Clinical trials: Prolonged Mechanical Ventilation
Mechanical Ventilation
Study of Muscle Effects of BYM338 in Mechanically Ventilated Patients
The purpose of this study is to evaluate the effect of BYM338 on muscle mass and function in Group III failure to wean patients, as compared to placebo controls.
- Trial name
- NCT01868685
- Testing
- BYM338
- Sponsor
- Novartis Pharmaceuticals
Critical Illness Polyneuropathies
Role of Anabolic Steroids on Intensive Care Unit-Acquired Weakness
The researchers intend to investigate possible anabolic effects of bi-weekly exogenous testosterone administration during intensive care unit (ICU) stay for up to 8 weeks.
- Trial name
- RAS-ICU (NCT03038919)
- Testing
- Testosterone cypionate, Standard nutrition and physical therapy at ICU
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Hospital de Clinicas de Porto Alegre
Nosocomial Infections
Bovine Lactoferrin as a Natural Regimen of Selective Decontamination of the Digestive Tract in Patients With Prolonged Mechanical Ventilation
Nosocomial infection with antibiotic-resistant strains is a major threat to critical care medicine. Selective decontamination of the digestive tract (SDD) is one of the strategies to reduce ventilator associated pneumonia and…
- Trial name
- LFasSDD (NCT01535170)
- Testing
- bovine Lactoferrin
- Where
- Taiwan
- Volunteers
- 280 people
- Sponsor
- China Medical University Hospital
Acute Mechanical Ventilatory Failure
Weaning From Prolonged Mechanical Ventilation
Patients requiring the use of artificial ventilation (also called mechanical ventilation) for more than 21 days account for more than 37% of all ICU costs.
- Trial name
- NCT01541462
- Testing
- Weaning
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- RML Specialty Hospital
Ventilator-Induced Diaphragm Dysfunction
Study of TransAeris® System for Enhanced Recovery After Surgery in France
This study will be conducted as a randomized trial of the TransAeris system for the prevention and treatment of ventilator-induced diaphragm dysfunction (VIDD) in patients identified prior to surgery to be at greater risk of…
- Trial name
- ERAS (NCT05404477)
- Testing
- TransAeris System
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Synapse Biomedical
Mechanical Ventilation Complication
Effects of Growth Hormone on Difficult Ventilator Weaning Patients
Major abdominal surgeries may be followed by postoperative pulmonary complications (PPCs). These complications are common and can cause significant morbidity and mortality.
- Trial name
- NCT03717168
- Testing
- Recombinant human growth hormone, Control
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Prolonged Mechanical Ventilation, Ventilator Weaning
Effects of Mobilization Using a Powered Lower-limb Exoskeleton With Prolonged Mechanical Ventilation
This study aims to evaluate the effects of powered lower-limb exoskeleton-assisted training on lower limb strength, respiratory parameters, 28-day ventilator-free days, and length of hospital stay in patients with prolonged…
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Ventilator Dependent, Exoskeleton Device
- Trial name
- NCT07445035
- Testing
- lower-limb exoskeleton, Standard medical treatment
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Fu Jen Catholic University
Mechanical Ventilation Complication
Effect of Intermittent Versus Continuous Subglottic Secretion Drainage on Tracheal Mucosa Damages
Endotracheal tubes with subglottic secretion drainage (incorporating a suction port above the cuff) have been shown to reduce the incidence of ventilator-associated pneumonia.
- Trial name
- ASPIRE (NCT01555229)
- Testing
- Intermittent subglottic secretion drainage, Continuous subglottic secretion drainage
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Rennes University Hospital
Adults With Cardiopulmonary Disease at Risk of Prolonged Weaning From Mechanical Ventilation
Neurally Adjusted Ventilatory Assist in Adults at Risk of Delayed Weaning From Mechanical Ventilation
Many patients admitted to intensive care have heart or lung problems. Patients with these conditions often require longer durations of support from breathing machines.
- Trial name
- RESTUS (NCT01826890)
- Testing
- NAVA Technology
- Where
- United Kingdom
- Volunteers
- 78 people
- Sponsor
- King's College Hospital NHS Trust
Tracheostomy, Prolonged Mechanical Ventilation
Incremental Dead Space Versus Capping Trial Before Tracheostomy Decannulation
Some critically ill patients need a breathing tube placed directly into the windpipe (tracheostomy) because they require long-term help from a breathing machine.
