Clinical trials: Prognostic Biomarkers
Carcinoma Ex Pleomorphic Adenoma of Salivary Glands, Pleomorphic Adenoma of Salivary Glands
Diagnostic and Prognostic Accuracy of Gold Nanoparticles in Salivary Gland Tumours
Nano-based diagnostic tool can provide promising highly sensitive, specific biomarker for early detection and treatment of salivary gland tumours compared to non-conjugated biomarkers and in turn improves patient prognosis and…
- Trial name
- NCT04907422
- Testing
- CD24-Gold Nanocomposite expression using Real-time quantitative polymerase chain reaction, non-conjugated CD24 expression using Real-time quantitative polymerase chain reaction
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Amina Fouad Farag
Lung Cancer, Lung Adenocarcinoma
Identify Prognostic Biomarkers of Lung Cancer
Multi-omics and Clinical Data Analysis is potential to predict the prognosis of lung cancer patients.
- Conditions
- Lung Cancer, Lung Adenocarcinoma, Lung Squamous Cell Carcinoma, Non Small Cell Lung Cancer
- Trial name
- NCT05010330
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Discriminate Obese Children at Risk for Diabetes.
Circulating microRNAs for Discriminating Obese Preschoolers at Risk of Diabetes
Childhood obesity certainly increases susceptibility to type 2 diabetes (T2D) in adulthood. Recently, microRNAs (miRNAs) are closely related to various diseases and have been suggested as valuable biomarkers.
- Trial name
- NCT02843139
- Where
- China
- Volunteers
- 535 people, healthy volunteers welcome
- Sponsor
- Nanjing Medical University
Amyotrophic Lateral Sclerosis, ALS
Study of miRNA Expression Pattern as Diagnostic and Prognostic Biomarker in Amyotrophic Lateral Sclerosis
The principal goal is to demonstrate that a specific pattern of microRNA (miRNA) expression can be correlated with the definite diagnostic of Amyotrophic Lateral Sclerosis (ALS).
- Trial name
- MIRSLA (NCT01992029)
- Testing
- Clinical evaluation, Muscular biopsy, Lumbar puncture
- Where
- France
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Parkinson Disease
Cohort Study to Identify Predictor Factors of Onset and Progression of Parkinson's Disease
Observational, prospective, monocentric study to assess clinical features, imaging and biologic biomarkers in Parkinson disease (PD) patients and rate of progression compared to healthy controls (HC) and subjects at risk to…
- Trial name
- ICEBERG (NCT02305147)
- Testing
- Clinical, biological and imaging followup
- Where
- France
- Volunteers
- 385 people, healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Bladder Cancer
Tumorspecific T-cell Immunity in Bladder Cancer as Prognostic Marker
Bladder cancer is generally susceptible to immunotherapeutic measures. The investigators will characterize 40 patients with muscle-invasive bladder cancer regarding the existence and frequency of tumorspecific T-cells and…
- Trial name
- NCT01198808
- Where
- Germany
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Ovarian Cancer, Borderline Ovarian Tumors
Treg, Th17 Cells, NKT in Epithelial Ovarian Tumor
The aim of the study was to estimate the percentage and of Treg, Th17 and NKT in peripheral blood and the tissue of the epithelial ovarian tumor and relationship with blood serum level of HE4, CA125, as well as algorithm ROMA.
- Conditions
- Ovarian Cancer, Borderline Ovarian Tumors, Benign Ovarian Tumor, Unexplained Infertility
- Trial name
- NCT03779399
- Testing
- Assessment of percentage of Treg, Th17, NKT and serum level of HE4, CA125 and ROMA.
- Where
- Poland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical University of Lublin
Triple Negative Breast Cancer, HER2-positive Breast Cancer
Exosome as the Prognostic and Predictive Biomarker in EBC Patients
This study is the experimental study for serial ctDNA and exosome evaluation in EBC patients
- Trial name
- NCT05955521
- Testing
- exosome and ctDNA evaluation
- Where
- South Korea
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Samsung Medical Center
Silent Cerebral Infarct, Biomarkers / Blood
Biomarkers as Prognostic Factors of Silent, Cerebral Infarctions in Patients Undergoing High-thromboembolic-risk Transcatheter Interventions
Background: The transcatheter interventions with high thromboembolic risk, as transcatheter carotid angioplasty or transcatheter ablation of cardiac arrhythmias are associated with asymptomatic strokes- silent strokes.
