Clinical trials: Proliferative Diabetic Retinopathy
Retinal Detachment
Internal Limiting Membrane Flaps for Coexistent Macular Hole and Retinal Detachment
Purpose: To evaluate the logical surgical approaches in closing macular holes in eyes of proliferative diabetic retinopathy with retinal detachment
- Trial name
- ILMFCMHRDPDR (NCT03618498)
- Testing
- ILM flaps insertion techniques or free ILM flaps.
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- Changhua Christian Hospital
Proliferative Diabetic Retinopathy
Vitreous Levels of Cysteine-rich 61 in Patients With Proliferative Diabetic Retinopathy
To determine the vitreous levels of fractalkine, cysteine-rich 61 (Cyr61), and VEGF in patients with PDR. Verifying that it is greater to that found in non-diabetic patients with different non-angiogenetic diseases.
- Trial name
- VL (NCT01920984)
- Testing
- intravitreal injection of 1.25 mg of bevacizumab
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Proliferative Diabetic Retinopathy
Intravitreal Ranibizumab For Persistent New Vessels In Diabetic Retinopathy(Inipe Study)
To evaluate the fluorescein angiographic and visual acuity effects of a single intravitreal injection of ranibizumab for the management of persistent new vessels associated with diabetic retinopathy.
- Trial name
- INIPE (NCT00993525)
- Testing
- Intravitreal injection of ranibizumab
- Volunteers
- 22 people
- Sponsor
- University of Sao Paulo
Diabetic Retinopathy
Computer Detection of Diabetic Retinopathy Compared to Clinical Examination
The hypothesis is that computer detection of the severity of diabetic retinopathy including the presence of clinically significant macular edema is not inferior to the detection using a dilated eye examination by a…
- Trial name
- CDDR (NCT01625598)
- Testing
- Photography of the retina, Retinal photography
- Where
- 7 sites in United States
- Volunteers
- 600 people
- Sponsor
- Digital Diagnostics, Inc.
Non-proliferative Diabetic Retinopathy (NPDR), Diabetic Retinal Microangiopathy
A Preliminary Exploratory Clinical Trial to Evaluate the Efficacy of NPDR-01 Eye Drops in the Treatment of Non-Proliferative Diabetic Retinopathy
This study aims to explore the preliminary clinical efficacy and safety of NPDR-01 eye drops in patients with non-proliferative diabetic retinopathy (NPDR).
- Conditions
- Non-proliferative Diabetic Retinopathy (NPDR), Diabetic Retinal Microangiopathy, Retinal Microaneurysms, Diabetic Retinopathy
- Trial name
- NCT07198815
- Testing
- Investigational Eye Drops (NPDR-01)
- Volunteers
- 10 people
- Sponsor
- Sichuan Academy of Medical Sciences
Proliferative Diabetic Retinopathy (PDR)
Multicenter 12 Months Clinical Study to Evaluate Efficacy and Safety of Ranibizumab Alone or in Combination With Laser Photocoagulation vs. Laser Photocoagulation Alone in Proliferative Diabetic Retinopathy (PRIDE)
The purpose of this study was to assess the efficacy and safety of the anti-Vascular Endothelial Growth Factor (VEGF) agent ranibizumab (0.5 mg) with or without Panretinal laser photocoagulation (PRP) compared to PRP alone in…
- Trial name
- PRIDE (NCT01594281)
- Testing
- Ranibizumab 0.5 mg, Panretinal laser photocoagulation
- Where
- 23 sites in Germany
- Volunteers
- 107 people
- Sponsor
- Novartis Pharmaceuticals
Diabetic Retinopathy, Macular Edema
ILM Peeling in PDR Patients Undergoing PPV for VH
Subjects undergoing ILM peeling during vitrectomy will have better visual acuity and lower rates of DME to control subjects
- Trial name
- NCT03660371
- Testing
- PPV/MP, PPV without MP
- Where
- Mexico
- Volunteers
- 258 people
- Sponsor
- Rush Eye Associates
Diabetic Retinopathy, Vitreous Hemorrhage
IVB for Post-vitrectomy Hemorrhage in Diabetic Eyes
Recurrent vitreous hemorrhage following pars plana vitrectomy (PPV) for proliferative diabetic retinopathy remains a significant complication with reported incidence ranging from 11 to 75%.
- Trial name
- NCT06559488
- Testing
- Bevacizumab Injection [Avastin], Pars Plana Vitrectomy
- Where
- Indonesia
- Volunteers
- 18 people
- Sponsor
- Universitas Padjadjaran
Severe Nonproliferative, Proliferative Diabetic Retinopathy
Intravitreal Bevacizumab for Diabetic Retinopathy
Background: to evaluate the 3-month efficacy of a single dose of intravitreal bevacizumab on the progression of severe non proliferative diabetic retinopathy, proliferative diabetic retinopathy and active photocoagulated diabetic…
- Conditions
- Severe Nonproliferative, Proliferative Diabetic Retinopathy, Active Photocoagulated Diabetic Retinopathy
- Trial name
- NCT00600262
- Testing
- intravitreal bevacizumab
- Where
- Mexico
- Sponsor
- Asociación para Evitar la Ceguera en México
Proliferative Diabetic Retinopathy
Intravitreal Injection of Ranibizumab Versus Sham Before Vitrectomy in Patients With Proliferative Diabetic Retinopathy
Certain percent of the eyes with proliferative diabetic retinopathymay require pars plana vitrectomy (PPV) due to vitreous haemorrhage, proliferative membrane, and tractional retinal detachment.
