Clinical trials: Prognostic Biomarkers
Benign Intracranial Hypertension
Diagnostic and Prognostic Biomarkers of Idiopathic Intracranial Hypertension
Idiopathic intracranial hypertension (IIH) is a condition of unknown etiology, primarily affecting overweight females of childbearing age.
- Trial name
- NCT04032379
- Testing
- Standard treatment
- Where
- 2 sites in Denmark
- Volunteers
- 300 people
- Sponsor
- Danish Headache Center
Glucose Fluctuations in Sepsis
Usage of Glucose Fluctuations as a Prognostic Marker in Septic Shock Patients
To determine whether glucose fluctuations prior to antibiotic administration are associated with sepsis severity and poor clinical outcomes.
- Trial name
- NCT07234526
- Volunteers
- 105 people
- Sponsor
- Assiut University
Aortic Valve Stenosis
Aortic Stenosis: Determinants and Prognostic Value of Preoperative Left Ventricular Remodeling After Valvular Replacement
Aortic stenosis (AS) is the most frequent valvulopathy in Western countries. The prevalence of AS is constantly increasing due to the aging of the population.
- Trial name
- NCT03411304
- Where
- France
- Volunteers
- 440 people
- Sponsor
- University Hospital, Rouen
Lung Cancer (NSCLC)
Application Research of Methylation Markers in Early-stage Lung Cancer Patients Treated With Co-ablation System Therapy
Lung cancer has the highest global incidence and mortality among malignancies. While surgery is the primary curative treatment for early-stage patients, approximately 25-35% are ineligible due to comorbidities.
- Trial name
- NCT07257471
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Beijing Haidian Hospital
Acute Heart Failure
Serial Measurements of Biomarker in Patients With Acute Decompensated Heart Failure
Evaluation of serial measurement of novel biomarker for diagnosis, prognosis or therapy monitoring in patients presenting with acute decompensated heart failure.
- Trial name
- NCT00514384
- Where
- 4 sites in Switzerland
- Volunteers
- 350 people
- Sponsor
- University Hospital, Basel, Switzerland
Lupus Nephritis, Systemic Lupus Erythematosus
SII and SIRI as Prognostic Biomarkers in Lupus Nephritis
This prospective observational study aims to evaluate the prognostic utility of the Systemic Immune-Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) as novel inflammatory biomarkers for monitoring disease…
- Conditions
- Lupus Nephritis, Systemic Lupus Erythematosus, Kidney Diseases
- Trial name
- NCT07780045
- Volunteers
- 100 people
- Sponsor
- Assiut University
Acute Kidney Injury
Incidence of Acute Kidney Injury and Mortality in Critically Ill Patients: Urinary Chloride as a Prognostic Marker
Acute kidney injury (AKI) is characterized by a rapid decrease in renal function. It is frequent in hospitalized patients and its incidence is higher in critically ill patients.
- Trial name
- NCT05542927
- Testing
- urine chloride
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Ain Shams University
Pancreatic Adenocarcinoma
A Prospective Translational Tissue Collection Study in Early and Advanced Pancreatic Ductal Adenocarcinoma and Pancreatic Neuroendocrine Tumours to Enable Further Disease Characterisation and the Development of Potential Predictive and Prognostic Biomarkers
There are several types of early pre-cancerous lesions found in the pancreas which have the potential to develop into pancreatic cancer.
- Trial name
- PaC-MAn (NCT03840460)
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- Royal Marsden NHS Foundation Trust
Cardiovascular Disease Other
Multimarker Approach in Acute Chest Pain
Chest pain is one of the most common causes of access in the Emergency Room, and it can be a clinical manifestation of a broad spectrum of diseases including those 'time dependent' conditions such as acute coronary syndrome…
- Trial name
- NCT06295978
- Testing
- Biochemical marker assays
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sepsis, Septic Shock
Comparing Blood-Based Ratios for Predicting Outcomes in Sepsis and Septic Shock
Sepsis and septic shock are serious conditions associated with a high risk of organ dysfunction and death. Simple laboratory-based markers may help identify critically ill patients who are at greater risk of poor outcomes.
