Clinical trials: Prognostic Biomarkers
Shortness of Breath, Heart Failure
Biomarkers in Acute Heart Failure
Primary Objectives 1. Mid Region pro Adrenomedullin (MR-proADM) is superior to BNP for the prognosis of heart failure (HF) patients and adds incremental value in predicting outcomes for patients presenting to the Emergency…
- Trial name
- BACH (NCT00537628)
- Where
- 15 sites in United States, Germany and 6 more
- Volunteers
- 1,641 people
- Sponsor
- Brahms AG
Biliary Tract Neoplasms
The Role of ctDNA and PBMC in Treatment of Biliary Tract Cancer
Our study aims to evaluate the role of ct-DNA and PBMC as biomarkers in the treatment of biliary tract cancer.
- Trial name
- NCT02809898
- Testing
- surgery or biopsy
- Where
- 4 sites in China
- Volunteers
- 30 people
- Sponsor
- RenJi Hospital
Myelodysplastic Syndrome
Prognostic Molecular Markers in Patients With Myelodysplastic Syndrome
In the era of hypomethylating agent in MDS treatment, the investigators aimed to investigate the prognostic impact of mutations in spliceosome machinery genes (SRSF2, U2AF1, and ZRSR2) on the outcomes of 1st line decitabine…
- Trial name
- NCT02060409
- Testing
- spliceosome
- Where
- South Korea
- Volunteers
- 58 people
- Sponsor
- Samsung Medical Center
Older Adults, ICU
Prognostic Modelling for Prediction of Mortality and Functional Disability in Critically-ill Elderly Patients
Prospective observational study recruiting elderly patients of 60 years and above admitted to Intensive Care Unit (ICU), to study multiple domains of biomarkers ability to predict mortality of patients during intensive care unit…
- Conditions
- Older Adults, ICU, Mortality Prediction, Functional Disability After ICU
- Trial name
- MYELDERLYICU (NCT06163976)
- Where
- 4 sites in Malaysia
- Volunteers
- 329 people
- Sponsor
- Clinical Research Centre, Malaysia
Critical Illness, Multiple Organ Failure
Intestinal-Specific Organ Function Assessment (iSOFA Study)
Importance of gastrointestinal (GI) function in critically ill patients has been recognized, but until now there is no validated clinical tool to monitor GI dysfunction as part of multiple organ dysfunction syndrome (MODS).
- Trial name
- iSOFA (NCT02613000)
- Testing
- No intervention
- Where
- Estonia
- Volunteers
- 544 people
- Sponsor
- University of Tartu
Multiple Sclerosis
Spinal Cord Monitoring in Multiple Sclerosis
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system and the most common cause of non-traumatic neurological disability in young adults.
- Trial name
- MSpine (NCT06827834)
- Where
- 5 sites in Netherlands
- Volunteers
- 155 people
- Sponsor
- Zuyderland Medisch Centrum
Ovarian Cancer
Study on the Dynamic Changes of Metabolic Biomarkers and Their Prognostic Relationship in Ovarian Cancer
Ovarian cancer is a highly lethal gynecological malignancy, often diagnosed at an advanced stage, with high rates of recurrence within 1-2 years after frontline treatment.
- Trial name
- NCT06019923
- Testing
- No intervention
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Osteosarcoma
The Prognostic Value of Serum Biomarkers in Osteosarcoma
Observational retrospective cohort study using laboratory data of blood tests prior to surgical and chemotherapy treatment and other histologic, clinical, and instrumental data related to patient history from digitized medical…
- Trial name
- NCT05093101
- Testing
- case series review of clinical data
- Where
- Italy
- Volunteers
- 600 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pneumonia, Bacterial
Diagnostic Accuracy of Infection Biomarkers in the Initial Investigation of Patients With Suspected Pneumonia
The aim of this study is to investigate the diagnostic and prognostic value of C-reactive protein (CRP), serum procalcitonin (PCT) and soluble urokinase plasminogen activator receptor (suPAR) in the initial investigation of…
- Trial name
- NCT04652167
- Testing
- PCT, suPAR, Standard care
- Where
- Denmark
- Volunteers
- 411 people
- Sponsor
- University of Southern Denmark
Periodontitis
Salivary Proteome in Response to Non-surgical Periodontal Treatment
This study aims to investigate salivary proteome changes in periodontitis patients before and after non-surgical treatment. Ten systemically healthy and non-smoker individuals with stage III, grade C periodontitis underwent…
- Trial name
- NCT05952895
- Testing
- Conventional quadrant-wise scaling and root planing (SRP)
- Where
- Turkey (Türkiye)
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Aydin Adnan Menderes University
Myocardial Infarction, Death, Sudden, Cardiac
Effect of High Dose Fish Oil Supplementation After Recent Heart Attack Using Magnetic Resonance Imaging
Doctors use magnetic resonance imaging (MRI) to obtain detailed pictures of the inside of the body. This study will evaluate a new MRI technique in people who have recently had a heart attack.
