Clinical trials: Proliferative Diabetic Retinopathy
Proliferative Diabetic Retinopathy
A Pilot Study on the Effects of ILARIS® on Patients With Proliferative Diabetic Retinopathy (PDRP)
The pilot study evaluates the efficacy and safety of Canakinumab (ILARIS®) in subjects with proliferative diabetic retinopathy secondary to type 1 and 2 diabetes.
- Trial name
- ILARIS (NCT01589029)
- Testing
- CANAKINUMAB (ILARIS®)
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- PD Dr. med. Stephan Michels
High Risk Proliferative Diabetic Retinopathy
Prospective, Randomized, Multicenter, Open Label, Phase II Study to Access Efficacy and Safety of Lucentis® Monotherapy Compared With Lucentis® Plus Panretinal Photocoagulation (PRP) and PRP in the Treatment of Patients With High Risk Proliferative Diabetic Retinopathy
The purpose of this trial is to evaluate safety and to compare the efficacy of intravitreous injection of ranibizumab alone (0.5 mg), versus combination of intravitreous injection of ranibizumab (0.5 mg) plus panretinal…
- Trial name
- NCT01280929
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of ranibizumab
- Where
- 7 sites in Portugal
- Volunteers
- 54 people
- Sponsor
- José Cunha-Vaz
Proliferative Diabetic Retinopathy
Efficacy of Higher Cutting Rate in Microincision Vitrectomy for Proliferative Diabetic Retinopathy
The medical records of 393 eyes of 326 patients with severe proliferative diabetic retinopathy were reviewed. Higher cutting rate instruments (5000 cut per minute) were used in 174 eyes and conventional instruments in 219 eyes…
- Trial name
- NCT02464800
- Testing
- Vitrectomy for proliferative diabetic retinopathy
- Where
- Japan
- Volunteers
- 326 people
- Sponsor
- Kyorin University
Central Retinal Vein Occlusion, Proliferative Diabetic Retinopathy
Impact of Intravitreal Aflibercept Injections on Capillary Non-Perfusion
The purpose of this study is to look at how effective, safe, and well tolerated Intravitreal Aflibercept Injection is in subjects with Central Retinal Vein Occlusion (CRVO) or Proliferative Diabetic Retinopathy (PDR).
- Trial name
- ANDROID (NCT01724554)
- Testing
- Intravitreal Aflibercept Injection
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Ophthalmic Consultants of Boston
Proliferative Diabetic Retinopathy
Retinal Laser by Multi-spot Photocoagulator and Driving Eligibility
The purpose of this study is to determine the risk of failing the visual field criteria to hold a driving license following retinal laser treatment delivered with a multi-spot photocoagulator.
- Trial name
- NCT01383772
- Testing
- Pan retinal Photocoagulation
- Where
- United Kingdom
- Volunteers
- 43 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Proliferative Diabetic Retinopathy (PDR)
Comparison of Changes of Inflammatory Proteins in Aqueous Humour of Subjects Treated With Avastin vs Lucentis
PDR is a leading cause of irreversible vision loss in North America. This disease is caused by the growth of abnormal blood vessels in the retina.
- Trial name
- Humour (NCT01760746)
- Testing
- Injection of Avastin / Lucentis, sampling aqueous humour
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of British Columbia
Diabetic Retinopathy, Diabetic Macular Edema
Bevacizumab Versus Ranibizumab for Diabetic Retinopathy
Treatment of diabetic macular edema with perifoveal focal/grid laser coagulation was found to be effective saving the visual acuity only in 50% of patients and only 3-14% of treated patients had an improved visual acuity…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Proliferative Diabetic Retinopathy
- Trial name
- NCT00545870
- Testing
- bevacizumab, Ranibizumab
- Where
- Austria
- Volunteers
- 30 people
- Sponsor
- Ursula Schmidt-Erfurth, M.D.
Proliferative Diabetic Retinopathy, Macular Edema
Topic Ketorolac Added to Panphotocoagulation in Proliferative Diabetic Retinopathy
The purpose of this study is to determine the efficacy and safety of topic ketorolac in treatment for center point thickness secondary to panphotocoagulation in proliferative diabetic retinopathy.
- Trial name
- NCT00907114
- Testing
- Ketorolac tromethamine, Polivynilic alcohol
- Where
- Mexico
- Volunteers
- 44 people
- Sponsor
- Hospital Juarez de Mexico
High Risk Proliferative Diabetic Retinopathy, Diabetes Mellitus Type I
Prospective, Randomized, Open Label, Phase II Study to Assess Efficacy and Safety of Macugen® (Pegaptanib 0.3 mg Intravitreal Injections) Plus Panretinal Photocoagulation and PRP (Monotherapy) in the Treatment With High Risk PDR.
To evaluate the safety and determine the efficacy of PRP monotherapy or combination therapy (pegaptanib 0.3 mg plus PRP) in patients with Type I or Type II diabetes mellitus and with high risk proliferative diabetic retinopathy.
- Conditions
- High Risk Proliferative Diabetic Retinopathy, Diabetes Mellitus Type I, Diabetes Mellitus Type II
- Trial name
- NCT01281098
- Testing
- Panretinal Photocoagulation (PRP), Intravitreous injection of pegaptanib
- Where
- Portugal
- Volunteers
- 22 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Proliferative Diabetic Retinopathy, Macular Edema
Morphological and Functional Retinal Changes Following Retinal Photocoagulation
Imaging of retinal morphological changes with time secondary to laser treatment as assessed with high definition optical coherence tomography (OCT).