- Trial name
- NCT02857491
- Testing
- ranibizumab, pars plana vitrectomy
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Sun Yat-sen University
Proliferative Diabetic Retinopathy
A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP)
The pilot study evaluates the efficacy and safety of Canakinumab (ILARIS®) in subjects with proliferative diabetic retinopathy secondary to type 1 and 2 diabetes.
- Trial name
- ILARIS (NCT01589029)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- PD Dr. med. Stephan Michels
Proliferative Diabetic Retinopathy
Propranolol for Diabetic Retinopathy
This study is investigating if the oral beta antagonist propranolol can induce regression of retinal neovascularization associated with proliferative diabetic retinopathy.
- Trial name
- NCT01535495
- Testing
- Propranolol
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- University of Wisconsin, Madison
Proliferative Diabetic Retinopathy
Evaluation of Treatment of High riSk proLiferative Diabetic retinopathY With Intravitreal Aflibercept injectioN
To assess the safety and efficacy of intravitreal aflibercept injection in the regression of retinal neovascularization secondary to high-risk PDR.
- Trial name
- ELYSIAN (NCT02630277)
- Testing
- Aflibercept
- Volunteers
- 30 people
- Sponsor
- Valley Retina Institute
Diabetes Mellitus
Fovea Sparing ILM Peeling in Diabetic Patients
The goal of this clinical trial is to compare between foveal sparing ILM peeling and total ILM peeling in diabetic patients (both type 1 and II) with proliferative diabetic retinopathy (PDR) indicated for pars plana vitrectomy…
- Trial name
- NCT07271719
- Testing
- Pars plana vitrectomy (PPV) with fovea sparing ILM peeling., PPV with total ILM peeling
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- David Nashaat Shafik Fahmy
Proliferative Diabetic Retinopathy
The Individually Marked Panretinal lasEr phoTokoagUlation for Proliferative Diabetic Retinopathy Study - DETECT
The purpose of this study is to determine the threshold level of proliferative diabetic retinopathy progression and regression after standard panretinal photocoagulation.
- Trial name
- IMPETUS-D (NCT02157350)
- Testing
- Panretinal laser photocoagulation
- Where
- Denmark
- Volunteers
- 65 people
- Sponsor
- Odense University Hospital
Proliferative Diabetic Retinopathy, Macular Degeneration
Analysis of Aqueous and Vitreous Humor
Clinical Retina research studies often collect aqueous samples in hopes of estimating levels of drug or cytokines in the vitreous. Little is known about how well vitreous and aqueous correlate.
- Conditions
- Proliferative Diabetic Retinopathy, Macular Degeneration, Macular Hole, Neovascular Glaucoma
- Trial name
- ARK (NCT02067013)
- Testing
- Ranibizumab, No Ranibizumab
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- California Retina Consultants
Wet AMD, Macular Oedema
Intravitreal Bevacizumab for Retinal Disorders
Bevacizumab is an anti-VEGF agent used in approved for use in metastatic colorectal carcinoma (FDA Approved). This study analyzes the safety and efficacy of off-label Intravitreal Injection of bevacizumab (Avastin) for CNVM…
- Conditions
- Wet AMD, Macular Oedema, Proliferative Diabetic Retinopathy
- Trial name
- NCT00403026
- Testing
- Bevacizumab ( Avastin)
- Where
- India
- Volunteers
- 150 people
- Sponsor
- Narayana Nethralaya
Proliferative Diabetic Retinopathy, Diabetic Macular Edema
Laser-Ranibizumab-Triamcinolone for Proliferative Diabetic Retinopathy
The purpose of the study is to find out if treatment with an intravitreal injection of triamcinolone or an intravitreal injection of ranibizumab can prevent loss of vision caused by panretinal photocoagulation treatment.
- Trial name
- LRTforDME+PRP (NCT00445003)
- Testing
- Ranibizumab, Triamcinolone Acetonide, Focal/grid laser
- Where
- 56 sites in United States
- Volunteers
- 333 people
- Sponsor
- Jaeb Center for Health Research
Rubeosis Iridis, Proliferative Diabetic Retinopathy
Use of Ranibizumab to Treat Rubeosis in Diabetics Prior to Cataract Surgery
The purpose of this study was to determine the safety of ranibizumab: a) as a surgical adjunct during cataract surgery in subjects with proliferative diabetic retinopathy (PDR) induced rubeosis and, b) in treatment of…
- Trial name
- NCT01069341
- Testing
- Ranibizumab
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Bhagat, Neelakshi, M.D., M.P.H.
Proliferative Diabetic Retinopathy, Diabetic Retinopathy
Single Session vs Multiple-Session Panretinal Photocoagulation for Treatment of Proliferative Diabetic Retinopathy
Proliferative diabetic retinopathy (PDR) is the leading cause for blindness in working-age adults. The current gold standard treatment for PDR is panretinal photocoagulation (PRP).
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Retinopathy, Diabetic Retinopathy Visually Threatening, Diabetic Macular Edema
- Trial name
- SMART-PRP (NCT06549023)
- Testing
- Single-session panretinal PRP (SS-PRP), Multiple-session panretinal PRP (MS-PRP)
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region