Clinical trials: Processes, Metabolic
Dehydration
Study of In-line Pressure Using Various Techniques of Subcutaneous Administration of Fluids Enabled by Human Recombinant Hyaluronidase (INFUSE-AT1A)
The purpose is to characterize the in-line pressure profiles associated with several infusion technique factors during subcutaneous (SC) infusion of Lactated Ringer's solution, preceded by recombinant human hyaluronidase…
- Trial name
- INFUSE-AT1A (NCT01116102)
- Testing
- Subcutaneous HYLENEX (recombinant human hyaluronidase) and Lactated Ringer's solution
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Metabolic Syndrome
Cardiac Autonomic Neuropathy in Patients With Metabolic Syndrome
The study will test whether damage of the heart nerves appears in patients before they develop diabetes.
- Trial name
- CAN (NCT00907127)
- Testing
- Exercise and Diet (Metabolic Fitness Program)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Infant Mortality, Preterm Birth
Antenatal Micronutrient Supplementation and Infant Survival
The purpose of this community-based randomized trial is to examine whether a daily antenatal and postnatal multiple micronutrient supplement given to women will enhance newborn and infant survival and health and other birth…
- Conditions
- Infant Mortality, Preterm Birth, Low Birth Weight, Neonatal Mortality
- Trial name
- JiVitA-3 (NCT00860470)
- Testing
- Iron (27 mg) - folic acid (600 ug), Multiple micronutrient
- Where
- 2 sites in United States, Bangladesh
- Volunteers
- 44,567 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Metabolic Disease, Inflammation
Effects of Salmon Fishmeal Ex Vivo (FishMeal Ex Vivo)
Diabetes contributes significantly to the burden of disease in Norway and cardiovascular disease is the main cause of mortality. Both lean and fatty fish are shown to have beneficial health effects.
- Conditions
- Metabolic Disease, Inflammation, Endocrine; Obesity
- Trial name
- NCT04078958
- Testing
- Salmon fishmeal, Whey
- Where
- Norway
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Poor Performance Status, Neurologic Deficits
Saving Brain in Uganda and Burkina Faso
The study will estimate the effect of peer-counseling for exclusive breast feeding (EBF) in the first 6 months of life on cognition and other determinants of human capital formation including behavioral and emotional status…
- Conditions
- Poor Performance Status, Neurologic Deficits, Mixed Behavior and Emotional Disorder, Malnutrition
- Trial name
- NCT01882335
- Testing
- Peer support for exclusive breastfeeding
- Where
- Uganda
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Makerere University
Preterm, Infant ALL
Effects of Touch on Brain Connectivity and Metabolic Biomarkers in Preterm Infants
Improving the quality of life of preterm children by 2035 is the top priority of worldwide health organisations, including the WHO.
- Conditions
- Preterm, Infant ALL, Premature, Disease
- Trial name
- NCT05853991
- Testing
- osteopathic manipulative treatment, Active comparator
- Where
- Italy
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Come Collaboration
Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp
Photodynamic Therapy in Root Canal Treatment of T2DM Patients: Microbiome Analysis Via Next-Gen Sequencing
This clinical study investigates the effectiveness of antimicrobial photodynamic therapy (aPDT) as an additional disinfection method in root canal treatment of patients with Type 2 Diabetes Mellitus (T2DM) who have apical…
- Conditions
- Type 2 Diabetes Mellitus (T2DM), Necrotic Pulp, Apical Periodontitis
- Trial name
- NCT06931678
- Testing
- aPDT
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Saglik Bilimleri Universitesi
Obesity
Human Intestinal Microbiota in Obesity and Nutritional Transition
The objectives of this study are: 1-To qualify the relationship between the gut microbiota and the host nutritional and metabolic status during dietary transition.2-To define the impact of nutritional transition on the intestinal…
- Trial name
- Micro-Obes (NCT01314690)
- Testing
- Caloric transition
- Where
- France
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Ceprodi S.A. Kot
Inflammation, Obesity
Systemic and White Adipose Tissue Inflammatory Profile in Lean Versus Obese Individuals
This study will compare the systemic and white adipose tissue inflammatory profile of individuals who are classified as lean and obese.
- Conditions
- Inflammation, Obesity, Inflammatory Response, Cardiovascular Risk Factor
- Trial name
- NCT04078776
- Testing
- No intervention
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Muscle Composition, Sarcopenia
Effects of Increased, Egg-Based Protein Intake on Muscle Composition,
This study is designed to assess the effect of a diet-controlled nutrition program utilizing an egg-based higher protein diet on muscle composition and size, and indices of metabolic health and markers of systemic inflammation in…
- Conditions
- Muscle Composition, Sarcopenia, Hypertrophy, Inflammation
- Trial name
- S25 (NCT01396915)
- Testing
- Dietary Protein Intake
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Purdue University
Insulin Sensitivity
Ischemia-reperfusion Exercise Study
The study investigates the relationship between activation of AMP-activated protein kinase (AMPK) in human skeletal muscle and the subsequent improvement in muscle insulin sensitivity for the stimulation of glucose uptake.