- Conditions
- Silent Cerebral Infarct, Biomarkers / Blood, Cardiac Ablation, Cognitive Impairment
- Trial name
- PRINCESS (NCT07844850)
- Testing
- High-thromboembolic-risk transcatheter interventions
- Where
- Greece
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Ovarian Cancer
Circulating Endothelial Cells (CECs) as Potential Predictive/Prognostic Biomarkers in Ovarian Cancer
Anti-angiogenic agents, such as Bevacizumab, have demonstrated survival benefits in ovarian cancer, particularly in patients at high risk of disease progression.
- Trial name
- NCT07807683
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Role of Neurofilment in Diagnosis of Multiple Sclerosis
Neurofilament Light Chain as Diagnostic and Prognostic Marker in naïve Multiple Sclerosis Patients
Neurofilament protein detected in the serum appears to be a good marker for the extent of active neurodegeneration. Chitinase may also be a good marker reflecting the degree of astrocyte activation, or damage in active lesions…
- Trial name
- NFLMS (NCT06197841)
- Where
- Egypt
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Assiut University
Colorectal Cancer Stage IV
Predictive and Prognostic Value of Inflammatory Markers and microRNA in Stage IV Colorectal Cancer
This study investigates the predictive and prognostic values of inflammatory markers and microRNA in stage IV colorectal cancer.
- Trial name
- NCT04149613
- Where
- Lebanon
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- American University of Beirut Medical Center
Platelet Aggregation Inhibitors, Aspirin
GM03 - Platelet RNA Signatures of Aspirin
This study will involve healthy volunteers and patients with Type 2 diabetes. Eligible healthy volunteers will be invited to enroll into one of two protocols (A or B) and eligible patients with diabetes will be enrolled into…
- Conditions
- Platelet Aggregation Inhibitors, Aspirin, Ticagrelor, RNA
- Trial name
- NCT05278637
- Testing
- Aspirin, Ticagrelor
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- Duke University
Heart Failure
Surfactant Derived Protocol in Heart Failure
Pulmonary surfactant is a highly surface-active lipoprotein complex that lines the alveoli and terminal airways, reducing surface tension and preventing alveolar collapse at the end of expiration.
- Trial name
- (SPB) (NCT06896461)
- Testing
- Cardiopulmonary exercise test, Lung function, Biomarkers evaluation
- Where
- Italy
- Volunteers
- 471 people, healthy volunteers welcome
- Sponsor
- Centro Cardiologico Monzino
Ocular Rosacea, Pachychoroid Disease
Research Into Diagnostic and Prognostic Molecular and Imaging Biomarkers of Ocular Disorders Associated With Neurovascular Deregulation: Biocor Cohort
BIOCOR is an interventional clinical trial whose main objectives are Objectif are identify molecular biomarker(s) of ocular rosacea and pachychoroid.
- Trial name
- BIOCOR (NCT06466018)
- Testing
- Schirmer test paper
- Where
- France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Clinact
Biomarkers
Metabolomics Profiling of Coronary Heart Disease
This study sought to assess the diagnostic and prognostic values of metabolomics in coronary artery disease(CAD).
- Trial name
- NCT05138731
- Testing
- treatments according guidelines
- Where
- 5 sites in China
- Volunteers
- 821 people, healthy volunteers welcome
- Sponsor
- General Hospital of Ningxia Medical University
Connective Tissue Diseases, Pulmonary Hypertension
Connective Tissue Disease Patients With Pulmonary Hypertension
Adult patients with suspected or confirmed Connective Tissue Disease Patients (CTD)With Pulmonary Hypertension(PH)will be recruited.
- Trial name
- NCT05980728
- Testing
- No Intervention
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Healthy, Major Depressive Disorder
Gamma Oscillations as a Prognostic Marker for Ketamine Therapy in Treatment Resistant Depression
The core objective of this study is to enhance the translational potential of this electroencephalogram (EEG) biomarker by using ketamine(KET)-induced gamma potentiation as a prognostic marker of 4-week treatment outcome.
- Conditions
- Healthy, Major Depressive Disorder, Treatment Resistant Depression
- Trial name
- NCT06480201
- Testing
- Ketamine, Saline
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Texas A&M University
Multiple Myeloma
Amplification of Zinc Finger Protein 217 Gene in Multiple Myeloma
Multiple myeloma (MM) is blood disorder characterized by the detection of a monoclonal paraprotein in serum or urine, which is often associated with the presence of clonal plasma cells (PCs) mainly in the bone marrow (BM) .The…
- Trial name
- NCT04212858
- Testing
- zinc-finger protein 217 gene
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Acute Coronary Syndrome, Myocardial Infarction
Hepatocyte Growth Factor (HGF) Concentration in Myocardial Infarction
This is the continuation of previous study (registration number: NCT00844987) which revealed that hepatocyte growth factor (HGF) is a very early, good marker of myocardial injury and prognostic factor for post myocardial…
- Trial name
- NCT01233336
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland