Clinical trials: Prolapse, Vaginal
Colon Cleansing
Will Cleaning the Bowel With an Enema Before Vaginal Prolapse Surgery Prevent Complications?
Traditionally, many gynecologic surgeons have asked patients to perform a cleansing enema the night before a vaginal surgery done to repair pelvic organ prolapse (dropped bladder, dropped uterus).
- Trial name
- NCT00981539
- Testing
- enema
- Where
- 2 sites in United States
- Volunteers
- 310 people, healthy volunteers welcome
- Sponsor
- Illinois Urogynecology, Ltd.
Cystocele, Uterine Prolapse
Outcomes of Anterior Colporrhaphy Versus Graft Reinforced Anterior Prolapse Repair
The purpose of this study is determine whether grafted anterior vaginal prolapse repair is more effective and associated with less complications than prolapse repair with suture.
- Conditions
- Cystocele, Uterine Prolapse, Urinary Incontinence
- Trial name
- NCT00535301
- Testing
- grafted anterior prolapse repair, sutured anterior vaginal prolapse repair
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Vaginal Vault Prolapse
Laparoscopic Sacropexy With Robot-Assisted Surgical System
The aim of the study is to evaluate safety and outcome of robot-assisted laparoscopic sacropexy regarding perioperative data, objective anatomical results and postoperative quality of life.
- Trial name
- RobPex (NCT00886223)
- Testing
- laparoscopic robot-assisted sacropexy
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Kantonsspital Aarau
Urinary Incontinence, Pelvic Organ Prolapse (POP)
The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation
The goal of this observational study with an embedded pilot clinical trial is to learn how the pelvic floor recovers after vaginal childbirth and whether early individualized pelvic floor muscle training can improve recovery in…
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse (POP), Bowel Symptoms, Postpartum
- Trial name
- RECOVER (NCT07430865)
- Testing
- Early individualized pelvic floor muscle training (PFMT)
- Where
- 2 sites in Sweden
- Volunteers
- 380 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Pelvic Organ Prolapse
Use of Pre-Emptive Pudendal Nerve Block for Pelvic Reconstructive Surgery
The purpose of this study is to determine the effectiveness of perineal pain control via injection of a local anesthetic to numb the pudendal nerve. The medication which is commonly used for this block is called marcaine.
- Trial name
- NCT02409498
- Testing
- pudendal block, no pudendal block
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pelvic Organ Prolapse, Gynecologic Disorders
Comparison of Learning Curves for Two Different Techniques in Vaginal Hysterectomy
Randomized prospective monocentric interventional study to compare learning curves for traditional vaginal hysterectomy and vaginal hysterectomy performed by bipolar coagulation comparing short-term outcomes for both procedures.
- Conditions
- Pelvic Organ Prolapse, Gynecologic Disorders, Surgery
- Trial name
- NCT06220253
- Testing
- vaginal hysterectomy by bipolar vessels sealing, vaginal hysterectomy by traditional technique
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Pelvic Organ Prolapse
Native Tissue Repair With Surgical Pelvic Organ Pessary - an RCT
This is an RCT looking at the primary outcome of composite success following anterior repair with native tissue at 6, 12, 24 months in two arms.
- Trial name
- NTRSPOP (NCT02808377)
- Testing
- Surgical Pelvic Organ Pessary
- Where
- United Kingdom
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Cambridge University Hospitals NHS Foundation Trust
Pelvic Organ Prolapse, Urinary Incontinence
Vaginal Estradiol Use in Pessary Care
The primary outcome of this study compare the rate of pessary discontinuation at 6 months post-pessary fitting in women using vaginal estradiol versus those not using vaginal estradiol.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Pessary Ulcer of Vagina, Vaginal Atrophy
- Trial name
- NCT05458375
- Testing
- Estradiol vaginal cream
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Urinary Incontinence, Pelvic Organ Prolapse
Evaluate Women After Vaginal Surgery for Urinary Symptoms and Sexual Function
Assess the outcomes of vaginal surgeries and its impact on sexual function and urinary symptoms.
- Conditions
- Urinary Incontinence, Pelvic Organ Prolapse, Surgery
- Trial name
- NCT00376441
- Testing
- Vaginal Surgery
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Corewell Health East
Postoperative Physical Functioning
PREPARE: Perioperative REhabilitation Around Vaginal Prolapse RepAir Surgery for Recovery Enhancement
Pelvic organ prolapse is a common problem faced by millions of patients in the United States, leading to an estimated 200,000 surgeries per year.
- Trial name
- PREPARE (NCT07265973)
- Testing
- Pelvic floor Home Exercise Program, this intervention is comprised of specific exercises that are easy to complete at home
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Opioid Use, Surgical Recovery
Paracervical Injection and Opioid Use After Vaginal Hysterectomy for Prolapse
The goal of the study to see if giving a numbing medicine around the cervix (called a paracervical block) during vaginal hysterectomy with prolapse repair helps people feel less pain and need fewer strong pain medicines…
- Conditions
- Opioid Use, Surgical Recovery, Vaginal Hysterectomy, Prolapse Pelvic
- Trial name
- NCT07213635
- Testing
- Bupivacaine-epinephrine, Normal saline
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Pelvic Organ Prolapse
Anterior Prolapse Repair With and Without Graft Augmentation
This is a randomized control trial comparing anterior colporrhaphy with augmentation with dermal allograft (ARCUS) to anterior colporrhaphy with a suture-based repair (native tissue).
- Trial name
- ARCUS (NCT04085952)
- Testing
- dermal graft (ARCUS repliform) for anterior colporrhaphy, suture based anterior colporrhaphy
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Pelvic Organ Prolapse
Vaginal Orthosis Use After Vaginal Reconstructive Surgery
A novel vaginal orthosis, or splint, made of silicone will be used daily to help support the healing vaginal reconstruction during the post-operative phase from week 2 to week 12.
- Trial name
- NOVa (NCT05812859)
- Testing
- Vaginal Orthosis (COSM Medical)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Pelvic Organ Prolapse, Surgery
Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse
To date no study has determined prospectively which technique is superior to prevent recurrent Pelvic Organ Prolapse (POP) after vaginal hysterectomy- a major unmet clinical need.
- Conditions
- Pelvic Organ Prolapse, Surgery, Quality of Life, Complication
- Trial name
- NCT03113513
- Testing
- fixation of the vaginal apex
- Where
- Austria
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Vaginal Wall Prolapse
Surgical Repair of Vaginal Wall Prolapse Using Gamma Irradiated Amniotic Membrane as a Scaffold
The surgical repair of vaginal wall prolapse continues to remain one of the most difficult challenges in female pelvic floor reconstruction. The recurrence rate after standard colporrhaphy ranges from 40-60 %.
- Trial name
- NCT05355623
- Testing
- Vaginal Repair
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Egymedicalpedia
Vaginal Prolapse
Using a Sheathed Speculum to Visualize and Access the Cervix In Women With Excessive Vaginal Tissue
The main objective of the study is to assess the effectiveness of the sheathed speculum in providing adequate visualization and access to the cervix in patients with excessive vaginal tissue.
- Trial name
- NCT01409902
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Constipation, Prolapse, Vaginal
Effect of Preoperative Fiber on Postoperative Bowel Function
Post-operative constipation is one of the most common complaints after pelvic organ prolapse surgery. Psyillum fiber is an FDA-approved, over the counter dietary supplement that is commonly used to treat constipation.
- Trial name
- NCT04882995
- Testing
- Psyillium fiber
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Urinary Retention, Pelvic Organ Prolapse
Urinary Retention After Removing Urinary Catheter at 24 Hour Versus 48 Hour in Patients With Vaginal Surgery
Comparison incident of urinary retention in patients with vaginal surgery of pelvic organ prolapse, who removed urinary catheter at 24 hours versus 48 hours after surgery
- Trial name
- NCT04954443
- Testing
- Removing urinary catheter
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery
A Comparison Between Vaginal Sacrospinous Ligament Fixation and Laparoscopic Uterosacral Ligament Suspension as a Uterine Preserving Surgery for Pelvic Organ Prolapse
The investigators present a literature review evaluating the current place of sacrospinous hysteropexy in the surgical management of pelvic organ prolapse.
- Conditions
- Pelvic Organ Prolapse (POP), Pelvic Organ Prolapse Vaginal Surgery, Hysterectomy
- Trial name
- POP-Q USS USLS (NCT06982157)
- Where
- Israel
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Vaginal Vault Prolapse
Study of Cytrix Use in Pelvic Floor Prolapse Treatment
To evaluate safety and effectiveness of using the fetal bovine dermis (Cytrix) in the treatment of pelvic organ prolapse.
- Trial name
- NCT01244165
- Testing
- Cytrix, Other treatments for pelvic organ prolapse
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Boston Scientific Corporation