- Trial name
- OmegaREMODEL (NCT00729430)
- Testing
- Omega-3 Fatty Acids (Fish Oil Supplements)
- Where
- United States
- Volunteers
- 358 people
- Sponsor
- Brigham and Women's Hospital
Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker
Phoenixin-14 Downregulation in Sepsis
Background: Sepsis is a leading cause of morbidity and mortality in intensive care units (ICUs) worldwide, accounting for millions of deaths annually.
- Conditions
- Sepsis - to Reduce Mortality in the Intensive Care Unit, Sepsis Biomarker, Phoenixin-14 Molecular Downregulation
- Trial name
- NCT07356739
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Firat University
Diabetic Kidney Disease
Prognostic Imaging Biomarkers for Diabetic Kidney Disease
Diabetic kidney disease (DKD) is a common complication of diabetes, and is now the most common form of chronic kidney disease. DKD is the leading cause of kidney disease requiring dialysis or kidney transplantation, and its…
- Trial name
- iBEAt (NCT03716401)
- Testing
- MRI (magnetic resonance imaging), US (ultrasound), Renal Biopsy
- Where
- 7 sites in Finland, France and 4 more
- Volunteers
- 500 people
- Sponsor
- University of Leeds
Colorectal Cancer
Circulating Tumour DNA (ctDNA) as a Prognostic and Predictive Marker in Colorectal Cancer - a Pilot Study
In clinical practice, there are currently no biomarkers that can guide colorectal cancer treatment in the primary and curative setting.
- Trial name
- CITCCA (NCT04726800)
- Where
- 8 sites in Norway, Sweden
- Volunteers
- 300 people
- Sponsor
- Anna Martling
Kidney Cancer
Biomarkers in Tumor Tissue Samples From Young Patients With Very Low Risk Wilms Tumors
RATIONALE: Studying samples of tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
- Trial name
- NCT01004783
- Testing
- DNA methylation analysis, gene expression analysis, loss of heterozygosity analysis
- Volunteers
- 165 people
- Sponsor
- Children's Oncology Group
COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related
Melatonin Levels on COVID-19 Positive Pregnant Women
This study aimed to investigate the prognostic value of serum melatonin as a biomarker for the determination of severe COVID-19 infection in pregnant women.
- Conditions
- COVID-19 Acute Respiratory Distress Syndrome, Pregnancy Related, Pregnancy Complications
- Trial name
- NCT05318144
- Where
- Turkey (Türkiye)
- Volunteers
- 228 people, healthy volunteers welcome
- Sponsor
- Nazan Yurtcu MD
Gastric Cancer
Prognostic and Predictive Impact of Circulating Tumor DNA in Gastric Cancer Treatment
The evaluation of the chemotherapy efficacy for gastric cancer patients is usually evaluated by computer tomography scans with RECIST criteria that are performed every two months during the treatment.
- Trial name
- PLAGAST (NCT02674373)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Association des Gastroentérologues Oncologues
Oropharyngeal Squamous Cell Carcinoma (OPSCC), HPV
Prognostic Biomarkers for Patients With Human Papillomavirus (HPV) Positive Oropharyngeal Squamous Cell Carcinoma
The purpose of this research study is to investigate the relationship between vascular habitats and treatment response AND to investigate the potential utility of dynamic contrast enhanced (DCE)-MRI derived parameters in…
- Conditions
- Oropharyngeal Squamous Cell Carcinoma (OPSCC), HPV, HPV Positive Oropharyngeal Squamous Cell Carcinoma
- Trial name
- OPSCC (NCT07797738)
- Testing
- MRI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Severe Eosinophilic Asthma
Clock Proteins as Prognostic Markers
Asthma is a chronic inflammatory disease of the airways that follows a strong circadian rhythm: Signs of inflammation and symptoms worsen especially in the early morning hours.
- Trial name
- CLOCK-PM (NCT06302959)
- Where
- Austria
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Severe Dyspnea, CAPD
BIOmarkers of Dyspnea IN Emergency Room
The purpose of this study is to evaluate the capacity of some novels biomarkers Procalcitonin (PCT), Midregional Proadrenomedullin (MR pro ADM), Midregional pro-atrial natriuretic peptide (MR pro ANP), Copeptin (CT pro arginine…
- Conditions
- Severe Dyspnea, CAPD, AE COPD, Acute Heart Failure
- Trial name
- BIODINER (NCT01227317)
- Testing
- Prognostic value of Biomarkers
- Where
- France
- Volunteers
- 444 people
- Sponsor
- ThermoFisher Scientific Brahms Biomarkers France