- Trial name
- NCT07819708
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Benha University
Acute Coronary Syndrome, Myocardial Infarction
Hepatocyte Growth Factor (HGF) Concentration in Myocardial Infarction
This is the continuation of previous study (registration number: NCT00844987) which revealed that hepatocyte growth factor (HGF) is a very early, good marker of myocardial injury and prognostic factor for post myocardial…
- Trial name
- NCT01233336
- Where
- Poland
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Warsaw, Poland
Gliomas
Location-Molecular Integrated Outcomes in 450 Cerebellar Glioma Microsurgical Cases
The goal of this observational study is to learn if refined anatomical location-combined with molecular biomarkers-can predict surgical success and long-term survival in 450 adults and children with cerebellar gliomas who…
- Trial name
- NCT07342699
- Where
- China
- Volunteers
- 450 people
- Sponsor
- West China Hospital
Acute Kidney Injury, Liver Cirrhoses
Prognostic Biomarkers For Acute Kidney Injury In Liver Cirrhosis
Acute kidney injury (AKI) is a common and under-diagnosed problem in patients with liver cirrhosis, and is associated with significant illness and preventable death.
- Conditions
- Acute Kidney Injury, Liver Cirrhoses, Biomarkers
- Trial name
- NCT03156426
- Testing
- Event of interest: Acute kidney injury
- Where
- United Kingdom
- Volunteers
- 52 people
- Sponsor
- University of Edinburgh
Ventilator Associated Pneumonia
Prognostic Biomarkers in Predicting Mortality in Respiratory Patients With Ventilator-Associated Pneumonia
The aim of this study is to evaluate prognostic efficiency RDW and NLR for mortality prediction in respiratory patients with VAP.
- Trial name
- NCT04739748
- Testing
- complete blood picture
- Where
- Egypt
- Volunteers
- 136 people
- Sponsor
- Assiut University
Myocardial Infarction
Stem Cell Migratory Activity: Prognostic Marker in Myocardial Ischemia
The present project aims to determine whether a deficit in migration of stem cells could be implicated in the failure to mount an adequate collateralization after Myocardial Infarction (MI) and thereby facilitate the development…
- Trial name
- NCT01271309
- Where
- 2 sites in Italy
- Volunteers
- 170 people
- Sponsor
- IRCCS Multimedica
Graft Dysfunction
Role of Anti-BK Virus Neutralizing Antibodies (BKV) as a Prognostic Marker for the Development of Nephropathy BK
BKV nephropathy (BKV) is one of the most frequent complications of kidney transplantation. In the absence of specific anti-BKV treatment, pre-emptive reduction of immunosuppression is the main strategy that has proven effective…
- Trial name
- NCT02826811
- Where
- France
- Volunteers
- 170 people
- Sponsor
- University Hospital, Strasbourg, France
Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy
Unstructured Eye Tracking as a Diagnostic and Prognostic Biomarker in Parkinsonian Disorders
Study Rationale: No accurate tests currently exist to diagnose Parkinson's disease (PD) and the conditions which mimic it (atypical parkinsonism) at a very early stage.
- Conditions
- Parkinson's Disease and Parkinsonism, Progressive Supranuclear Palsy, Multiple System Atrophy, Corticobasal Degeneration
- Trial name
- NCT05638477
- Testing
- Free-viewing eye tracking
- Where
- Ireland
- Volunteers
- 122 people
- Sponsor
- Conor Fearon
Stroke, Hypothermia Treatment
Prognostic Biomarkers for Selective Intra-Arterial Cooling Infusion Combined with Endovascular Thrombectomy in Acute Ischemic Stroke Based on Proteomics and Metabolomics.
Endovascular Thrombectomy has emerged as a pivotal treatment modality for acute ischemic stroke. However, despite successful thrombus removal, a substantial proportion of patients still experience poor outcomes.
- Trial name
- NCT06665386
- Testing
- hypothermia
- Where
- China
- Volunteers
- 258 people
- Sponsor
- Capital Medical University
Rapid Diagnosis of Spontaneous Infection of Ascitic Fluid
Calprotectin for Rapid Diagnostic Infection Spontaneous of Ascites
The prognosis of spontaneous bacterial peritonitis (ISLA) remains a serious complication of cirrhosis. Rapid diagnosis of ISLA is a key issue for improving the prognosis.
- Trial name
- Ca-DRISLA (NCT02857101)
- Testing
- dosage of calprotectin
- Where
- France
- Volunteers
- 218 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Amyotrophic Lateral Sclerosis
Identification of Diagnostic And Prognostic Biomarkers From Amyotrophic Lateral Sclerosis (ALS) Skin and Adipose Samples
The purpose of the project is to obtain skin and adipose tissue samples from patients with ALS to develop new diagnostic and prognostic markers of the disease.
- Trial name
- ALS-TDI PEG (NCT01948102)
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- Wake Forest University Health Sciences