Clinical trials: Processes, Metabolic
Diabetic Ulcer
Evaluation of Topical Wound Oxygen (two2) Therapy
The purpose of this study is to evaluate the efficacy of the Topical Wound Oxygen (two2) therapy system on the healing of diabetic lower extremity ulcers.
- Trial name
- NCT00871312
- Testing
- Topical wound oxygen therapy
- Where
- 3 sites in United States, Canada
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- AOTI Ltd.
Healthy, Postprandial
Acute Effects of Wine Consumption on Healthy Volunteers
The purpose of this study is to investigate whether red and white wine consumption has acute effects on postprandial biochemical markers related to platelet aggregation, inflammation and oxidative stress compared to water or…
- Trial name
- winepost (NCT01627912)
- Testing
- Robola, Cabernet Sauvignon wines
- Where
- Greece
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Malnutrition, Frailty
Feasibility of Estimating the Prevalence of Malnutrition, Frailty and Sarcopenia in Older People in UK Biobank, Cross-sectional Study: A Study Protocol
Background: measuring the prevalence of malnutrition, frailty and sarcopenia in same group of older adults is effective in understanding the relation between these conditions.
- Conditions
- Malnutrition, Frailty, Sarcopenia
- Trial name
- NCT04655456
- Where
- United Kingdom
- Volunteers
- 381,000 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Obesity, Inflammation
Evaluation of New Beverages Rich in Bioactive Compounds for the Modulation of Energetic Metabolism in Overweight Adults
During last decades, an excessive intake of sugars has been observed in westernized countries, mainly due to the consumption of sugar-rich soft drinks.
- Conditions
- Obesity, Inflammation, Insulin Sensitivity
- Trial name
- BEBESANO (NCT04016337)
- Testing
- Beverages
- Where
- Spain
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Universidad Católica San Antonio de Murcia
Dementia (Diagnosis), Alzheimer Dementia (AD)
Speech-Based Artificial Intelligence for Detection of Dementia in Danish Patients (DetectAI)
The goal of this observational study is to learn if an artificial intelligence (AI)-based speech analysis tool can identify which patients with memory problems need specialist evaluation at a memory clinic.
- Conditions
- Dementia (Diagnosis), Alzheimer Dementia (AD), Vascular Dementia (VaD), Lewy Body Dementia (LBD)
- Trial name
- DetectAI (NCT07200739)
- Testing
- Mini-mental State Examination, Addenbrooke's Cognitive Examination, Speech Task - Picture Description
- Where
- Denmark
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Obesity
Cognition and Magnetic Resonance Imaging of Brain Inflammation in Obesity
The rate of obesity in the United States is high and is a risk factor for concurrent cognitive impairment and, in late life, dementias such as Alzheimer's disease.
- Trial name
- NIFOB (NCT04116229)
- Testing
- Oral glucose tolerance test, Cognitive testing, Magnetic resonance imaging
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Diabetic Retinopathy, Neurodegeneration
Glycemic Control and Retinal Microvascular Changes
The goal of this prospective, observational study is to compare in the association of glycemic control and retinal microvascular changes in patients with type 2 diabetes mellitus (T2DM) without diabetic retinopathy (DR).
- Conditions
- Diabetic Retinopathy, Neurodegeneration, Blood Sugar; High
- Trial name
- NCT06150495
- Where
- South Korea
- Volunteers
- 259 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Iron-deficiency, Inflammation
Iron and Muscular Damage: FEmale Metabolism and Menstrual Cycle During Exercise
This project is an observational controlled randomized counterbalance study. One hundred and three physically active and healthy women were selected to participate in the IronFEMME Study, of which 57 were eumenorrheic, 30 were…
- Conditions
- Iron-deficiency, Inflammation, Exercise Induced Iron-deficiency, Exercise Induced Muscle Damage
- Trial name
- IronFEMME (NCT04458662)
- Testing
- Interval running protocol / eccentric-based resistance exercise protocol
- Where
- Spain
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- Universidad Politecnica de Madrid
Low Birthweight, Preterm Birth
Enhancing Nutrition and Antenatal Infection Treatment for Maternal and Child Health in Ethiopia
The ENAT study will test the impact of packages of antenatal interventions to enhance maternal nutrition and manage pregnancy infections on the outcomes of infant birth size, gestational length, and infant growth in the first 6…
- Conditions
- Low Birthweight, Preterm Birth, Maternal; Malnutrition, Affecting Fetus, Sexually Transmitted Diseases
- Trial name
- ENAT (NCT04171388)
- Testing
- Azithromycin 500 mg, Multiple Micronutrient or Fortified Balanced Energy Protein Supplement, Enhanced Infection Management Package (EIMP)
- Volunteers
- healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Post-COVID-19 Syndrome, Long COVID
Magnesium and Vitamin D Combination for Post-COVID Syndrome
The goal of this double-blind randomized controlled clinical trial is to determine the efficacy of the administration of magnesium chloride + vitamin D as an adjuvant in the treatment of post-Coronavirus Disease (COVID) syndrome.
