Volunteers and in Patients With Chronic Renal Failure
This study was done to determine whether Simvastatin (a medication commonly used to treat patients with high cholesterol levels in the blood increases blood flow to the kidneys and improves renal function in normal volunteers and…
- Conditions
- Hyperlipidemia, Hypertension, Chronic Renal Failure
- Trial name
- NCT02511418
- Testing
- Simvastatin
- Volunteers
- healthy volunteers welcome
- Sponsor
- Mayo Clinic
Metabolic Syndrome, Type 2 Diabetes
Bed Rest, Alternate Daily Fasting and Incretin Effect
Bed rest produces insulin resistance in healthy volunteers. In this study the investigators aim to investigate the effect of 8 days bed rest on the incretin effect and how alternate daily fasting affects cognitive function and…
- Conditions
- Metabolic Syndrome, Type 2 Diabetes, Critical Illness
- Trial name
- NCT02134860
- Testing
- Bed rest, OGTT, IVGTT
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Gut Microbiome, Gastrointestinal Microbiome
A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Disease
This study seeks to correlate microbiome sequencing data with information provided by patients and their medical records.
- Conditions
- Gut Microbiome, Gastrointestinal Microbiome, Autism, Autism Spectrum Disorder
- Trial name
- NCT04031469
- Testing
- There is no intervention in this study
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- ProgenaBiome
Insulin Resistance, Diabetes Mellitus, Type 2
Identification of New Biomarkers of Insulin Resistance
Diabetes is a chronic metabolic disease affecting 415 million people worldwide, 90% of cases are type 2 which is frequently associated with obesity and a sedentary lifestyle.
- Conditions
- Insulin Resistance, Diabetes Mellitus, Type 2, Inflammation, Gastrointestinal Microbiome
- Trial name
- NCT03362554
- Testing
- Controlled diet and exercise.
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bath
Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
Comparative Effectiveness of Metformin for Type 2 Diabetes With Chronic Kidney Disease
This is a proposal for a retrospective observational study of the safety of metformin use in patients with chronic kidney disease, compared to other commonly used diabetes drugs.
- Trial name
- NCT03921242
- Testing
- Metformin, Sulfonylurea, DPP-4 inhibitor
- Where
- 2 sites in United States
- Volunteers
- 4,888 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Chronic Kidney Diseases, Mineral Metabolism Disorder
Diurnal Variation in Markers of Mineral and Bone Disease in Chronic Kidney Disease
The purpose of this study is to examine whether there are diurnal variations in magnesium and other markers related to mineral metabolism in blood from patients with chronic kidney disease (CKD) compared to healthy controls.
- Trial name
- NCT03698422
- Testing
- Blood and urine samples
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Herlev Hospital
Peer Support and Chronic Disease, Obesity
Peer Support Dyads in Churches
The purpose of this study is to explore how working with a partner can influence participation in a church wellness program. There are many different types of church wellness programs.
- Conditions
- Peer Support and Chronic Disease, Obesity, Type II Diabetes, Cardiovascular Disease
- Trial name
- NCT03463941
- Testing
- Peer Support Dyad Intervention
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Duke University
Chronic Kidney Disease, Osteoporosis
Clinical Study on a New Diagnostic Strategy for Osteoporosis and Sarcopenia in Chronic Kidney Disease Patients Based on MRI-FF
This is a single-center, observational cohort study aiming to validate the diagnostic value of MRI-FF in identifying osteoporosis and sarcopenia in patients with chronic kidney disease (CKD).
- Trial name
- NCT07645794
- Testing
- MRI-FF Scan
- Where
- China
- Volunteers
- 868 people, healthy volunteers welcome
- Sponsor
- Capital Medical University
Obesity
BMI-based Vitamins in Obese Pregnant Women
The purpose of this study is to devise and pilot a BMI-based prenatal vitamin for obese pregnant women. Currently, all pregnant women, regardless of body mass index, take the same prenatal vitamin.
- Trial name
- NCT02802566
- Testing
- BMI-based prenatal vitamin, Standard prenatal vitamin
- Where
- 2 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
HIV Testing, Linkage to Care
Multidisciplinary Services to Enhance HIV Testing and Linkage to Care Among MSM
Objectives 1. To determine the impact of MSM-targeted multidisciplinary services on uptake of HIV voluntary counseling and testing (VCT) 2.
