Clinical trials: Prolonged Air Leak
Prolonged Air Leak, Postoperative Air Leak
Neoveil® Versus TachoSil® for the Treatment of Pulmonary Air Leaks Following Lung Operation
Postoperative prolonged air leak (PAL), referring to the passage of air from the lung parenchyma into the pleural space, is one of the most frequent postoperative complications after lung resection.
- Trial name
- NCT04065880
- Testing
- TachoSil®, Neoveil®
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Basel, Switzerland
Postoperative Air Leak
Prolonged Air Leakage After Major Lung Resection
The goal of this prospective randomized controlled trial is to investigate the clinical effects of autologous blood pleurodesis in the treatment of pulmonary air leaks on the first postoperative day following VATS pulmonary…
- Trial name
- PRAL (NCT05638113)
- Testing
- Pleural injection of autologous blood
- Where
- Denmark
- Volunteers
- 182 people
- Sponsor
- Odense University Hospital
Prolonged Air Leak
IBV Valve System for the Treatment of Prolonged Air Leak Under HDE H060002 - Post Approval Study
Study to collect post-market safety data for HUD IBV Valve System, a device to control prolonged air leaks of the lung, or significant air leaks that are likely to become prolonged air leaks following lobectomy, segmentectomy, or…
- Trial name
- HUD-PAS (NCT01166516)
- Testing
- Treatment with HUD IBV Valve System
- Where
- 13 sites in United States
- Volunteers
- 32 people
- Sponsor
- Olympus Corporation of the Americas
Prolonged Air Leak, Phrenic Nerve
Postoperative Effects of Intraoperative Temporary Phrenic Nerve Paralysis in Lung Resection Surgery
This prospective clinical study aimed to evaluate the postoperative effects of temporary phrenic nerve paralysis induced by intraoperative phrenic nerve crush during lung resection surgery.
- Conditions
- Prolonged Air Leak, Phrenic Nerve, EMG
- Trial name
- PNCrush (NCT07259031)
- Testing
- İntraoperative phrenic nerve compression
- Where
- Turkey (Türkiye)
- Volunteers
- 55 people
- Sponsor
- Ferdane Melike Duran
Lung Cancer
Prolonged Air Leak (PAL) Autologous Blood Patch Intervention Trial
A postoperative autologous blood patch (ABP) intervention trial for patients who underwent lung resection for cancer to examine its effectiveness in preventing a prolonged air leak.
- Trial name
- NCT04954625
- Testing
- Autologous Blood Patch, Standard of Care (per Physician)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Rush University Medical Center
Prolonged Air Leak, Post-operative Pain
Phrenic Nerve Infiltration: Pulmonary Expansion and Pain Control
Between January 2021-2023, 65 consecutive patients at risk for PAL (defined in accordance to "2019 Society of Thoracic Surgery score-criteria of PAL") underwent lung resection (lobectomy or sublobar resection) for malignancy.
- Trial name
- NCT06356038
- Testing
- intra-operative phrenic nerve infiltration
- Where
- Italy
- Volunteers
- 66 people
- Sponsor
- Azienda Ospedaliera "Sant'Andrea"
Pulmonary Air Leaks
Spiration Valves Against Standard Therapy
VAST is a multicenter, prospective, randomized, controlled study designed to evaluate treatment of persistent air leak with the SVS as compared to standard chest tube drainage management and other standard-of-care interventions…
- Trial name
- VAST (NCT02382614)
- Testing
- Spiration Valve System
- Where
- 20 sites in United States
- Volunteers
- 75 people
- Sponsor
- Olympus Corporation of the Americas
Surgical Procedures, Operative
A Study Comparing ETHICON™ 4000 Stapler System With Standard of Care Stapling Devices in Adults Undergoing Gastric and Thoracic Procedures
The purpose of this study is to compare how well the ETHICON™ 4000 Stapler works as compared to the standard stapling devices by assessing how often air leaks and bleeding along the staple line occur during lung and stomach…
- Trial name
- NCT07744568
- Testing
- ETHICON™ 4000 Stapler System, Standard of Care Stapler and Reloads
- Volunteers
- 300 people
- Sponsor
- Ethicon Endo-Surgery
Pronlongated Alveolar Air Leak (PAAL)
Predictive Value of Intraoperative Ventilatory Leak Flow in Prolonged Alveolar Air Leak After Lung Resection Surgery
After lung resection surgery, patients usually receive a postoperative pleural drain. Prolongated alveolar air leak (PAAL) is a frequent complication after lung surgery (6 to 26% of patients), defined by the European Society of…
- Trial name
- AIR-LEAK (NCT03742739)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Montpellier
Thoracic Surgery Lung, Post-operative Thoracic Air Leak
A Phase II Prospective, Single Blinded, Randomized Trial of Hemopatch Compared to Standard Techniques to Achieve Air Leak Control After Complex Thoracic Surgical Procedures
The purpose of this study is to explore whether the addition of Hemopatch to standard care can reduce prolonged air leaks and shorten the use of air drainage tube after surgery in thoracic lung surgery patients at high risk for…
- Trial name
- Hemopatch (NCT02364791)
- Testing
- standard techniques used to achieve air leak control, Hemopatch
- Where
- Italy
- Volunteers
- 120 people
- Sponsor
- National Cancer Institute, Naples
Lung, Lung Adenocarcinoma
Reinforced and Non-Reinforced Staple Lines in Fissureless Lobectomy
Prolonged Air Leak (PAL) is a common and serious problem after lung surgery. It can lead to worse patient outcomes, longer hospital stays, and higher costs.
- Conditions
- Lung, Lung Adenocarcinoma, Lung Adenosquamous Carcinoma, Lung Cancer, Non-Small Cell
- Trial name
- NCT06602661
- Testing
- Fissureless Lobectomy with Reinforced Staple Lines, Fissureless Lobectomy with Non-Reinforced Staple Lines
- Where
- Canada
- Volunteers
- 65 people
- Sponsor
- Surrey Thoracic Surgery Group
Prolonged Air Leak, Lung Resection
Effectiveness Novel Tissue Sealant, Prevention Prolonged Air Leak (PAL) After Lung Resection
The effectiveness of tissue sealants to prevent Prolonged Air Leak (PAL) after lung resection procedures remains unproved. The investigators hypothesize that one of the main reasons for that is the heterogeneity of previously…
- Trial name
- NCT02491671
- Testing
- Hemopatch, standard preventive measures
- Where
- 6 sites in Spain
- Volunteers
- 260 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Prolonged Air Leak, Persistent Air Leak
Comparison of 40% Glucose Solution and Autologous Blood Patch Pleurodesis for Postoperative Air Leak After Lung Resections
Prolonged or persistent air leak (PAL) is one of the most common complications in patients after surgery on the lung parenchyma.
- Trial name
- GLUC-PAL (NCT06936969)
- Testing
- Autologous blood patch pleurodesis, 40% glucose solution pleurodesis
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Wielkopolskie Centrum Pulmonologii i Torakochirurgii
Prolonged Air Leak
Discharged With Indwelling Chest Tube and Valve
This study is a multicenter, randomized trial for the treatment of subjects discharging from the hospital with a chest tube and valve in place.
- Trial name
- NCT03943511
- Testing
- Oral Antibiotics-Close Monitoring, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 25 people
- Sponsor
- Mayo Clinic