- Trial name
- pascal (NCT00682240)
- Testing
- laser treatment with PASCAL®, laser treatment with conventional laser system
- Where
- Austria
- Volunteers
- 64 people
- Sponsor
- Medical University of Vienna
Type 2 Diabetes, Non Proliferative Diabetic Retinopathy
Identifying Progression of Retinal Disease in Eyes With NPDR in Diabetes Type 2 Using Non-invasive Procedures
The purpose of this study is to identify eyes that show worsening and disease progression (progressor phenotypes).
- Trial name
- NCT01145599
- Where
- Portugal
- Volunteers
- 374 people
- Sponsor
- European Vision Institute Clinical Research Network
Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2
Diabetes Visual Function Supplement Study
This study will evaluate the effects of a novel multi-component dietary supplement on the visual function and retinal structure of patients with diabetes with both no diabetic retinopathy and mild to moderate diabetic…
- Conditions
- Diabetes Mellitus - Type 1, Diabetes Mellitus - Type 2, Non-proliferative Diabetic Retinopathy
- Trial name
- DiVFuSS (NCT01646047)
- Testing
- multi-component nutritional supplement capsules, multi-component dietary supplement
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- ZeaVision, LLC
Proliferative Diabetic Retinopathy
Vitrous Analysis in Proliferative Diabetic Retinopathy
Analysis of vitreous proteins in patients undergoing pars plana vitrectomy for proliferative diabetic retinopathy
- Trial name
- NCT01478763
- Where
- Sweden
- Volunteers
- 200 people
- Sponsor
- Anders Kvanta
Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment
Prospective Randomized Controlled Study of Intravitreal Injection of Bevacizumab for Proliferative Diabetic Retinopathy
We hypothesized that to reduce the adverse effects of intravitreal bevacizumab on ocular tissue and whole body, intravitreal injection of a low concentration of bevacizumab and conducting vitrectomy shortly after the injection is…
- Conditions
- Proliferative Diabetic Retinopathy, Diabetic Traction Retinal Detachment, Vitreous Hemorrhage
- Trial name
- NCT01854593
- Testing
- Bevacizumab, Vitrectomy
- Where
- Japan
- Volunteers
- 69 people
- Sponsor
- Nihon University
Proliferative Diabetic Retinopathy
A Study of the Safety, Tolerability, and Efficacy of IVT Pre-op 0.3mg Pegaptanib Sodium Versus Sham, for Management of Tractional Retinal Detachment and Vitreous Hemorrhage With Proliferative Diabetic Retinopathy
The purpose of this study is to assess whether preoperative pegaptanib sodium safely improves vitreous hemorrhage prior to surgical intervention and to evaluate the stability of pre-existing tractional retinal detachment.
- Trial name
- No-Crunch01 (NCT01589718)
- Testing
- Macugen
- Where
- United States
- Sponsor
- Greater Houston Retina Research
Non-proliferative Diabetic Retinopathy, Diabetes Mellitus Type 2
Efficacy of Ubiquinone and Combined Antioxidant Therapy in Non-proliferative Diabetic Retinopathy
The purpose of this study is to evaluate the efficacy of ubiquinone and combined antioxidant therapy on progression, clinical regression, oxidative stress markers and mitochondrial dysfunction in non-proliferative diabetic…
- Trial name
- NCT02062034
- Testing
- Ubiquinone, Combined antioxidant therapy
- Where
- Mexico
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Guadalajara
Proliferative Diabetic Retinopathy
PASCAL Laser Versus ETDRS Laser Associated With Intravitreal Ranibizumab (IVR) Versus Only IVR for Proliferative Diabetic Retinopathy
Objectives: Primary objective: To evaluate the effects on retinal morphophysiology of full scatter single target panretinal photocoagulation (PRP) versus full scatter multiple target panretinal photocoagulation (both combined…
- Trial name
- NCT02005432
- Testing
- Intravitreal Ranibizumabe, panfotocoagulation (PASCAL), panfotocoagulation (PRP) single shoot (ETDRS)
- Where
- Brazil
- Volunteers
- 31 people
- Sponsor
- University of Sao Paulo
Proliferative Diabetic Retinopathy
Gene Expression in Patients With Epiretinal Membranes
The purpose of this study was to investigate the expression of selected genes both in epiretinal membranes (ERMs) and peripheral blood mononuclear cells (PBMCs) from patients with primary and secondary epiretinal membranes in…
- Trial name
- NCT01946451
- Where
- Poland
- Sponsor
- Medical University of Silesia
Proliferative Diabetic Retinopathy
Vitreous Levels of Cysteine-rich 61 in Patients With Proliferative Diabetic Retinopathy
To determine the vitreous levels of fractalkine, cysteine-rich 61 (Cyr61), and VEGF in patients with PDR. Verifying that it is greater to that found in non-diabetic patients with different non-angiogenetic diseases.
- Trial name
- VL (NCT01920984)
- Testing
- intravitreal injection of 1.25 mg of bevacizumab
- Where
- Taiwan
- Volunteers
- 100 people
- Sponsor
- National Taiwan University Hospital
Non Proliferative Diabetic Retinopathy, Proliferative Diabetic Retinopathy
Effect of Folic Acid, Vitamin B6 and Vitamin B12 in Diabetic Retinopathy
Homocysteine, a well-known inducer of vascular endothelial cell damage has been associated with extracellular matrix changes. Many studies demonstrated that high levels of this aminoacid in diabetic patients increases…
- Trial name
- NCT01921192
- Testing
- Folic Acid, vit B6 and B12
- Where
- Italy
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Catania