- Trial name
- NCT01637324
- Where
- Thailand
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Thai Red Cross AIDS Research Centre
Cardiovascular Diseases, Heart Diseases
The North Kynouria Project
The North Kynouria Project was initiated to study cardiovascular/stroke risk factors by employing mass screening and long-term surveillance of an adult population in the municipality of North Kynouria, in the county of Arcadia…
- Conditions
- Cardiovascular Diseases, Heart Diseases, Cerebrovascular Disease, Coronary Disease
- Trial name
- NCT06115213
- Testing
- Patient counselling
- Where
- Greece
- Volunteers
- 7,000 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ioannina
Overweight, Obesity
Hockey Fans in Training (Hockey FIT): A Pilot Pragmatic Randomized Controlled Trial
The Hockey Fans in Training (Hockey FIT) program aims to improve overweight men's physical fitness, eating habits and health-related lifestyle choices through a lifestyle modification program in collaboration with two Ontario…
- Trial name
- NCT02396524
- Testing
- Hockey FIT Program
- Where
- 2 sites in Canada
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Western University, Canada
Osteoporosis, Inflammation
Yogurt Supplementation to Alter Bone Biomarkers, the Gut Microbiota and Inflammation in Older Adults
Caribbean Latino adults are a vulnerable population at risk for developing osteoporosis. In addition to lifestyle factors, such as dietary intake, the investigators hypothesize that a unhealthy gut microbial environment coupled…
- Trial name
- NCT05350579
- Testing
- Yogurt Intervention
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Lowell
Hyperemesis; Gravidarum, With Dehydration
Endothelial Dysfunction in Hyperemesis Gravidarum
The purpose of the study is to determine serum inflammatory adhesion molecules levels in hyperemesis gravidarum
- Trial name
- NCT02989337
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Kayseri Education and Research Hospital
Overweight and/or Obesity, Perimenopausal Women
Effects of a 6-months Fiber- and Polyphenol-rich Diet on Brain Inflammatory Processes in Perimenopausal Women Living With Overweight or Obesity
People living with obesity have a higher risk of late-life cognitive decline and developing dementia. In women, the risk of cognitive decline may further raise during the menopausal transition, a period of substantial hormonal…
- Trial name
- INFLAME (NCT07501377)
- Testing
- Polybiotic dietary intervention
- Where
- Germany
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Max Planck Institute for Human Cognitive and Brain Sciences
Metabolic Syndrome, Inflammation
Impacts of Aronia on Inflammation and the Gut Microbiome
The overall goal of this project is to determine the inflammation lowering impact of anthocyanin-rich Aronia berries. Inflammation is an underlying mechanism driving the development of several diseases.
- Conditions
- Metabolic Syndrome, Inflammation, Hypertriglyceridemia, Obesity
- Trial name
- NCT04128839
- Testing
- Aronia berry juice
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Montana State University
Gout; Hyperuricemia
Single Dose Study of SHR4640 in Healthy Subjects
The objective of the study is to assess the safety, tolerance, food effect, pharmacokinetic and pharmacodynamic properties of single dose adminstration of SHR4640 in healthy volunteers.
- Trial name
- NCT02815839
- Testing
- SHR4640
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Jiangsu HengRui Medicine Co., Ltd.
Lipid Metabolism, Inborn Errors, Sitosterolemia
Genetic Study of Sitosterolemia
OBJECTIVES: I. Identify the genetic defect and fine map the gene that causes sitosterolemia.
- Trial name
- NCT00004481
- Testing
- genetic testing
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
Dehydration
The Role of Hydration on Exercise Performance - ODIN
During exercise in the heat, there is a need to replenish fluids in order to avoid dehydration and decrease the risk for heat illness. What drives this urge to drink is the thirst mechanism.
- Trial name
- ODIN (NCT02980939)
- Testing
- iv fluid infusion
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of Arkansas, Fayetteville
Maternal; Malnutrition, Infant Malnutrition
Impact of Maternal Stress on Infant Stunting
This study takes place in rural Mam-Mayan communities of Guatemala characterized by high rates of childhood stunting. It aims to characterize women's exposure to nutrition, infection and psychosocial stressors vs.
- Conditions
- Maternal; Malnutrition, Infant Malnutrition, Physiological Stress, Emotional Stress
- Trial name
- NCT02755012
- Volunteers
- 271 people, healthy volunteers welcome
- Sponsor
- McGill University
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