- Trial name
- NCT04872426
- Testing
- Exercise, insulin infusion
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Impact of Health Information Exchange on Patient Care, (Focus on Diabetes, Asthma, Hypertension, CHF, COPD, CAD,
Evaluation of a Regional Electronic Health Information Exchange's Clinical Health Record
The Shared Health CHR™ (Clinical Health Record) offers point-of-care clinical reporting and decision support based primarily on patient claims data aggregated across various health care settings, and is one example of the types…
- Conditions
- Impact of Health Information Exchange on Patient Care, (Focus on Diabetes, Asthma, Hypertension, CHF, COPD, CAD,, Gastroenteritis, Seizures, and Bacterial Pneumonia)
- Trial name
- NCT00978744
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Dehydration
Effects of Two Novel Hydration Beverage Formulas on Rehydration in Adults
The electrolyte test products are composed of powder and provided in individual stick packs with 5 vitamins including Vitamins B3, B5, B6, B12 and Vitamin C.
- Trial name
- NCT06063655
- Testing
- Control: Water, Liquid IV hydration multiplier, Liquid IV sugar-free hydration multiplier
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Memphis
Heart Failure With Preserved Ejection Fraction (HFPEF)
The Effect of Adiposity on Muscle and Microvascular Function in HFpEF
This project is an observational study in patients with heart failure with preserved ejection fraction (HFpEF) who are candidates for treatment with weight loss medication to manage obesity or diabetes as part of their standard…
- Trial name
- NCT06930495
- Testing
- Weight loss SOC Treatment with second generation anti-diabetic medications
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Cancer, Obesity
Community Activation for Prevention (CAPs): A Study of Community Gardening
The investigators previous studies show that community gardening is associated with reduction of key health behaviors for cancer prevention in diverse populations.
- Conditions
- Cancer, Obesity, Lifestyle, Sedentary, Physical Activity
- Trial name
- CAPs (NCT03089177)
- Testing
- Community Garden Intervention
- Where
- United States
- Volunteers
- 296 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Dehydration
Fluid Balance During Exercise in the Heat With Water, Flavored Placebo, or a Carbohydrate-electrolyte Beverage Intake (The APEX Study)
The purpose of the APEX study is to determine whether carbohydrate-electrolyte beverage intake promotes fluid balance during exercise in the heat compared with water or placebo intake.
- Trial name
- APEX (NCT01893853)
- Testing
- Exercise Intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Obesity, Hyperlipidemia
Body Worlds 3 Nutrition Display
Primary Aim # 1: Determine the willingness of the public to participate in an intervention trial - NutritionQuest's Alive!TM - available in a public forum.
- Trial name
- NCT00669500
- Testing
- Lifestyle intervention
- Where
- United States
- Volunteers
- 3,188 people, healthy volunteers welcome
- Sponsor
- Oregon Health and Science University
Gastrectomy, Oesophagectomy
Metabolic Consequences of Gastrointestinal Surgery
Surgery on the gastrointestinal (GI) tract results in profound changes to the metabolic profile. This is well described, including the rapid resolution of diabetes seen after bariatric surgery.
- Conditions
- Gastrectomy, Oesophagectomy, Dumping Syndrome, Hypoglycaemia
- Trial name
- MaS (NCT02836353)
- Testing
- Somatostatin, Rifaximin
- Where
- United Kingdom
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Inflammation, Pregnancy Related
Docosahexaenoic Acid (DHA) Supplementation in High Risk Pregnancies
Purpose: Determine the effects of maternal docosahexaenoic acid (DHA) supplementation during pregnancy on levels of DHA, synaptamide (novel anti-inflammatory metabolite), and inflammatory biomarkers during pregnancy and at…
- Trial name
- NCT04069195
- Testing
- DHA supplement, Corn Oil: Soybean Oil
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Walter Reed National Military Medical Center
Hypoglycaemia
Mechanisms of Insulin Resistance in Critical Illness: Role of Systemic Inflammation and GLP-1
The purpose of this study is to determine the role of inflammation and the insulin regulating hormone GLP-1 during critical illness.
- Trial name
- NCT01347801
- Testing
- GLP-1, TNF-alfa, OGTT
- Where
- 2 sites in Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
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