- Conditions
- Post-COVID-19 Syndrome, Long COVID, Vitamin D Deficiency, Magnesium Deficiency
- Trial name
- NCT05630339
- Testing
- Magnesium chloride, Vitamin D
- Where
- Mexico
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Diabetes Mellitus, Geriatric
Burst Suppressions in Diabetic Elderly
This observational study aims to learn about the effects of diabetes mellitus in intraoperative electroencephalography (EEG) of elderly patients receiving general anesthesia.
- Conditions
- Diabetes Mellitus, Geriatric, General Anaesthesia, Electroencephalography
- Trial name
- NCT07037186
- Testing
- Electroencephalogram
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Haseki Training and Research Hospital
Sarcopenia, Muscle Atrophy
Vitamin D and Resistance Exercise Training; Effects on Musculoskeletal Health in Frail Older Men and Women
This study aims to determine whether vitamin D3 supplementation is any more effective in improving musculoskeletal function when combined with exercise training compared with exercise training alone.
- Conditions
- Sarcopenia, Muscle Atrophy, Osteoporosis
- Trial name
- EXVITD (NCT02467153)
- Testing
- RET, Vitamin D3
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Peripheral Arterial Occlusive Disease Fontaine Stage IIa
Acute Local Metabolomic Alterations in Blood and Muscle Tissue in Intermittent Claudication
The most common clinical presentation of lower extremity arterial disease is intermittent claudication. Current understanding of the pathophysiology of intermittent claudication, as well as its treatment options are limited.
- Trial name
- NCT05111379
- Where
- Estonia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Tartu
Immune System Tolerance, Depression
ESAN II - Energy Sensing in Depression
The purpose of this study is to assess the effects of polyphenols from natural aronia juice on the immune system. Therefore, the study aims to distinguish the effects of natural juices that are rich in phytonutrients such as…
- Conditions
- Immune System Tolerance, Depression, Obesity, Microbial Colonization
- Trial name
- NCT05432362
- Testing
- Aronia Juice
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Twin Diseases, Immune Development
Twins Born in Guangzhou
The 2-BIG is a twin birth cohort study located in Guangzhou, China.Its initial aim is to facilitate research on understanding the interplay between genes and environmental factors on disease etiology.
- Conditions
- Twin Diseases, Immune Development, Childhood Obesity, Host and Microbiome
- Trial name
- 2-BIG (NCT03331133)
- Testing
- No intervention
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Guangzhou Women and Children's Medical Center
Overweight and Obesity, Inflammation
Clinical Trials of Five Different Food Supplements With Restriction Diet in Adults
In recent years, dietary supplement are of great interest for the improvement of human health. This study is designed as a parallel, randomized, double blind study exploring the efficacy of two months daily oral dosing of five…
- Conditions
- Overweight and Obesity, Inflammation, Hypercholesterolemia, Hypertension
- Trial name
- FOODSU (NCT05333315)
- Testing
- IP1, IP2, IP3
- Where
- Slovenia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Primorska
Diabetes, Obesity
A Study to Evaluate the Effect of Lipid Infusion on Toll Like Receptor 4 (TLR4) Signaling
The purpose of this study is to determine whether a lipid infusion can up-regulate toll-like receptor 4 (TLR4) signaling in human subjects
- Trial name
- NCT01740817
- Testing
- Intralipid 20%, Saline
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Inflammation, Healthy
Impact of Cottonseed Oil on Oxidative Stress, Inflammation, and Metabolism
Recent research evidence suggests that cottonseed oil (CSO) may have both direct and indirect anti-inflammatory and anti-oxidative impacts linked to bioactive components of CSO and favorable alterations in lipid metabolism.
- Conditions
- Inflammation, Healthy, Oxidative Stress, Metabolic Syndrome
- Trial name
- NCT05439590
- Testing
- High dose CSO, Low dose CSO, Low dose OO
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Montana State University
Gut Microbiota, Metabolic Syndrome
Effect of Mango on Gut Microbiota and Metabolic Health
Mango is rich in bioactive compounds such as dietary polyphenols and carotenoids, which may explain its beneficial effect on health. Polyphenols accumulate in the gut where they can positively modulate the microbiota.
- Trial name
- NCT03825276
- Testing
- Mango consumption
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Laval University
Metabolic Syndrome, Microbiome
Fermented and Fiber-rich Food (FeFiFo) Study
The primary objective is to contrast the degree to which increased consumption of dietary fiber vs. fermented food can decrease inflammation, increase microbiota diversity and can impact microbiota production of short-chain fatty…
- Conditions
- Metabolic Syndrome, Microbiome, Immune Function, Inflammation
- Trial name
- NCT03275662
- Testing
- Dietary Fiber, Fermented Foods
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Stanford University
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