- Conditions
- Tracheostomy, Prolonged Mechanical Ventilation, Tracheostomy Decannulation
- Trial name
- NCT07810166
- Testing
- Incremental Instrumental Dead Space, Capping Trial
- Where
- Chile
- Volunteers
- 22 people
- Sponsor
- Pontificia Universidad Catolica de Chile
Prolonged Mechanical Ventilation in Pediatric Intensive Care Unit
LongVentKids Study
Scientific advances, population growth, lower mortality, and increasing complexity of diseases have boosted up the number of patients requiring prolonged breathing assistance with mechanical ventilators in the pediatric intensive…
- Trial name
- LVK (NCT04112459)
- Testing
- prolonged mechanical ventilation
- Where
- Canada
- Volunteers
- 6,000 people
- Sponsor
- St. Justine's Hospital
Respiratory Failure, Respiration, Artificial
Proportional Assisted Ventilation and Pressure Support Ventilation in Adult Patients With Prolonged Ventilation
A prospective randomized controlled trial was conducted to collect patients with prolonged mechanical ventilation. Patients were randomly assigned to receive PAV+ or PSV as weaning mode.
- Trial name
- NCT04140682
- Testing
- PAV+ mode, PSV mode
- Where
- Taiwan
- Volunteers
- 44 people
- Sponsor
- Kaohsiung Veterans General Hospital.
Dysphagia, NeuroMuscular Electrical Stimulation
Effectiveness of Transcutaneous NMES as an Adjunct for Swallowing Disorders in Tracheotomized Patients
Dysphagia can reach a prevalence of up to 80% in intensive care patients. The implementation or prolonged presence of medical devices such as the intubation tube, tracheostomy, or nasogastric tube alters the physiology of…
- Trial name
- SWALEC (NCT07529210)
- Testing
- Neuromuscular Electrical Stimulation (NMES)
- Volunteers
- 238 people
- Sponsor
- Hopital Forcilles
Delirium, Cognitive Impairment
The SOMNUS Study: Sedative Optimization Via Monitoring Neurological Status
A combined strategy of Richmond Agitation and Sedation Scale (RASS) clinical targeting plus bispectral index (BIS) guided sedation in mechanically ventilated, critically ill patients will decrease time on mechanical ventilation…
- Conditions
- Delirium, Cognitive Impairment, Critically Ill
- Trial name
- SOMNUS (NCT00469482)
- Testing
- Sedation,RASS Targeted plus BIS Monitoring, Sedation, RASS Targeted
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Vanderbilt University Medical Center
Prolonged Mechanical Ventilation
Epidemiological Survey of Children With Prolonged Mechanical Ventilation.
Mechanical ventilation is an effective treatment for respiratory failure, no more than ten percent of patients with respiratory failure need long-term mechanical ventilation.
- Trial name
- NCT04511741
- Testing
- no intervention, it is an observational study.
- Where
- China
- Volunteers
- 346 people
- Sponsor
- Children's Hospital of Fudan University
PMV
Abdominal Weight Training Assisted by Cough Assist Machine on Lung Function
The patients with prolonged mechanical ventilation (PMV) have the risk of ineffective coughing and infection due to diaphragm weakness, making it more difficult to wean.
- Trial name
- NCT05295381
- Testing
- cough machine (CM), abdominal weight training (AWT)
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Liu Shih Feng
Patients With Postoperative Mechanical Ventilation After Liver Transplantation
Inflammatory Gene Polymorphism and Prolonged Mechanical Ventilation After Liver Transplantation
Mechanical ventilatory lung care is essential for postoperative care in liver transplantation recipients, for such patients are under massive fluid challenge and hemodynamic alterations perioperatively.
- Trial name
- NCT02402634
- Testing
- Mechanical ventilatory lung care
- Where
- South Korea
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Prolonged Mechanical Ventilation, Ventilator Weaning
Standardized Tracheostomy Weaning Protocol for Prolonged Mechanical Ventilation
This study evaluated the feasibility and clinical outcomes of a standardized weaning protocol for tracheostomized patients requiring prolonged mechanical ventilation.
- Conditions
- Prolonged Mechanical Ventilation, Ventilator Weaning, Tracheostomy
- Trial name
- NCT06642714
- Testing
- Standardized Stepwise Weaning Protocol
- Where
- China
- Volunteers
- 250 people
- Sponsor
- Capital Medical University
High Flow Oxygen Therapy
Physiologic and Clinical Effect of High-flow Oxygen Therapy in Tracheostomized Patients With Prolonged Mechanical Ventilation Undergoing Weaning Trials
This study is aimed at patients who have been admitted to the respiratory care center of this hospital who meet the PMV conditions (defined as continuous use of the ventilator for at least ten days) who are about to receive the…
- Trial name
- NCT06357390
- Where
- Taiwan
- Volunteers
- 10 people
- Sponsor
- National Taiwan University Hospital
Respiration, Artificial
Use of a New Isokinetic Device for Inspiratory Muscle Training
Introduction: It is well established that physical fitness improves muscle performance either in sedentary people or in athletes.
- Trial name
- NCT02932189
- Testing
- Inspiratory muscle training
- Where
- Brazil
- Volunteers
- 102 people
- Sponsor
- Universidade Federal Fluminense